BR112019027133B8 - Uso de uma célula imune modificada deficiente para suv39h1 - Google Patents

Uso de uma célula imune modificada deficiente para suv39h1

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Publication number
BR112019027133B8
BR112019027133B8 BR112019027133A BR112019027133A BR112019027133B8 BR 112019027133 B8 BR112019027133 B8 BR 112019027133B8 BR 112019027133 A BR112019027133 A BR 112019027133A BR 112019027133 A BR112019027133 A BR 112019027133A BR 112019027133 B8 BR112019027133 B8 BR 112019027133B8
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Brazil
Prior art keywords
immune cell
suv39h1
modified immune
deficient
genetically modified
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BR112019027133A
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English (en)
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BR112019027133A2 (pt
BR112019027133B1 (pt
Inventor
Amigorena Sebastian
Piaggio Eliane
Goudot Christel
Pace Luigia
Almouzni Geneviève
Niborski Leticia
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Inst Curie
Inst Nat Sante Rech Med
Centre Nat Rech Scient
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Application filed by Inst Curie, Inst Nat Sante Rech Med, Centre Nat Rech Scient filed Critical Inst Curie
Priority to BR122020025496A priority Critical patent/BR122020025496B8/pt
Publication of BR112019027133A2 publication Critical patent/BR112019027133A2/pt
Publication of BR112019027133B1 publication Critical patent/BR112019027133B1/pt
Publication of BR112019027133B8 publication Critical patent/BR112019027133B8/pt

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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4613—Natural-killer cells [NK or NK-T]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
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    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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Abstract

A presente invenção refere-se a uma célula imune modificada deficiente para Suv39h1. Preferencialmente, a referida célula imune modificada compreende ainda um receptor de antígeno geneticamente modificado que se liga especificamente a um antígeno alvo. A presente invenção também se refere a um método para obter uma célula imune modificada geneticamente compreendendo uma etapa que consiste em inibir a expressão e/ou atividade de Suv39h1 na célula imune; e ainda opcionalmente compreendendo uma etapa que consiste em introduzir, na referida célula imune, um receptor de antígeno geneticamente modificado que se liga especificamente a um antígeno alvo. A invenção também abrange a referida célula imune modificada para uso em terapia adotiva, notadamente para o tratamento de câncer.
BR112019027133A 2017-06-20 2018-06-20 Uso de uma célula imune modificada deficiente para suv39h1 BR112019027133B8 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122020025496A BR122020025496B8 (pt) 2017-06-20 2018-06-20 Método de produção de uma célula imune modificada, em que a célula imune é uma célula t alogênica ou autóloga

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17305757 2017-06-20
EP17305757.1 2017-06-20
PCT/EP2018/066387 WO2018234370A1 (en) 2017-06-20 2018-06-20 DEFECTIVE IMMUNE CELLS AGAINST SUV39H1

Publications (3)

Publication Number Publication Date
BR112019027133A2 BR112019027133A2 (pt) 2020-07-07
BR112019027133B1 BR112019027133B1 (pt) 2022-07-19
BR112019027133B8 true BR112019027133B8 (pt) 2022-08-09

Family

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BR112019027133A BR112019027133B8 (pt) 2017-06-20 2018-06-20 Uso de uma célula imune modificada deficiente para suv39h1
BR122020025496A BR122020025496B8 (pt) 2017-06-20 2018-06-20 Método de produção de uma célula imune modificada, em que a célula imune é uma célula t alogênica ou autóloga

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Country Status (22)

Country Link
US (4) US10576103B2 (pt)
EP (2) EP3828264A1 (pt)
JP (2) JP7388798B2 (pt)
KR (1) KR20200027512A (pt)
CN (3) CN110997902B (pt)
AU (1) AU2018287042A1 (pt)
BR (2) BR112019027133B8 (pt)
CA (1) CA3067446A1 (pt)
CY (1) CY1124069T1 (pt)
DK (1) DK3538645T3 (pt)
ES (1) ES2871400T3 (pt)
HR (1) HRP20210567T1 (pt)
HU (1) HUE053760T2 (pt)
IL (1) IL271618B1 (pt)
LT (1) LT3538645T (pt)
MX (2) MX2019015841A (pt)
PL (1) PL3538645T3 (pt)
PT (1) PT3538645T (pt)
RS (1) RS61691B1 (pt)
SG (1) SG11201912455VA (pt)
SI (1) SI3538645T1 (pt)
WO (1) WO2018234370A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200027512A (ko) 2017-06-20 2020-03-12 엥스띠뛰 퀴리 Suv39h1에 결함이 있는 면역 세포
MX2022000922A (es) * 2019-07-23 2022-05-03 Mnemo Therapeutics Celulas inmunes defectuosas para suv39h1.
WO2023284721A1 (zh) * 2021-07-13 2023-01-19 苏州沙砾生物科技有限公司 一种免疫细胞的培养方法及其用途
WO2023126458A1 (en) * 2021-12-28 2023-07-06 Mnemo Therapeutics Immune cells with inactivated suv39h1 and modified tcr
WO2023137472A2 (en) * 2022-01-14 2023-07-20 Tune Therapeutics, Inc. Compositions, systems, and methods for programming t cell phenotypes through targeted gene repression
WO2023139269A1 (en) 2022-01-21 2023-07-27 Mnemo Therapeutics Modulation of suv39h1 expression by rnas
EP4279085A1 (en) 2022-05-20 2023-11-22 Mnemo Therapeutics Compositions and methods for treating a refractory or relapsed cancer or a chronic infectious disease
WO2024074713A1 (en) 2022-10-07 2024-04-11 Institut National de la Santé et de la Recherche Médicale Method to generate improving car-t cells

