JP2012500184A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012500184A5 JP2012500184A5 JP2011507735A JP2011507735A JP2012500184A5 JP 2012500184 A5 JP2012500184 A5 JP 2012500184A5 JP 2011507735 A JP2011507735 A JP 2011507735A JP 2011507735 A JP2011507735 A JP 2011507735A JP 2012500184 A5 JP2012500184 A5 JP 2012500184A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- antigen
- peptide
- hla
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 34
- 150000001413 amino acids Chemical class 0.000 claims description 28
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 27
- 239000000427 antigen Substances 0.000 claims description 18
- 108091007433 antigens Proteins 0.000 claims description 18
- 102000036639 antigens Human genes 0.000 claims description 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 17
- 206010028980 Neoplasm Diseases 0.000 claims description 14
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 14
- 201000011510 cancer Diseases 0.000 claims description 14
- 230000001939 inductive effect Effects 0.000 claims description 13
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 11
- 102000040430 polynucleotide Human genes 0.000 claims description 9
- 108091033319 polynucleotide Proteins 0.000 claims description 9
- 239000002157 polynucleotide Substances 0.000 claims description 9
- 102000011786 HLA-A Antigens Human genes 0.000 claims description 8
- 108010075704 HLA-A Antigens Proteins 0.000 claims description 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 5
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 5
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 4
- 230000006698 induction Effects 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 206010005003 Bladder cancer Diseases 0.000 claims description 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 3
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 3
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 3
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 3
- 206010038389 Renal cancer Diseases 0.000 claims description 3
- 206010068771 Soft tissue neoplasm Diseases 0.000 claims description 3
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 3
- 201000010881 cervical cancer Diseases 0.000 claims description 3
- 201000004101 esophageal cancer Diseases 0.000 claims description 3
- 206010017758 gastric cancer Diseases 0.000 claims description 3
- 230000028993 immune response Effects 0.000 claims description 3
- 201000010982 kidney cancer Diseases 0.000 claims description 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 3
- 201000008968 osteosarcoma Diseases 0.000 claims description 3
- 201000002528 pancreatic cancer Diseases 0.000 claims description 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 3
- 201000011549 stomach cancer Diseases 0.000 claims description 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 3
- 208000006990 cholangiocarcinoma Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000002980 postoperative effect Effects 0.000 claims description 2
- 229960005486 vaccine Drugs 0.000 claims description 2
- 238000012217 deletion Methods 0.000 claims 3
- 230000037430 deletion Effects 0.000 claims 3
- 238000003780 insertion Methods 0.000 claims 3
- 230000037431 insertion Effects 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 2
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 101000839066 Homo sapiens Hypoxia-inducible lipid droplet-associated protein Proteins 0.000 description 7
- 102100028891 Hypoxia-inducible lipid droplet-associated protein Human genes 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 101100221606 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) COS7 gene Proteins 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 229940022399 cancer vaccine Drugs 0.000 description 1
- 238000009566 cancer vaccine Methods 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 108010091748 peptide A Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8997208P | 2008-08-19 | 2008-08-19 | |
| US61/089,972 | 2008-08-19 | ||
| PCT/JP2009/003897 WO2010021112A1 (en) | 2008-08-19 | 2009-08-14 | Hig2 and urlc10 epitope peptide and vaccines containing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012500184A JP2012500184A (ja) | 2012-01-05 |
| JP2012500184A5 true JP2012500184A5 (enExample) | 2012-09-27 |
| JP5633025B2 JP5633025B2 (ja) | 2014-12-03 |
Family
ID=41707003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011507735A Active JP5633025B2 (ja) | 2008-08-19 | 2009-08-14 | Ｈｉｇ２およびｕｒｌｃ１０エピトープペプチドならびにそれを含むワクチン |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9119800B2 (enExample) |
| EP (1) | EP2328600B9 (enExample) |
| JP (1) | JP5633025B2 (enExample) |
| KR (1) | KR101713581B1 (enExample) |
| CN (2) | CN102186491B (enExample) |
| AU (1) | AU2009283763B2 (enExample) |
| BR (1) | BRPI0917391A2 (enExample) |
| CA (1) | CA2734467C (enExample) |
| DK (1) | DK2328600T3 (enExample) |
| ES (1) | ES2566011T3 (enExample) |
