HRP20171483T1 - Topikalni pripravak koji se sastoji od botulinskog toksina i boje - Google Patents
Topikalni pripravak koji se sastoji od botulinskog toksina i boje Download PDFInfo
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- HRP20171483T1 HRP20171483T1 HRP20171483TT HRP20171483T HRP20171483T1 HR P20171483 T1 HRP20171483 T1 HR P20171483T1 HR P20171483T T HRP20171483T T HR P20171483TT HR P20171483 T HRP20171483 T HR P20171483T HR P20171483 T1 HRP20171483 T1 HR P20171483T1
- Authority
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- Croatia
- Prior art keywords
- preparation according
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- botulinum toxin
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- 108030001720 Bontoxilysin Proteins 0.000 title claims 6
- 229940053031 botulinum toxin Drugs 0.000 title claims 6
- 230000000699 topical effect Effects 0.000 title claims 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims 2
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 claims 1
- DHHFDKNIEVKVKS-FMOSSLLZSA-N Betanin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC(C[C@H]2C([O-])=O)=C1[N+]2=C\C=C\1C=C(C(O)=O)N[C@H](C(O)=O)C/1 DHHFDKNIEVKVKS-FMOSSLLZSA-N 0.000 claims 1
- DHHFDKNIEVKVKS-MVUYWVKGSA-N Betanin Natural products O=C(O)[C@@H]1NC(C(=O)O)=C/C(=C\C=[N+]/2\[C@@H](C(=O)[O-])Cc3c\2cc(O)c(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)c3)/C1 DHHFDKNIEVKVKS-MVUYWVKGSA-N 0.000 claims 1
- 244000017106 Bixa orellana Species 0.000 claims 1
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 claims 1
- 240000004160 Capsicum annuum Species 0.000 claims 1
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 claims 1
- 240000005605 Clitoria ternatea Species 0.000 claims 1
- 235000008358 Clitoria ternatea Nutrition 0.000 claims 1
- 244000124209 Crocus sativus Species 0.000 claims 1
- 235000015655 Crocus sativus Nutrition 0.000 claims 1
- 244000163122 Curcuma domestica Species 0.000 claims 1
- 235000003392 Curcuma domestica Nutrition 0.000 claims 1
- RZSYLLSAWYUBPE-UHFFFAOYSA-L Fast green FCF Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC(O)=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 RZSYLLSAWYUBPE-UHFFFAOYSA-L 0.000 claims 1
- 108010043121 Green Fluorescent Proteins Proteins 0.000 claims 1
- 102000004144 Green Fluorescent Proteins Human genes 0.000 claims 1
- 240000002390 Pandanus odoratissimus Species 0.000 claims 1
- 239000005083 Zinc sulfide Substances 0.000 claims 1
- DPKHZNPWBDQZCN-UHFFFAOYSA-N acridine orange free base Chemical compound C1=CC(N(C)C)=CC2=NC3=CC(N(C)C)=CC=C3C=C21 DPKHZNPWBDQZCN-UHFFFAOYSA-N 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 235000012665 annatto Nutrition 0.000 claims 1
- 239000010362 annatto Substances 0.000 claims 1
- 235000012677 beetroot red Nutrition 0.000 claims 1
- 239000001654 beetroot red Substances 0.000 claims 1
- DZBUGLKDJFMEHC-UHFFFAOYSA-N benzoquinolinylidene Natural products C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 claims 1
- 235000002185 betanin Nutrition 0.000 claims 1
- 239000001511 capsicum annuum Substances 0.000 claims 1
- 235000013736 caramel Nutrition 0.000 claims 1
- 235000012730 carminic acid Nutrition 0.000 claims 1
