JP2010514669A5 - - Google Patents
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- JP2010514669A5 JP2010514669A5 JP2009524039A JP2009524039A JP2010514669A5 JP 2010514669 A5 JP2010514669 A5 JP 2010514669A5 JP 2009524039 A JP2009524039 A JP 2009524039A JP 2009524039 A JP2009524039 A JP 2009524039A JP 2010514669 A5 JP2010514669 A5 JP 2010514669A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- cells
- hla
- seq
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 81
- 210000004027 cell Anatomy 0.000 claims description 34
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- 150000001413 amino acids Chemical group 0.000 claims description 16
- 239000000427 antigen Substances 0.000 claims description 16
- 108091007433 antigens Proteins 0.000 claims description 16
- 102000036639 antigens Human genes 0.000 claims description 16
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 14
- 102000040430 polynucleotide Human genes 0.000 claims description 14
- 108091033319 polynucleotide Proteins 0.000 claims description 14
- 239000002157 polynucleotide Substances 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- 210000001808 exosome Anatomy 0.000 claims description 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 9
- 229940024606 amino acid Drugs 0.000 claims description 8
- 230000001939 inductive effect Effects 0.000 claims description 7
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 6
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 6
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 6
- 229930182817 methionine Natural products 0.000 claims description 6
- 108010013476 HLA-A24 Antigen Proteins 0.000 claims description 5
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 4
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 4
- 229960005486 vaccine Drugs 0.000 claims description 3
- 108010088729 HLA-A*02:01 antigen Proteins 0.000 claims description 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 229960000310 isoleucine Drugs 0.000 claims description 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 239000004474 valine Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 description 21
- 108010074328 Interferon-gamma Proteins 0.000 description 21
- 241000699670 Mus sp. Species 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000008177 pharmaceutical agent Substances 0.000 description 6
- 239000010432 diamond Substances 0.000 description 5
- 238000011510 Elispot assay Methods 0.000 description 4
- 108010074032 HLA-A2 Antigen Proteins 0.000 description 4
- 102000025850 HLA-A2 Antigen Human genes 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 description 4
- 238000012286 ELISA Assay Methods 0.000 description 3
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 2
- 108010075704 HLA-A Antigens Proteins 0.000 description 2
- 102000011786 HLA-A Antigens Human genes 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000005917 in vivo anti-tumor Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87861507P | 2007-01-03 | 2007-01-03 | |
| US60/878,615 | 2007-01-03 | ||
| US89647207P | 2007-03-22 | 2007-03-22 | |
| US60/896,472 | 2007-03-22 | ||
| PCT/JP2007/001466 WO2008081581A1 (en) | 2007-01-03 | 2007-12-26 | Foxp3 peptide vaccine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010514669A JP2010514669A (ja) | 2010-05-06 |
| JP2010514669A5 true JP2010514669A5 (enExample) | 2011-02-17 |
| JP5339375B2 JP5339375B2 (ja) | 2013-11-13 |
Family
ID=39588270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009524039A Expired - Fee Related JP5339375B2 (ja) | 2007-01-03 | 2007-12-26 | Ｆｏｘｐ３ペプチドワクチン |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8563516B2 (enExample) |
