PL3538645T3 - Komórki odpornościowe z defektem suv39h1 - Google Patents

Komórki odpornościowe z defektem suv39h1

Info

Publication number
PL3538645T3
PL3538645T3 PL18731460T PL18731460T PL3538645T3 PL 3538645 T3 PL3538645 T3 PL 3538645T3 PL 18731460 T PL18731460 T PL 18731460T PL 18731460 T PL18731460 T PL 18731460T PL 3538645 T3 PL3538645 T3 PL 3538645T3
Authority
PL
Poland
Prior art keywords
suv39h1
defect
immune cells
immune
cells
Prior art date
Application number
PL18731460T
Other languages
English (en)
Inventor
Sebastian Amigorena
Eliane Piaggio
Christel GOUDOT
Luigia PACE
Geneviève Almouzni
Original Assignee
Institut Curie
INSERM (Institut National de la Santé et de la Recherche Médicale)
Centre National De La Recherche Scientifique - Cnrs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Curie, INSERM (Institut National de la Santé et de la Recherche Médicale), Centre National De La Recherche Scientifique - Cnrs filed Critical Institut Curie
Publication of PL3538645T3 publication Critical patent/PL3538645T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL18731460T 2017-06-20 2018-06-20 Komórki odpornościowe z defektem suv39h1 PL3538645T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17305757 2017-06-20
EP18731460.4A EP3538645B1 (en) 2017-06-20 2018-06-20 Immune cells defective for suv39h1
PCT/EP2018/066387 WO2018234370A1 (en) 2017-06-20 2018-06-20 DEFECTIVE IMMUNE CELLS AGAINST SUV39H1

Publications (1)

Publication Number Publication Date
PL3538645T3 true PL3538645T3 (pl) 2021-11-08

Family

ID=59295130

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18731460T PL3538645T3 (pl) 2017-06-20 2018-06-20 Komórki odpornościowe z defektem suv39h1

Country Status (23)

Country Link
US (5) US10576103B2 (pl)
EP (2) EP3538645B1 (pl)
JP (2) JP7388798B2 (pl)
KR (1) KR20200027512A (pl)
CN (3) CN110997902B (pl)
AU (1) AU2018287042A1 (pl)
BR (2) BR112019027133B8 (pl)
CA (1) CA3067446A1 (pl)
CY (1) CY1124069T1 (pl)
DK (1) DK3538645T3 (pl)
ES (1) ES2871400T3 (pl)
HR (1) HRP20210567T1 (pl)
HU (1) HUE053760T2 (pl)
IL (1) IL271618B2 (pl)
LT (1) LT3538645T (pl)
MX (2) MX2019015841A (pl)
PL (1) PL3538645T3 (pl)
PT (1) PT3538645T (pl)
RS (1) RS61691B1 (pl)
SG (1) SG11201912455VA (pl)
SI (1) SI3538645T1 (pl)
SM (1) SMT202100206T1 (pl)
WO (1) WO2018234370A1 (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110997902B (zh) 2017-06-20 2021-11-30 居里研究所 Suv39h1缺陷的免疫细胞
EP4003407A1 (en) * 2019-07-23 2022-06-01 Mnemo Therapeutics Immune cells defective for suv39h1
CN116406421A (zh) * 2021-07-13 2023-07-07 苏州沙砾生物科技有限公司 一种免疫细胞的培养方法及其用途
JP2025501272A (ja) * 2021-12-28 2025-01-17 ムネモ・セラピューティクス 不活性化されたｓｕｖ３９ｈ１及び改変ｔｃｒを有する免疫細胞
EP4463549A2 (en) * 2022-01-14 2024-11-20 Tune Therapeutics, Inc. Compositions, systems, and methods for programming t cell phenotypes through targeted gene repression
AU2023209589A1 (en) 2022-01-21 2024-08-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Modulation of suv39h1 expression by rnas
EP4279085A1 (en) 2022-05-20 2023-11-22 Mnemo Therapeutics Compositions and methods for treating a refractory or relapsed cancer or a chronic infectious disease
WO2024074713A1 (en) 2022-10-07 2024-04-11 Institut National de la Santé et de la Recherche Médicale Method to generate improving car-t cells
CN118995620B (zh) * 2023-05-16 2026-06-05 清华大学 一种嵌合抗原受体、重组免疫细胞及用途
CN121013867A (zh) * 2023-06-07 2025-11-25 Fbd生物制品有限公司 工程化的il-7变体及其使用方法
WO2025052001A1 (en) 2023-09-07 2025-03-13 Mnemo Therapeutics Methods and compositions for improving immune response
EP4520334A1 (en) 2023-09-07 2025-03-12 Mnemo Therapeutics Methods and compositions for improving immune response

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Also Published As

Publication number Publication date
IL271618B1 (en) 2024-02-01
US20220040235A1 (en) 2022-02-10
US20200171090A1 (en) 2020-06-04
ES2871400T3 (es) 2021-10-28
BR122020025496B8 (pt) 2023-10-24
CA3067446A1 (en) 2018-12-27
EP3538645A1 (en) 2019-09-18
JP7388798B2 (ja) 2023-11-29
BR122020025496B1 (pt) 2023-09-26
BR112019027133A2 (pt) 2020-07-07
US10576103B2 (en) 2020-03-03
US20250011389A1 (en) 2025-01-09
LT3538645T (lt) 2021-04-26
CN110997902A (zh) 2020-04-10
KR20200027512A (ko) 2020-03-12
MX2023006039A (es) 2023-06-02
EP3828264A1 (en) 2021-06-02
US20230201264A1 (en) 2023-06-29
SI3538645T1 (sl) 2021-08-31
BR112019027133B8 (pt) 2022-08-09
CN114058590A (zh) 2022-02-18
IL271618A (en) 2020-02-27
CY1124069T1 (el) 2022-05-27
SG11201912455VA (en) 2020-01-30
US20190365807A1 (en) 2019-12-05
JP7706523B2 (ja) 2025-07-11
US12371471B2 (en) 2025-07-29
PT3538645T (pt) 2021-04-15
ES2871400T8 (es) 2022-03-31
RS61691B1 (sr) 2021-05-31
WO2018234370A1 (en) 2018-12-27
BR112019027133B1 (pt) 2022-07-19
JP2024023299A (ja) 2024-02-21
DK3538645T3 (da) 2021-04-19
AU2018287042A1 (en) 2020-02-06
HRP20210567T1 (hr) 2021-09-03
US11285176B2 (en) 2022-03-29
CN110997902B (zh) 2021-11-30
JP2020523995A (ja) 2020-08-13
HUE053760T2 (hu) 2021-07-28
CN114350613B (zh) 2024-12-31
MX2019015841A (es) 2020-08-03
US11622978B2 (en) 2023-04-11
CN114058590B (zh) 2024-08-06
SMT202100206T1 (it) 2021-07-12
IL271618B2 (en) 2024-06-01
RU2020101755A3 (pl) 2021-08-16
CN114350613A (zh) 2022-04-15
RU2020101755A (ru) 2021-07-20
EP3538645B1 (en) 2021-01-20

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