JP2020040969A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020040969A5 JP2020040969A5 JP2019209416A JP2019209416A JP2020040969A5 JP 2020040969 A5 JP2020040969 A5 JP 2020040969A5 JP 2019209416 A JP2019209416 A JP 2019209416A JP 2019209416 A JP2019209416 A JP 2019209416A JP 2020040969 A5 JP2020040969 A5 JP 2020040969A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- subject
- therapeutic cells
- polypeptide
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 22
- 230000001225 therapeutic effect Effects 0.000 claims 19
- 102000004039 Caspase-9 Human genes 0.000 claims 9
- 108090000566 Caspase-9 Proteins 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 239000003446 ligand Substances 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 230000004083 survival effect Effects 0.000 claims 3
- 102100027913 Peptidyl-prolyl cis-trans isomerase FKBP1A Human genes 0.000 claims 2
- 108010006877 Tacrolimus Binding Protein 1A Proteins 0.000 claims 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 2
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 2
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 210000000663 muscle cell Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021195285A JP2022024158A (ja) | 2013-06-05 | 2021-12-01 | カスパーゼポリペプチドを使用して部分的なアポトーシスを誘導するための方法 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361831428P | 2013-06-05 | 2013-06-05 | |
| US61/831,428 | 2013-06-05 | ||
| US201461949847P | 2014-03-07 | 2014-03-07 | |
| US61/949,847 | 2014-03-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018152650A Division JP6818720B6 (ja) | 2013-06-05 | 2018-08-14 | カスパーゼポリペプチドを使用して部分的なアポトーシスを誘導するための方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021195285A Division JP2022024158A (ja) | 2013-06-05 | 2021-12-01 | カスパーゼポリペプチドを使用して部分的なアポトーシスを誘導するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020040969A JP2020040969A (ja) | 2020-03-19 |
| JP2020040969A5 true JP2020040969A5 (enExample) | 2020-07-09 |
Family
ID=52008744
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016517976A Expired - Fee Related JP6467406B2 (ja) | 2013-06-05 | 2014-06-04 | カスパーゼポリペプチドを使用して部分的なアポトーシスを誘導するための方法 |
| JP2018152650A Expired - Fee Related JP6818720B6 (ja) | 2013-06-05 | 2018-08-14 | カスパーゼポリペプチドを使用して部分的なアポトーシスを誘導するための方法 |
| JP2019209416A Pending JP2020040969A (ja) | 2013-06-05 | 2019-11-20 | カスパーゼポリペプチドを使用して部分的なアポトーシスを誘導するための方法 |
| JP2021195285A Pending JP2022024158A (ja) | 2013-06-05 | 2021-12-01 | カスパーゼポリペプチドを使用して部分的なアポトーシスを誘導するための方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016517976A Expired - Fee Related JP6467406B2 (ja) | 2013-06-05 | 2014-06-04 | カスパーゼポリペプチドを使用して部分的なアポトーシスを誘導するための方法 |
| JP2018152650A Expired - Fee Related JP6818720B6 (ja) | 2013-06-05 | 2018-08-14 | カスパーゼポリペプチドを使用して部分的なアポトーシスを誘導するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021195285A Pending JP2022024158A (ja) | 2013-06-05 | 2021-12-01 | カスパーゼポリペプチドを使用して部分的なアポトーシスを誘導するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9913882B2 (enExample) |
| EP (2) | EP3569253A1 (enExample) |
| JP (4) | JP6467406B2 (enExample) |
| AU (1) | AU2014274916B2 (enExample) |
| CA (1) | CA2912172A1 (enExample) |
| DK (1) | DK3004329T3 (enExample) |
| ES (1) | ES2791598T3 (enExample) |
