|
WO1994022914A1
(en)
*
|
1993-04-06 |
1994-10-13 |
Fred Hutchinson Cancer Research Center |
Chimeric cytokine receptors in lymphocytes
|
|
US6051227A
(en)
|
1995-07-25 |
2000-04-18 |
The Regents Of The University Of California, Office Of Technology Transfer |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US5811097A
(en)
|
1995-07-25 |
1998-09-22 |
The Regents Of The University Of California |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US5855887A
(en)
|
1995-07-25 |
1999-01-05 |
The Regents Of The University Of California |
Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
|
|
EP1690927A1
(en)
|
1997-04-30 |
2006-08-16 |
Hans Klingemann |
Natural killer cell lines and methods of use
|
|
US8034332B2
(en)
|
1997-04-30 |
2011-10-11 |
Conkwest, Inc. |
Interleukin-secreting natural killer cell lines and methods of use
|
|
US6645490B2
(en)
*
|
1998-03-02 |
2003-11-11 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Chimeric proteins with cell-targeting specificity and apoptosis-inducing activities
|
|
DZ2788A1
(fr)
*
|
1998-05-15 |
2003-12-01 |
Bayer Ag |
Agonistes et antagonistes selectifs à IL-2.
|
|
EE05627B1
(et)
|
1998-12-23 |
2013-02-15 |
Pfizer Inc. |
CTLA-4 vastased inimese monoklonaalsed antikehad
|
|
CN102766210B
(zh)
|
1999-08-24 |
2015-07-08 |
E.R.施贵宝&圣斯有限责任公司 |
人ctla-4抗体及其应用
|
|
US7605238B2
(en)
|
1999-08-24 |
2009-10-20 |
Medarex, Inc. |
Human CTLA-4 antibodies and their uses
|
|
DE60035057T2
(de)
|
1999-10-04 |
2008-01-31 |
Novartis Vaccines and Diagnostics, Inc., Emeryville |
CD40 Antagonist zur Behandlung von Psoriasis
|
|
US20030059427A1
(en)
|
2000-04-28 |
2003-03-27 |
Force Walker R. |
Isolation and characterization of highly active anti-CD40 antibody
|
|
EP2011802A3
(en)
|
2001-04-27 |
2009-04-15 |
Kyowa Hakko Kirin Co., Ltd. |
Anti-CD40 monoclonal antibody
|
|
WO2002088346A2
(en)
|
2001-05-01 |
2002-11-07 |
National Research Council Of Canada |
A system for inducible expression in eukaryotic cells
|
|
PT1537878E
(pt)
|
2002-07-03 |
2010-11-18 |
Ono Pharmaceutical Co |
Composições de imunopotenciação
|
|
JP2007506789A
(ja)
|
2003-09-25 |
2007-03-22 |
ザイモジェネティクス, インコーポレイテッド |
Il−21を用いた自己免疫疾患の治療方法
|
|
US8277810B2
(en)
|
2003-11-04 |
2012-10-02 |
Novartis Vaccines & Diagnostics, Inc. |
Antagonist anti-CD40 antibodies
|
|
CN100379762C
(zh)
*
|
2003-12-08 |
2008-04-09 |
中国人民解放军军事医学科学院生物工程研究所 |
人血清白蛋白与白细胞介素2的融合蛋白及其编码基因
|
|
KR101223373B1
(ko)
|
2003-12-25 |
2013-01-16 |
교와 핫꼬 기린 가부시키가이샤 |
항 cd40 항체의 변이체
|
|
US7674621B2
(en)
|
2004-05-21 |
2010-03-09 |
The United States Of America As Represented By The Department Of Health And Human Services |
Plasmids and phages for homologous recombination and methods of use
|
|
PL2921500T3
(pl)
|
