CN113699159A - 涉及经工程改造的cd16的多肽、细胞和方法 - Google Patents

涉及经工程改造的cd16的多肽、细胞和方法 Download PDF

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CN113699159A
CN113699159A CN202110757729.3A CN202110757729A CN113699159A CN 113699159 A CN113699159 A CN 113699159A CN 202110757729 A CN202110757729 A CN 202110757729A CN 113699159 A CN113699159 A CN 113699159A
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cell
cells
population
cd16a
pluripotent stem
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B·K·沃尔彻克
D·S·考夫曼
吴建明
Y·京
倪振亚
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University of Minnesota System
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CN202110757729.3A 2014-03-28 2015-03-27 涉及经工程改造的cd16的多肽、细胞和方法 Pending CN113699159A (zh)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114774469A (zh) * 2022-06-22 2022-07-22 南京艾尔普再生医学科技有限公司 一种adcc功能增强的nk细胞的制作方法、nk细胞及其组合物
CN116948012A (zh) * 2022-04-13 2023-10-27 星奕昂(上海)生物科技有限公司 增强细胞功能的cd16抗剪切突变体
WO2024067682A1 (zh) * 2022-09-29 2024-04-04 上海先博生物科技有限公司 工程改造的免疫效应细胞及其组合物和应用

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113699159A (zh) * 2014-03-28 2021-11-26 明尼苏达大学评议会 涉及经工程改造的cd16的多肽、细胞和方法
US10626372B1 (en) 2015-01-26 2020-04-21 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
CN108473961B (zh) 2015-11-04 2022-11-29 菲特治疗公司 用于诱导造血细胞分化的方法和组合物
KR20250141836A (ko) * 2015-11-04 2025-09-29 페이트 세러퓨틱스, 인코포레이티드 만능 세포의 유전자 조작
KR20180123214A (ko) * 2015-12-09 2018-11-15 난트 홀딩스 아이피, 엘엘씨 Her2 양성 전이성 유방암의 치료를 위한 조성물 및 방법
CA3011529A1 (en) 2016-01-15 2017-07-20 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta t-cells
US10137144B2 (en) 2016-01-15 2018-11-27 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells
ES2911448T3 (es) 2016-03-09 2022-05-19 American Gene Tech Int Inc Vectores combinados y métodos para el tratamiento del cáncer
CN110913870A (zh) * 2016-12-30 2020-03-24 细胞结构公司 遗传修饰的自然杀伤细胞
EP3700542A4 (en) * 2017-10-26 2020-12-09 Regents of the University of Minnesota RECOMBINANT IMMUNE CELLS, METHODS OF MANUFACTURING AND METHODS OF USE
CA3083779A1 (en) 2017-12-22 2019-06-27 Fate Therapeutics, Inc. Enhanced immune effector cells and use thereof
EP3755349A4 (en) * 2018-02-21 2021-11-17 Board of Regents, The University of Texas System PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES
CN111954715A (zh) * 2018-03-29 2020-11-17 菲特治疗公司 工程改造的免疫效应细胞和其用途
WO2020097049A1 (en) 2018-11-05 2020-05-14 American Gene Technologies International Inc. Vector system for expressing regulatory rna
KR20210099601A (ko) 2018-12-02 2021-08-12 페이트 세러퓨틱스, 인코포레이티드 향상된 iPSC 유래 효과기 세포를 사용한 면역요법
US20230355759A1 (en) * 2019-07-31 2023-11-09 Celularity Inc. Populations of natural killer cells comprising a cleavage resistant cd16
WO2021113849A1 (en) * 2019-12-05 2021-06-10 Celularity Inc. Her2+ cancer treatment with populations of natural killer cells comprising a cleavage resistant cd16
US12275955B2 (en) 2020-06-19 2025-04-15 Fate Therapeutics, Inc. Combining iPSC derived effector cell types for immunotherapy use
AU2021392032A1 (en) 2020-12-03 2023-06-22 Century Therapeutics, Inc. Genetically engineered cells and uses thereof
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
EP4263600A1 (en) 2020-12-18 2023-10-25 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity
KR20230147060A (ko) * 2021-01-21 2023-10-20 아메리칸 진 테크놀로지스 인터내셔널 인코포레이티드 조작된 nk 세포 및 암 치료 방법
EP4596576A1 (en) * 2021-09-29 2025-08-06 Carots Co., Ltd. Novel recombinant fc receptor and cells comprising same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1852976A (zh) * 2003-07-26 2006-10-25 特鲁比昂药品公司 结合构建体及其使用方法
CN101583625A (zh) * 2005-05-26 2009-11-18 阿菲姆德农业医药公司 抗-cd16结合分子
CN101627054A (zh) * 2005-07-11 2010-01-13 马克罗基因公司 用人源化抗cd16a抗体治疗自身免疫疾病的方法
CN102858985A (zh) * 2009-07-24 2013-01-02 西格马-奥尔德里奇有限责任公司 基因组编辑方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US121788A (en) * 1871-12-12 Improvement in match-boxes
US6444789B1 (en) * 1995-05-03 2002-09-03 Applied Research Systems Ars Holding N.V. CD16-II variants
KR20070001931A (ko) 2003-12-22 2007-01-04 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 면역 반응 장애의 치료 전략을 위한 진단법으로서 fc수용체 다형성의 용도
US7618817B2 (en) * 2004-07-10 2009-11-17 Fox Chase Cancer Center Genetically modified human natural killer cell lines
US20080003225A1 (en) * 2006-06-29 2008-01-03 Henri Vie Method for enhancing the antibody-dependent cellular cytotoxicity (ADCC) and uses of T cells expressing CD16 receptors
US8440811B2 (en) * 2008-10-03 2013-05-14 Arizona Board of Regents, a body corporate acting for and on behalf of Arizona State University DNA nanostructures that promote cell-cell interaction and use thereof
CN113699159A (zh) 2014-03-28 2021-11-26 明尼苏达大学评议会 涉及经工程改造的cd16的多肽、细胞和方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1852976A (zh) * 2003-07-26 2006-10-25 特鲁比昂药品公司 结合构建体及其使用方法
CN101583625A (zh) * 2005-05-26 2009-11-18 阿菲姆德农业医药公司 抗-cd16结合分子
CN101627054A (zh) * 2005-07-11 2010-01-13 马克罗基因公司 用人源化抗cd16a抗体治疗自身免疫疾病的方法
CN102858985A (zh) * 2009-07-24 2013-01-02 西格马-奥尔德里奇有限责任公司 基因组编辑方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116948012A (zh) * 2022-04-13 2023-10-27 星奕昂(上海)生物科技有限公司 增强细胞功能的cd16抗剪切突变体
CN114774469A (zh) * 2022-06-22 2022-07-22 南京艾尔普再生医学科技有限公司 一种adcc功能增强的nk细胞的制作方法、nk细胞及其组合物
WO2024067682A1 (zh) * 2022-09-29 2024-04-04 上海先博生物科技有限公司 工程改造的免疫效应细胞及其组合物和应用

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CN106715467A (zh) 2017-05-24
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US20200017570A1 (en) 2020-01-16
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US20240417441A1 (en) 2024-12-19
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