BR112019011277A2 - polinucleotídeo, sistema de expressão recombinante, vetor, polipeptídeo, célula recombinante, polipeptídeo de receptor imune sintético isolado ou heterodímero de polipeptídeo, célula efetora imune ou célula-tronco, população de células imunes ou efetoras, métodos de fabricação de uma célula efetora imune que expressa sir, de geração de uma população de células modificadas por rna, de fornecimento de imunidade antidoença e de tratamento ou prevenção de uma doença, composição, uso ou método, kit, e, sequência de aminoácidos. - Google Patents

polinucleotídeo, sistema de expressão recombinante, vetor, polipeptídeo, célula recombinante, polipeptídeo de receptor imune sintético isolado ou heterodímero de polipeptídeo, célula efetora imune ou célula-tronco, população de células imunes ou efetoras, métodos de fabricação de uma célula efetora imune que expressa sir, de geração de uma população de células modificadas por rna, de fornecimento de imunidade antidoença e de tratamento ou prevenção de uma doença, composição, uso ou método, kit, e, sequência de aminoácidos.

Info

Publication number
BR112019011277A2
BR112019011277A2 BR112019011277A BR112019011277A BR112019011277A2 BR 112019011277 A2 BR112019011277 A2 BR 112019011277A2 BR 112019011277 A BR112019011277 A BR 112019011277A BR 112019011277 A BR112019011277 A BR 112019011277A BR 112019011277 A2 BR112019011277 A2 BR 112019011277A2
Authority
BR
Brazil
Prior art keywords
immune
cell
polypeptide
effector cell
disease
Prior art date
Application number
BR112019011277A
Other languages
English (en)
Inventor
M Chaudhary Preet
Original Assignee
Univ Southern California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Southern California filed Critical Univ Southern California
Publication of BR112019011277A2 publication Critical patent/BR112019011277A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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Abstract

a revelação fornece receptores imunes sintéticos (sirs), ácidos nucleicos que codificam os sirs, métodos de fabricação e de uso dos sirs em, por exemplo, terapia celular adotiva.
BR112019011277A 2016-12-02 2017-12-02 polinucleotídeo, sistema de expressão recombinante, vetor, polipeptídeo, célula recombinante, polipeptídeo de receptor imune sintético isolado ou heterodímero de polipeptídeo, célula efetora imune ou célula-tronco, população de células imunes ou efetoras, métodos de fabricação de uma célula efetora imune que expressa sir, de geração de uma população de células modificadas por rna, de fornecimento de imunidade antidoença e de tratamento ou prevenção de uma doença, composição, uso ou método, kit, e, sequência de aminoácidos. BR112019011277A2 (pt)

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US201662429597P 2016-12-02 2016-12-02
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PCT/US2017/064379 WO2018102795A2 (en) 2016-12-02 2017-12-02 Synthetic immune receptors and methods of use thereof

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BR112019011277A BR112019011277A2 (pt) 2016-12-02 2017-12-02 polinucleotídeo, sistema de expressão recombinante, vetor, polipeptídeo, célula recombinante, polipeptídeo de receptor imune sintético isolado ou heterodímero de polipeptídeo, célula efetora imune ou célula-tronco, população de células imunes ou efetoras, métodos de fabricação de uma célula efetora imune que expressa sir, de geração de uma população de células modificadas por rna, de fornecimento de imunidade antidoença e de tratamento ou prevenção de uma doença, composição, uso ou método, kit, e, sequência de aminoácidos.