| EP (2) | EP2114987A4 (enExample) |
| JP (1) | JP5339375B2 (enExample) |
| KR (1) | KR20090099075A (enExample) |
| CN (1) | CN101641369B (enExample) |
| AU (1) | AU2007340834B2 (enExample) |
| BR (1) | BRPI0720794A2 (enExample) |
| CA (1) | CA2674365A1 (enExample) |
| IL (1) | IL199622A0 (enExample) |
| MX (1) | MX2009007261A (enExample) |
| RU (1) | RU2473557C2 (enExample) |
| SG (1) | SG177199A1 (enExample) |
| TW (1) | TWI441648B (enExample) |
| WO (1) | WO2008081581A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009050486A2 (en) * | 2007-10-19 | 2009-04-23 | The University Of Surrey | Peptide manipulators of regulatory t cell activity |
| CZ2008565A3 (cs) * | 2008-09-15 | 2009-11-18 | Vysoká škola chemicko technologická v Praze | Príprava monoklonálních protilátek proti FoxP3 proteinu s použitím modifikovaných virum podobných cástic Masonova-Pfizerova opicího viru |
| BRPI0923402A2 (pt) * | 2008-12-24 | 2015-08-04 | Oncotherapy Science Inc | Peptídeos c10rf59 e vacinas incluindo os mesmos. |
| TWI507204B (zh) * | 2009-05-26 | 2015-11-11 | Oncotherapy Science Inc | Ｃｄｃ４５ｌ胜肽與含此胜肽之疫苗 |
| JP5564730B2 (ja) * | 2011-08-12 | 2014-08-06 | オンコセラピー・サイエンス株式会社 | Ｍｐｈｏｓｐｈ１ペプチドおよびそれを含むワクチン |
| CN102603892B (zh) * | 2012-02-22 | 2013-10-30 | 尉军 | 一种肿瘤标志物foxp3抗原多肽及应用 |
| CN109069627A (zh) * | 2016-01-14 | 2018-12-21 | 纪念斯隆-凯特琳癌症中心 | 对foxp3衍生肽特异性的t细胞受体样抗体 |
| CN111375055B (zh) * | 2020-02-20 | 2021-09-03 | 陈宛莎 | 一种2019-nCoV亚单位疫苗组合物及其免疫方法 |
| WO2025136809A2 (en) * | 2023-12-19 | 2025-06-26 | Regeneron Pharmaceuticals, Inc. | Foxp3 peptides and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO116459B1 (ro) | 1991-07-25 | 2001-02-28 | Idec Pharma Corp | Compozitie imunogena |
| EP1967525B1 (en) * | 2001-05-08 | 2012-11-14 | Darwin Molecular Corporation | A method for regulating immune function in primates using the foxp3 protein |
| DE60327786D1 (de) | 2002-09-12 | 2009-07-09 | Oncotherapy Science Inc | Kdr-peptide und diese enthaltende impfstoffe |
| GB0417430D0 (en) | 2004-08-05 | 2004-09-08 | Uc3 | A novel HPV vaccine comprising peptides from host cell proteins |
| JP4628208B2 (ja) * | 2004-08-10 | 2011-02-09 | オンコセラピー・サイエンス株式会社 | Ｃｘａｄｒｌ１またはｇｃｕｄ１タンパク質を発現する胃癌または結腸直腸癌の治療のためのペプチドワクチン |
| JP4840866B2 (ja) | 2005-01-19 | 2011-12-21 | 学校法人慶應義塾 | 癌ワクチン |
-
2007
- 2007-12-25 TW TW096149888A patent/TWI441648B/zh not_active IP Right Cessation
- 2007-12-26 RU RU2009129531/10A patent/RU2473557C2/ru not_active IP Right Cessation
- 2007-12-26 EP EP07849885A patent/EP2114987A4/en not_active Withdrawn
- 2007-12-26 BR BRPI0720794-8A patent/BRPI0720794A2/pt not_active IP Right Cessation
- 2007-12-26 JP JP2009524039A patent/JP5339375B2/ja not_active Expired - Fee Related
- 2007-12-26 CN CN200780051977.4A patent/CN101641369B/zh not_active Expired - Fee Related
- 2007-12-26 MX MX2009007261A patent/MX2009007261A/es active IP Right Grant
- 2007-12-26 EP EP12153796A patent/EP2481748A3/en not_active Withdrawn
- 2007-12-26 KR KR1020097015693A patent/KR20090099075A/ko not_active Abandoned
- 2007-12-26 CA CA002674365A patent/CA2674365A1/en not_active Abandoned
- 2007-12-26 AU AU2007340834A patent/AU2007340834B2/en not_active Ceased
- 2007-12-26 SG SG2011091279A patent/SG177199A1/en unknown
- 2007-12-26 WO PCT/JP2007/001466 patent/WO2008081581A1/en not_active Ceased
- 2007-12-26 US US12/522,066 patent/US8563516B2/en not_active Expired - Fee Related
-
2009
- 2009-06-30 IL IL199622A patent/IL199622A0/en unknown
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