SG11201807038UA - Rodents having a humanized tmprss gene - Google Patents
Rodents having a humanized tmprss geneInfo
- Publication number
- SG11201807038UA SG11201807038UA SG11201807038UA SG11201807038UA SG11201807038UA SG 11201807038U A SG11201807038U A SG 11201807038UA SG 11201807038U A SG11201807038U A SG 11201807038UA SG 11201807038U A SG11201807038U A SG 11201807038UA SG 11201807038U A SG11201807038U A SG 11201807038UA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- new york
- tarrytown
- rule
- rodents
- Prior art date
Links
- 241000283984 Rodentia Species 0.000 title abstract 6
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 239000003814 drug Substances 0.000 abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 235000011512 Angelica atropurpurea Nutrition 0.000 abstract 1
- 101100207058 Mus musculus Tmprss2 gene Proteins 0.000 abstract 1
- 101100260872 Mus musculus Tmprss4 gene Proteins 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 241000700159 Rattus Species 0.000 abstract 1
- 244000068666 Smyrnium olusatrum Species 0.000 abstract 1
- 235000007036 Smyrnium olusatrum Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0337—Animal models for infectious diseases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization IIIMI41101110101011111 HO 11111011101 Ell 01011111101100111110 1111 III International Bureau 0.. .... .. (10) International Publication Number ..... ...,/ (43) International Publication Date WO 2017/151453 Al 8 September 2017 (08.09.2017) WIP0 I PCT (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, AO1K 67/027 (2006.01) Cl 2N 9/64 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, PCT/US2017/019574 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (22) International Filing Date: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 27 February 2017 (27.02.2017) NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (25) Filing Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (26) Publication Language: English ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 62/301,023 29 February 2016 (29.02.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: REGENERON PHARMACEUTICALS, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, INC. [US/US]; 777 Old Saw Mill River Road, Tarrytown, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, New York 10591-6707 (US). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) L Inventors: PURCELL NGAMBO, Lisa; c/o Regeneron V, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Pharmaceuticals, Inc., 777 Old Saw Mill River Road, GW, KM, ML, MR, NE, SN, TD, TG). Tarrytown, New York 10591-6707 (US). MUJICA, Alex- ander 0.; c/o Regeneron Pharmaceuticals, Inc., 777 Old Declarations under Rule 4.17: Saw Mill River Road, Tarrytown, New York 10591-6707 — as to applicant's entitlement to apply for and be a granted (US). TANG, Yajun; c/o Regeneron Pharmaceuticals, patent (Rule 4.17(ii)) Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591-6707 (US). — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Agent: GROLZ, Edward W.; Scully, Scott, Murphy & (74) Presser, 400 Garden City Plaza, Suite 300, Garden City, Published: New York 11530 (US). — with international search report (Art. 21(3)) Designated States (unless otherwise indicated, for every _ with sequence listing part of description (Rule 5.2(a)) kind of national protection available): AE, AG, AL, AM, (81) Il M kir) 71- 1-1 kir) 1-1 IN 1-1 © (54) ei Title: RODENTS HAVING A HUMANIZED TMPRSS GENE 0 (57) : Genetically modified rodents such as mice and rats, and methods and compositions for making and using the same, are provided. The rodents comprise a humanization of at least one endogenous rodent Tmprss gene, such as an endogenous rodent Tmprss2, Tmprss4, or Tmprss 1 1 d gene.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662301023P | 2016-02-29 | 2016-02-29 | |