| WO (1) | WO2014197638A2 (enExample) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| AU2013204922B2 (en) | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| US9434935B2 (en) | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
| WO2014151960A2 (en) | 2013-03-14 | 2014-09-25 | Bellicum Pharmaceuticals, Inc. | Methods for controlling t cell proliferation |
| HK1220205A1 (zh) | 2013-03-15 | 2017-04-28 | Celgene Corporation | 修饰的t淋巴细胞 |
| WO2014197638A2 (en) | 2013-06-05 | 2014-12-11 | Bellicum Pharmaceuticals, Inc. | Methods for inducing partial apoptosis using caspase polypeptides |
| CN111849912B (zh) | 2014-02-14 | 2024-03-15 | 贝里坤制药股份有限公司 | 用诱导型嵌合多肽活化t细胞的方法 |
| EP4406610A3 (en) | 2014-04-07 | 2024-10-30 | Novartis AG | Treatment of cancer using anti-cd19 chimeric antigen receptor |
| US10888608B2 (en) | 2014-09-02 | 2021-01-12 | Bellicum Pharmaceuticals, Inc. | Costimulation of chimeric antigen receptors by MyD88 and CD40 polypeptides |
| PT3194434T (pt) * | 2014-09-15 | 2019-09-10 | Molmed Spa | Recetores de antigénios quiméricos |
| CN114107424A (zh) | 2014-10-08 | 2022-03-01 | 诺华股份有限公司 | 预测针对嵌合抗原受体疗法的治疗应答性的生物标志及其用途 |
| JP6718444B2 (ja) | 2014-11-03 | 2020-07-08 | アカデミッシュ ザイケンホイス レイデン （エイチ．オー．ディー．エヌ． エルユーエムシー） | Ｂｏｂ１に対して指向されるＴ細胞レセプターおよびその使用 |
| US20160166613A1 (en) * | 2014-12-15 | 2016-06-16 | Bellicum Pharmaceuticals, Inc. | Methods for controlled elimination of therapeutic cells |
| US20160175359A1 (en) * | 2014-12-15 | 2016-06-23 | Bellicum Pharmaceuticals, Inc. | Methods for controlled activation or elimination of therapeutic cells |
| KR20250075716A (ko) | 2014-12-29 | 2025-05-28 | 노파르티스 아게 | 키메라 항원 수용체-발현 세포를 제조하는 방법 |
| US11596652B2 (en) | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
| US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11000548B2 (en) | 2015-02-18 | 2021-05-11 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| AU2016221305B2 (en) * | 2015-02-18 | 2021-05-27 | Enlivex Therapeutics Rdo Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| GB201503133D0 (en) * | 2015-02-24 | 2015-04-08 | Ucl Business Plc And Syncona Partners Llp | Chimeric protein |
| JP2018510627A (ja) | 2015-03-10 | 2018-04-19 | レイデン ユニバーシティ メディカル センター | メラノーマ優先発現抗原に対して向けられたｔ細胞レセプターおよびその使用 |
| HUE059218T2 (hu) | 2015-04-08 | 2022-11-28 | Novartis Ag | CD20-terápiák, CD22-terápiák és kombinációs terápiák CD19 kiméra antigénreceptort (CAR-t) expresszáló sejttel |
| WO2016168773A2 (en) * | 2015-04-15 | 2016-10-20 | The California Institute For Biomedical Research | Optimized pne-based chimeric receptor t cell switches and uses thereof |
| SG11201708516YA (en) | 2015-04-17 | 2017-11-29 | David Maxwell Barrett | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
| EP4140492A1 (en) | 2015-04-21 | 2023-03-01 | Enlivex Therapeutics Rdo Ltd | Therapeutic pooled blood apoptotic cell preparations and uses thereof |
| SG10201912978PA (en) | 2015-07-21 | 2020-02-27 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
| EP3344996A2 (en) | 2015-09-03 | 2018-07-11 | The Trustees Of The University Of Pennsylvania | Biomarkers predictive of cytokine release syndrome |
| CA3007473A1 (en) * | 2015-12-14 | 2017-06-22 | Bellicum Pharmaceuticals, Inc. | Dual controls for therapeutic cell activation or elimination |
