JP2010514421A5 - - Google Patents

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Publication number
JP2010514421A5
JP2010514421A5 JP2009543253A JP2009543253A JP2010514421A5 JP 2010514421 A5 JP2010514421 A5 JP 2010514421A5 JP 2009543253 A JP2009543253 A JP 2009543253A JP 2009543253 A JP2009543253 A JP 2009543253A JP 2010514421 A5 JP2010514421 A5 JP 2010514421A5
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JP
Japan
Prior art keywords
vegf
animal
hum
nucleic acid
acid molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2009543253A
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English (en)
Japanese (ja)
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JP2010514421A (ja
JP5389665B2 (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/088537 external-priority patent/WO2008080052A1/en
Publication of JP2010514421A publication Critical patent/JP2010514421A/ja
Publication of JP2010514421A5 publication Critical patent/JP2010514421A5/ja
Application granted granted Critical
Publication of JP5389665B2 publication Critical patent/JP5389665B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2009543253A 2006-12-22 2007-12-21 ヒト化ｖｅｇｆを発現するトランスジェニックマウス Expired - Fee Related JP5389665B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87173606P 2006-12-22 2006-12-22
US60/871,736 2006-12-22
PCT/US2007/088537 WO2008080052A1 (en) 2006-12-22 2007-12-21 Transgenic mice expressing humanized vegf

Publications (3)

Publication Number Publication Date
JP2010514421A JP2010514421A (ja) 2010-05-06
JP2010514421A5 true JP2010514421A5 (enExample) 2011-08-18
JP5389665B2 JP5389665B2 (ja) 2014-01-15

Family

ID=39367511

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009543253A Expired - Fee Related JP5389665B2 (ja) 2006-12-22 2007-12-21 ヒト化ｖｅｇｆを発現するトランスジェニックマウス

Country Status (5)

Country Link
US (1) US8110720B2 (enExample)
EP (1) EP2099920B1 (enExample)
JP (1) JP5389665B2 (enExample)
ES (1) ES2497496T3 (enExample)
WO (1) WO2008080052A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105950654B (zh) 2010-11-27 2020-03-20 朱坚 一种人源化的转基因动物
WO2014131833A1 (en) * 2013-02-27 2014-09-04 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Gene editing in the oocyte by cas9 nucleases
US20140273031A1 (en) * 2013-03-15 2014-09-18 The Cleveland Clinic Foundation In-vitro method for monoclonal antibody production
ES2691529T3 (es) 2014-05-30 2018-11-27 Regeneron Pharmaceuticals, Inc. Animales con dipeptidil peptidasa iv (dpp4) humanizada
EP3405790B1 (en) * 2016-01-19 2023-06-28 Celgene Corporation Transgenic mouse expressing human cereblon

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5332671A (en) * 1989-05-12 1994-07-26 Genetech, Inc. Production of vascular endothelial cell growth factor and DNA encoding same
US6130071A (en) * 1997-02-05 2000-10-10 Helsinki University Licensing, Ltd. Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof
US6479729B1 (en) * 1998-02-06 2002-11-12 The Johns Hopkins University Mouse model for ocular neovascularization
WO2005042575A2 (en) * 2003-10-30 2005-05-12 Pharmexa A/S Method for down-regulation of vegf

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