PCT/US2017/019574 WO2017151453A1 (en) | 2016-02-29 | 2017-02-27 | Rodents having a humanized tmprss gene |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201807038UA true SG11201807038UA (en) | 2018-09-27 |
Family
ID=58264641
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201807038UA SG11201807038UA (en) | 2016-02-29 | 2017-02-27 | Rodents having a humanized tmprss gene |
SG10202001578RA SG10202001578RA (en) | 2016-02-29 | 2017-02-27 | Rodents having a humanized tmprss gene |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202001578RA SG10202001578RA (en) | 2016-02-29 | 2017-02-27 | Rodents having a humanized tmprss gene |
Country Status (14)
Country | Link |
---|---|
US (4) | US10070632B2 (en) |
EP (2) | EP3422845B1 (en) |
JP (1) | JP6980674B2 (en) |
KR (2) | KR20230021759A (en) |
CN (1) | CN109068621B (en) |
AU (1) | AU2017228293B2 (en) |
CA (1) | CA3014645C (en) |
DK (1) | DK3422845T3 (en) |
ES (1) | ES2886958T3 (en) |
IL (1) | IL261139B (en) |
PT (1) | PT3422845T (en) |
RU (1) | RU2749715C2 (en) |
SG (2) | SG11201807038UA (en) |
WO (1) | WO2017151453A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT3422845T (en) | 2016-02-29 | 2021-08-26 | Regeneron Pharma | Rodents having a humanized tmprss gene |
CN111163633B (en) * | 2017-09-29 | 2022-09-09 | 瑞泽恩制药公司 | Non-human animals comprising humanized TTR loci and methods of use thereof |
LT3638698T (en) | 2018-01-26 | 2021-04-12 | Regeneron Pharmaceuticals, Inc. | Anti-tmprss2 antibodies and antigen-binding fragments |
CN116200426A (en) | 2018-07-16 | 2023-06-02 | 瑞泽恩制药公司 | Non-human animal model of DITRA disease and uses thereof |
EP3911154A1 (en) | 2019-01-17 | 2021-11-24 | Regeneron Pharmaceuticals, Inc. | A rodent model of mood disorders |
CA3163164A1 (en) | 2020-02-10 | 2021-08-19 | Alina Baum | Anti-tmprss2 antibodies and antigen-binding fragments |
CN115161326A (en) * | 2021-06-21 | 2022-10-11 | 百奥赛图(北京)医药科技股份有限公司 | SOST gene humanized non-human animal and construction method and application thereof |
WO2023122506A1 (en) * | 2021-12-20 | 2023-06-29 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising humanized ace2 and tmprss loci |
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BR112017021250A2 (en) | 2015-04-06 | 2018-06-26 | Regeneron Pharma | humanized t-cell mediated immune responses in non-human animals |
AU2016358101B2 (en) | 2015-11-20 | 2022-12-01 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized Lymphocyte-activation gene 3 |
PT3422845T (en) | 2016-02-29 | 2021-08-26 | Regeneron Pharma | Rodents having a humanized tmprss gene |
KR101693243B1 (en) | 2016-06-15 | 2017-01-05 | 재단법인 한국파스퇴르연구소 | Novel human gene crucial for the replication of influenza virus and use thereof |
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2017
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- 2017-02-27 US US15/442,857 patent/US10070632B2/en active Active
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EP3422845B1 (en) | 2021-06-02 |
CN109068621B (en) | 2021-07-20 |
DK3422845T3 (en) | 2021-08-30 |
US10070632B2 (en) | 2018-09-11 |
US20170245482A1 (en) | 2017-08-31 |
ES2886958T3 (en) | 2021-12-21 |
SG10202001578RA (en) | 2020-04-29 |
CN109068621A (en) | 2018-12-21 |
CA3014645A1 (en) | 2017-09-08 |
EP3422845A1 (en) | 2019-01-09 |
JP6980674B2 (en) | 2021-12-15 |
RU2749715C2 (en) | 2021-06-16 |
US20210068377A1 (en) | 2021-03-11 |
IL261139B (en) | 2022-04-01 |
US20170290308A1 (en) | 2017-10-12 |
KR20230021759A (en) | 2023-02-14 |
US10863729B2 (en) | 2020-12-15 |
KR20180117122A (en) | 2018-10-26 |
US20180332831A1 (en) | 2018-11-22 |
US11910787B2 (en) | 2024-02-27 |
AU2017228293A1 (en) | 2018-08-23 |
WO2017151453A1 (en) | 2017-09-08 |
RU2018131152A3 (en) | 2020-07-13 |
IL261139A (en) | 2018-10-31 |
JP2019511918A (en) | 2019-05-09 |
EP3895529A1 (en) | 2021-10-20 |
US10070631B2 (en) | 2018-09-11 |
KR102493894B1 (en) | 2023-01-31 |
RU2018131152A (en) | 2020-04-01 |
CA3014645C (en) | 2022-10-25 |
PT3422845T (en) | 2021-08-26 |
AU2017228293B2 (en) | 2023-05-25 |
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