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US131A (en) 1837-02-24 Machine foe cutting eur fedm skins
US6566A (en) 1849-07-03 Manufacture of bags and sacks
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5049386A (en) 1985-01-07 1991-09-17 Syntex (U.S.A.) Inc. N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4946787A (en) 1985-01-07 1990-08-07 Syntex (U.S.A.) Inc. N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4690915A (en) 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans
US5219740A (en) 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
AU7979491A (en) 1990-05-03 1991-11-27 Vical, Inc. Intracellular delivery of biologically active substances by means of self-assembling lipid complexes
US5487994A (en) 1992-04-03 1996-01-30 The Johns Hopkins University Insertion and deletion mutants of FokI restriction endonuclease
US5356802A (en) 1992-04-03 1994-10-18 The Johns Hopkins University Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease
US5436150A (en) 1992-04-03 1995-07-25 The Johns Hopkins University Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
DE19608753C1 (de) 1996-03-06 1997-06-26 Medigene Gmbh Transduktionssystem und seine Verwendung
WO1997034634A1 (en) 1996-03-20 1997-09-25 Sloan-Kettering Institute For Cancer Research Single chain fv constructs of anti-ganglioside gd2 antibodies
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
US6566131B1 (en) 2000-10-04 2003-05-20 Isis Pharmaceuticals, Inc. Antisense modulation of Smad6 expression
WO2000014257A1 (en) 1998-09-04 2000-03-16 Sloan-Kettering Institute For Cancer Research Fusion receptors specific for prostate-specific membrane antigen and uses thereof
US6410323B1 (en) 1999-08-31 2002-06-25 Isis Pharmaceuticals, Inc. Antisense modulation of human Rho family gene expression
WO2000023573A2 (en) 1998-10-20 2000-04-27 City Of Hope Cd20-specific redirected t cells and their use in cellular immunotherapy of cd20+ malignancies
US6107091A (en) 1998-12-03 2000-08-22 Isis Pharmaceuticals Inc. Antisense inhibition of G-alpha-16 expression
US5981732A (en) 1998-12-04 1999-11-09 Isis Pharmaceuticals Inc. Antisense modulation of G-alpha-13 expression
US6046321A (en) 1999-04-09 2000-04-04 Isis Pharmaceuticals Inc. Antisense modulation of G-alpha-i1 expression
GB9927444D0 (en) 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
EP1272630A2 (en) 2000-03-16 2003-01-08 Genetica, Inc. Methods and compositions for rna interference
CA2410510A1 (en) 2000-06-02 2001-12-13 Memorial Sloan-Kettering Cancer Center Artificial antigen presenting cells and methods of use thereof
US6365354B1 (en) 2000-07-31 2002-04-02 Isis Pharmaceuticals, Inc. Antisense modulation of lysophospholipase I expression
US6566135B1 (en) 2000-10-04 2003-05-20 Isis Pharmaceuticals, Inc. Antisense modulation of caspase 6 expression
WO2002077029A2 (en) 2000-11-07 2002-10-03 City Of Hope Cd19-specific redirected immune cells
US7070995B2 (en) 2001-04-11 2006-07-04 City Of Hope CE7-specific redirected immune cells
US20090257994A1 (en) 2001-04-30 2009-10-15 City Of Hope Chimeric immunoreceptor useful in treating human cancers
US20030170238A1 (en) 2002-03-07 2003-09-11 Gruenberg Micheal L. Re-activated T-cells for adoptive immunotherapy
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
US20050129671A1 (en) 2003-03-11 2005-06-16 City Of Hope Mammalian antigen-presenting T cells and bi-specific T cells
US20050025763A1 (en) 2003-05-08 2005-02-03 Protein Design Laboratories, Inc. Therapeutic use of anti-CS1 antibodies
MXPA06008700A (es) 2004-02-06 2007-01-19 Morphosys Ag Anticuerpos anti-cd38 humanos y usos para los mismos.
US20090304679A1 (en) 2004-05-27 2009-12-10 Weidanz Jon A Antibodies as T cell receptor mimics, methods of production and uses thereof
SI2567976T1 (sl) 2005-03-23 2017-11-30 Genmab A/S Protitelesa usmerjena proti cd38 za zdravljenje multiplega mieloma
EP1914242A1 (en) 2006-10-19 2008-04-23 Sanofi-Aventis Novel anti-CD38 antibodies for the treatment of cancer