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Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11701384B2 (en) 2016-09-02 2023-07-18 The Regents Of The University Of California Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments
WO2019000223A1 (en) * 2017-06-27 2019-01-03 Nanjing Legend Biotech Co., Ltd. ENABLERS OF IMMUNE EFFECTOR CELLS OF CHIMERIC ANTIBODIES AND METHODS OF USE THEREOF
US11517591B2 (en) 2017-09-01 2022-12-06 Dana-Farber Cancer Institute, Inc. Immunogenic peptides specific to BCMA and TACI antigens
EP3723787A4 (en) * 2017-12-14 2021-09-01 Bluebird Bio, Inc. DARIC INTERLEUKIN RECEPTORS
GB201801920D0 (en) * 2018-02-06 2018-03-21 Autolus Ltd Polypeptides and methods
TW202017592A (zh) * 2018-03-07 2020-05-16 美商波西達治療公司 ＣＡＲＴｙｒｉｎ組成物和使用方法
IT201800003464A1 (it) * 2018-03-13 2019-09-13 Ospedale Pediatrico Bambino Gesu Cellule T CAR-CD30 per il trattamento di tumori CD30+
BR112020024246A2 (pt) * 2018-06-01 2021-03-02 University Of Southern California pelo menos um polinucleotídeo recombinante, célula recombinante, receptor de antígeno quimérico, polinucleotídeo que codifica o receptor de antígeno quimérico, vetor, vírus, composição farmacêutica, e, método para tratar câncer
WO2019236681A1 (en) * 2018-06-05 2019-12-12 H. Lee Moffitt Cancer Center And Research Institute, Inc. Rapid production, expansion, and increased purity of car-t cells using beads with protein l
EP3807321A4 (en) * 2018-06-18 2022-03-02 Anwita Biosciences, Inc. ANTI-MESOTHELIN CONSTRUCTS AND USES THEREOF
KR20210033025A (ko) * 2018-07-18 2021-03-25 암젠 인크 Steap1에 대한 키메라 수용체 및 이의 사용 방법
CN110818802B (zh) * 2018-08-08 2022-02-08 华夏英泰（北京）生物技术有限公司 一种嵌合t细胞受体star及其应用
TW202024330A (zh) * 2018-08-29 2020-07-01 大陸商南京傳奇生物科技有限公司 抗間皮素嵌合抗原受體(car)構築體及其用途
WO2020061256A1 (en) * 2018-09-19 2020-03-26 FUJIFILM Cellular Dynamics, Inc. Protein l for activation and expansion of chimeric antigen receptor-modified immune cells
SG11202103832SA (en) * 2018-11-07 2021-05-28 Crispr Therapeutics Ag Anti-cd33 immune cell cancer therapy
CN113015750A (zh) * 2018-11-07 2021-06-22 克里斯珀医疗股份公司 抗liv1免疫细胞癌症疗法
US11673964B2 (en) 2018-12-19 2023-06-13 The Trustees Of The University Of Pennsylvania Use of CD2/5/7 knock-out anti-CD2/5/7 chimeric antigen receptor T cells against T cell lymphomas and leukemias
CN113226475A (zh) * 2018-12-26 2021-08-06 麒麟控股株式会社 改造tcr及其制造方法
CN113272319A (zh) * 2018-12-27 2021-08-17 国立大学法人京都大学 T细胞受体的变体
US20220064326A1 (en) * 2019-01-11 2022-03-03 The University Of North Carolina At Chapel Hill Highly modular biepitopic and bispecific car-t cells for cancer immunotherapy
CN114106183B (zh) * 2019-01-15 2023-06-23 浙江道尔生物科技有限公司 抗cld18a2纳米抗体及其应用
AU2020207962A1 (en) * 2019-01-18 2021-07-22 University Of Southern California Methods and compositions to improve the safety and efficacy of cellular therapies
KR20210142628A (ko) * 2019-02-22 2021-11-25 메모리얼 슬로안 케터링 캔서 센터 Cd33 항체 및 이를 사용하여 암을 치료하는 방법
CA3131138A1 (en) * 2019-03-06 2020-09-10 Dana-Farber Cancer Institute, Inc. T cell receptors specific to b-cell maturation antigen for treatment of cancer
US20220175781A1 (en) * 2019-03-08 2022-06-09 Obsidian Therapeutics, Inc. Cd40l compositions and methods for tunable regulation
