JP2015510393A5 - - Google Patents
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- Publication number
- JP2015510393A5 JP2015510393A5 JP2014553578A JP2014553578A JP2015510393A5 JP 2015510393 A5 JP2015510393 A5 JP 2015510393A5 JP 2014553578 A JP2014553578 A JP 2014553578A JP 2014553578 A JP2014553578 A JP 2014553578A JP 2015510393 A5 JP2015510393 A5 JP 2015510393A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- amino acid
- peptide according
- agent
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 25
- 150000001413 amino acids Chemical group 0.000 claims 10
- 235000001014 amino acid Nutrition 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 3
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 3
- 108091000080 Phosphotransferase Proteins 0.000 claims 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 3
- 235000004279 alanine Nutrition 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 102000020233 phosphotransferase Human genes 0.000 claims 3
- 239000004474 valine Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- 108030004415 Non-specific serine/threonine protein kinases Proteins 0.000 claims 2
- 108091008611 Protein Kinase B Proteins 0.000 claims 2
- 102000001332 SRC Human genes 0.000 claims 2
- 108060006706 SRC Proteins 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 101150107888 AKT2 gene Proteins 0.000 claims 1
- 101150051155 Akt3 gene Proteins 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 108091006116 chimeric peptides Proteins 0.000 claims 1
- 210000000805 cytoplasm Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 108060006633 protein kinase Proteins 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2012900259A AU2012900259A0 (en) | 2012-01-24 | Agents for use in cancer therapy | |
| AU2012900259 | 2012-01-24 | ||
| AU2012904368 | 2012-10-06 | ||
| AU2012904368A AU2012904368A0 (en) | 2012-10-06 | Anti-cancer peptides | |
| PCT/AU2013/000045 WO2013110120A1 (en) | 2012-01-24 | 2013-01-24 | Peptide agents for cancer therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015510393A JP2015510393A (ja) | 2015-04-09 |
| JP2015510393A5 true JP2015510393A5 (enExample) | 2016-03-17 |
| JP6249447B2 JP6249447B2 (ja) | 2017-12-20 |
Family
ID=48872819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014553578A Expired - Fee Related JP6249447B2 (ja) | 2012-01-24 | 2013-01-24 | 癌治療用ペプチド剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9403877B2 (enExample) |
| EP (1) | EP2807180B1 (enExample) |
| JP (1) | JP6249447B2 (enExample) |
| CN (1) | CN104271590B (enExample) |
| AU (1) | AU2013202137B2 (enExample) |
| CA (1) | CA2862485C (enExample) |
| WO (1) | WO2013110120A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101644982B1 (ko) * | 2015-07-23 | 2016-08-02 | 주식회사 엔솔바이오사이언스 | 신규 펩타이드 및 그 용도 |
| CN105294839A (zh) * | 2015-10-28 | 2016-02-03 | 上海大学 | 对新生血管形成有阻断功能的多肽化合物及其应用 |
| CN106146620A (zh) * | 2016-07-09 | 2016-11-23 | 青岛大学 | 具有抑制癌细胞生长活性的肽及其应用 |
| CN106167513A (zh) * | 2016-07-09 | 2016-11-30 | 青岛大学 | 具有抑制癌细胞生长活性的肽及其应用 |
| CN106084012A (zh) * | 2016-07-09 | 2016-11-09 | 青岛大学 | 具有抑制癌细胞生长活性的肽及其应用 |
| CN105936643A (zh) * | 2016-07-09 | 2016-09-14 | 青岛大学 | 具有抑制癌细胞生长活性的肽及其应用 |
| CN105936642A (zh) * | 2016-07-09 | 2016-09-14 | 青岛大学 | 具有抑制癌细胞生长活性的肽及其应用 |
| GB201706472D0 (en) * | 2017-04-24 | 2017-06-07 | Cancer Res Tech Ltd | Tumour-targeting peptide variants |
| CN111094324B (zh) * | 2018-03-14 | 2023-10-10 | 武汉博威德生物技术有限公司 | 一种溶瘤病毒、合成dna序列及其应用 |
| KR20210021984A (ko) * | 2018-05-15 | 2021-03-02 | 인터크 펩타이드 테라퓨틱스 리미티드 | 펩타이드 활성화 제제 |
| US12134663B2 (en) * | 2018-05-15 | 2024-11-05 | Interk Peptide Therapeutics Limited | Cationic peptides for activating Lck |
| KR20210097729A (ko) * | 2018-11-30 | 2021-08-09 | 인터크 펩타이드 테라퓨틱스 리미티드 | 피부 병태를 개선하기 위한 폴리펩타이드 및 방법 |
| CN110893236A (zh) * | 2019-10-09 | 2020-03-20 | 中山大学 | 溶酶体靶向的抗体药物偶联物及其应用 |