| EP3397755B1 (en) | 2015-12-28 | 2024-11-06 | Novartis AG | Methods of making chimeric antigen receptor -expressing cells |
| US11730761B2 (en) | 2016-02-18 | 2023-08-22 | Enlivex Therapeutics Rdo Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Ｃａｒ ｔ細胞療法のための方法および組成物 |
| US11499168B2 (en) | 2016-04-25 | 2022-11-15 | Universitat Basel | Allele editing and applications thereof |
| US20210177896A1 (en) | 2016-06-02 | 2021-06-17 | Novartis Ag | Therapeutic regimens for chimeric antigen receptor (car)- expressing cells |
| ES2845023T3 (es) * | 2016-06-03 | 2021-07-23 | Institut National De Rech Pour Lagriculture Lalimentation Et Lenvironnement | Expresión controlada por la dieta de un ácido nucleico que codifica una proteína pro-apoptósica |
| MX2019003983A (es) | 2016-10-06 | 2019-06-10 | Poseida Therapeutics Inc | Caspasas inducibles y metodos de uso. |
| MY200337A (en) | 2016-10-07 | 2023-12-20 | Novartis Ag | Nucleic acid molecules encoding chimeric antigen receptors comprising a cd20 binding domain |
| EP4092049A1 (en) * | 2016-10-20 | 2022-11-23 | Celgene Corporation | Cereblon-based heterodimerizable chimeric antigen receptors |
| SG11201903454VA (en) * | 2016-11-02 | 2019-05-30 | Univ Basel | Immunologically discernible cell surface variants for use in cell therapy |
| EP3579870A4 (en) | 2017-02-07 | 2020-12-30 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | PHOSPHOLIPID ETHER (PLE) T CAR-LYMPHOCYTE TUMOR (CTCT) TARGETING AGENTS |
| US11530388B2 (en) | 2017-02-14 | 2022-12-20 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods of engineering human induced pluripotent stem cells to produce liver tissue |
| JP7178355B2 (ja) | 2017-02-28 | 2022-11-25 | エンドサイト・インコーポレイテッド | Ｃａｒ ｔ細胞療法のための組成物および方法 |
| CA3060443A1 (en) | 2017-04-19 | 2018-10-25 | Board Of Regents, The University Of Texas System | Immune cells expressing engineered antigen receptors |
| WO2018208849A1 (en) | 2017-05-09 | 2018-11-15 | Bellicum Pharmaceuticals, Inc. | Methods to augment or alter signal transduction |
| CN107365798B (zh) * | 2017-07-13 | 2020-07-14 | 山东省齐鲁细胞治疗工程技术有限公司 | 一种携带iCasp9自杀基因的CD19-CAR-T细胞及其应用 |
| AU2018329741B2 (en) | 2017-09-08 | 2025-02-20 | Poseida Therapeutics, Inc. | Compositions and methods for chimeric ligand receptor (CLR)-mediated conditional gene expression |
| CN107488636A (zh) * | 2017-09-30 | 2017-12-19 | 山东兴瑞生物科技有限公司 | 一种携带分子开关的抗her2嵌合抗原受体修饰的免疫细胞及其应用 |
| MX2020004229A (es) | 2017-10-25 | 2020-07-22 | Novartis Ag | Metodos de produccion de celulas que expresan receptores antigenicos quimericos. |
| CN111295189B (zh) * | 2017-11-01 | 2023-09-15 | 艾洛基治疗公司 | 修饰的胱天蛋白酶-9多肽及其使用方法 |
| WO2019113509A2 (en) | 2017-12-08 | 2019-06-13 | Bellicum Pharmaceuticals, Inc. | Methods for enhancing and maintaining car-t cell efficacy |
| US20200308144A1 (en) | 2017-12-20 | 2020-10-01 | Bellicum Pharmaceuticals, Inc. | Multimeric piperidine derivatives |
| BR112020012555A2 (pt) | 2017-12-20 | 2020-11-24 | Poseida Therapeutics, Inc. | composições de vcar e métodos para uso |
| CA3089319A1 (en) | 2018-01-22 | 2019-07-25 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of use for car t cells |
| BR112020015884A2 (pt) | 2018-02-06 | 2020-12-08 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Receptores de antígeno quimérico (cars) específicos de fluoresceína exibindo a função de célula t ótima contra os tumores marcados por fl-ple |