WO2020198413A1 (en) * 2019-03-27 2020-10-01 The Trustees Of The University Of Pennsylvania Tn-muc1 chimeric antigen receptor (car) t cell therapy
EP3952885A4 (en) * 2019-04-12 2023-01-18 The Trustees of The University of Pennsylvania COMPOSITIONS AND METHODS COMPRISING A HIGH AFFINITY CHIMERIC ANTIGEN RECEPTOR (CAR) HAVING CROSS-REACTIVITY TO CLINICALLY RELEVANT EGFR MUTETED PROTEINS
WO2020227071A1 (en) * 2019-05-04 2020-11-12 Inhibrx, Inc. Cd123-binding polypeptides and uses thereof
US20220220212A1 (en) * 2019-05-13 2022-07-14 The Research Foundation For The State University Of New York Compositions and methods to block and bind ccr2 to modulate cellular function
CN110251695B (zh) * 2019-07-10 2021-12-21 莎穆(上海)生物科技有限公司 一种靶向her2的放射性配合物及其制备方法和应用
US20210128617A1 (en) * 2019-08-27 2021-05-06 The Trustees Of The University Of Pennsylvania SYNTHETIC CARS TO TREAT IL13R-alpha-2 POSITIVE HUMAN AND CANINE TUMORS
KR102329720B1 (ko) 2019-08-30 2021-11-23 한국과학기술연구원 단백질 키나아제 저해 활성을 갖는 신규한 피리미도[4,5-d]피리미딘-2-온 유도체
WO2021044439A1 (en) * 2019-09-08 2021-03-11 Immunoadaptive Cell Therapy Pvt Ltd. Inducible cytokine signals & methods for immunotherapy
AU2020345943A1 (en) 2019-09-10 2022-03-31 Obsidian Therapeutics, Inc. CA2-IL15 fusion proteins for tunable regulation
CN110964113B (zh) * 2019-12-24 2021-09-03 北京纽安博生物技术有限公司 介导结合免疫球蛋白的单域抗体、由其构建的双功能抗体及其应用
CN110964122B (zh) * 2019-12-24 2022-04-15 南京北恒生物科技有限公司 T细胞受体融合蛋白及其用途
KR20220131253A (ko) * 2019-12-30 2022-09-27 차이나 이뮤노테크 (베이징) 바이오테크놀로지 컴퍼니 리미티드 향상된 t-세포 수용체 star 및 이의 적용
CN113122628B (zh) * 2019-12-30 2023-08-11 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） Clec5a基因作为标志物在子宫内膜癌中诊断及治疗的应用
CN111154889B (zh) * 2020-01-16 2021-08-03 广西扬翔股份有限公司 一种与猪体重相关的snp分子标记及其应用和获取方法
WO2021168274A1 (en) 2020-02-21 2021-08-26 Silverback Therapeutics, Inc. Nectin-4 antibody conjugates and uses thereof
US20210277149A1 (en) * 2020-03-06 2021-09-09 Mustang Bio, Inc. Anti-idiotype antibodies and methods of using the same
CN111320703A (zh) * 2020-03-11 2020-06-23 北京双赢科创生物科技有限公司 靶向cd22的嵌合抗原受体及其应用
EP4121079A1 (en) * 2020-03-16 2023-01-25 University Of Southern California Novel antigen binding domains and synthetic antigen receptors incorporating the same
GB202004371D0 (en) * 2020-03-26 2020-05-13 Glaxosmithkline Ip Dev Ltd CAR constructs
BR112022019380A2 (pt) * 2020-03-27 2022-11-29 2Seventy Bio Inc Receptores de células t
GB202007532D0 (en) * 2020-05-20 2020-07-01 Alchemab Therapeutics Ltd Polypeptides
EP4112721A4 (en) * 2020-06-11 2024-02-28 Bioheng Therapeutics Ltd IMMUNE CELL EXPRESSING AN NK INHIBITORY MOLECULE AND ASSOCIATED USE
WO2021252654A1 (en) * 2020-06-11 2021-12-16 Innovative Cellular Therapeutics Holdings, Ltd. Cell/gene therapies targeting mage-a4 peptide
CN111826400A (zh) * 2020-07-21 2020-10-27 中科宝承生物医学科技有限公司 一种双特异性抗体nk细胞制备方法及其细胞和应用
GB202011993D0 (en) 2020-07-31 2020-09-16 Adc Therapeutics Sa ANTI-IL 13Ra2 antibodies
CN112285347B (zh) * 2020-09-30 2023-12-22 西北农林科技大学 一种猪血清样中病原抗体elisa检测试剂盒
WO2022099062A2 (en) * 2020-11-09 2022-05-12 The General Hospital Corporation Antibodies and single-chain variable region proteins recognizing click products
CN112458094B (zh) * 2020-11-16 2023-05-05 武汉华美生物工程有限公司 Gprc5d蛋白的制备方法和应用
IL303809A (en) * 2020-12-22 2023-08-01 Neogene Therapeutics B V Peptide markers for tracking genetically engineered cells
