JP2008530975A5 - - Google Patents
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- Publication number
- JP2008530975A5 JP2008530975A5 JP2007531118A JP2007531118A JP2008530975A5 JP 2008530975 A5 JP2008530975 A5 JP 2008530975A5 JP 2007531118 A JP2007531118 A JP 2007531118A JP 2007531118 A JP2007531118 A JP 2007531118A JP 2008530975 A5 JP2008530975 A5 JP 2008530975A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- amino acid
- seq
- cytotoxic
- amino acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 claims description 82
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 66
- 238000000034 method Methods 0.000 claims description 5
- 108010013476 HLA-A24 Antigen Proteins 0.000 claims description 3
- 229940024606 amino acid Drugs 0.000 claims 45
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 31
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 18
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 18
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 18
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 18
- 229930182817 methionine Natural products 0.000 claims 18
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 18
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 9
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 9
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 9
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 9
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 9
- 229960000310 isoleucine Drugs 0.000 claims 9
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 9
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 9
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 210000001808 exosome Anatomy 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 239000000463 material Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65685705P | 2005-02-25 | 2005-02-25 | |
| PCT/JP2006/303354 WO2006090810A2 (en) | 2005-02-25 | 2006-02-17 | Peptide vaccines for lung cancers expressing ttk, urlc10 or koc1 polypeptides |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009058801A Division JP2009173661A (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009058798A Division JP4493053B2 (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009058802A Division JP4493054B2 (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008530975A JP2008530975A (ja) | 2008-08-14 |
| JP2008530975A5 true JP2008530975A5 (enExample) | 2009-05-28 |
| JP4461179B2 JP4461179B2 (ja) | 2010-05-12 |
Family
ID=36570330
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531118A Expired - Fee Related JP4461179B2 (ja) | 2005-02-25 | 2006-02-17 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009058801A Pending JP2009173661A (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009058802A Expired - Lifetime JP4493054B2 (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009058798A Expired - Lifetime JP4493053B2 (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009295766A Pending JP2010143924A (ja) | 2005-02-25 | 2009-12-25 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009058801A Pending JP2009173661A (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009058802A Expired - Lifetime JP4493054B2 (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009058798A Expired - Lifetime JP4493053B2 (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009295766A Pending JP2010143924A (ja) | 2005-02-25 | 2009-12-25 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7847060B2 (enExample) |
| EP (3) | EP1853703B1 (enExample) |
| JP (5) | JP4461179B2 (enExample) |
| DE (1) | DE602006021283D1 (enExample) |
| DK (2) | DK2325306T3 (enExample) |
| ES (3) | ES2459466T3 (enExample) |
| PL (2) | PL2325306T3 (enExample) |
| PT (2) | PT2325305E (enExample) |
| WO (1) | WO2006090810A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200413725A (en) * | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| TW200831673A (en) * | 2006-12-13 | 2008-08-01 | Oncotherapy Science Inc | TTK as tumor marker and therapeutic target for lung cancer |
| AU2012261723B2 (en) * | 2007-02-21 | 2014-11-27 | Oncotherapy Science, Inc. | Peptide vaccines for cancers expressing tumor-associated antigens |