| EP3755349A4 (en) | 2018-02-21 | 2021-11-17 | Board of Regents, The University of Texas System | PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES |
| US12240870B2 (en) | 2018-02-23 | 2025-03-04 | Purdue Research Foundation | Sequencing method for CAR T cell therapy |
| JP7526101B2 (ja) | 2018-03-02 | 2024-07-31 | アロジーン セラピューティクス，インコーポレイテッド | 誘導性キメラサイトカイン受容体 |
| EP3788369A1 (en) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
| EP3801769A1 (en) | 2018-05-25 | 2021-04-14 | Novartis AG | Combination therapy with chimeric antigen receptor (car) therapies |
| US20210171909A1 (en) | 2018-08-31 | 2021-06-10 | Novartis Ag | Methods of making chimeric antigen receptor?expressing cells |
| DK3844267T3 (da) | 2018-08-31 | 2025-09-22 | Novartis Ag | Fremgangsmåder til fremstilling af kimære antigenreceptorudtrykkende celler |
| EP3856782A1 (en) | 2018-09-28 | 2021-08-04 | Novartis AG | Cd19 chimeric antigen receptor (car) and cd22 car combination therapies |
| EP3856779A1 (en) | 2018-09-28 | 2021-08-04 | Novartis AG | Cd22 chimeric antigen receptor (car) therapies |
| JP2022512789A (ja) | 2018-10-31 | 2022-02-07 | ベリカム ファーマシューティカルズ， インコーポレイテッド | 自殺スイッチを有するｔ細胞 |
| MY206523A (en) | 2019-03-01 | 2024-12-19 | Allogene Therapeutics Inc | Constitutively active chimeric cytokine receptors |
| EP3931208A1 (en) | 2019-03-01 | 2022-01-05 | Allogene Therapeutics, Inc. | Chimeric cytokine receptors bearing a pd-1 ectodomain |
| US20220168389A1 (en) | 2019-04-12 | 2022-06-02 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| US11162079B2 (en) | 2019-05-10 | 2021-11-02 | The Regents Of The University Of California | Blood type O Rh-hypo-immunogenic pluripotent cells |
| BR112021022458A2 (pt) | 2019-05-10 | 2021-12-28 | Univ California | Células pluripotentes modificadas ou uma célula derivada das mesmas, método de transplantar uma célula, método de tratamento de uma doença em um paciente em necessidade de células transplantadas, método para gerar uma célula pluripotente modificada, método para gerar uma célula hipoimunogênica pluripotente, e método de transplante de uma célula pluripotente hipoimunogênica (hip) ou célula derivada da mesma |
| JP7403241B2 (ja) * | 2019-06-07 | 2023-12-22 | 小林製薬株式会社 | 内臓脂肪の視認性向上方法 |
| US11160832B2 (en) | 2019-07-09 | 2021-11-02 | The Children's Mercy Hospital | Engineered regulatory T cells |
| EP3769816A1 (en) * | 2019-07-25 | 2021-01-27 | Ospedale Pediatrico Bambino Gesù | Car-cd123 vector and uses thereof |
| EP3812465A1 (en) | 2019-10-21 | 2021-04-28 | Universität Ulm | Adenovirus comprising a modified adenovirus hexon protein |
| WO2021150300A1 (en) * | 2020-01-22 | 2021-07-29 | Massachusetts Institute Of Technology | Inducible tissue constructs and uses thereof |
| EP4104187A1 (en) | 2020-02-14 | 2022-12-21 | Novartis AG | Method of predicting response to chimeric antigen receptor therapy |
| IL295470A (en) | 2020-02-24 | 2022-10-01 | Allogene Therapeutics Inc | Bcma car-t cells with enhanced activities |
| CN115175695A (zh) | 2020-02-27 | 2022-10-11 | 诺华股份有限公司 | 制备表达嵌合抗原受体的细胞的方法 |
