JP2012500001A5 - - Google Patents
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- JP2012500001A5 JP2012500001A5 JP2011507725A JP2011507725A JP2012500001A5 JP 2012500001 A5 JP2012500001 A5 JP 2012500001A5 JP 2011507725 A JP2011507725 A JP 2011507725A JP 2011507725 A JP2011507725 A JP 2011507725A JP 2012500001 A5 JP2012500001 A5 JP 2012500001A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- antigen
- group
- cancer
- hla
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 58
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 27
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 21
- 239000000427 antigen Substances 0.000 claims description 18
- 102000036639 antigens Human genes 0.000 claims description 18
- 108091007433 antigens Proteins 0.000 claims description 18
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 102000040430 polynucleotide Human genes 0.000 claims description 14
- 108091033319 polynucleotide Proteins 0.000 claims description 14
- 239000002157 polynucleotide Substances 0.000 claims description 14
- 206010028980 Neoplasm Diseases 0.000 claims description 13
- 150000001413 amino acids Chemical class 0.000 claims description 13
- 201000011510 cancer Diseases 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 230000001939 inductive effect Effects 0.000 claims description 11
- 206010041067 Small cell lung cancer Diseases 0.000 claims description 8
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 8
- 208000000587 small cell lung carcinoma Diseases 0.000 claims description 8
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 8
- 210000001808 exosome Anatomy 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 5
- 210000004027 cell Anatomy 0.000 claims description 5
- 229920001184 polypeptide Polymers 0.000 claims description 5
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 4
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 4
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 4
- 206010038389 Renal cancer Diseases 0.000 claims description 4
- 206010068771 Soft tissue neoplasm Diseases 0.000 claims description 4
- 208000006990 cholangiocarcinoma Diseases 0.000 claims description 4
- 201000004101 esophageal cancer Diseases 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 4
- 201000010982 kidney cancer Diseases 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 2
- 229930182817 methionine Natural products 0.000 claims description 2
- 229960005486 vaccine Drugs 0.000 claims description 2
- 239000004474 valine Substances 0.000 claims description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 description 2
- 239000008177 pharmaceutical agent Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
- 101100221606 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) COS7 gene Proteins 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8997308P | 2008-08-19 | 2008-08-19 | |
| US61/089,973 | 2008-08-19 | ||
| PCT/JP2009/003894 WO2010021111A1 (en) | 2008-08-19 | 2009-08-14 | Inhbb epitope peptides and vaccines containing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012500001A JP2012500001A (ja) | 2012-01-05 |
| JP2012500001A5 true JP2012500001A5 (enExample) | 2012-09-20 |
Family
ID=41707002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011507725A Ceased JP2012500001A (ja) | 2008-08-19 | 2009-08-14 | Ｉｎｈｂｂエピトープペプチドおよびそれを含むワクチン |
Country Status (13)
| Country | Link |
|---|---|
| US (7) | US20110280898A1 (enExample) |
| EP (1) | EP2326718A4 (enExample) |
| JP (1) | JP2012500001A (enExample) |
| KR (1) | KR20110063456A (enExample) |
| CN (1) | CN102186977A (enExample) |