| TWI615403B (zh) * | 2007-02-21 | 2018-02-21 | 腫瘤療法 科學股份有限公司 | 表現腫瘤相關抗原之癌症的胜肽疫苗 |
| WO2009016691A1 (en) * | 2007-07-30 | 2009-02-05 | Oncotherapy Science, Inc. | Cancer associated gene ly6k |
| MX2010002018A (es) | 2007-08-20 | 2010-05-27 | Oncotherapy Science Inc | Peptido de cdh3 y agente medicinal que comprende al mismo. |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
| TWI580431B (zh) | 2008-08-19 | 2017-05-01 | 腫瘤療法 科學股份有限公司 | Ｈｉｇ２與ｕｒｌｃ１０抗原決定位胜肽以及含此胜肽之疫苗 |
| WO2010047062A1 (en) | 2008-10-22 | 2010-04-29 | Oncotherapy Science, Inc. | Rab6kifl/kif20a epitope peptide and vaccines containing the same |
| TWI539160B (zh) | 2008-12-05 | 2016-06-21 | 腫瘤療法 科學股份有限公司 | Ｗｄｒｐｕｈ抗原決定位胜肽以及含此胜肽之疫苗 |
| RU2011130796A (ru) | 2008-12-24 | 2013-01-27 | Онкотерапи Сайенс, Инк. | Пептиды c1orf59 и содержащие их вакцины |
| CA2753681A1 (en) * | 2009-03-04 | 2010-09-10 | Oncotherapy Science, Inc. | Vangl1 peptides and vaccines including the same |
| TW201100090A (en) * | 2009-04-01 | 2011-01-01 | Oncotherapy Science Inc | C6orf167 peptides and vaccines containing the same |
| TW201102081A (en) * | 2009-05-11 | 2011-01-16 | Oncotherapy Science Inc | TTK peptides and vaccines including the same |
| WO2011027807A1 (ja) * | 2009-09-03 | 2011-03-10 | 東レ株式会社 | 免疫誘導剤 |
| TW201124530A (en) * | 2009-12-01 | 2011-07-16 | Oncotherapy Science Inc | IMP-3 oligopeptides and vaccines including the same |
| TW201200525A (en) * | 2009-12-04 | 2012-01-01 | Oncotherapy Science Inc | MYBL2 peptides and vaccines containing the same |
| TW201211250A (en) * | 2010-09-07 | 2012-03-16 | Oncotherapy Science Inc | VANGL1 peptides and vaccines including the same |
| WO2013133405A1 (ja) | 2012-03-09 | 2013-09-12 | オンコセラピー・サイエンス株式会社 | ペプチドを含む医薬組成物 |
| US9644010B2 (en) | 2012-07-10 | 2017-05-09 | Oncotherapy Science, Inc. | LY6K epitope peptides for TH1 cells and vaccines containing the same |
| TWI627182B (zh) * | 2013-05-24 | 2018-06-21 | 腫瘤療法 科學股份有限公司 | 對於ｔｈ１細胞之ｉｍｐ－３抗原決定位胜肽及含此之疫苗 |
| SG10201900835XA (en) | 2014-08-04 | 2019-03-28 | Oncotherapy Science Inc | Urlc10-derived peptide and vaccine containing same |
| EP3981416B1 (en) * | 2014-08-04 | 2024-03-20 | OncoTherapy Science, Inc. | Koc1-derived peptide and vaccine including same |
| WO2016080367A1 (ja) | 2014-11-18 | 2016-05-26 | 塩野義製薬株式会社 | 安定化されたペプチド組成物 |
| WO2021060343A1 (ja) * | 2019-09-24 | 2021-04-01 | オンコセラピー・サイエンス株式会社 | Ｕｒｌｃ１０由来ペプチドまたはｄｅｐｄｃ１由来ペプチドを認識するヒトｔ細胞が発現するｔ細胞受容体 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5804566A (en) | 1993-08-26 | 1998-09-08 | The Regents Of The University Of California | Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides |
| US5679647A (en) | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
| US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| US5922687A (en) | 1995-05-04 | 1999-07-13 | Board Of Trustees Of The Leland Stanford Junior University | Intracellular delivery of nucleic acids using pressure |
| ATE319477T1 (de) | 1995-08-03 | 2006-03-15 | Univ Leiden | Antigen presentierende bläschen, die von zellen ableiten |
| US5853719A (en) | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
| CA2262006A1 (en) | 1996-07-26 | 1998-02-05 | Sloan-Kettering Institute For Cancer Research | Method and reagents for genetic immunization |
| EP1007671B1 (de) * | 1997-04-07 | 2002-02-13 | Roche Diagnostics GmbH | Fanconi-gen ii |
| AU723543B2 (en) | 1997-04-07 | 2000-08-31 | Roche Diagnostics Gmbh | Fanconi-gene II |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| US6255055B1 (en) | 1998-03-09 | 2001-07-03 | Wisconsin Alumni Research Foundation | c-myc coding region determinant-binding protein (CRD-BP) and its nucleic acid sequence |
| US20030236209A1 (en) | 1998-03-18 | 2003-12-25 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US20030045491A1 (en) * | 2001-02-23 | 2003-03-06 | Christoph Reinhard | TTK in diagnosis and as a therapeutic target in cancer |
| US20020119156A1 (en) | 2000-03-29 | 2002-08-29 | Sei-Yu Chen | Compositions and methods of diagnosing, monitoring, staging, imaging and treating lung cancer |
| AU2002215345A1 (en) | 2000-10-13 | 2002-04-22 | Eos Biotechnology, Inc. | Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer |
| AU2002220265A1 (en) * | 2000-11-03 | 2002-05-15 | University Of Vermont And State Agricultural College | Compositions for inhibiting grb7 |
| ATE553112T1 (de) | 2001-02-21 | 2012-04-15 | Novartis Vaccines & Diagnostic | Ttk in der diagnose und als therapeutisches target bei krebs |
| JP2005527180A (ja) | 2001-04-18 | 2005-09-15 | プロテイン デザイン ラブス， インコーポレイテッド | 肺がんの診断方法、肺がんの修飾因子の組成及びスクリーニングの方法 |
| US7189507B2 (en) * | 2001-06-18 | 2007-03-13 | Pdl Biopharma, Inc. | Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer |
| JP2005531280A (ja) | 2001-10-31 | 2005-10-20 | ファイザー・プロダクツ・インク | 赤血球生成障害用治療薬および診断薬 |
| WO2003042661A2 (en) | 2001-11-13 | 2003-05-22 | Protein Design Labs, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
| EP1497454A2 (en) | 2001-11-13 | 2005-01-19 | Protein Design Labs, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
| US20030232350A1 (en) * | 2001-11-13 | 2003-12-18 | Eos Biotechnology, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
| EP1534739A4 (en) | 2002-01-18 | 2006-05-31 | Bristol Myers Squibb Co | IDENTIFICATION OF POLYNUCLEOTIDES AND POLYPEPTIDES FOR PREDICTING THE ACTIVITY OF COMPOUNDS THAT INTERACT WITH TYROSINE KINASE PROTEINS AND / OR TYROSINE KINASE PROTEIN PATHWAYS |
| SI1513934T1 (sl) * | 2002-06-06 | 2011-06-30 | Oncotherapy Science Inc | Geni in polipeptidi, povezani s humanimi raki kolona |
| DK2261249T3 (en) | 2002-09-12 | 2015-02-16 | Oncotherapy Science Inc | KDR peptides and vaccines comprising the same |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| US20060024692A1 (en) * | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| WO2005002509A2 (en) | 2003-06-09 | 2005-01-13 | Corixa Corporation | Dna vectors |
| WO2005073374A1 (ja) | 2004-01-29 | 2005-08-11 | Dainippon Sumitomo Pharma Co., Ltd. | 新規腫瘍抗原蛋白質及びその利用 |
| US20050186610A1 (en) * | 2004-02-20 | 2005-08-25 | Yeon-Su Lee | Breast cancer related protein, gene encoding the same, and method of diagnosing breast cancer using the protein and gene |
| TW200600785A (en) | 2004-03-23 | 2006-01-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancer |
| EP1854473A1 (en) | 2005-03-03 | 2007-11-14 | Takeda Pharmaceutical Company Limited | Preventive/therapeutic agent for cancer |
| TW200831673A (en) | 2006-12-13 | 2008-08-01 | Oncotherapy Science Inc | TTK as tumor marker and therapeutic target for lung cancer |
| WO2009016691A1 (en) | 2007-07-30 | 2009-02-05 | Oncotherapy Science, Inc. | Cancer associated gene ly6k |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
-
2006
- 2006-02-17 EP EP06714493A patent/EP1853703B1/en not_active Expired - Lifetime
- 2006-02-17 PT PT100104389T patent/PT2325305E/pt unknown
- 2006-02-17 EP EP10010438.9A patent/EP2325305B1/en not_active Expired - Lifetime
- 2006-02-17 EP EP10010439.7A patent/EP2325306B1/en not_active Expired - Lifetime
- 2006-02-17 DE DE602006021283T patent/DE602006021283D1/de not_active Expired - Lifetime
- 2006-02-17 DK DK10010439.7T patent/DK2325306T3/en active
- 2006-02-17 DK DK10010438.9T patent/DK2325305T3/en active
- 2006-02-17 WO PCT/JP2006/303354 patent/WO2006090810A2/en not_active Ceased
- 2006-02-17 ES ES10010439.7T patent/ES2459466T3/es not_active Expired - Lifetime
- 2006-02-17 PT PT100104397T patent/PT2325306E/pt unknown
- 2006-02-17 JP JP2007531118A patent/JP4461179B2/ja not_active Expired - Fee Related
- 2006-02-17 ES ES06714493T patent/ES2364670T3/es not_active Expired - Lifetime
- 2006-02-17 PL PL10010439T patent/PL2325306T3/pl unknown
- 2006-02-17 ES ES10010438.9T patent/ES2459492T3/es not_active Expired - Lifetime
- 2006-02-17 US US11/816,616 patent/US7847060B2/en not_active Expired - Lifetime
- 2006-02-17 PL PL10010438T patent/PL2325305T3/pl unknown
-
2009
- 2009-03-12 JP JP2009058801A patent/JP2009173661A/ja active Pending
- 2009-03-12 JP JP2009058802A patent/JP4493054B2/ja not_active Expired - Lifetime
- 2009-03-12 JP JP2009058798A patent/JP4493053B2/ja not_active Expired - Lifetime
- 2009-12-25 JP JP2009295766A patent/JP2010143924A/ja active Pending
-
2010
- 2010-10-13 US US12/903,961 patent/US8614176B2/en active Active
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