| CN116635062A (zh) | 2020-11-13 | 2023-08-22 | 诺华股份有限公司 | 使用表达嵌合抗原受体（car）的细胞的组合疗法 |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| JP2023553419A (ja) | 2020-12-03 | 2023-12-21 | センチュリー セラピューティクス，インコーポレイテッド | 遺伝子操作細胞およびその使用 |
| WO2022133169A1 (en) | 2020-12-18 | 2022-06-23 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| CN114042030B (zh) * | 2021-11-29 | 2022-06-24 | 上海天安智谷干细胞科技集团有限公司 | 一种含有脂肪间充质干细胞冻干粉的化妆品及抗炎药物 |
| EP4507699A1 (en) * | 2022-04-11 | 2025-02-19 | The Regents of The University of Michigan | Chemogenetic regulation of peptide function |
| WO2024011250A1 (en) | 2022-07-08 | 2024-01-11 | Viromissile, Inc. | Oncolytic vaccinia viruses and recombinant viruses and methods of use thereof |
| CN119907680A (zh) | 2022-09-15 | 2025-04-29 | 诺华股份有限公司 | 使用嵌合抗原受体疗法的自身免疫性障碍的治疗 |
| WO2024202583A1 (ja) * | 2023-03-28 | 2024-10-03 | 学校法人慈恵大学 | 非ヒト動物、キット及び置換臓器の製造方法 |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4514506A (en) | 1982-02-23 | 1985-04-30 | The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services | Method for the identification and purification of human lung tumor-associated antigens (hLTAA) and clinical detection and determination of these antigens |
| EP0273085A1 (en) | 1986-12-29 | 1988-07-06 | IntraCel Corporation | A method for internalizing nucleic acids into eukaryotic cells |
| FR2610631B1 (fr) | 1987-02-09 | 1989-11-24 | Pasteur Institut | Molecules comportant au moins une sequence peptidique porteuse d'un ou plusieurs, epitope caracteristique d'une proteine produite par p. falciparum dans les hepatocytes, et leurs utilisations, notamment pour le diagnostic du paludisme ou dans des compositions de vaccins contre le paludisme |
| US5869608A (en) | 1989-03-17 | 1999-02-09 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and amino acid sequences of the four variable domains of the major outer membrane proteins of Chlamydia trachomatis |
| US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| GB9105383D0 (en) | 1991-03-14 | 1991-05-01 | Immunology Ltd | An immunotherapeutic for cervical cancer |
| CA2067031C (en) | 1991-04-26 | 2003-02-18 | Shigekazu Nagata | Dna coding for human cell surface antigen |
| US5780036A (en) | 1991-08-26 | 1998-07-14 | The Scripps Research Institute | Peptides for inducing cytotoxic T lymphocyte responses to hepattis B virus |
| US5610042A (en) | 1991-10-07 | 1997-03-11 | Ciba-Geigy Corporation | Methods for stable transformation of wheat |
| DE4228457A1 (de) | 1992-08-27 | 1994-04-28 | Beiersdorf Ag | Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen |
| GB9222888D0 (en) | 1992-10-30 | 1992-12-16 | British Tech Group | Tomography |
| CA2155728C (en) | 1993-02-12 | 2000-04-25 | Gerald R. Crabtree | Regulated transcription of targeted genes and other biological events |
| US5869337A (en) | 1993-02-12 | 1999-02-09 | President And Fellows Of Harvard College | Regulated transcription of targeted genes and other biological events |
| US5834266A (en) | 1993-02-12 | 1998-11-10 | President & Fellows Of Harvard College | Regulated apoptosis |
| US5830462A (en) | 1993-02-12 | 1998-11-03 | President & Fellows Of Harvard College | Regulated transcription of targeted genes and other biological events |
| US5426027A (en) | 1993-05-20 | 1995-06-20 | The Government Of The United States Of America As Represented By The Secretary | Nucleic acid probes and methods for detecting Candida DNA cells in blood |