2004-07-10 |
2024-02-05 |
The Institute For Cancer Research |
Genetycznie zmodyfikowane ludzkie linie komórkowe naturalni zabójcy
|
|
US20080280781A1
(en)
|
2005-01-16 |
2008-11-13 |
Georgia Tech Research Corporation |
Methods and Compositions for Increasing Membrane Permeability
|
|
PL2161336T5
(pl)
|
2005-05-09 |
2017-10-31 |
Ono Pharmaceutical Co |
Ludzkie przeciwciała monoklonalne przeciwko białku Programmed Death 1 (PD-1) oraz sposoby leczenia raka z zastosowaniem samych przeciwciał anty-PD-1 lub w połączeniu z innymi środkami immunoterapeutycznymi
|
|
GEP20125628B
(en)
|
2006-04-21 |
2012-09-10 |
Novartis Ag |
Pharmaceutical compositions containing antagonist anti-cd40 antibody
|
|
AU2007275689A1
(en)
|
2006-07-21 |
2008-01-24 |
Gilead Sciences, Inc. |
AZA-peptide protease inhibitors
|
|
US20090025274A1
(en)
|
2007-07-23 |
2009-01-29 |
Tim Lail |
Animal trap
|
|
GB0815216D0
(en)
*
|
2008-08-21 |
2008-09-24 |
Asterion Ltd |
Interleukin
|
|
PL2342226T3
(pl)
|
2008-09-26 |
2017-01-31 |
Dana-Farber Cancer Institute, Inc. |
Ludzkie przeciwciała anty-PD-1, PD-L1 i PD-L2 oraz ich zastosowania
|
|
NZ602020A
(en)
|
2010-03-31 |
2014-05-30 |
Boehringer Ingelheim Int |
Anti-cd40 antibodies
|
|
EP2553101A4
(en)
*
|
2010-04-02 |
2013-09-04 |
Univ Rochester |
PROTEASE-ACTIVATED CYTOKINES
|
|
WO2011155607A1
(ja)
|
2010-06-11 |
2011-12-15 |
協和発酵キリン株式会社 |
抗tim-3抗体
|
|
JP5458188B2
(ja)
|
2011-02-17 |
2014-04-02 |
協和発酵キリン株式会社 |
抗cd40抗体の高濃度製剤
|
|
ES2709654T3
(es)
|
2011-04-29 |
2019-04-17 |
Apexigen Inc |
Anticuerpos anti-CD40 y métodos de uso
|
|
WO2013006490A2
(en)
|
2011-07-01 |
2013-01-10 |
Cellerant Therapeutics, Inc. |
Antibodies that specifically bind to tim3
|
|
US9624298B2
(en)
|
2011-11-28 |
2017-04-18 |
Merck Patent Gmbh |
Anti-PD-L1 antibodies and uses thereof
|
|
US9844582B2
(en)
*
|
2012-05-22 |
2017-12-19 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents
|
|
CN104918957B
(zh)
|
2012-10-30 |
2018-11-16 |
埃派斯进有限公司 |
抗-cd40抗体及其使用方法
|
|
AU2014214850C1
(en)
|
2013-02-06 |
2018-12-06 |
Celgene Corporation |
Modified T lymphocytes having improved specificity
|
|
CN105658206A
(zh)
|
2013-06-03 |
2016-06-08 |
诺华股份有限公司 |
抗pd-l1抗体与mek抑制剂和/或braf抑制剂的组合
|
|
CN106459916A
(zh)
|
2014-06-18 |
2017-02-22 |
乔治-施派尔-豪斯化学疗法研究所 |
作为细胞治疗剂的car‑表达nk‑92细胞
|
|
BR112017000497B1
(pt)
|
2014-07-11 |
2023-12-26 |
Ventana Medical Systems, Inc |
Anticorpo isolado, célula hospedeira procariótica, imunoconjugado e método de detecção da presença ou do nível de expressão de pd-l1
|
|
MA40094B1
(fr)
*
|
2014-08-06 |
2022-05-31 |
Univ Miami |
Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation
|
|
JO3663B1
(ar)
|
2014-08-19 |
2020-08-27 |
Merck Sharp & Dohme |
الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
