JP2010519176A5 - - Google Patents
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- JP2010519176A5 JP2010519176A5 JP2009534784A JP2009534784A JP2010519176A5 JP 2010519176 A5 JP2010519176 A5 JP 2010519176A5 JP 2009534784 A JP2009534784 A JP 2009534784A JP 2009534784 A JP2009534784 A JP 2009534784A JP 2010519176 A5 JP2010519176 A5 JP 2010519176A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- peptide
- amino acid
- hla
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 34
- 150000001413 amino acids Chemical class 0.000 claims 21
- 229940024606 amino acid Drugs 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 8
- 230000001939 inductive effect Effects 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 210000001808 exosome Anatomy 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 229960005486 vaccine Drugs 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims 3
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims 3
- 108010013476 HLA-A24 Antigen Proteins 0.000 claims 3
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 3
- 229930182817 methionine Natural products 0.000 claims 3
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 201000009273 Endometriosis Diseases 0.000 claims 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 206010068771 Soft tissue neoplasm Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 2
- 208000024334 diffuse gastric cancer Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 201000004101 esophageal cancer Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 208000025189 neoplasm of testis Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000008968 osteosarcoma Diseases 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 201000003120 testicular cancer Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 108010088729 HLA-A*02:01 antigen Proteins 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90294907P | 2007-02-21 | 2007-02-21 | |
| US60/902,949 | 2007-02-21 | ||
| PCT/JP2008/000290 WO2008102557A1 (en) | 2007-02-21 | 2008-02-21 | Peptide vaccines for cancers expressing tumor-associated antigens |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010021234A Division JP5239104B2 (ja) | 2007-02-21 | 2010-02-02 | 腫瘍関連抗原を発現する癌に対するペプチドワクチン |
| JP2012260412A Division JP5614761B2 (ja) | 2007-02-21 | 2012-11-29 | 腫瘍関連抗原を発現する癌に対するペプチドワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010519176A JP2010519176A (ja) | 2010-06-03 |
| JP2010519176A5 true JP2010519176A5 (enExample) | 2012-07-05 |
| JP5239103B2 JP5239103B2 (ja) | 2013-07-17 |
Family
ID=39709837
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009534784A Active JP5239103B2 (ja) | 2007-02-21 | 2008-02-21 | 腫瘍関連抗原を発現する癌に対するペプチドワクチン |
| JP2010021234A Active JP5239104B2 (ja) | 2007-02-21 | 2010-02-02 | 腫瘍関連抗原を発現する癌に対するペプチドワクチン |
| JP2012260412A Active JP5614761B2 (ja) | 2007-02-21 | 2012-11-29 | 腫瘍関連抗原を発現する癌に対するペプチドワクチン |
| JP2012260421A Active JP5608953B2 (ja) | 2007-02-21 | 2012-11-29 | 腫瘍関連抗原を発現する癌に対するペプチドワクチン |
