JP2010506826A5 - - Google Patents
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- JP2010506826A5 JP2010506826A5 JP2009516776A JP2009516776A JP2010506826A5 JP 2010506826 A5 JP2010506826 A5 JP 2010506826A5 JP 2009516776 A JP2009516776 A JP 2009516776A JP 2009516776 A JP2009516776 A JP 2009516776A JP 2010506826 A5 JP2010506826 A5 JP 2010506826A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- cancer
- cell
- hla
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 27
- 150000001413 amino acids Chemical group 0.000 claims 12
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 10
- 230000001939 inductive effect Effects 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 229940024606 amino acid Drugs 0.000 claims 6
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 6
- 210000001808 exosome Anatomy 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 229960005486 vaccine Drugs 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims 3
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims 3
- 108010013476 HLA-A24 Antigen Proteins 0.000 claims 3
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229930182817 methionine Natural products 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 206010068771 Soft tissue neoplasm Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000008968 osteosarcoma Diseases 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108010088729 HLA-A*02:01 antigen Proteins 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85257506P | 2006-10-17 | 2006-10-17 | |
| US60/852,575 | 2006-10-17 | ||
| PCT/JP2007/001122 WO2008047473A1 (en) | 2006-10-17 | 2007-10-16 | Peptide vaccines for cancers expressing mphosph1 or depdc1 polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013006870A Division JP2013116115A (ja) | 2006-10-17 | 2013-01-18 | Ｍｐｈｏｓｐｈ１またはｄｅｐｄｃ１ポリペプチドを発現する癌に対するペプチドワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010506826A JP2010506826A (ja) | 2010-03-04 |
| JP2010506826A5 true JP2010506826A5 (enExample) | 2010-12-02 |
| JP5339292B2 JP5339292B2 (ja) | 2013-11-13 |
Family
ID=39313729
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009516776A Active JP5339292B2 (ja) | 2006-10-17 | 2007-10-16 | Ｍｐｈｏｓｐｈ１またはｄｅｐｄｃ１ポリペプチドを発現する癌に対するペプチドワクチン |
| JP2013006870A Pending JP2013116115A (ja) | 2006-10-17 | 2013-01-18 | Ｍｐｈｏｓｐｈ１またはｄｅｐｄｃ１ポリペプチドを発現する癌に対するペプチドワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013006870A Pending JP2013116115A (ja) | 2006-10-17 | 2013-01-18 | Ｍｐｈｏｓｐｈ１またはｄｅｐｄｃ１ポリペプチドを発現する癌に対するペプチドワクチン |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US8557955B2 (enExample) |
| EP (7) | EP2091965B9 (enExample) |
| JP (2) | JP5339292B2 (enExample) |
| KR (4) | KR101493773B1 (enExample) |
| CN (5) | CN102850435B (enExample) |
| AU (1) | AU2007311395B2 (enExample) |
| BR (1) | BRPI0717651A2 (enExample) |
| CA (2) | CA2667030C (enExample) |
| DK (1) | DK2091965T3 (enExample) |
| ES (4) | ES2545817T3 (enExample) |
| IL (4) | IL198186A (enExample) |
| MX (1) | MX2009004147A (enExample) |
| PL (1) | PL2091965T3 (enExample) |
| PT (1) | PT2091965E (enExample) |
| RU (1) | RU2469044C2 (enExample) |
| SG (2) | SG175566A1 (enExample) |
| WO (1) | WO2008047473A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2295601A1 (en) | 2005-02-10 | 2011-03-16 | Oncotherapy Science, Inc. | Method of diagnosing bladder cancer |
| MX2010002018A (es) * | 2007-08-20 | 2010-05-27 | Oncotherapy Science Inc | Peptido de cdh3 y agente medicinal que comprende al mismo. |
| EP2362904B1 (en) | 2008-08-28 | 2016-11-16 | Oncotherapy Science, Inc. | Method of screening compounds for use in inhibiting depdc1 - znf224 binding |
| CA2753681A1 (en) * | 2009-03-04 | 2010-09-10 | Oncotherapy Science, Inc. | Vangl1 peptides and vaccines including the same |
| TW201211250A (en) * | 2010-09-07 | 2012-03-16 | Oncotherapy Science Inc | VANGL1 peptides and vaccines including the same |
| JP5564730B2 (ja) | 2011-08-12 | 2014-08-06 | オンコセラピー・サイエンス株式会社 | Ｍｐｈｏｓｐｈ１ペプチドおよびそれを含むワクチン |
| JP2013058294A (ja) * | 2011-09-09 | 2013-03-28 | Toshiba Corp | 磁気記録媒体及び磁気記録媒体の製造方法 |
| WO2013124474A2 (en) | 2012-02-23 | 2013-08-29 | Stage Cell Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| WO2013133405A1 (ja) | 2012-03-09 | 2013-09-12 | オンコセラピー・サイエンス株式会社 | ペプチドを含む医薬組成物 |
