JP2019194251A5 - - Google Patents
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- Publication number
- JP2019194251A5 JP2019194251A5 JP2019131603A JP2019131603A JP2019194251A5 JP 2019194251 A5 JP2019194251 A5 JP 2019194251A5 JP 2019131603 A JP2019131603 A JP 2019131603A JP 2019131603 A JP2019131603 A JP 2019131603A JP 2019194251 A5 JP2019194251 A5 JP 2019194251A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- botulinum toxin
- subject
- toxin component
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 27
- 108030001720 Bontoxilysin Proteins 0.000 claims 21
- 229940053031 botulinum toxin Drugs 0.000 claims 21
- 238000002347 injection Methods 0.000 claims 4
- 239000007924 injection Substances 0.000 claims 4
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021183197A JP2022028770A (ja) | 2008-12-31 | 2021-11-10 | 注射用ボツリヌス毒素製剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14206308P | 2008-12-31 | 2008-12-31 | |
| US61/142,063 | 2008-12-31 | ||
| JP2018141384A JP6559849B2 (ja) | 2008-12-31 | 2018-07-27 | 注射用ボツリヌス毒素製剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018141384A Division JP6559849B2 (ja) | 2008-12-31 | 2018-07-27 | 注射用ボツリヌス毒素製剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021183197A Division JP2022028770A (ja) | 2008-12-31 | 2021-11-10 | 注射用ボツリヌス毒素製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019194251A JP2019194251A (ja) | 2019-11-07 |
| JP2019194251A5 true JP2019194251A5 (enExample) | 2020-01-16 |
| JP6976997B2 JP6976997B2 (ja) | 2021-12-08 |
Family
ID=42285690
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011543704A Expired - Fee Related JP5866202B2 (ja) | 2008-12-31 | 2009-12-28 | 注射用ボツリヌス毒素製剤 |
| JP2015027842A Expired - Fee Related JP6145465B2 (ja) | 2008-12-31 | 2015-02-16 | 注射用ボツリヌス毒素製剤 |
| JP2017096249A Pending JP2017178954A (ja) | 2008-12-31 | 2017-05-15 | 注射用ボツリヌス毒素製剤 |
| JP2018141384A Expired - Fee Related JP6559849B2 (ja) | 2008-12-31 | 2018-07-27 | 注射用ボツリヌス毒素製剤 |
| JP2019131603A Active JP6976997B2 (ja) | 2008-12-31 | 2019-07-17 | 注射用ボツリヌス毒素製剤 |
| JP2021183197A Pending JP2022028770A (ja) | 2008-12-31 | 2021-11-10 | 注射用ボツリヌス毒素製剤 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011543704A Expired - Fee Related JP5866202B2 (ja) | 2008-12-31 | 2009-12-28 | 注射用ボツリヌス毒素製剤 |
| JP2015027842A Expired - Fee Related JP6145465B2 (ja) | 2008-12-31 | 2015-02-16 | 注射用ボツリヌス毒素製剤 |
| JP2017096249A Pending JP2017178954A (ja) | 2008-12-31 | 2017-05-15 | 注射用ボツリヌス毒素製剤 |
| JP2018141384A Expired - Fee Related JP6559849B2 (ja) | 2008-12-31 | 2018-07-27 | 注射用ボツリヌス毒素製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021183197A Pending JP2022028770A (ja) | 2008-12-31 | 2021-11-10 | 注射用ボツリヌス毒素製剤 |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US9956435B2 (enExample) |
| EP (2) | EP2379104B1 (enExample) |
| JP (6) | JP5866202B2 (enExample) |
| KR (4) | KR102363878B1 (enExample) |
| CN (2) | CN107343859A (enExample) |
| AU (5) | AU2009332947C1 (enExample) |