| JP2014150295A Expired - Fee Related JP5874158B2 (ja) | 2007-02-21 | 2014-07-24 | 腫瘍関連抗原を発現する癌に対するペプチドワクチン |
| JP2015252737A Pending JP2016094459A (ja) | 2007-02-21 | 2015-12-25 | 腫瘍関連抗原を発現する癌に対するペプチドワクチン |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010021234A Active JP5239104B2 (ja) | 2007-02-21 | 2010-02-02 | 腫瘍関連抗原を発現する癌に対するペプチドワクチン |
| JP2012260412A Active JP5614761B2 (ja) | 2007-02-21 | 2012-11-29 | 腫瘍関連抗原を発現する癌に対するペプチドワクチン |
| JP2012260421A Active JP5608953B2 (ja) | 2007-02-21 | 2012-11-29 | 腫瘍関連抗原を発現する癌に対するペプチドワクチン |
| JP2014150295A Expired - Fee Related JP5874158B2 (ja) | 2007-02-21 | 2014-07-24 | 腫瘍関連抗原を発現する癌に対するペプチドワクチン |
| JP2015252737A Pending JP2016094459A (ja) | 2007-02-21 | 2015-12-25 | 腫瘍関連抗原を発現する癌に対するペプチドワクチン |
Country Status (27)
| Country | Link |
|---|---|
| EP (20) | EP2574623A3 (enExample) |
| JP (6) | JP5239103B2 (enExample) |
| KR (8) | KR101543623B1 (enExample) |
| CN (4) | CN104292299B (enExample) |
| AR (1) | AR068302A1 (enExample) |
| AU (1) | AU2008218463B2 (enExample) |
| BR (1) | BRPI0808421B1 (enExample) |
| CA (3) | CA2678755C (enExample) |
| CO (1) | CO6190536A2 (enExample) |
| CY (2) | CY1114590T1 (enExample) |
| DK (3) | DK2121731T3 (enExample) |
| ES (6) | ES2530777T3 (enExample) |
| HR (3) | HRP20131044T1 (enExample) |
| IL (10) | IL200478A (enExample) |
| MX (4) | MX337417B (enExample) |
| MY (2) | MY173379A (enExample) |
| NZ (4) | NZ579768A (enExample) |
| PH (1) | PH12014501642A1 (enExample) |
| PL (3) | PL2121731T3 (enExample) |
| PT (2) | PT2121731E (enExample) |
| RU (1) | RU2464275C2 (enExample) |
| SG (3) | SG10201506589WA (enExample) |
| SI (3) | SI2465864T1 (enExample) |
| TW (5) | TWI615403B (enExample) |
| UA (1) | UA100372C2 (enExample) |
| WO (1) | WO2008102557A1 (enExample) |
| ZA (1) | ZA200905881B (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2005019475A2 (en) | 2003-08-20 | 2005-03-03 | Oncotherapy Science, Inc. | Hypoxia-inducible protein 2 (hig2), a novel therapeutic potential target of renal cell carcinoma (rcc) |
| MX2010002018A (es) * | 2007-08-20 | 2010-05-27 | Oncotherapy Science Inc | Peptido de cdh3 y agente medicinal que comprende al mismo. |
| JP5593560B2 (ja) | 2008-06-30 | 2014-09-24 | オンコセラピー・サイエンス株式会社 | 放射性同位体標識で標識された抗ｃｄｈ３抗体およびその使用 |
| TW201008574A (en) * | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
| TWI580431B (zh) | 2008-08-19 | 2017-05-01 | 腫瘤療法 科學股份有限公司 | Ｈｉｇ２與ｕｒｌｃ１０抗原決定位胜肽以及含此胜肽之疫苗 |
| WO2010047062A1 (en) * | 2008-10-22 | 2010-04-29 | Oncotherapy Science, Inc. | Rab6kifl/kif20a epitope peptide and vaccines containing the same |
| TWI539160B (zh) * | 2008-12-05 | 2016-06-21 | 腫瘤療法 科學股份有限公司 | Ｗｄｒｐｕｈ抗原決定位胜肽以及含此胜肽之疫苗 |
| RU2011130796A (ru) * | 2008-12-24 | 2013-01-27 | Онкотерапи Сайенс, Инк. | Пептиды c1orf59 и содержащие их вакцины |
| TW201102081A (en) * | 2009-05-11 | 2011-01-16 | Oncotherapy Science Inc | TTK peptides and vaccines including the same |
