JP2019519528A5 - - Google Patents
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- Publication number
- JP2019519528A5 JP2019519528A5 JP2018561641A JP2018561641A JP2019519528A5 JP 2019519528 A5 JP2019519528 A5 JP 2019519528A5 JP 2018561641 A JP2018561641 A JP 2018561641A JP 2018561641 A JP2018561641 A JP 2018561641A JP 2019519528 A5 JP2019519528 A5 JP 2019519528A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- domain monomer
- domain
- sequence
- construct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims description 126
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 126
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 126
- 239000000178 monomer Substances 0.000 claims description 66
- 239000006143 cell culture medium Substances 0.000 claims description 13
- 230000035772 mutation Effects 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 10
- 239000004471 Glycine Substances 0.000 claims description 8
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 8
- 150000001413 amino acids Chemical group 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 239000004472 Lysine Substances 0.000 claims description 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 4
- 210000004899 c-terminal region Anatomy 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 150000002333 glycines Chemical class 0.000 claims description 4
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 4
- 238000012986 modification Methods 0.000 claims description 4
- 230000004048 modification Effects 0.000 claims description 4
- 208000023275 Autoimmune disease Diseases 0.000 claims description 2
- 206010061218 Inflammation Diseases 0.000 claims description 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 230000005931 immune cell recruitment Effects 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 230000004054 inflammatory process Effects 0.000 claims description 2
- 102000040430 polynucleotide Human genes 0.000 claims description 2
- 108091033319 polynucleotide Proteins 0.000 claims description 2
- 239000002157 polynucleotide Substances 0.000 claims description 2
- 230000028327 secretion Effects 0.000 claims description 2
- 238000004113 cell culture Methods 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022044109A JP7295301B2 (ja) | 2016-05-23 | 2022-03-18 | 操作されたＦｃコンストラクトに関する組成物及び方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662340322P | 2016-05-23 | 2016-05-23 | |
| US62/340,322 | 2016-05-23 | ||
| US201762443451P | 2017-01-06 | 2017-01-06 | |
| US62/443,451 | 2017-01-06 | ||
| PCT/US2017/034084 WO2017205434A1 (en) | 2016-05-23 | 2017-05-23 | Compositions and methods related to engineered fc constructs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022044109A Division JP7295301B2 (ja) | 2016-05-23 | 2022-03-18 | 操作されたＦｃコンストラクトに関する組成物及び方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2019519528A JP2019519528A (ja) | 2019-07-11 |
| JP2019519528A5 true JP2019519528A5 (enExample) | 2020-07-02 |
| JP7045333B2 JP7045333B2 (ja) | 2022-03-31 |
| JP7045333B6 JP7045333B6 (ja) | 2022-05-06 |
Family
ID=60412547
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561639A Withdrawn JP2019519527A (ja) | 2016-05-23 | 2017-05-23 | 操作されたＦｃコンストラクトに関する組成物及び方法 |
| JP2018561641A Active JP7045333B6 (ja) | 2016-05-23 | 2017-05-23 | 操作されたＦｃコンストラクトに関する組成物及び方法 |
| JP2022010912A Pending JP2022068176A (ja) | 2016-05-23 | 2022-01-27 | 操作されたＦｃコンストラクトに関する組成物及び方法 |
| JP2022044109A Active JP7295301B2 (ja) | 2016-05-23 | 2022-03-18 | 操作されたＦｃコンストラクトに関する組成物及び方法 |