| BR (1) | BRPI0923731B1 (enExample) |
| CA (1) | CA2749757C (enExample) |
| CO (1) | CO6400199A2 (enExample) |
| CY (1) | CY1120137T1 (enExample) |
| DK (2) | DK3332805T3 (enExample) |
| ES (2) | ES2669020T3 (enExample) |
| HR (1) | HRP20180739T1 (enExample) |
| HU (1) | HUE037595T2 (enExample) |
| IL (3) | IL213668A (enExample) |
| LT (1) | LT2379104T (enExample) |
| MX (1) | MX2011007059A (enExample) |
| NO (1) | NO2379104T3 (enExample) |
| PL (1) | PL2379104T3 (enExample) |
| PT (1) | PT2379104T (enExample) |
| RU (1) | RU2011125775A (enExample) |
| SG (3) | SG10202100698QA (enExample) |
| SI (1) | SI2379104T1 (enExample) |
| SM (1) | SMT201800215T1 (enExample) |
| WO (1) | WO2010078242A1 (enExample) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9211248B2 (en) * | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| JP2007527431A (ja) | 2004-03-03 | 2007-09-27 | ルバンス セラピュティックス | 局所的診断及び治療用の輸送のための組成物及び方法 |
| EP1861112A4 (en) | 2005-03-03 | 2009-07-22 | Revance Therapeutics Inc | COMPOSITIONS AND METHODS FOR TOPICAL APPLICATION AND TRANSDERMAL DELIVERY OF BOTULINUM TOXINES |
| AU2007340158A1 (en) * | 2006-12-29 | 2008-07-10 | Revance Therapeutics, Inc. | Transport molecules using reverse sequence HIV-TAT polypeptides |
| BRPI0813627B1 (pt) * | 2007-07-26 | 2021-09-14 | Revance Therapeutics, Inc | Composição farmacêutica ou cosmética compreendendo um peptídeo catiônico e kit para administração da mesma |
| US9345836B2 (en) | 2007-10-02 | 2016-05-24 | Medimop Medical Projects Ltd. | Disengagement resistant telescoping assembly and unidirectional method of assembly for such |
| US7967795B1 (en) | 2010-01-19 | 2011-06-28 | Lamodel Ltd. | Cartridge interface assembly with driving plunger |
| BRPI0817907B8 (pt) | 2007-10-02 | 2021-06-22 | Lamodel Ltd | aparelho para administrar uma substância a um indivíduo |
| US10420880B2 (en) | 2007-10-02 | 2019-09-24 | West Pharma. Services IL, Ltd. | Key for securing components of a drug delivery system during assembly and/or transport and methods of using same |
| US9656019B2 (en) | 2007-10-02 | 2017-05-23 | Medimop Medical Projects Ltd. | Apparatuses for securing components of a drug delivery system during transport and methods of using same |
| EP4588519A3 (en) | 2008-03-14 | 2025-10-15 | Allergan, Inc. | Immuno-based botulinum toxin serotype a activity assays |
| US12097357B2 (en) | 2008-09-15 | 2024-09-24 | West Pharma. Services IL, Ltd. | Stabilized pen injector |
| US9393369B2 (en) | 2008-09-15 | 2016-07-19 | Medimop Medical Projects Ltd. | Stabilized pen injector |
| LT2379104T (lt) | 2008-12-31 | 2018-04-10 | Revance Therapeutics, Inc. | Injekcinės botulino toksino vaisto formos |
| BRPI1015938A2 (pt) | 2009-06-25 | 2016-09-27 | Revance Therapeutics Inc | formulações da toxina botulínica livre de albumina |
| US10071198B2 (en) | 2012-11-02 | 2018-09-11 | West Pharma. Servicees IL, Ltd. | Adhesive structure for medical device |