- 239000004106 carminic acid Substances 0.000 claims 1
- 229940080423 cochineal Drugs 0.000 claims 1
- 238000004040 coloring Methods 0.000 claims 1
- 235000003373 curcuma longa Nutrition 0.000 claims 1
- 235000012754 curcumin Nutrition 0.000 claims 1
- 239000004148 curcumin Substances 0.000 claims 1
- 229940109262 curcumin Drugs 0.000 claims 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 235000019240 fast green FCF Nutrition 0.000 claims 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 1
- 229940020947 fluorescein sodium Drugs 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 235000002864 food coloring agent Nutrition 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 239000005090 green fluorescent protein Substances 0.000 claims 1
- KHLVKKOJDHCJMG-QDBORUFSSA-L indigo carmine Chemical compound [Na+].[Na+].N/1C2=CC=C(S([O-])(=O)=O)C=C2C(=O)C\1=C1/NC2=CC=C(S(=O)(=O)[O-])C=C2C1=O KHLVKKOJDHCJMG-QDBORUFSSA-L 0.000 claims 1
- 235000012738 indigotine Nutrition 0.000 claims 1
- 239000004179 indigotine Substances 0.000 claims 1
- 239000000974 natural food coloring agent Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 1
- 229940043267 rhodamine b Drugs 0.000 claims 1
- 235000013974 saffron Nutrition 0.000 claims 1
- 239000004248 saffron Substances 0.000 claims 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 claims 1
- 235000013976 turmeric Nutrition 0.000 claims 1
- 229910052984 zinc sulfide Inorganic materials 0.000 claims 1
- DRDVZXDWVBGGMH-UHFFFAOYSA-N zinc;sulfide Chemical compound [S-2].[Zn+2] DRDVZXDWVBGGMH-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
Claims (12)
1. Topikalni ili transdermalni pripravak koji se sastoji od botulinskog toksina i boje.
2. Pripravak prema zahtjevu 1, naznačen time, što se spomenuti pripravak sastoji od nosača, pri čemu se spomenuti nosač sastoji od pozitivno nabijene okosnice polipeptida koja je vezana za jednu ili više grupa učinkovitosti odabranih iz grupe koja se sastoji od (gly)p-RGRDDRRQRRR-(gly)q, (gly)p-YGRKKRRQRRR-(gly)q i (gly)p-RKKRRQRRR(gly)q, pri čemu potpisani p i q zasebno predstavljaju cijeli broj od 0 do 20.
3. Pripravak prema zahtjevu 2, naznačen time, što se nosač sastoji od sekvence aminokiseline RKKRRQRRR-G(K)15-G-RKKRRQRRR.
4. Pripravak prema zahtjevu 1, naznačen time, što je botulinski toksin odabran iz grupe koja se sastoji od serotipa botulinskog toksina A, B, C1, D, E, F i G.
5. Pripravak prema zahtjevu 4, naznačen time, što je botulinski toksin molekula pročišćenog botulinskog toksina.
6. Pripravak prema zahtjevu 1, naznačen time, što je boja vidljiva boja.
7. Pripravak prema zahtjevu 6, naznačen time, što je vidljiva boja umjetna boja.
8. Pripravak prema zahtjevu 6, naznačen time, što je boja odabrana iz grupe koja se sastoji od FD&C Blue No. 1, FD&C Blue No. 2, FD&C Green No. 3, FD&C Red No. 40, FD&C Red No. 3, FD&C Yellow No. 5 i FD&C Red No. 6.
9. Pripravak prema zahtjevu 6, naznačen time, što je vidljiva boja prirodna boja za hranu.
10. Pripravak prema zahtjevu 9, naznačen time, što je prirodna boja za hranu odabrana iz grupe koja se sastoji od karamela bojila, anata, košenila, betanina, kurkuma, šafrana, paprike, pandana i plavog graška.