| CN112646018B (zh) * | 2021-01-25 | 2023-04-28 | 井冈山大学 | 一种抑制肿瘤细胞增殖和转移的生物活性肽及其应用 |
| CN117979985A (zh) * | 2021-08-20 | 2024-05-03 | 英特肽治疗有限公司 | 用于治疗包括与癌症和癌症疗法相关的自身免疫在内的自身免疫的组合物和方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030162956A1 (en) | 1997-04-07 | 2003-08-28 | Human Genome Sciences, Inc. | Leukocyte regulatory factors 1 and 2 |
| ATE385503T1 (de) | 1999-06-28 | 2008-02-15 | Inter K Pty Ltd | Verfahren zur modulierung von integrin- vermittelter zellaktivitaet und hierfuer geeignete reagenzien |
| MXPA02012198A (es) | 2000-06-09 | 2004-08-19 | Teni Boulikas | Encapsulacion de polinucleotidos y drogas en liposomas objetivos. |
| US6696546B1 (en) * | 2000-11-06 | 2004-02-24 | The Trustees Of Columbia University In The City Of New York | Peptide that kills growing but not stationary cells |
| AUPR230500A0 (en) * | 2000-12-22 | 2001-01-25 | University Of Newcastle Research Associates Limited, The | A method of modulating map kinase mediated cellular activity and agents useful in same |
| WO2002053726A2 (en) * | 2001-01-02 | 2002-07-11 | Hybrigenics | Protein-protein interactions in adipocyte cells |
| US20030194798A1 (en) | 2001-05-24 | 2003-10-16 | Surber Mark W. | Minicell compositions and methods |
| PT2302063T (pt) | 2001-10-15 | 2016-07-28 | Engeneic Molecular Delivery Pty Ltd | Minicélulas intactas, como vetores para a transferência de adn e terapêutica genética in vitro e in vivo |
| CN101905024A (zh) | 2001-11-16 | 2010-12-08 | 杰南技术公司 | 含有血管生成素-样蛋白质3angptl3的组合物及其使用方法 |
| WO2005009346A2 (en) | 2003-06-24 | 2005-02-03 | Mirus Corporation | Inhibition of gene function by delivery of polynucleotide-based gene expression inhibitors to mammalian cells in vivo |
| US7611885B2 (en) | 2003-06-24 | 2009-11-03 | Engeneic Molecular Delivery Pty, Ltd. | Pharmaceutically compatible method for purifying intact bacterial minicells |
| AU2004281077B2 (en) * | 2003-10-17 | 2010-12-02 | Inter-K Pty Limited | Methods and agents for the treatment of cancer |
| US7183257B2 (en) * | 2004-04-14 | 2007-02-27 | The Brigham And Women's Hospital, Inc. | Use of RPL41 to treat infections and inhibit cancer |
| US20060194319A1 (en) | 2004-09-02 | 2006-08-31 | Webb Carol F | Promoter substitution for immunoglobulin therapy |
| WO2006029981A1 (en) | 2004-09-13 | 2006-03-23 | Vib Vzw | Abin-mediated protection against lung inflammatory disease |
| ATE470454T1 (de) | 2004-09-13 | 2010-06-15 | Genzyme Corp | Multimere konstrukte |
| US7429481B2 (en) | 2004-09-14 | 2008-09-30 | University Of Pittsburgh | Targeting viruses using a modified sindbis glycoprotein |
| GB0520068D0 (en) | 2005-10-03 | 2005-11-09 | Cancer Res Technology | av peptide ligand |
| US7912214B2 (en) | 2007-07-20 | 2011-03-22 | Amadeus S.A.S. | Method and system for generating and controlling the distribution and use of personal promotion codes by targeted customers |
| WO2009103127A1 (en) * | 2008-02-22 | 2009-08-27 | Inter-K Pty Limited | Therapeutic peptides |
| EP2254592B1 (en) | 2008-02-28 | 2019-06-05 | Dako Denmark A/S | Mhc multimers in borrelia diagnostics and disease |
| WO2010039778A2 (en) * | 2008-09-30 | 2010-04-08 | Zirus, Inc. | Mammalian genes involved in infection |
| JP2012518602A (ja) | 2009-02-23 | 2012-08-16 | インター−ケイ ピーティーワイ リミテッド | 複数の細胞活性化経路の阻害 |
-
2013
- 2013-01-24 CN CN201380016372.7A patent/CN104271590B/zh active Active
- 2013-01-24 US US14/374,245 patent/US9403877B2/en active Active
- 2013-01-24 CA CA2862485A patent/CA2862485C/en active Active
- 2013-01-24 WO PCT/AU2013/000045 patent/WO2013110120A1/en not_active Ceased
- 2013-01-24 JP JP2014553578A patent/JP6249447B2/ja not_active Expired - Fee Related
- 2013-01-24 EP EP13740583.3A patent/EP2807180B1/en active Active
- 2013-01-24 AU AU2013202137A patent/AU2013202137B2/en active Active
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