| US5648226A (en) | 1993-07-22 | 1997-07-15 | Ludwig Institute For Cancer Research | Isolated peptides derived from tumor rejection antigens, and their use |
| JPH09502086A (ja) | 1993-08-06 | 1997-03-04 | サイテル コーポレイション | 完全ｍａｇｅ１遺伝子のクローニング及び特性決定 |
| US5550214A (en) | 1994-02-10 | 1996-08-27 | Brigham And Women's Hospital | Isolated antigenic oncogene peptide fragments and uses |
| US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
| FR2722208B1 (fr) | 1994-07-05 | 1996-10-04 | Inst Nat Sante Rech Med | Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique |
| EP0785992A4 (en) | 1994-10-25 | 1999-12-22 | Univ Leland Stanford Junior | TRANSFORMATION OF THE STATE OF CELLS PRODUCED BY GENETIC ENGINEERING |
| US6077947A (en) | 1995-02-02 | 2000-06-20 | Cell Genesys, Inc. | DNA encoding an intracellular chimeric receptor comprising Janus kinase |
| US6103521A (en) | 1995-02-06 | 2000-08-15 | Cell Genesys, Inc. | Multispecific chimeric receptors |
| US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
| US5840839A (en) | 1996-02-09 | 1998-11-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
| US5853719A (en) | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
| US6010878A (en) | 1996-05-20 | 2000-01-04 | Smithkline Beecham Corporation | Interleukin-1 β converting enzyme like apoptotic protease-6 |
| AU705647B2 (en) | 1996-07-10 | 1999-05-27 | Immunex Corporation | Method of activating dendritic cells |
| US5955596A (en) | 1996-07-26 | 1999-09-21 | American Cyanamid Company | NucA protein of Haemophilus influenzae and the gene encoding that protein |
| US6046158A (en) | 1996-12-20 | 2000-04-04 | Board Of Regents The University Of Texas Systems | Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof |
| US5965242A (en) | 1997-02-19 | 1999-10-12 | Eastman Kodak Company | Glow-in-the-dark medium and method of making |
| US6969609B1 (en) | 1998-12-09 | 2005-11-29 | The United States Of America As Represented By The Department Of Health And Human Serivces | Recombinant vector expressing multiple costimulatory molecules and uses thereof |
| US6403765B1 (en) | 1998-06-16 | 2002-06-11 | Thomas Jefferson University | Truncated Apaf-1 and methods of use thereof |
| US6558951B1 (en) | 1999-02-11 | 2003-05-06 | 3M Innovative Properties Company | Maturation of dendritic cells with immune response modifying compounds |
| GB9930616D0 (en) | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
| EP1254953A4 (en) | 1999-12-28 | 2004-06-02 | Toyoshima Kumao | Maturity-triggering agent for immature dendritic cells |
| US7435585B2 (en) | 2000-01-03 | 2008-10-14 | University Of Pennsylvania | Auto-stimulating cells and methods for making and using the same |
| SE0001642D0 (sv) | 2000-05-04 | 2000-05-04 | Sahltech Ab | Reagent for detection of biomolecules, and use thereof |
| US20030232055A1 (en) | 2000-07-31 | 2003-12-18 | Ruslan Medzhitov | Innate immune system-directed vaccines |
| US6943245B2 (en) | 2000-08-10 | 2005-09-13 | Board Of Regents, The University Of Texas System | Tumor suppressor CAR-1 |
| AU2002221780A1 (en) | 2000-10-31 | 2002-05-15 | F.Hoffmann-La Roche Ag | Nucleic acids encoding cd40/cd40l chimeric polypeptides, methods for their production and uses thereof |