| JP6041297B2 (ja) * | 2012-08-24 | 2016-12-07 | 国立大学法人山口大学 | 犬リンパ腫の診断方法及び診断キット |
| EP2975125B1 (en) * | 2013-03-13 | 2020-04-29 | Li, Zhong | Microvesicle, and manufacturing method for same |
| EP3132247B1 (en) | 2014-04-16 | 2021-08-18 | Juno Therapeutics GmbH | Methods, kits and apparatus for expanding a population of cells |
| BR112017006969A2 (pt) | 2014-10-07 | 2017-12-19 | Cytlimic Inc | peptídeo derivado de hsp70, composição farmacêutica para o tratamento ou a prevenção de câncer usando o mesmo, indutor de imunidade e método de produção de célula apresentadora de antígeno |
| WO2016080367A1 (ja) | 2014-11-18 | 2016-05-26 | 塩野義製薬株式会社 | 安定化されたペプチド組成物 |
| TW202115102A (zh) | 2015-03-09 | 2021-04-16 | 日商賽多利克公司 | 來自gpc3之胜肽、使用此胜肽之用於治療或預防癌症之醫藥組成物、免疫誘導劑、及抗原呈現細胞之製造方法 |
| ES2844049T3 (es) | 2015-04-07 | 2021-07-21 | Cytlimic Inc | Adyuvante para vacunas contra el cáncer |
| WO2017026503A1 (ja) * | 2015-08-12 | 2017-02-16 | オンコセラピー・サイエンス株式会社 | Ｄｅｐｄｃ１由来ペプチドおよびそれを含むワクチン |
| US10793599B2 (en) * | 2015-10-08 | 2020-10-06 | Oncotherapy Science, Inc. | MPHOSPH1-derived peptide, and vaccine including same |
| EP3365453A2 (en) | 2015-10-22 | 2018-08-29 | Juno Therapeutics GmbH | Methods, kits, agents and apparatuses for transduction |
| EP3365678A1 (en) | 2015-10-22 | 2018-08-29 | Juno Therapeutics GmbH | Methods for culturing cells and kits and apparatus for same |
| IL258844B2 (en) | 2015-10-22 | 2024-03-01 | Juno Therapeutics Gmbh | Methods for culturing cells and kits and apparatus for same |
| BR112019006075A2 (pt) | 2016-10-11 | 2019-06-18 | Cytlimic Inc | medicamento |
| JP2019535270A (ja) * | 2016-11-18 | 2019-12-12 | オンコセラピー・サイエンス株式会社 | Ｔｈ１細胞のためのＤＥＰＤＣ１エピトープペプチドおよびこれを含有するワクチン |
| JP2020501524A (ja) * | 2016-11-18 | 2020-01-23 | オンコセラピー・サイエンス株式会社 | Ｔｈ１細胞のためのＭＰＨＯＳＰＨ１エピトープペプチドおよびこれを含有するワクチン |
| CN109923121B (zh) * | 2016-11-22 | 2022-12-23 | 武汉华大吉诺因生物科技有限公司 | 多肽及其应用 |
| CN114917189B (zh) | 2017-01-25 | 2024-05-14 | 奥塞免疫疗法公司 | 用于肽递送的稳定乳液的制造方法 |
| EP4647493A3 (en) | 2017-04-27 | 2026-01-14 | Juno Therapeutics, Inc. | Oligomeric particle reagents and methods of use thereof |
| PT3652606T (pt) * | 2017-07-12 | 2023-03-16 | Nouscom Ag | Vacina universal baseada em neoantigénios tumorais partilhados para prevenção e tratamento de cancros com microssatélites instáveis (msi) |
| KR102673699B1 (ko) * | 2017-12-13 | 2024-06-17 | 이노비오 파마수티컬즈, 인크. | Lemd1을 표적화하는 암 백신 및 이의 용도 |
| CN109932510B (zh) * | 2017-12-18 | 2022-07-12 | 天津云检医学检验所有限公司 | 一种宫颈癌生物标志物及其检测试剂盒 |
| CA3108657A1 (en) | 2018-08-09 | 2020-02-13 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| US12522660B2 (en) | 2018-10-31 | 2026-01-13 | C3S2 Gmbh | Methods for selection and stimulation of cells and apparatus for same |
| CN112142824B (zh) * | 2019-06-27 | 2022-03-11 | 深圳市东贵博康生化科技有限公司 | 具有诱导细胞毒性t淋巴细胞能力的多肽及其应用 |
| WO2021060343A1 (ja) * | 2019-09-24 | 2021-04-01 | オンコセラピー・サイエンス株式会社 | Ｕｒｌｃ１０由来ペプチドまたはｄｅｐｄｃ１由来ペプチドを認識するヒトｔ細胞が発現するｔ細胞受容体 |
| CA3198427A1 (en) * | 2020-10-15 | 2022-04-21 | Myneo Nv | Method, system and computer program product for determining peptide immunogenicity |
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| JP5564730B2 (ja) | 2011-08-12 | 2014-08-06 | オンコセラピー・サイエンス株式会社 | Ｍｐｈｏｓｐｈ１ペプチドおよびそれを含むワクチン |
-
2007
- 2007-10-16 BR BRPI0717651-1A2A patent/BRPI0717651A2/pt not_active IP Right Cessation
- 2007-10-16 US US12/445,729 patent/US8557955B2/en active Active
- 2007-10-16 CN CN201210305732.2A patent/CN102850435B/zh active Active
- 2007-10-16 CN CN2007800467286A patent/CN101568550B/zh active Active
- 2007-10-16 RU RU2009118432/10A patent/RU2469044C2/ru not_active IP Right Cessation
- 2007-10-16 DK DK07827901.5T patent/DK2091965T3/da active
- 2007-10-16 EP EP07827901.5A patent/EP2091965B9/en active Active
- 2007-10-16 EP EP20130189400 patent/EP2695895A1/en not_active Withdrawn
- 2007-10-16 CA CA2667030A patent/CA2667030C/en not_active Expired - Fee Related
- 2007-10-16 CN CN201210305207.0A patent/CN102850433B/zh active Active
- 2007-10-16 ES ES12155444.8T patent/ES2545817T3/es active Active
- 2007-10-16 WO PCT/JP2007/001122 patent/WO2008047473A1/en not_active Ceased
- 2007-10-16 EP EP12155446.3A patent/EP2476698B1/en active Active
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