| US10071196B2 (en) | 2012-05-15 | 2018-09-11 | West Pharma. Services IL, Ltd. | Method for selectively powering a battery-operated drug-delivery device and device therefor |
| US8157769B2 (en) | 2009-09-15 | 2012-04-17 | Medimop Medical Projects Ltd. | Cartridge insertion assembly for drug delivery system |
| PL2490986T3 (pl) * | 2009-10-21 | 2019-03-29 | Revance Therapeutics, Inc. | Sposoby i systemy oczyszczania nieskompleksowanej neurotoksyny botulinowej |
| US10288611B2 (en) | 2009-11-23 | 2019-05-14 | The Johns Hopkins University | Lateral flow device for diagnosing microbial infections |
| US10585098B2 (en) | 2009-11-23 | 2020-03-10 | The Johns Hopkins University | Optimizing diagnostics for galactofuranose containing antigens |
| US8348898B2 (en) | 2010-01-19 | 2013-01-08 | Medimop Medical Projects Ltd. | Automatic needle for drug pump |
| EP2569031B1 (en) * | 2010-05-10 | 2017-10-11 | Medimop Medical Projects Ltd. | Low volume accurate injector |
| KR101134146B1 (ko) * | 2010-05-31 | 2012-04-19 | 메덱스젠 주식회사 | 국소 근마비 효과를 갖는 비확산형 보툴리눔 독소와 그의 정제방법 |
| HRP20171483T1 (hr) * | 2011-01-07 | 2017-12-01 | Revance Therapeutics, Inc. | Topikalni pripravak koji se sastoji od botulinskog toksina i boje |
| USD702834S1 (en) | 2011-03-22 | 2014-04-15 | Medimop Medical Projects Ltd. | Cartridge for use in injection device |
| US9072827B2 (en) | 2012-03-26 | 2015-07-07 | Medimop Medical Projects Ltd. | Fail safe point protector for needle safety flap |
| MX370929B (es) | 2012-10-28 | 2020-01-08 | Revance Therapeutics Inc | Composiciones y usos de las mismas para el tratamiento seguro de la rinitis. |
| US9421323B2 (en) | 2013-01-03 | 2016-08-23 | Medimop Medical Projects Ltd. | Door and doorstop for portable one use drug delivery apparatus |
| US9011164B2 (en) | 2013-04-30 | 2015-04-21 | Medimop Medical Projects Ltd. | Clip contact for easy installation of printed circuit board PCB |
| RU2535115C1 (ru) | 2013-05-15 | 2014-12-10 | Бости Трейдинг Лтд | Фармацевтический состав, содержащий нейротоксин ботулина |
| GB201312317D0 (en) * | 2013-07-09 | 2013-08-21 | Syntaxin Ltd | Cationic neurotoxins |
| US9480731B2 (en) | 2013-12-12 | 2016-11-01 | Medy-Tox, Inc. | Long lasting effect of new botulinum toxin formulations |
| WO2015095195A1 (en) | 2013-12-16 | 2015-06-25 | The Johns Hopkins University | Interferon-gamma release assays for diagnosis of invasive fungal infections |
| ES2642916T3 (es) * | 2014-06-06 | 2017-11-20 | Galit KLEINER-FISMAN | Toxina botulínica para su uso en el tratamiento de la paratonia |
| US11484580B2 (en) | 2014-07-18 | 2022-11-01 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
| ES2821731T3 (es) * | 2014-07-31 | 2021-04-27 | Allergan Inc | Formulaciones de productos biológicos para instilación intravesical |
| JP6643324B2 (ja) * | 2014-09-02 | 2020-02-12 | アメリカン シルヴァー リミテッド ライアビリティ カンパニー | ボツリヌス毒素及びコロイド状銀粒子 |
| EP3590500B1 (en) | 2014-12-23 | 2025-06-25 | Merz Pharma GmbH & Co. KGaA | Botulinum toxin prefilled container |