11. Pripravak prema zahtjevu 1, naznačen time, što je boja fluorescentna boja.
12. Pripravak prema zahtjevu 11, naznačen time, što je fluorescentna boja odabrana iz grupe koja se sastoji od fluorescein natrija, rodamina B, akridin narančaste, zelenog fluorescentnog proteina, kurkumina i cinkovog sulfida.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161430868P | 2011-01-07 | 2011-01-07 | |
| EP11855190.2A EP2661276B1 (en) | 2011-01-07 | 2011-12-22 | Topical composition comprising botulinum toxin and a dye |
| PCT/US2011/066728 WO2012094163A1 (en) | 2011-01-07 | 2011-12-22 | Methods and kits for topical application, removal, and inactivation of therapeutic or cosmetic toxin compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171483T1 true HRP20171483T1 (hr) | 2017-12-01 |
Family
ID=46457668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171483TT HRP20171483T1 (hr) | 2011-01-07 | 2017-10-04 | Topikalni pripravak koji se sastoji od botulinskog toksina i boje |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20140154237A1 (hr) |
| EP (2) | EP3248614A1 (hr) |
| JP (4) | JP6444032B2 (hr) |
| BR (1) | BR112013017311A2 (hr) |
| CY (1) | CY1119427T1 (hr) |
| DK (1) | DK2661276T3 (hr) |
| ES (1) | ES2641068T3 (hr) |
| HK (1) | HK1247553A1 (hr) |
| HR (1) | HRP20171483T1 (hr) |
| HU (1) | HUE035057T2 (hr) |
| LT (1) | LT2661276T (hr) |
| NO (1) | NO2661276T3 (hr) |
| PL (1) | PL2661276T3 (hr) |
| PT (1) | PT2661276T (hr) |
| RS (1) | RS56460B1 (hr) |
| SI (1) | SI2661276T1 (hr) |
| WO (1) | WO2012094163A1 (hr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102499981B (zh) * | 2005-03-03 | 2016-08-03 | 雷文斯治疗公司 | 用于局部施用和经皮肤递送肉毒杆菌毒素的组合物和方法 |
| KR102005930B1 (ko) | 2008-12-31 | 2019-07-31 | 레반스 테라퓨틱스, 아이엔씨. | 주사용 보툴리눔 독소 제제 |
| CN102869373B (zh) | 2009-06-25 | 2017-05-10 | 雷文斯治疗公司 | 不含白蛋白的肉毒杆菌毒素制剂 |
| KR20140139010A (ko) * | 2012-03-22 | 2014-12-04 | 레반스 테라퓨틱스, 아이엔씨. | 국소 화학탈신경제를 이용한 주름 치료 방법 |
| JP6955491B2 (ja) * | 2015-10-29 | 2021-10-27 | ルバンス セラピュティックス インク．Ｒｅｖａｎｃｅ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 治療効果又は美容効果の長い持続時間を有する、注射用ボツリヌス毒素製剤及びこれらの使用方法 |
| HRP20191966T4 (hr) | 2016-09-13 | 2022-09-16 | Allergan, Inc. | Stabilizirani neproteinski klostridijalni pripravci toksina |
| MX2019013716A (es) * | 2017-05-18 | 2020-10-12 | Revance Therapeutics Inc | Métodos de tratamiento para la distonía cervical. |
| US20210162026A1 (en) | 2017-08-28 | 2021-06-03 | Revance Therapeutics, Inc. | Transmucosal botulinum toxin compositions, kits, and methods for treating bladder disorders |
| US20210321696A1 (en) * | 2020-04-20 | 2021-10-21 | First Step Holdings, Llc | Covid mask |
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| CA2678563C (en) * | 2007-03-06 | 2013-04-16 | Steris Inc. | Shelf assembly |
| JP2009001423A (ja) * | 2007-05-21 | 2009-01-08 | Life:Kk | 感染性廃棄物用回収袋又は容器および感染性廃棄物処理方法 |
| WO2009042165A2 (en) * | 2007-09-25 | 2009-04-02 | Thomas Jefferson University | Mutant botulinum neurotoxin serotype a polypeptide and uses thereof |