EP2141997B1 (en) 2007-03-30 2012-10-31 Memorial Sloan-Kettering Cancer Center Constitutive expression of costimulatory ligands on adoptively transferred t lymphocytes
US8479118B2 (en) 2007-12-10 2013-07-02 Microsoft Corporation Switching search providers within a browser search box
EP2238168B8 (en) 2007-12-26 2014-07-23 Biotest AG Agents targeting cd138 and uses thereof
WO2009126537A1 (en) * 2008-04-07 2009-10-15 Syndax Pharmaceuticals, Inc. Administration of an inhibitor of hdac and an hmt inhibitor
JP5173594B2 (ja) 2008-05-27 2013-04-03 キヤノン株式会社 管理装置、画像形成装置及びそれらの処理方法
TWI543767B (zh) 2008-08-19 2016-08-01 腫瘤療法 科學股份有限公司 Ｈｉｇ２與ｕｒｌｃ１０抗原決定位胜肽以及含此胜肽之疫苗
WO2010051391A1 (en) 2008-10-31 2010-05-06 Facet Biotech Corporation Use of anti-cs1 antibodies for treatment of rare lymphomas
WO2011009173A1 (en) 2009-07-23 2011-01-27 Mater Medical Research Institute Cancer immunotherapy
AU2010327998B2 (en) 2009-12-10 2015-11-12 Iowa State University Research Foundation, Inc. TAL effector-mediated DNA modification
WO2011146121A1 (en) 2010-05-17 2011-11-24 Sangamo Biosciences, Inc. Novel dna-binding proteins and uses thereof
EP3305798A1 (en) 2010-12-09 2018-04-11 The Trustees of The University of Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
JOP20210044A1 (ar) 2010-12-30 2017-06-16 Takeda Pharmaceuticals Co الأجسام المضادة لـ cd38
CN106074601A (zh) 2011-03-23 2016-11-09 弗雷德哈钦森癌症研究中心 用于细胞免疫治疗的方法和组合物
CN106632677B (zh) 2011-04-01 2021-10-26 纪念斯隆-凯特琳癌症中心 对hla-a2呈递的wt1肽特异的t细胞受体样抗体
US8398282B2 (en) 2011-05-12 2013-03-19 Delphi Technologies, Inc. Vehicle front lighting assembly and systems having a variable tint electrowetting element
ES2711086T3 (es) * 2011-10-03 2019-04-30 Univ Bruxelles Reactivación de la expresión génica del VIH-1 para tratar la infección persistente por VIH
JP2014528959A (ja) * 2011-10-03 2014-10-30 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Ｔｈ２介在性疾患の処置のための方法および薬学的組成物
EP2776451B1 (en) 2011-11-11 2018-07-18 Fred Hutchinson Cancer Research Center Cyclin a1-targeted t-cell immunotherapy for cancer
EP3594245A1 (en) 2012-02-13 2020-01-15 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
WO2013126726A1 (en) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Double transgenic t cells comprising a car and a tcr and their methods of use
CA2872471C (en) 2012-05-03 2022-11-22 Fred Hutchinson Cancer Research Center Enhanced affinity t cell receptors and methods for making the same
ES2962571T3 (es) 2012-05-25 2024-03-19 Cellectis Métodos para modificar células T alogénicas y resistentes a la inmunosupresión para inmunoterapia
RU2019126655A (ru) 2012-08-20 2019-11-12 Фред Хатчинсон Кансэр Рисёч Сентер Нуклеиновые кислоты, кодирующие химерные рецепторы, полипептидные химерные рецепторы, кодируемые ими, векторы экспрессии, содержащие их, выделенные клетки-хозяева, содержащие их, композиции, содержащие выделенные клетки-хозяева, а также способы получения выделенных клеток-хозяев in vitro, способы выбора нуклеиновых кислот, кодирующих химерные рецепторы, in vitro и способы проведения клеточной иммунотерапии у субъекта, имеющего опухоль
US9181535B2 (en) 2012-09-24 2015-11-10 The Chinese University Of Hong Kong Transcription activator-like effector nucleases (TALENs)
CN112430580A (zh) 2012-10-02 2021-03-02 纪念斯隆-凯特琳癌症中心 用于免疫疗法的组合物和方法
AU2013329186B2 (en) 2012-10-10 2019-02-14 Sangamo Therapeutics, Inc. T cell modifying compounds and uses thereof
JP6465803B2 (ja) * 2012-10-22 2019-02-06 シティ・オブ・ホープＣｉｔｙ ｏｆ Ｈｏｐｅ Ｅｔｐ誘導体
US20140161785A1 (en) * 2012-12-10 2014-06-12 Feiyan Liu Verticillin A Inhibition of Histone Methyltransferases
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
JP5372297B1 (ja) 2012-12-20 2013-12-18 三菱電機株式会社 車載装置及びプログラム
US9108442B2 (en) 2013-08-20 2015-08-18 Ricoh Company, Ltd. Image forming apparatus
MA42895A (fr) 2015-07-15 2018-05-23 Juno Therapeutics Inc Cellules modifiées pour thérapie cellulaire adoptive
KR20200027512A (ko) * 2017-06-20 2020-03-12 엥스띠뛰 퀴리 Suv39h1에 결함이 있는 면역 세포

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