| US10293120B2 (en) | 2015-04-10 | 2019-05-21 | West Pharma. Services IL, Ltd. | Redundant injection device status indication |
| KR102099326B1 (ko) * | 2015-04-13 | 2020-04-09 | 주식회사 엘지생활건강 | 폴리페놀 전달용 용해성 마이크로니들 |
| CN107427474A (zh) | 2015-04-13 | 2017-12-01 | 株式会社Lg生活健康 | 含有调节神经递质释放的成分的可溶性微针 |
| US10149943B2 (en) | 2015-05-29 | 2018-12-11 | West Pharma. Services IL, Ltd. | Linear rotation stabilizer for a telescoping syringe stopper driverdriving assembly |
| CN107683158B (zh) | 2015-06-04 | 2021-05-14 | 麦迪麦珀医疗工程有限公司 | 用于药物释放装置的筒插入 |
| US10576207B2 (en) | 2015-10-09 | 2020-03-03 | West Pharma. Services IL, Ltd. | Angled syringe patch injector |
| US9987432B2 (en) | 2015-09-22 | 2018-06-05 | West Pharma. Services IL, Ltd. | Rotation resistant friction adapter for plunger driver of drug delivery device |
| CN108472438B (zh) | 2015-10-09 | 2022-01-28 | 西医药服务以色列分公司 | 至预填充的流体储存器的弯曲流体路径附加装置 |
| CA3003447A1 (en) * | 2015-10-29 | 2017-05-04 | Revance Therapeutics, Inc. | Injectable botulinum toxin formulations and methods of use thereof having long duration of therapeutic or cosmetic effect |
| CN109310816B (zh) | 2016-01-21 | 2020-04-21 | 西医药服务以色列有限公司 | 针插入和缩回机构 |
| JP6885960B2 (ja) | 2016-01-21 | 2021-06-16 | ウェスト ファーマ サービシーズ イスラエル リミテッド | 視覚的インジケータを有する薬剤デリバリデバイス |
| EP3405227B1 (en) | 2016-01-21 | 2020-06-17 | West Pharma. Services Il, Ltd. | Force containment in an automatic injector |
| US20170209553A1 (en) * | 2016-01-22 | 2017-07-27 | Transderm, Inc. | Delivery of botulinum with microneedle arrays |
| US11389597B2 (en) | 2016-03-16 | 2022-07-19 | West Pharma. Services IL, Ltd. | Staged telescopic screw assembly having different visual indicators |
| JP6957525B2 (ja) | 2016-06-02 | 2021-11-02 | ウェスト ファーマ サービシーズ イスラエル リミテッド | 3つの位置による針の退避 |
| JP7059251B2 (ja) | 2016-08-01 | 2022-04-25 | ウェスト ファーマ サービシーズ イスラエル リミテッド | ドアの半閉じを防止するスプリング |
| WO2018026387A1 (en) | 2016-08-01 | 2018-02-08 | Medimop Medical Projects Ltd. | Anti-rotation cartridge pin |
| RU2762607C2 (ru) | 2016-09-13 | 2021-12-21 | Аллерган, Инк. | Стабилизированные небелковые композиции клостридиального токсина |
| KR102487144B1 (ko) * | 2016-11-21 | 2023-01-12 | 에이리온 테라퓨틱스, 인코포레이티드 | 큰 물질의 경피 전달 |
| KR102401856B1 (ko) * | 2017-02-17 | 2022-05-26 | 알레간 인코포레이티드 | 활성 성분을 갖는 마이크로니들 어레이 |
| EP3600221A4 (en) * | 2017-03-22 | 2021-01-13 | Bonti, Inc. | BOTULINARY NEUROTOXINS FOR USE IN THERAPY |
| CN107185042B (zh) * | 2017-04-29 | 2020-09-01 | 杭州维多利亚医疗美容医院有限公司 | 一种美容注射剂及其制备方法 |
| AU2018270092B2 (en) * | 2017-05-18 | 2025-04-17 | Revance Therapeutics, Inc. | Methods of treatment for cervical dystonia |
| US11819666B2 (en) | 2017-05-30 | 2023-11-21 | West Pharma. Services IL, Ltd. | Modular drive train for wearable injector |
| US12161703B2 (en) | 2017-08-28 | 2024-12-10 | Revance Therapeutics, Inc. | Transmucosal botulinum toxin compositions, kits, and methods for treating bladder disorders |
| KR20190038292A (ko) * | 2017-09-29 | 2019-04-08 | 한국프라임제약주식회사 | 효능 지속시간이 연장된 보툴리눔 독소 조성물 |