|
|
WO2016061142A1
(en)
|
2014-10-14 |
2016-04-21 |
Novartis Ag |
Antibody molecules to pd-l1 and uses thereof
|
|
ES2763548T3
(es)
|
2014-11-06 |
2020-05-29 |
Hoffmann La Roche |
Anticuerpos anti-TIM3 y procedimientos de uso
|
|
US10336810B2
(en)
*
|
2015-02-12 |
2019-07-02 |
University Health Network |
Chimeric antigen receptors, encoding nucleic acids and methods of use thereof
|
|
CN107922484A
(zh)
|
2015-03-06 |
2018-04-17 |
索伦托治疗有限公司 |
结合tim3的抗体治疗剂
|
|
KR102751730B1
(ko)
|
2015-03-27 |
2025-01-10 |
이뮤너티바이오, 인크. |
암의 치료를 위한 유전적으로 변형된 nk-92 세포 및 모노클로날 항체
|
|
KR20180004740A
(ko)
|
2015-04-20 |
2018-01-12 |
이펙터 테라퓨틱스, 인크. |
암 및 감염 치료에 사용하기 위한 면역 체크포인트 조절 인자의 억제제
|
|
CN114853891A
(zh)
|
2015-07-22 |
2022-08-05 |
索伦托药业有限公司 |
与lag3结合的抗体治疗剂
|
|
EP3331919A1
(en)
|
2015-08-07 |
2018-06-13 |
GlaxoSmithKline Intellectual Property Development Limited |
Combination therapy comprising anti ctla-4 antibodies
|
|
AR105654A1
(es)
|
2015-08-24 |
2017-10-25 |
Lilly Co Eli |
Anticuerpos pd-l1 (ligando 1 de muerte celular programada)
|
|
LU92821B1
(en)
|
2015-09-09 |
2017-03-20 |
Mologen Ag |
Combination comprising immunostimulatory oligonucleotides
|
|
DK3356411T3
(da)
|
2015-10-02 |
2021-09-06 |
Hoffmann La Roche |
Bispecifikke antistoffer, der er specifikke for PD1 og TIM3
|
|
TWI756187B
(zh)
|
2015-10-09 |
2022-03-01 |
美商再生元醫藥公司 |
抗lag3抗體及其用途
|
|
US20190127435A1
(en)
*
|
2016-04-20 |
2019-05-02 |
Fred Hutchinson Cancer Research Center |
Immunomodulatory il2r fusion proteins and uses thereof
|
|
UA127200C2
(uk)
|
2016-05-18 |
2023-06-07 |
Бьорінгер Інгельхайм Інтернаціональ Гмбх |
Молекула антитіла до pd1
|
|
SG11201900026TA
(en)
|
2016-07-14 |
2019-01-30 |
Bristol Myers Squibb Co |
Antibodies against tim3 and uses thereof
|
|
JP2020510422A
(ja)
|
2017-02-28 |
2020-04-09 |
シアトル ジェネティックス, インコーポレイテッド |
抗tigit抗体
|
|
SG11201909154SA
(en)
|
2017-04-05 |
2019-10-30 |
Hoffmann La Roche |
Bispecific antibodies specifically binding to pd1 and lag3
|
|
US12385061B2
(en)
|
2017-09-08 |
2025-08-12 |
Poseida Therapeutics, Inc. |
Compositions and methods for chimeric ligand receptor (CLR)-mediated conditional gene expression
|
|
BR112021003156A2
(pt)
|
2018-08-23 |
2021-05-11 |
Seagen, Inc. |
composição, anticorpo que se liga ao tigit humano, formulação farmacêutica, polinucleotídeo isolado, vetor, célula hospedeira, métodos para a produção de um anticorpo que se liga ao tigit humano e de anticorpos afucosilados que se ligam a tigit e para o tratamento de um câncer, e, kit.
|
|
WO2022232796A1
(en)
|
2021-04-28 |
2022-11-03 |
The General Hospital Corporation |
Il2 tethered to its receptor il2rbeta and pore-forming proteins as a platform to enhance immune cell activity
|