| AU (1) | AU2009283762A1 (enExample) |
| CA (1) | CA2734515A1 (enExample) |
| IL (1) | IL211131A0 (enExample) |
| MX (1) | MX2011001880A (enExample) |
| RU (1) | RU2011110504A (enExample) |
| SG (1) | SG193214A1 (enExample) |
| TW (1) | TW201008574A (enExample) |
| WO (1) | WO2010021111A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DK2325306T3 (en) * | 2005-02-25 | 2014-03-03 | Oncotherapy Science Inc | Peptide vaccines against lung cancers expressing TTK, URLC10 or KOC1 polypeptide |
| US9732131B2 (en) | 2006-02-27 | 2017-08-15 | Calviri, Inc. | Identification and use of novopeptides for the treatment of cancer |
| CN101432022A (zh) * | 2006-02-28 | 2009-05-13 | 肿瘤疗法科学股份有限公司 | 利用抗-EphA4抗体效应物作用损伤细胞的方法 |
| EP2004687A1 (en) * | 2006-02-28 | 2008-12-24 | Oncotherapy Science, Inc. | Methods for damaging cells using effector functions of anti-cdh3 antibodies |
| EP2468887A1 (en) * | 2006-12-13 | 2012-06-27 | Oncotherapy Science, Inc. | TTK as tumor marker and therapeutic target for lung cancer |
| EP2185732A1 (en) * | 2007-07-30 | 2010-05-19 | Oncotherapy Science, Inc. | Cancer associated gene ly6k |
| UA100127C2 (ru) * | 2007-08-20 | 2012-11-26 | Онкотерапи Саенс, Инк. | Пептид cdh3 и лекарственное средство, содержащее его |
| CA2729403A1 (en) | 2008-06-30 | 2010-01-07 | Oncotherapy Science, Inc. | Anti-cdh3 antibodies labeled with radioisotope label and uses thereof |
| TWI543767B (zh) | 2008-08-19 | 2016-08-01 | 腫瘤療法 科學股份有限公司 | Ｈｉｇ２與ｕｒｌｃ１０抗原決定位胜肽以及含此胜肽之疫苗 |
| MX2011004176A (es) | 2008-10-22 | 2011-09-21 | Oncotherapy Science Inc | Peptido-epitope rab6kifl/kif20a y vacunas que contienen el mismo. |
| TWI539160B (zh) | 2008-12-05 | 2016-06-21 | 腫瘤療法 科學股份有限公司 | Ｗｄｒｐｕｈ抗原決定位胜肽以及含此胜肽之疫苗 |
| TW201102081A (en) | 2009-05-11 | 2011-01-16 | Oncotherapy Science Inc | TTK peptides and vaccines including the same |
| CN102781964B (zh) | 2009-12-28 | 2015-11-25 | 肿瘤疗法科学股份有限公司 | 抗cdh3抗体及其用途 |
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| TWI538685B (zh) * | 2010-04-02 | 2016-06-21 | 腫瘤療法 科學股份有限公司 | Ｅｃｔ２胜肽及含此胜肽之疫苗 |
| EP2795329A2 (en) * | 2011-12-23 | 2014-10-29 | Medical Research Council | Selective ligands for the angiotensin ii receptors |
| KR20140138900A (ko) * | 2012-03-09 | 2014-12-04 | 온코세라피 사이언스 가부시키가이샤 | 펩티드를 포함한 의약 조성물 |
| EP2872531A4 (en) * | 2012-07-10 | 2016-04-06 | Oncotherapy Science Inc | LY6K EPITOPE PEPTIDES FOR TH1 CELLS AND VACCINES CONTAINING SAME |
| WO2014010231A1 (en) * | 2012-07-10 | 2014-01-16 | Oncotherapy Science, Inc. | Kif20a epitope peptides for th1 cells and vaccines containing the same |
| SG11201504558TA (en) | 2012-12-11 | 2015-07-30 | Einstein Coll Med | Methods for high throughput receptor:ligand identification |
| TWI658049B (zh) * | 2013-03-12 | 2019-05-01 | 腫瘤療法 科學股份有限公司 | Ｋｎｔｃ２胜肽及含此胜肽之疫苗 |
| GB201315946D0 (en) * | 2013-09-06 | 2013-10-23 | Immune Targeting Systems Its Ltd | Oncology vaccine |
| MX2016017393A (es) | 2014-07-01 | 2017-09-05 | Pfizer | Diacuerpos heterodimericos biespecificos y sus usos. |
| US10576097B2 (en) * | 2014-08-04 | 2020-03-03 | Oncotherapy Science, Inc. | URLC10-derived peptide and vaccine containing same |
| AU2015313268B2 (en) | 2014-09-08 | 2018-12-20 | National Cancer Center | Cancer-cell-specific antibody, anticancer agent, and cancer testing method |
| WO2016090177A1 (en) | 2014-12-03 | 2016-06-09 | Verik Bio, Inc. | Identification, selection and use of high curative potential t cell epitopes |
| GB201604458D0 (en) * | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against cancers |
| SG11201808552XA (en) | 2016-05-18 | 2018-10-30 | Cue Biopharma Inc | T-cell modulatory multimeric polypeptides and methods of use thereof |