| JP2024193057A Withdrawn JP2025026880A (ja) | 2016-05-23 | 2024-11-01 | 操作されたＦｃコンストラクトに関する組成物及び方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561639A Withdrawn JP2019519527A (ja) | 2016-05-23 | 2017-05-23 | 操作されたＦｃコンストラクトに関する組成物及び方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022010912A Pending JP2022068176A (ja) | 2016-05-23 | 2022-01-27 | 操作されたＦｃコンストラクトに関する組成物及び方法 |
| JP2022044109A Active JP7295301B2 (ja) | 2016-05-23 | 2022-03-18 | 操作されたＦｃコンストラクトに関する組成物及び方法 |
| JP2024193057A Withdrawn JP2025026880A (ja) | 2016-05-23 | 2024-11-01 | 操作されたＦｃコンストラクトに関する組成物及び方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US11155640B2 (enExample) |
| EP (2) | EP3484514B1 (enExample) |
| JP (5) | JP2019519527A (enExample) |
| KR (3) | KR102635635B1 (enExample) |
| CN (4) | CN109789203B (enExample) |
| AU (2) | AU2017272111B2 (enExample) |
| BR (2) | BR112018074056A2 (enExample) |
| CA (2) | CA3025306A1 (enExample) |
| DK (1) | DK3484514T3 (enExample) |
| ES (1) | ES2973251T3 (enExample) |
| IL (3) | IL263211B2 (enExample) |
| NZ (2) | NZ749292A (enExample) |
| PL (1) | PL3484514T3 (enExample) |
| SG (3) | SG11201810466PA (enExample) |
| WO (2) | WO2017205436A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106661125B (zh) | 2014-05-02 | 2021-10-01 | 动量制药公司 | 涉及工程化Fc构建体的组合物和方法 |
| US12391759B2 (en) | 2016-03-02 | 2025-08-19 | Momenta Pharmaceuticals, Inc. | Methods related to engineered Fc constructs |
| KR102635635B1 (ko) * | 2016-05-23 | 2024-02-14 | 모멘타 파머슈티컬스 인코포레이티드 | 유전자 조작 Fc 작제물에 관한 조성물 및 방법 |
| CN110650748B (zh) | 2017-01-06 | 2024-01-02 | 动量制药公司 | 与经工程改造的Fc构建体相关的组合物和方法 |
| CN113164592A (zh) * | 2018-07-11 | 2021-07-23 | 动量制药公司 | 与工程化Fc-抗原结合结构域构建体有关的组合物和方法 |
| CA3106207A1 (en) * | 2018-07-11 | 2020-01-16 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered fc-antigen binding domain constructs targeted to ctla-4 |
| CN112996910A (zh) * | 2018-07-11 | 2021-06-18 | 动量制药公司 | 与靶向PD-L1的工程化Fc-抗原结合结构域构建体有关的组合物和方法 |
| CA3106254A1 (en) * | 2018-07-11 | 2020-01-16 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered fc-antigen binding domain constructs |
| US20250346676A1 (en) * | 2018-07-11 | 2025-11-13 | Momenta Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS RELATED TO ENGINEERED Fc-ANTIGEN BINDING DOMAIN CONSTRUCTS TARGETED TO CCR4 |
| BR112021000392A2 (pt) * | 2018-07-11 | 2021-04-06 | Momenta Pharmaceuticals, Inc. | Composições e métodos relacionados a construtos do domínio de ligação fc-antígeno manipulados |
| CA3106142A1 (en) * | 2018-07-11 | 2020-01-16 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered fc-antigen binding domain constructs targeted to cd38 |
| BR112021000415A2 (pt) * | 2018-07-11 | 2021-04-06 | Momenta Pharmaceuticals, Inc. | Composições e métodos relacionados a construtos do domínio de ligação fc-antígeno manipulados |
| KR102661494B1 (ko) | 2019-03-08 | 2024-04-29 | 에이치엘만도 주식회사 | 랙구동형 동력 보조 조향장치 |
| KR20220062084A (ko) | 2019-09-13 | 2022-05-13 | 체에스엘 베링 렝나우 아게 | 면역 복합체 매개된 콩팥 장애의 치료를 위한 재조합 IgG Fc 다량체 |
| JP2023505493A (ja) * | 2019-12-06 | 2023-02-09 | ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト | Ｆｃ多量体の安定組成物 |
| CN111808170A (zh) * | 2020-06-29 | 2020-10-23 | 江苏为真生物医药技术股份有限公司 | 多肽、hla-dr蛋白及其制备方法和应用 |
| WO2022125355A1 (en) * | 2020-12-07 | 2022-06-16 | Invetx Inc. | Compositions for increasing half-life of a therapeutic agent in livestock animals and methods of use |