| WO2019090257A1 (en) * | 2017-11-03 | 2019-05-09 | Revance Therapeutics, Inc. | Botulinum toxin formulations and methods of use thereof in plantar fasciitis with extended duration of effect |
| MX2020005785A (es) * | 2017-12-04 | 2020-10-28 | Revance Therapeutics Inc | Formulaciones inyectables de toxina botulínica y métodos de uso de las mismas que tienen una alta tasa de respuesta y una larga duración del efecto. |
| WO2019126421A1 (en) | 2017-12-22 | 2019-06-27 | West Pharma. Services Il., Ltd. | Injector usable with different dimension cartridges |
| KR102088104B1 (ko) | 2018-06-29 | 2020-03-11 | 호서대학교 산학협력단 | 개망초 꽃 에센셜 오일을 포함하는 신경 근육 관련 질환 예방 및 치료용 조성물 |
| WO2020117564A1 (en) | 2018-12-03 | 2020-06-11 | Eirion Therapeutics, Inc. | Improved delivery of large agents |
| CA3139983A1 (en) | 2019-05-14 | 2020-11-19 | Eirion Therapeutics, Inc. | Delaying peak effect and/or extending duration of response |
| WO2021195968A1 (zh) | 2020-03-31 | 2021-10-07 | 台湾浩鼎生技股份有限公司 | A型肉毒杆菌毒素复合物、其配制剂和使用方法 |
| US20230165946A1 (en) * | 2020-04-08 | 2023-06-01 | Medytox Inc. | Botulinum toxin pre-filled injectable formulation that facilitates discharge rate control and is stable |
| CN120437268A (zh) | 2020-06-12 | 2025-08-08 | 凯尔格恩有限公司 | 包含五肽作为活性成分的组合物 |
| KR20220114183A (ko) * | 2021-02-08 | 2022-08-17 | 주식회사 대웅 | 장기 저장이 가능한 보툴리눔 독소 동결건조 제형 조성물 |
| WO2023239229A1 (ko) | 2022-06-10 | 2023-12-14 | (주)메디톡스 | 보툴리눔 독소 안정화 조성물, 이를 포함하는 보툴리눔 독소 제제 및 이에 사용하기 위한 폴리펩티드 |
| KR102714765B1 (ko) * | 2023-05-04 | 2024-10-11 | 주식회사 파마리서치바이오 | Dna 단편 혼합물 및 보툴리눔 독소를 포함하는 보툴리눔 독소의 생체 내 지속성이 증가된 지속성 제제 |
| WO2025064729A1 (en) | 2023-09-19 | 2025-03-27 | Revance Therapeutics, Inc. | Treatment with botulinum toxin in patients in need of a rapid onset cosmetic effect and smoother skin appearance |
| WO2025229073A1 (en) * | 2024-05-01 | 2025-11-06 | Fastox Pharma Sa | Aqueous compositions of dantrolene |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804604A (en) | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
| US5877278A (en) | 1992-09-24 | 1999-03-02 | Chiron Corporation | Synthesis of N-substituted oligomers |
| CZ290342B6 (cs) | 1992-10-02 | 2002-07-17 | Genetics Institute Inc. | Kompozice stabilní při skladování, obsahující koagulační faktor VIII a neiontovou povrchově aktivní látku a způsob její výroby |
| EP1790352B1 (en) | 1993-12-28 | 2008-07-09 | Allergan, Inc. | Use of botulinum toxin for the manufacture of a medicament for reducing low back pain |
| US5512547A (en) | 1994-10-13 | 1996-04-30 | Wisconsin Alumni Research Foundation | Pharmaceutical composition of botulinum neurotoxin and method of preparation |
| US5756468A (en) | 1994-10-13 | 1998-05-26 | Wisconsin Alumni Research Foundation | Pharmaceutical compositions of botulinum toxin or botulinum neurotoxin and methods of preparation |
| GB9508204D0 (en) | 1995-04-21 | 1995-06-07 | Speywood Lab Ltd | A novel agent able to modify peripheral afferent function |
| US6444209B1 (en) | 1996-10-28 | 2002-09-03 | Wisconsin Alumni Research Foundation | Hybrid botulinal neurotoxins |
