JP2017511135A5 - - Google Patents
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- JP2017511135A5 JP2017511135A5 JP2016559573A JP2016559573A JP2017511135A5 JP 2017511135 A5 JP2017511135 A5 JP 2017511135A5 JP 2016559573 A JP2016559573 A JP 2016559573A JP 2016559573 A JP2016559573 A JP 2016559573A JP 2017511135 A5 JP2017511135 A5 JP 2017511135A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- patient
- therapeutic
- proximal region
- bike
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims 20
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 9
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 9
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 7
- 239000012528 membrane Substances 0.000 claims 6
- 230000001225 therapeutic effect Effects 0.000 claims 5
- 239000012636 effector Substances 0.000 claims 4
- 238000012986 modification Methods 0.000 claims 4
- 230000004048 modification Effects 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 230000035945 sensitivity Effects 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims 2
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 102000043279 ADAM17 Human genes 0.000 claims 1
- 108091007505 ADAM17 Proteins 0.000 claims 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 229960004641 rituximab Drugs 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461971996P | 2014-03-28 | 2014-03-28 | |
| US61/971,996 | 2014-03-28 | ||
| PCT/US2015/022998 WO2015148926A1 (en) | 2014-03-28 | 2015-03-27 | Polypeptides, cells, and methods involving engineered cd16 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020188582A Division JP7091423B2 (ja) | 2014-03-28 | 2020-11-12 | 改変ｃｄ１６が関係するポリペプチド、細胞、及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017511135A JP2017511135A (ja) | 2017-04-20 |
| JP2017511135A5 true JP2017511135A5 (enExample) | 2018-05-17 |
| JP6795399B2 JP6795399B2 (ja) | 2020-12-02 |
Family
ID=52829414
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016559573A Active JP6795399B2 (ja) | 2014-03-28 | 2015-03-27 | 改変ｃｄ１６が関係するポリペプチド、細胞、及び方法 |
| JP2020188582A Active JP7091423B2 (ja) | 2014-03-28 | 2020-11-12 | 改変ｃｄ１６が関係するポリペプチド、細胞、及び方法 |
| JP2022096496A Active JP7575426B2 (ja) | 2014-03-28 | 2022-06-15 | 改変ｃｄ１６が関係するポリペプチド、細胞、及び方法 |
| JP2024182081A Pending JP2025004257A (ja) | 2014-03-28 | 2024-10-17 | 改変ｃｄ１６が関係するポリペプチド、細胞、及び方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020188582A Active JP7091423B2 (ja) | 2014-03-28 | 2020-11-12 | 改変ｃｄ１６が関係するポリペプチド、細胞、及び方法 |
| JP2022096496A Active JP7575426B2 (ja) | 2014-03-28 | 2022-06-15 | 改変ｃｄ１６が関係するポリペプチド、細胞、及び方法 |
| JP2024182081A Pending JP2025004257A (ja) | 2014-03-28 | 2024-10-17 | 改変ｃｄ１６が関係するポリペプチド、細胞、及び方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US10464989B2 (enExample) |
| EP (2) | EP3122769B1 (enExample) |
| JP (4) | JP6795399B2 (enExample) |
| CN (2) | CN113699159A (enExample) |
| AU (3) | AU2015235852B2 (enExample) |
| CA (1) | CA2944199C (enExample) |
| ES (1) | ES2941679T3 (enExample) |
| PT (1) | PT3122769T (enExample) |
| WO (1) | WO2015148926A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10464989B2 (en) | 2014-03-28 | 2019-11-05 | Regents Of The University Of Minnesota | Polypeptides, cells, and methods involving engineered CD16 |
| JP6800859B2 (ja) | 2015-01-26 | 2020-12-16 | フェイト セラピューティクス，インコーポレイテッド | 造血細胞分化を誘導するための方法および組成物 |
| CN108368520B (zh) * | 2015-11-04 | 2023-01-17 | 菲特治疗公司 | 多能细胞的基因组工程改造 |
| JP7534070B2 (ja) | 2015-11-04 | 2024-08-14 | フェイト セラピューティクス，インコーポレイテッド | 造血細胞分化を誘導するための方法および組成物 |
| WO2017100709A1 (en) * | 2015-12-09 | 2017-06-15 | Nant Holdings Ip, Llc | Compositions and methods for treatment of her2 positive metastatic breast cancer |
| US10137144B2 (en) | 2016-01-15 | 2018-11-27 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
| CN116064678A (zh) | 2016-01-15 | 2023-05-05 | 美国基因技术国际有限公司 | 用于活化γ-δT细胞的方法和组合物 |
| DK3426777T3 (da) | 2016-03-09 | 2022-04-25 | American Gene Tech Int Inc | Kombinationsvektorer og fremgangsmåder til behandling af cancer |
| BR112019013282A2 (pt) * | 2016-12-30 | 2019-12-17 | Celularity Inc | células natural killer geneticamente modificadas |
| AU2018355462B9 (en) * | 2017-10-26 | 2022-04-28 | Regents Of The University Of Minnesota | Recombinant immune cells, methods of making, and methods of use |
| KR20250048610A (ko) | 2017-12-22 | 2025-04-09 | 페이트 세러퓨틱스, 인코포레이티드 | 향상된 면역 효과기 세포 및 이의 용도 |
| US12473336B2 (en) * | 2018-02-21 | 2025-11-18 | Board Of Regents, The University Of Texas System | Methods for activation and expansion of natural killer cells and uses thereof |
