BR112017019140A2 - métodos de tratamento de câncer usando células t ativadas - Google Patents

métodos de tratamento de câncer usando células t ativadas

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Publication number
BR112017019140A2
BR112017019140A2 BR112017019140-7A BR112017019140A BR112017019140A2 BR 112017019140 A2 BR112017019140 A2 BR 112017019140A2 BR 112017019140 A BR112017019140 A BR 112017019140A BR 112017019140 A2 BR112017019140 A2 BR 112017019140A2
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Brazil
Prior art keywords
cells
methods
individual
tumor
activated
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BR112017019140-7A
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English (en)
Inventor
Zhou Xiangjun
Li Jin
Han Yanyan
Wu Dongyun
Liu Junyun
Tao Ran
Tang Longqing
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Syz Cell Therapy Co.
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Publication date
Application filed by Syz Cell Therapy Co. filed Critical Syz Cell Therapy Co.
Publication of BR112017019140A2 publication Critical patent/BR112017019140A2/pt

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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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Abstract

a presente invenção fornece um método de tratamento de um câncer em um indivíduo usando células t ou pbmcs induzidas por células apresentadoras de antígeno (como células dendríticas) carregadas com uma pluralidade de peptídeos antigênicos tumorais. o método pode compreender, ainda, a administração das células apresentadoras de antígeno carregadas com a pluralidade de peptídeos antigênicos tumorais ao indivíduo. os métodos podem ser usados isoladamente ou em combinação com um inibidor do ponto de checagem imune. também são fornecidos métodos de terapia de precisão personalizados para o indivíduo usando peptídeos neoantigênicos ou com base na carga de mutação no tumor do indivíduo, métodos para preparar as células t ativadas, métodos de monitoramento do tratamento, métodos de clonagem de receptores de célula t tumor-específico, uma população isolada de células que compreende as células t ativadas, e composições e kits úteis para imunoterapia de câncer.
BR112017019140-7A 2015-03-13 2016-03-11 métodos de tratamento de câncer usando células t ativadas BR112017019140A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2015/074227 2015-03-13
PCT/CN2015/074227 WO2016145578A1 (en) 2015-03-13 2015-03-13 Methods of cancer treatment using activated t cells
PCT/CN2016/076165 WO2016146035A1 (en) 2015-03-13 2016-03-11 Methods of cancer treatment using activated t cells

Publications (1)

Publication Number Publication Date
BR112017019140A2 true BR112017019140A2 (pt) 2018-05-02

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BR112017019140-7A BR112017019140A2 (pt) 2015-03-13 2016-03-11 métodos de tratamento de câncer usando células t ativadas

Country Status (11)

Country Link
US (4) US10967054B2 (pt)
EP (2) EP3268465B1 (pt)
JP (3) JP6856534B2 (pt)
KR (2) KR20240069809A (pt)
CN (3) CN107735492B (pt)
BR (1) BR112017019140A2 (pt)
CA (1) CA2975602A1 (pt)
HK (1) HK1249130A1 (pt)
IL (2) IL253795B (pt)
RU (1) RU2729362C2 (pt)
WO (2) WO2016145578A1 (pt)

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