| AU2002248180A1 (en) | 2000-12-14 | 2002-07-16 | The Burnham Institute | Non-apoptotic forms of cell death and methods of modulation |
| US20020160975A1 (en) * | 2001-02-08 | 2002-10-31 | Thomas Jefferson University | Conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO for mediating apoptosis |
| US6838263B2 (en) | 2001-07-09 | 2005-01-04 | Oklahoma Medical Research Foundation | Targeted fusion proteins and methods for the characterization of cellular membrane domains |
| EP1425040A2 (en) | 2001-09-14 | 2004-06-09 | Cytos Biotechnology AG | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| US20050215472A1 (en) | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
| US20030082163A1 (en) | 2001-10-26 | 2003-05-01 | Suyu Shu | Fused cells, methods of forming same, and therapies utilizing same |
| EP1641927B1 (en) | 2003-02-18 | 2015-07-08 | Baylor College of Medicine | Induced activation in dendritic cells |
| US20080274140A1 (en) | 2004-11-19 | 2008-11-06 | David B Weiner | Vaccines and Methods for Using the Same |
| CN101203247A (zh) | 2005-01-10 | 2008-06-18 | 研究发展基金会 | 用于癌症治疗的靶向嵌合分子 |
| WO2006133398A2 (en) | 2005-06-08 | 2006-12-14 | Invitrogen Corporation | In vitro activated donor t-cells to promote transplant engraftment |
| KR100705981B1 (ko) | 2005-10-12 | 2007-04-10 | 주식회사 리제론 | 인간 성장호르몬을 포함하는 탈모방지 또는 발모촉진용조성물 |
| US20080300202A1 (en) * | 2006-05-18 | 2008-12-04 | The State of Oregon acting by and through the State Board of Higher Education on behalf of the | Subtractive transgenics |
| US20100196336A1 (en) | 2006-05-23 | 2010-08-05 | Dongsu Park | Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods |
| WO2008006087A2 (en) | 2006-07-07 | 2008-01-10 | The Regents Of The University Of California | Antibodies to conformationally trapped proteins |
| US8691210B2 (en) | 2006-10-19 | 2014-04-08 | David M Spencer | Methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptors and adaptors thereof |
| EP3878949B1 (en) | 2007-04-07 | 2025-06-04 | Whitehead Institute for Biomedical Research | Reprogramming of somatic cells |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| US9213999B2 (en) | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
| EP2006376A1 (en) | 2007-06-21 | 2008-12-24 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | Fusion protein comprising a caspase domain and a nuclear hormone receptor binding domain and methods and uses thereof |
| EA201692127A1 (ru) | 2007-11-07 | 2017-08-31 | Селлдекс Терапьютикс Инк. | Антитела, связывающиеся с человеческим dec-205 |
| CA2717538A1 (en) | 2008-03-03 | 2009-09-11 | Dyax Corp. | Metalloproteinase 12 binding proteins |
| WO2010033949A1 (en) | 2008-09-22 | 2010-03-25 | Baylor College Of Medicine | Methods and compositions for generating an immune response by inducing cd40 and pattern recognition receptor adapters |
| WO2011035018A2 (en) | 2009-09-18 | 2011-03-24 | Fate Therapeutics, Inc. | Suicide ready cells |
| AU2011239569B2 (en) | 2010-04-16 | 2014-07-24 | Baylor College Of Medicine | Method for treating solid tumors |
| US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| US20130071414A1 (en) | 2011-04-27 | 2013-03-21 | Gianpietro Dotti | Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies |
| EP2755487B1 (en) | 2011-09-16 | 2018-12-19 | Baylor College Of Medicine | Targeting the tumor microenvironment using manipulated nkt cells |
| US9434935B2 (en) | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
| WO2014197638A2 (en) | 2013-06-05 | 2014-12-11 | Bellicum Pharmaceuticals, Inc. | Methods for inducing partial apoptosis using caspase polypeptides |
| AU2015226960A1 (en) | 2014-03-07 | 2016-09-15 | Bellicum Pharmaceuticals, Inc. | Caspase polypeptides having modified activity and uses thereof |
| US10888608B2 (en) | 2014-09-02 | 2021-01-12 | Bellicum Pharmaceuticals, Inc. | Costimulation of chimeric antigen receptors by MyD88 and CD40 polypeptides |
| US20160166613A1 (en) * | 2014-12-15 | 2016-06-16 | Bellicum Pharmaceuticals, Inc. | Methods for controlled elimination of therapeutic cells |
| US20160175359A1 (en) | 2014-12-15 | 2016-06-23 | Bellicum Pharmaceuticals, Inc. | Methods for controlled activation or elimination of therapeutic cells |
-
2014
- 2014-06-04 WO PCT/US2014/040964 patent/WO2014197638A2/en not_active Ceased
- 2014-06-04 EP EP19173088.6A patent/EP3569253A1/en not_active Withdrawn
- 2014-06-04 US US14/296,404 patent/US9913882B2/en active Active
- 2014-06-04 AU AU2014274916A patent/AU2014274916B2/en active Active
- 2014-06-04 ES ES14807405T patent/ES2791598T3/es active Active
- 2014-06-04 EP EP14807405.7A patent/EP3004329B1/en active Active
- 2014-06-04 CA CA2912172A patent/CA2912172A1/en active Pending
- 2014-06-04 DK DK14807405.7T patent/DK3004329T3/da active
- 2014-06-04 JP JP2016517976A patent/JP6467406B2/ja not_active Expired - Fee Related
-
2018
- 2018-02-05 US US15/888,948 patent/US10525110B2/en active Active
- 2018-08-14 JP JP2018152650A patent/JP6818720B6/ja not_active Expired - Fee Related
-
2019
- 2019-11-20 JP JP2019209416A patent/JP2020040969A/ja active Pending
-
2020
- 2020-01-03 US US16/734,104 patent/US11839647B2/en active Active
-
2021
- 2021-12-01 JP JP2021195285A patent/JP2022024158A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020040969A5 (enExample) | ||
| EP3490605B1 (en) | Replacement of cytotoxic preconditioning before cellular immunotherapy | |
| Feldman | Hypoxia within the glioblastoma tumor microenvironment: a master saboteur of novel treatments | |
| KR102738546B1 (ko) | 암-표적화된 ｉｌ-12 면역요법 | |
| JP2019519528A5 (enExample) | ||
| JP2014169326A5 (enExample) | ||
| JP2016521709A5 (enExample) | ||
| JP2011502954A5 (enExample) | ||
| CN108392633A (zh) | Pcsk9抑制剂在恶性肿瘤免疫治疗中的应用 | |
| JP2014509841A5 (enExample) | ||
| JP2012529294A5 (enExample) | ||
| CN109310746A (zh) | 过继细胞转移与溶瘤病毒组合疗法 | |
| JP2014500278A5 (enExample) | ||
| JP2018500390A5 (enExample) | ||
| JP2012100676A5 (enExample) | ||
| JP2020517692A5 (enExample) | ||
| TW201206474A (en) | Treating breast cancer with anti-IL-19 antibody | |
| WO2023070000A1 (en) | Methods of use and administration of encapsulated cells | |
| JP2009532326A5 (enExample) | ||
| Zhang et al. | Hematopoietic stem and immune cells in chronic HIV infection | |
| TW201806970A (zh) | 嵌合抗原受體、及其利用 | |
| EP0684842B1 (fr) | Composition pour le traitement de tumeurs et l'immunisation d'organismes a l'encontre de tumeurs | |
| JP2018522881A5 (enExample) | ||
| JP2018500882A5 (enExample) | ||
| JP2019512216A5 (enExample) |