| JP7575271B2 (ja) | 2018-03-29 | 2024-10-29 | フェイト セラピューティクス，インコーポレイテッド | 操作された免疫エフェクター細胞およびその使用 |
| JP2022506515A (ja) | 2018-11-05 | 2022-01-17 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | 制御性ｒｎａを発現させるためのベクターシステム |
| EP3891177A4 (en) | 2018-12-02 | 2023-03-08 | Fate Therapeutics, Inc. | IMMUNOTHERAPIES USING EXTENDED IPSC-DERIVED EFFECTOR CELLS |
| US20220275333A1 (en) | 2019-07-17 | 2022-09-01 | Fate Therapeutics, Inc. | Immune effector cell engineering and use thereof |
| US20230355759A1 (en) * | 2019-07-31 | 2023-11-09 | Celularity Inc. | Populations of natural killer cells comprising a cleavage resistant cd16 |
| WO2021113849A1 (en) * | 2019-12-05 | 2021-06-10 | Celularity Inc. | Her2+ cancer treatment with populations of natural killer cells comprising a cleavage resistant cd16 |
| IL299106A (en) | 2020-06-19 | 2023-02-01 | Fate Therapeutics Inc | Combination of effector immune cells, derived from induced pluripotent stem cells for use in immunotherapy |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| KR20230118887A (ko) | 2020-12-03 | 2023-08-14 | 센츄리 쎄라퓨틱스 인코포레이티드 | 유전자 조작 세포 및 이의 용도 |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス，インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
| KR20230147060A (ko) * | 2021-01-21 | 2023-10-20 | 아메리칸 진 테크놀로지스 인터내셔널 인코포레이티드 | 조작된 nk 세포 및 암 치료 방법 |
| KR102894135B1 (ko) * | 2021-09-29 | 2025-12-04 | 카오티에스 주식회사 | 신규한 재조합 Fc 수용체 및 이를 포함하는 세포 |
| CN116948012B (zh) * | 2022-04-13 | 2024-07-26 | 星奕昂(上海)生物科技有限公司 | 增强细胞功能的cd16抗剪切突变体 |
| CN116716342A (zh) * | 2022-06-22 | 2023-09-08 | 南京艾尔普再生医学科技有限公司 | 一种adcc功能增强的nk细胞的制作方法、nk细胞及其组合物 |
| CN119907854A (zh) * | 2022-09-29 | 2025-04-29 | 上海先博生物科技有限公司 | 工程改造的免疫效应细胞及其组合物和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US121788A (en) * | 1871-12-12 | Improvement in match-boxes | ||
| US6444789B1 (en) * | 1995-05-03 | 2002-09-03 | Applied Research Systems Ars Holding N.V. | CD16-II variants |
| US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| JP2007515185A (ja) | 2003-12-22 | 2007-06-14 | カイロン コーポレイション | 免疫応答障害に対する処置ストラテジーのための診断法としてのＦｃレセプター多型の使用 |
| EP1771471B1 (en) * | 2004-07-10 | 2009-09-16 | Fox Chase Cancer Center | Genetically modified human natural killer cell lines |
| GB0510790D0 (en) * | 2005-05-26 | 2005-06-29 | Syngenta Crop Protection Ag | Anti-CD16 binding molecules |
| MX2008000030A (es) * | 2005-07-11 | 2008-04-02 | Macrogenics Inc | Metodos para el tratamiento de enfermedad autoinmune utilizando anticuerpos anti-cd16a humanizados. |
| US20080003225A1 (en) * | 2006-06-29 | 2008-01-03 | Henri Vie | Method for enhancing the antibody-dependent cellular cytotoxicity (ADCC) and uses of T cells expressing CD16 receptors |
| WO2010040091A1 (en) * | 2008-10-03 | 2010-04-08 | Arizona Board of Regents, a body corporate acting for and on behalf of Arizona State University | Novel dna nanostructures that promote cell-cell interaction and use thereof |
| CN102858985A (zh) * | 2009-07-24 | 2013-01-02 | 西格马-奥尔德里奇有限责任公司 | 基因组编辑方法 |
| US10464989B2 (en) | 2014-03-28 | 2019-11-05 | Regents Of The University Of Minnesota | Polypeptides, cells, and methods involving engineered CD16 |
-
2015
- 2015-03-27 US US15/300,024 patent/US10464989B2/en active Active
- 2015-03-27 WO PCT/US2015/022998 patent/WO2015148926A1/en not_active Ceased
- 2015-03-27 EP EP15716303.1A patent/EP3122769B1/en active Active
- 2015-03-27 AU AU2015235852A patent/AU2015235852B2/en active Active
- 2015-03-27 JP JP2016559573A patent/JP6795399B2/ja active Active
- 2015-03-27 CA CA2944199A patent/CA2944199C/en active Active
- 2015-03-27 PT PT157163031T patent/PT3122769T/pt unknown
- 2015-03-27 ES ES15716303T patent/ES2941679T3/es active Active
- 2015-03-27 EP EP22210531.4A patent/EP4227318A1/en active Pending
- 2015-03-27 CN CN202110757729.3A patent/CN113699159A/zh active Pending
- 2015-03-27 CN CN201580028172.2A patent/CN106715467B/zh active Active
-
2019
- 2019-09-19 US US16/575,624 patent/US12098182B2/en active Active
- 2019-10-16 AU AU2019250155A patent/AU2019250155B2/en active Active
-
2020
- 2020-11-12 JP JP2020188582A patent/JP7091423B2/ja active Active
-
2021
- 2021-04-19 US US17/233,979 patent/US11370825B2/en active Active
-
2022
- 2022-06-14 AU AU2022204134A patent/AU2022204134B2/en active Active
- 2022-06-15 JP JP2022096496A patent/JP7575426B2/ja active Active
-
2024
- 2024-08-12 US US18/800,744 patent/US20240417441A1/en active Pending
- 2024-10-17 JP JP2024182081A patent/JP2025004257A/ja active Pending
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