| US20030095927A1 (en) | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating muscular and skeletal disorders |
| JP2002501033A (ja) | 1998-01-26 | 2002-01-15 | ユニバーシティー オブ マサチューセッツ | A型ボツリヌス菌の生物学的活性赤血球凝集素とその使用法 |
| TW574036B (en) | 1998-09-11 | 2004-02-01 | Elan Pharm Inc | Stable liquid compositions of botulinum toxin |
| US6358917B1 (en) | 1999-08-24 | 2002-03-19 | Jean D. A. Carruthers | Cosmetic use of botulinum toxin for treatment of downturned mouth |
| US6544548B1 (en) * | 1999-09-13 | 2003-04-08 | Keraplast Technologies, Ltd. | Keratin-based powders and hydrogel for pharmaceutical applications |
| US6844324B1 (en) | 1999-11-12 | 2005-01-18 | Massachusetts Institute Of Technology | Modular peptide mediated intracellular delivery system and uses therefore |
| IL149778A0 (en) | 1999-11-22 | 2002-11-10 | Universal Preservation Technologies Inc | Preservation of sensitive biological material |
| US20030118598A1 (en) | 2000-02-08 | 2003-06-26 | Allergan, Inc. | Clostridial toxin pharmaceutical compositions |
| EP1514556B1 (en) | 2000-02-08 | 2011-08-10 | Allergan, Inc. | Botulinum toxin pharmaceutical compositions |
| US7780967B2 (en) | 2000-02-08 | 2010-08-24 | Allergan, Inc. | Reduced toxicity Clostridial toxin pharmaceutical compositions |
| US6670322B2 (en) * | 2000-06-01 | 2003-12-30 | Wisconsin Alumni Research Foundation | Method of targeting pharmaceuticals to motor neurons |
| US20040033241A1 (en) | 2000-06-02 | 2004-02-19 | Allergan, Inc. | Controlled release botulinum toxin system |
| US6306423B1 (en) | 2000-06-02 | 2001-10-23 | Allergan Sales, Inc. | Neurotoxin implant |
| AU8466501A (en) | 2000-07-21 | 2002-02-05 | Essentia Biosystems Inc | Multi-component biological transport systems |
| US20040220100A1 (en) * | 2000-07-21 | 2004-11-04 | Essentia Biosystems, Inc. | Multi-component biological transport systems |
| US20030215412A1 (en) * | 2000-07-21 | 2003-11-20 | Essentia Biosystems, Inc. | Induction of hair growth with vascular endothelial growth factor |
| US6787517B1 (en) | 2000-12-29 | 2004-09-07 | Allergan, Inc. | Agent and methods for treating pain |
| WO2003000193A2 (en) | 2001-06-21 | 2003-01-03 | Surromed, Inc. | Covalent coupling of botulinum toxin with polyethylene glycol |
| MXPA04007924A (es) | 2002-02-14 | 2005-05-17 | Chugai Pharmaceutical Co Ltd | Formulaciones en solucion que contienen anticuerpo. |
| US7691394B2 (en) * | 2002-05-28 | 2010-04-06 | Botulinum Toxin Research Associates, Inc. | High-potency botulinum toxin formulations |
| US20030224020A1 (en) | 2002-05-31 | 2003-12-04 | Zabudkin Alexander F. | Pharmaceutical preparation of botulinum neurotoxin, methods of synthesis and methods of clinical use |
| US20040009180A1 (en) | 2002-07-11 | 2004-01-15 | Allergan, Inc. | Transdermal botulinum toxin compositions |
| US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| RU2206337C1 (ru) | 2002-10-29 | 2003-06-20 | Общество с ограниченной ответственностью "Токсины и сопутствующие продукты" | Лекарственный препарат для лечения мышечных дистоний и способ его получения |