| US8703808B2 (en) | 2009-06-23 | 2014-04-22 | Centre National De La Recherche Scientifique | Use of derivatives of indoles for the treatment of cancer |
| JP5728718B2 (ja) | 2009-12-28 | 2015-06-03 | オンコセラピー・サイエンス株式会社 | 抗ｃｄｈ３抗体およびその使用 |
| WO2011116026A2 (en) | 2010-03-15 | 2011-09-22 | The Board Of Trustees Of The University Of Illinois | Inhibitors of beta integrin-g protein alpha subunit binding interactions |
| TWI538685B (zh) * | 2010-04-02 | 2016-06-21 | 腫瘤療法 科學股份有限公司 | Ｅｃｔ２胜肽及含此胜肽之疫苗 |
| CN103339253B (zh) * | 2010-12-02 | 2015-09-09 | 肿瘤疗法科学股份有限公司 | Tomm34肽及包含它们的疫苗 |
| CN109276717B (zh) | 2011-12-14 | 2022-04-12 | 得克萨斯系统大学董事会 | 用于癌症疗法的连带基因失活生物标志和靶标 |
| WO2013133405A1 (ja) | 2012-03-09 | 2013-09-12 | オンコセラピー・サイエンス株式会社 | ペプチドを含む医薬組成物 |
| EP2872530A4 (en) | 2012-07-10 | 2016-04-06 | Oncotherapy Science Inc | KIF20A EPITOPE PEPTIDES FOR TH1 CELLS AND VACCINES CONTAINING SAME |
| US9644010B2 (en) | 2012-07-10 | 2017-05-09 | Oncotherapy Science, Inc. | LY6K epitope peptides for TH1 cells and vaccines containing the same |
| US9683016B2 (en) | 2012-08-31 | 2017-06-20 | Genestem Co., Ltd. | PSF1-derived peptide |
| RU2663350C2 (ru) | 2012-09-11 | 2018-08-03 | Онкотерапи Сайенс, Инк. | Пептиды ube2t и содержащие их вакцины |
| WO2014141652A1 (en) * | 2013-03-11 | 2014-09-18 | Oncotherapy Science, Inc. | Smyd3 peptides and vaccines containing the same |
| TWI658049B (zh) * | 2013-03-12 | 2019-05-01 | 腫瘤療法 科學股份有限公司 | Ｋｎｔｃ２胜肽及含此胜肽之疫苗 |
| EP3020806A4 (en) * | 2013-07-12 | 2017-05-31 | Sumitomo Dainippon Pharma Co., Ltd. | Tumor antigen peptide |
| JP2015227292A (ja) * | 2014-05-30 | 2015-12-17 | 国立大学法人高知大学 | 膵がん細胞浸潤転移抑制ワクチン |
| MX2016017393A (es) | 2014-07-01 | 2017-09-05 | Pfizer | Diacuerpos heterodimericos biespecificos y sus usos. |
| SG10201900835XA (en) | 2014-08-04 | 2019-03-28 | Oncotherapy Science Inc | Urlc10-derived peptide and vaccine containing same |
| GB201507719D0 (en) * | 2015-05-06 | 2015-06-17 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers |
| CN104975082B (zh) * | 2015-06-05 | 2018-11-02 | 复旦大学附属肿瘤医院 | 一组用于评估肺癌预后的基因及其应用 |
| CN109310739A (zh) * | 2016-03-31 | 2019-02-05 | 内恩疗法公司 | 新抗原及其使用方法 |
| WO2018090257A1 (zh) * | 2016-11-16 | 2018-05-24 | 深圳华大基因研究院 | 多肽及其应用 |
| CN114917189B (zh) | 2017-01-25 | 2024-05-14 | 奥塞免疫疗法公司 | 用于肽递送的稳定乳液的制造方法 |
| CA3058434A1 (en) * | 2017-03-28 | 2018-10-04 | Zhenglun Zhu | Methods of treating neoplastic diseases |
| EP3666888A4 (en) * | 2017-08-10 | 2021-09-01 | Good T Cells, Inc. | T-CELL ACTIVATION METHOD FOR CANCER TREATMENT |
| CN111788214B (zh) * | 2018-02-15 | 2021-06-22 | 国立大学法人旭川医科大学 | 癌症抗原肽 |
| KR102335916B1 (ko) * | 2019-04-22 | 2021-12-08 | 한국과학기술연구원 | 인간 백혈구 항원 a02:01 대립유전자에 특이적으로 결합하는 펩타이드 및 이의 용도 |
| KR102322832B1 (ko) * | 2019-04-22 | 2021-11-12 | 한국과학기술연구원 | 인간 백혈구 항원 a24:02 대립유전자에 특이적으로 결합하는 펩타이드 및 이의 용도 |
| CN113117055A (zh) * | 2019-12-31 | 2021-07-16 | 上海细胞治疗集团有限公司 | 一种特异性结合hla-a24分型的多肽组合物及应用 |
| CN117143206B (zh) * | 2023-08-03 | 2024-09-03 | 华南农业大学 | Alv-j mhc-b21限制性表位肽及其筛选方法和应用 |
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