| WO2024206820A1 (en) * | 2023-03-30 | 2024-10-03 | Dna Twopointo, Inc. | Fc engineering for heterodimeric antibody format |
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| US7951917B1 (en) * | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
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| BRPI0811857A2 (pt) | 2007-05-14 | 2014-10-21 | Biogen Idec Inc | Regiões fc (scfc) de cadeia simples, polipeptídeos de aglutinação que as compreendem e métodos relacionados. |
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| CN106661125B (zh) | 2014-05-02 | 2021-10-01 | 动量制药公司 | 涉及工程化Fc构建体的组合物和方法 |
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| US12391759B2 (en) | 2016-03-02 | 2025-08-19 | Momenta Pharmaceuticals, Inc. | Methods related to engineered Fc constructs |
| KR102635635B1 (ko) | 2016-05-23 | 2024-02-14 | 모멘타 파머슈티컬스 인코포레이티드 | 유전자 조작 Fc 작제물에 관한 조성물 및 방법 |
| CN110650748B (zh) * | 2017-01-06 | 2024-01-02 | 动量制药公司 | 与经工程改造的Fc构建体相关的组合物和方法 |
-
2017
- 2017-05-23 KR KR1020227037780A patent/KR102635635B1/ko active Active
- 2017-05-23 BR BR112018074056-0A patent/BR112018074056A2/pt active Search and Examination
- 2017-05-23 PL PL17803463.3T patent/PL3484514T3/pl unknown
- 2017-05-23 IL IL263211A patent/IL263211B2/en unknown
- 2017-05-23 CA CA3025306A patent/CA3025306A1/en active Pending
- 2017-05-23 SG SG11201810466PA patent/SG11201810466PA/en unknown
- 2017-05-23 JP JP2018561639A patent/JP2019519527A/ja not_active Withdrawn
- 2017-05-23 US US16/303,793 patent/US11155640B2/en active Active
- 2017-05-23 SG SG11201810465RA patent/SG11201810465RA/en unknown
- 2017-05-23 ES ES17803463T patent/ES2973251T3/es active Active
- 2017-05-23 JP JP2018561641A patent/JP7045333B6/ja active Active
- 2017-05-23 NZ NZ749292A patent/NZ749292A/en unknown
- 2017-05-23 CA CA3025310A patent/CA3025310A1/en active Pending
- 2017-05-23 SG SG10202011624SA patent/SG10202011624SA/en unknown
- 2017-05-23 NZ NZ749279A patent/NZ749279A/en unknown
- 2017-05-23 AU AU2017272111A patent/AU2017272111B2/en active Active
- 2017-05-23 CN CN201780045710.8A patent/CN109789203B/zh active Active
- 2017-05-23 CN CN202410270902.0A patent/CN118206639A/zh active Pending
- 2017-05-23 DK DK17803463.3T patent/DK3484514T3/da active
- 2017-05-23 BR BR112018074032-2A patent/BR112018074032A2/pt unknown
- 2017-05-23 WO PCT/US2017/034087 patent/WO2017205436A1/en not_active Ceased
- 2017-05-23 IL IL309293A patent/IL309293A/en unknown
- 2017-05-23 CN CN202210924611.XA patent/CN116063540A/zh active Pending
- 2017-05-23 KR KR1020187037345A patent/KR102590061B1/ko active Active
- 2017-05-23 AU AU2017272109A patent/AU2017272109B2/en active Active
- 2017-05-23 EP EP17803463.3A patent/EP3484514B1/en active Active
- 2017-05-23 IL IL263213A patent/IL263213B2/en unknown
- 2017-05-23 US US16/303,831 patent/US11623964B2/en active Active
- 2017-05-23 KR KR1020187037334A patent/KR102462084B1/ko active Active
- 2017-05-23 EP EP17803465.8A patent/EP3464376A4/en active Pending
- 2017-05-23 CN CN201780045688.7A patent/CN109963869A/zh active Pending
- 2017-05-23 WO PCT/US2017/034084 patent/WO2017205434A1/en not_active Ceased
-
2021
- 2021-10-01 US US17/491,677 patent/US12297291B2/en active Active
-
2022
- 2022-01-27 JP JP2022010912A patent/JP2022068176A/ja active Pending
- 2022-03-18 JP JP2022044109A patent/JP7295301B2/ja active Active
-
2023
- 2023-04-10 US US18/298,131 patent/US20240067757A1/en active Pending
-
2024
- 2024-11-01 JP JP2024193057A patent/JP2025026880A/ja not_active Withdrawn
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