| US20040086532A1 (en) | 2002-11-05 | 2004-05-06 | Allergan, Inc., | Botulinum toxin formulations for oral administration |
| DE10333317A1 (de) | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| US20060210614A1 (en) | 2003-12-26 | 2006-09-21 | Nastech Pharmaceutical Company Inc. | Method of treatment of a metabolic disease using intranasal administration of exendin peptide |
| US20100266638A1 (en) | 2004-02-26 | 2010-10-21 | Allergan, Inc. | Headache treatment method |
| US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| ES2691498T3 (es) * | 2004-03-03 | 2018-11-27 | Revance Therapeutics, Inc. | Aplicación tópica y liberación transdérmica de toxinas botulínicas |
| JP2007527431A (ja) * | 2004-03-03 | 2007-09-27 | ルバンス セラピュティックス | 局所的診断及び治療用の輸送のための組成物及び方法 |
| GB2416122A (en) | 2004-07-12 | 2006-01-18 | Ipsen Ltd | Botulinum neurotoxin composition |
| CA2578250C (en) | 2004-07-26 | 2013-03-05 | Merz Pharma Gmbh & Co. Kgaa | Therapeutic composition with a botulinum neurotoxin |
| US20070196364A1 (en) | 2004-07-27 | 2007-08-23 | Human Genome Sciences, Inc. | Pharmaceutical Formulation and Process |
| US20080102090A1 (en) | 2004-08-04 | 2008-05-01 | Naveed Panjwani | Pharmaceutical Compositon Containing Botulinum Neurotoxin A2 |
| PL1776137T3 (pl) | 2004-08-04 | 2015-03-31 | Ipsen Biopharm Ltd | Kompozycja farmaceutyczna zawierająca neurotoksynę botulinową |
| GB2419526A (en) | 2004-10-28 | 2006-05-03 | Ipsen Ltd | Pharmaceutical composition containing botulinum neurotoxin |
| US7727537B2 (en) | 2005-02-14 | 2010-06-01 | Dpm Therapeutics Corp. | Stabilized compositions for topical administration and methods of making same |
| US7838011B2 (en) | 2005-02-14 | 2010-11-23 | Pankaj Modi | Stabilized protein compositions for topical administration and methods of making same |
| BRPI0608091A2 (pt) * | 2005-03-03 | 2009-11-10 | Revance Therapeutics Inc | composições e processos para aplicação tópica e distribuição transdérmica de um oligopeptìdeo |
| EP1861112A4 (en) * | 2005-03-03 | 2009-07-22 | Revance Therapeutics Inc | COMPOSITIONS AND METHODS FOR TOPICAL APPLICATION AND TRANSDERMAL DELIVERY OF BOTULINUM TOXINES |
| KR20070116710A (ko) * | 2005-03-03 | 2007-12-11 | 알러간, 인코포레이티드 | 보툴리눔 독소를 정제하기 위한 동물 산물이 없는 시스템및 프로세스 |
| CN101228187A (zh) | 2005-03-25 | 2008-07-23 | 特拉维夫大学拉莫特有限公司 | 针对突变p53的共同表位的人合成单链抗体及其用途 |
| US8323666B2 (en) | 2005-08-01 | 2012-12-04 | Allergan, Inc. | Botulinum toxin compositions |
| US8137677B2 (en) | 2005-10-06 | 2012-03-20 | Allergan, Inc. | Non-protein stabilized clostridial toxin pharmaceutical compositions |
| CA2629499A1 (en) | 2005-11-17 | 2007-05-24 | Revance Therapeutics, Inc. | Compositions and methods of topical application and transdermal delivery of botulinum toxins with reduced non-toxin proteins |
| US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
| AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
| FR2910327B1 (fr) | 2006-12-22 | 2013-04-26 | Scras | Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida. |
| AU2007340162B2 (en) | 2006-12-29 | 2013-08-01 | Revance Therapeutics, Inc. | Compositions and methods of topical application and transdermal delivery of botulinum toxins stabilized with polypeptide fragments derived from HIV-TAT |
| MX2009012990A (es) | 2007-06-01 | 2010-04-01 | Merz Pharma Gmbh & Co Kgaa | Proceso para proporcionar un relajante muscular estable a la temperatura sobre la base del componente neurotoxico de toxina botulinica. |
| BRPI0813627B1 (pt) * | 2007-07-26 | 2021-09-14 | Revance Therapeutics, Inc | Composição farmacêutica ou cosmética compreendendo um peptídeo catiônico e kit para administração da mesma |
| WO2009056651A1 (en) | 2007-11-02 | 2009-05-07 | Cytos Biotechnology Ag | Angiotensin-carrier formulation |
| US9107815B2 (en) | 2008-02-22 | 2015-08-18 | Allergan, Inc. | Sustained release poloxamer containing pharmaceutical compositions |
| KR20090120222A (ko) | 2008-05-19 | 2009-11-24 | (주)메디톡스 | 식물 유래 성분 함유 배지 및 가요성 폐쇄 용기를 이용하여클로스트리디움 보툴리눔 독소를 생산하는 방법 |
| WO2010056922A2 (en) * | 2008-11-12 | 2010-05-20 | Kythera Biopharmaceuticals, Inc. | Systems and methods for delivery of biologically active agents |
| EP3067049A1 (en) | 2008-12-10 | 2016-09-14 | Allergan, Inc. | Clostridial toxin pharmaceutical compositions |
| LT2379104T (lt) * | 2008-12-31 | 2018-04-10 | Revance Therapeutics, Inc. | Injekcinės botulino toksino vaisto formos |
| EP2248518B1 (en) | 2009-04-17 | 2013-01-16 | Merz Pharma GmbH & Co. KGaA | Formulation for stabilizing proteins, peptides or mixtures thereof. |
| BRPI1015938A2 (pt) | 2009-06-25 | 2016-09-27 | Revance Therapeutics Inc | formulações da toxina botulínica livre de albumina |
| PL2490986T3 (pl) | 2009-10-21 | 2019-03-29 | Revance Therapeutics, Inc. | Sposoby i systemy oczyszczania nieskompleksowanej neurotoksyny botulinowej |
| US20110106021A1 (en) | 2009-10-30 | 2011-05-05 | Revance Therapeutics, Inc. | Device and Method for Topical Application of Therapeutics or Cosmetic Compositions |
| EP2627318B1 (en) | 2010-10-12 | 2017-08-16 | Merz Pharma GmbH & Co. KGaA | Formulation suitable for stabilizing proteins, which is free of mammalian excipients |
| HRP20171483T1 (hr) | 2011-01-07 | 2017-12-01 | Revance Therapeutics, Inc. | Topikalni pripravak koji se sastoji od botulinskog toksina i boje |
| DK2692350T4 (da) | 2011-03-31 | 2023-09-04 | Medy Tox Inc | Lyofiliseret præparat af botulinumtoksin |
| US20130224268A1 (en) | 2012-02-27 | 2013-08-29 | Newgen Biopharma Corp. | Topical delivery of hormonal and non hormonal nano formulations, methods of making and using the same |
| EP3590500B1 (en) | 2014-12-23 | 2025-06-25 | Merz Pharma GmbH & Co. KGaA | Botulinum toxin prefilled container |
| KR102399451B1 (ko) | 2016-05-27 | 2022-05-23 | 입센 바이오팜 리미티드 | 트립토판 또는 타이로신으로 안정화된 액체 신경독 제형 |
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