| US20090148342A1 (en) | 2007-10-29 | 2009-06-11 | Bromberg Steven E | Hypochlorite Technology |
| US20090250626A1 (en) * | 2008-04-04 | 2009-10-08 | Hexatech, Inc. | Liquid sanitization device |
| KR102005930B1 (ko) * | 2008-12-31 | 2019-07-31 | 레반스 테라퓨틱스, 아이엔씨. | 주사용 보툴리눔 독소 제제 |
| CN102869373B (zh) | 2009-06-25 | 2017-05-10 | 雷文斯治疗公司 | 不含白蛋白的肉毒杆菌毒素制剂 |
-
2011
- 2011-12-22 JP JP2013548424A patent/JP6444032B2/ja not_active Expired - Fee Related
- 2011-12-22 EP EP17178151.1A patent/EP3248614A1/en active Pending
- 2011-12-22 PL PL11855190T patent/PL2661276T3/pl unknown
- 2011-12-22 HU HUE11855190A patent/HUE035057T2/en unknown
- 2011-12-22 SI SI201131290T patent/SI2661276T1/sl unknown
- 2011-12-22 EP EP11855190.2A patent/EP2661276B1/en not_active Revoked
- 2011-12-22 DK DK11855190.2T patent/DK2661276T3/en active
- 2011-12-22 BR BR112013017311A patent/BR112013017311A2/pt not_active Application Discontinuation
- 2011-12-22 NO NO11855190A patent/NO2661276T3/no unknown
- 2011-12-22 US US13/978,673 patent/US20140154237A1/en not_active Abandoned
- 2011-12-22 RS RS20171000A patent/RS56460B1/sr unknown
- 2011-12-22 US US13/334,283 patent/US20120294844A1/en not_active Abandoned
- 2011-12-22 ES ES11855190.2T patent/ES2641068T3/es active Active
- 2011-12-22 PT PT118551902T patent/PT2661276T/pt unknown
- 2011-12-22 LT LTEP11855190.2T patent/LT2661276T/lt unknown
- 2011-12-22 WO PCT/US2011/066728 patent/WO2012094163A1/en active Application Filing
-
2016
- 2016-09-09 JP JP2016177053A patent/JP6605420B2/ja not_active Expired - Fee Related
-
2017
- 2017-09-13 CY CY20171100970T patent/CY1119427T1/el unknown
- 2017-10-04 HR HRP20171483TT patent/HRP20171483T1/hr unknown
-
2018
- 2018-05-25 HK HK18106889.1A patent/HK1247553A1/zh unknown
- 2018-07-05 JP JP2018128169A patent/JP2018188447A/ja active Pending
-
2020
- 2020-07-02 JP JP2020114910A patent/JP2020172519A/ja active Pending
- 2020-12-07 US US17/114,486 patent/US20210189326A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2661276A4 (en) | 2014-09-03 |
| JP6605420B2 (ja) | 2019-11-13 |
| JP6444032B2 (ja) | 2018-12-26 |
| CY1119427T1 (el) | 2018-03-07 |
| JP2017025083A (ja) | 2017-02-02 |
| WO2012094163A1 (en) | 2012-07-12 |
| HK1247553A1 (zh) | 2018-09-28 |
| EP3248614A1 (en) | 2017-11-29 |
| EP2661276B1 (en) | 2017-08-02 |
| PL2661276T3 (pl) | 2018-03-30 |
| HUE035057T2 (en) | 2018-05-02 |
| LT2661276T (lt) | 2017-12-11 |
| DK2661276T3 (en) | 2017-10-02 |
| EP2661276A1 (en) | 2013-11-13 |
| RS56460B1 (sr) | 2018-01-31 |
| US20120294844A1 (en) | 2012-11-22 |
| SI2661276T1 (sl) | 2017-12-29 |
| US20140154237A1 (en) | 2014-06-05 |
| NO2661276T3 (hr) | 2017-12-30 |
| ES2641068T3 (es) | 2017-11-07 |
| JP2014502969A (ja) | 2014-02-06 |
| US20210189326A1 (en) | 2021-06-24 |
| JP2018188447A (ja) | 2018-11-29 |
| JP2020172519A (ja) | 2020-10-22 |
| PT2661276T (pt) | 2017-10-06 |
| BR112013017311A2 (pt) | 2016-10-04 |
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