WO2022171068A1 (en) * 2021-02-09 2022-08-18 Nanjing Legend Biotech Co., Ltd. Engineered cells and uses thereof
CA3208358A1 (en) * 2021-02-16 2022-08-25 Stuart Sheldon Winter Methods for treating b-all by administering a pre-bcr complex antagonist
KR20230153529A (ko) * 2021-02-19 2023-11-06 프리트 엠. 쇼드하리 다양한 면역세포를 위한 단일사슬 및 다중사슬 합성 항원 수용체
CN114957481A (zh) * 2021-02-25 2022-08-30 华夏英泰（北京）生物技术有限公司 针对cd19和cd22的双靶点star
CN117480247A (zh) * 2021-04-15 2024-01-30 恺兴生命科技(上海)有限公司 嵌合t细胞受体及其应用
CN115232797A (zh) * 2021-04-23 2022-10-25 南京北恒生物科技有限公司 工程化免疫细胞及其用途
EP4330271A1 (en) * 2021-04-26 2024-03-06 Easemedcontrol R & D GmbH & Co KG Identification of b-cell and t-cell receptor chains for diagnosis and treatment of inflammatory diseases
KR20240008916A (ko) * 2021-05-19 2024-01-19 셀에디트 엘엘씨 이중특이적 키메라 항원 수용체 및 이를 발현하는 유전적으로 조작된 면역 세포
CN117897411A (zh) * 2021-06-30 2024-04-16 华夏英泰（北京）生物技术有限公司 一种多靶点合成t细胞受体抗原/抗体受体及其应用
CN117980326A (zh) 2021-07-14 2024-05-03 2赛文缇生物公司 与来自抗体的结合结构域融合的经工程化的t细胞受体
CN113671187A (zh) * 2021-08-12 2021-11-19 上海交通大学医学院附属上海儿童医学中心 一种用于检测mycn蛋白的ihc检测试剂盒
US11970548B2 (en) * 2021-08-27 2024-04-30 Innovative Cellular Therapeutics Holdings, Ltd. Nanobody target GCC and uses in chimeric antigen receptor cell therapy
WO2023070126A1 (en) * 2021-10-22 2023-04-27 Regents Of The University Of Minnesota Genetically engineered t cell receptors
US20230310605A1 (en) 2021-10-28 2023-10-05 Lyell Immunopharma, Inc. Methods for culturing cells expressing ror1-binding protein
CN114044823B (zh) * 2021-11-05 2022-07-05 深圳市人民医院 靶向钙粘蛋白17的纳米抗体及其应用
WO2023215725A1 (en) * 2022-05-02 2023-11-09 Fred Hutchinson Cancer Center Compositions and methods for cellular immunotherapy
WO2024064952A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells overexpressing c-jun
WO2024064958A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL86278A (en) * 1988-05-04 2003-06-24 Yeda Res & Dev Endowing cells with antibody specificity using chimeric t cell receptor
US7569664B2 (en) * 2002-10-09 2009-08-04 Immunocore Limited Single chain recombinant T cell receptors
NZ550815A (en) * 2004-05-19 2009-04-30 Immunocore Ltd Method of improving T cell receptors
EP3363907A1 (en) * 2004-05-27 2018-08-22 The Trustees of the University of Pennsylvania Novel artificial antigen presenting cells and uses therefor
JP2008514685A (ja) * 2004-10-01 2008-05-08 メディジーン リミテッド 治療剤に連結した、非天然型ジスルフィド鎖間結合を含有するｔ細胞レセプター
EP2944652A1 (en) * 2014-05-13 2015-11-18 Technische Universität München Glypican-3-specific T-cell receptors and their uses for immunotherapy of hepatocellular carcinoma
DK3149031T3 (da) * 2014-05-29 2020-03-16 Us Health Anti-human papillomavirus 16 e7 t-cellereceptorer
WO2016022400A1 (en) * 2014-08-04 2016-02-11 Fred Hutchinson Cancer Research Center T cell immunotherapy specific for wt-1
EP3212774A4 (en) * 2014-10-31 2018-04-11 Baylor College of Medicine Survivin specific t-cell receptor targeting tumor but not t cells
US9422547B1 (en) * 2015-06-09 2016-08-23 Gigagen, Inc. Recombinant fusion proteins and libraries from immune cell repertoires
AU2016342041B2 (en) * 2015-10-23 2021-12-02 Eureka Therapeutics, Inc. Antibody/T-cell receptor chimeric constructs and uses thereof

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