| IL (1) | IL211117A (enExample) |
| MX (2) | MX355054B (enExample) |
| RU (1) | RU2529373C2 (enExample) |
| SG (2) | SG10201610206VA (enExample) |
| TW (2) | TWI580431B (enExample) |
| WO (1) | WO2010021112A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI615403B (zh) * | 2007-02-21 | 2018-02-21 | 腫瘤療法 科學股份有限公司 | 表現腫瘤相關抗原之癌症的胜肽疫苗 |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
| SMT201800444T1 (it) * | 2010-11-17 | 2018-09-13 | Aduro Biotech Inc | Metodi e composizioni per indurre una risposta immunitaria contro egfrviii |
| JP6255594B2 (ja) | 2012-07-10 | 2018-01-10 | オンコセラピー・サイエンス株式会社 | Ｔｈ１細胞のＬＹ６Ｋエピトープペプチドおよびこれを含有するワクチン |
| MX2017001651A (es) | 2014-08-04 | 2017-04-27 | Oncotherapy Science Inc | Peptido derivado de urlc10 y vacuna que lo contiene. |
| MX392412B (es) | 2015-08-10 | 2025-03-24 | Toray Industries | Polipéptidos que tienen actividad inductora de inmunidad. |
| RU2765574C2 (ru) | 2015-08-12 | 2022-02-01 | Онкотерапи Сайенс, Инк. | Пептид, полученный из depdc1, и содержащая его вакцина |
| CN110741016A (zh) | 2017-04-26 | 2020-01-31 | 优瑞科生物技术公司 | 嵌合抗体/t-细胞受体构筑体及其用途 |
| PL3538645T3 (pl) | 2017-06-20 | 2021-11-08 | Institut Curie | Komórki odpornościowe z defektem suv39h1 |
| CN115300609A (zh) * | 2021-05-08 | 2022-11-08 | 西湖大学 | 缺氧诱导脂滴相关蛋白(hilpda)在预防或治疗高血脂相关疾病中的应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070014787A1 (en) | 1998-07-15 | 2007-01-18 | Human Genome Sciences, Inc. | 71 human secreted proteins |
| ES2340357T3 (es) * | 1999-08-05 | 2010-06-02 | Green Peptide Co., Ltd. | Antigeno tumoral. |
| WO2001023426A2 (en) | 1999-09-30 | 2001-04-05 | Varian Associates, Inc. | Hypoxia-related human genes, proteins, and uses thereof |
| AU2002215345A1 (en) | 2000-10-13 | 2002-04-22 | Eos Biotechnology, Inc. | Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer |
| US20030232350A1 (en) | 2001-11-13 | 2003-12-18 | Eos Biotechnology, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
| US20070015271A1 (en) | 2002-04-04 | 2007-01-18 | Rosen Craig A | Human secreted proteins |
| US20060024692A1 (en) | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| CN1882698B (zh) | 2003-08-20 | 2011-05-25 | 肿瘤疗法科学股份有限公司 | 低氧可诱导的蛋白2(hig2)作为新的治疗肾细胞癌(rcc)的潜在标靶 |
| JPWO2005123122A1 (ja) | 2004-06-21 | 2008-04-10 | 株式会社グリーンペプタイド | 癌治療ペプチドワクチン |
| EP2011885B1 (en) | 2005-02-10 | 2015-04-22 | Oncotherapy Science, Inc. | Method of diagnosing bladder cancer |
| ES2459492T3 (es) | 2005-02-25 | 2014-05-09 | Oncotherapy Science, Inc. | Vacunas de péptidos para cánceres de pulmón que expresan polipéptidos TTK, URLC10 o KOC1 |
| EP1854473A1 (en) | 2005-03-03 | 2007-11-14 | Takeda Pharmaceutical Company Limited | Preventive/therapeutic agent for cancer |
| WO2007013575A2 (en) | 2005-07-28 | 2007-02-01 | Oncotherapy Science, Inc. | Method for diagnosing and treating renal cell carcinoma |
| WO2007029778A1 (ja) | 2005-09-07 | 2007-03-15 | Nec Corporation | Ｈｌａ結合性ペプチド、それをコードするｄｎａ断片および組み換えベクター |
| JP4840858B2 (ja) * | 2006-03-16 | 2011-12-21 | 学校法人慶應義塾 | 癌ワクチン |
| ES2365077T3 (es) | 2006-06-16 | 2011-09-21 | Onco Therapy Science, Inc. | Péptido antígeno anticáncer derivado de sparc y composición farmacéutica que comprende el mismo. |
| TWI615403B (zh) * | 2007-02-21 | 2018-02-21 | 腫瘤療法 科學股份有限公司 | 表現腫瘤相關抗原之癌症的胜肽疫苗 |
| JP2010535014A (ja) | 2007-07-30 | 2010-11-18 | オンコセラピー・サイエンス株式会社 | 癌関連遺伝子ｌｙ６ｋ |
| TW201000115A (en) | 2008-06-11 | 2010-01-01 | Oncotherapy Science Inc | IQGAP3 epitope peptides and vaccines containing the same |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
-
2009
- 2009-08-13 TW TW103132024A patent/TWI580431B/zh not_active IP Right Cessation
- 2009-08-13 TW TW098127226A patent/TWI543767B/zh active
- 2009-08-14 ES ES09808048.4T patent/ES2566011T3/es active Active
- 2009-08-14 SG SG10201610206VA patent/SG10201610206VA/en unknown
- 2009-08-14 SG SG2013062690A patent/SG193806A1/en unknown
- 2009-08-14 RU RU2011110376/10A patent/RU2529373C2/ru not_active IP Right Cessation
- 2009-08-14 MX MX2013010331A patent/MX355054B/es unknown
- 2009-08-14 MX MX2011001883A patent/MX337756B/es active IP Right Grant
- 2009-08-14 WO PCT/JP2009/003897 patent/WO2010021112A1/en not_active Ceased
- 2009-08-14 US US13/059,618 patent/US9119800B2/en active Active
- 2009-08-14 CA CA2734467A patent/CA2734467C/en active Active
- 2009-08-14 CN CN200980141320.6A patent/CN102186491B/zh active Active
- 2009-08-14 EP EP09808048.4A patent/EP2328600B9/en active Active
- 2009-08-14 KR KR1020117005809A patent/KR101713581B1/ko active Active
- 2009-08-14 AU AU2009283763A patent/AU2009283763B2/en not_active Ceased
- 2009-08-14 BR BRPI0917391A patent/BRPI0917391A2/pt not_active Application Discontinuation
- 2009-08-14 CN CN201510236002.5A patent/CN104958753B/zh active Active
- 2009-08-14 DK DK09808048.4T patent/DK2328600T3/en active
- 2009-08-14 JP JP2011507735A patent/JP5633025B2/ja active Active
-
2011
- 2011-02-08 IL IL211117A patent/IL211117A/en not_active IP Right Cessation