| IL262606B2 (en) | 2016-05-18 | 2023-04-01 | Albert Einstein College Medicine Inc | pd-l1 variant polypeptides, T-cell modulatory multimeric polypeptides, and methods of using them |
| DE102016123893A1 (de) | 2016-12-08 | 2018-06-14 | Immatics Biotechnologies Gmbh | T-Zellrezeptoren mit verbesserter Bindung |
| CN110325205B (zh) | 2016-12-22 | 2023-08-15 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
| US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| BR112019018307A2 (pt) * | 2017-03-03 | 2020-03-31 | Treos Bio Zrt | Plataforma para identificação de peptídeos imunogênicos baseada em população |
| KR20240005989A (ko) | 2017-03-15 | 2024-01-12 | 큐 바이오파마, 인크. | 면역 반응을 조절하는 방법 |
| EP3630131B1 (en) | 2017-06-02 | 2022-08-31 | Arizona Board of Regents on behalf of Arizona State University | A method to create personalized canine cancer vaccines |
| US12025615B2 (en) | 2017-09-15 | 2024-07-02 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods of classifying response to immunotherapy for cancer |
| WO2019139896A1 (en) | 2018-01-09 | 2019-07-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| CN113329761A (zh) | 2018-09-04 | 2021-08-31 | 特雷斯生物有限公司 | 肽疫苗 |
| EP4038222A4 (en) | 2019-10-02 | 2023-10-18 | Arizona Board of Regents on behalf of Arizona State University | Methods and compositions for identifying neoantigens for use in treating and preventing cancer |
| IL296209A (en) | 2020-05-12 | 2022-11-01 | Cue Biopharma Inc | Multimeric t-cell modulatory polypeptides and methods of using them |
| JP2023541366A (ja) | 2020-09-09 | 2023-10-02 | キュー バイオファーマ， インコーポレイテッド | １型真性糖尿病（ｔ１ｄ）を治療するためのｍｈｃクラスｉｉ ｔ細胞調節多量体ポリペプチド及びその使用方法 |
| CN120842365B (zh) * | 2025-07-25 | 2026-05-29 | 广州医科大学附属第一医院（广州呼吸中心） | 淋巴细胞抗原6复合物位点k的抗原表位肽及其应用 |
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2009
- 2009-08-13 TW TW098127225A patent/TW201008574A/zh unknown
- 2009-08-14 WO PCT/JP2009/003894 patent/WO2010021111A1/en not_active Ceased
- 2009-08-14 CN CN2009801413475A patent/CN102186977A/zh not_active Withdrawn
- 2009-08-14 SG SG2013062708A patent/SG193214A1/en unknown
- 2009-08-14 EP EP09808047A patent/EP2326718A4/en not_active Withdrawn
- 2009-08-14 KR KR1020117005944A patent/KR20110063456A/ko not_active Withdrawn
- 2009-08-14 AU AU2009283762A patent/AU2009283762A1/en not_active Abandoned
- 2009-08-14 JP JP2011507725A patent/JP2012500001A/ja not_active Ceased
- 2009-08-14 CA CA2734515A patent/CA2734515A1/en not_active Abandoned
- 2009-08-14 US US13/059,617 patent/US20110280898A1/en not_active Abandoned
- 2009-08-14 RU RU2011110504/10A patent/RU2011110504A/ru not_active Application Discontinuation
- 2009-08-14 MX MX2011001880A patent/MX2011001880A/es not_active Application Discontinuation
- 2009-08-17 US US12/542,638 patent/US8383590B2/en active Active
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2011
- 2011-02-09 IL IL211131A patent/IL211131A0/en unknown
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2012
- 2012-05-04 US US13/464,831 patent/US8623829B2/en active Active
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2013
- 2013-01-17 US US13/744,354 patent/US8759481B2/en not_active Expired - Fee Related
- 2013-11-13 US US14/079,144 patent/US9067973B2/en active Active
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2014
- 2014-05-09 US US14/274,373 patent/US9284349B2/en active Active
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2016
- 2016-01-06 US US14/989,741 patent/US20160200764A1/en not_active Abandoned
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