JP2012500001A - Inhbbエピトープペプチドおよびそれを含むワクチン - Google Patents
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| US9732131B2 (en) | 2006-02-27 | 2017-08-15 | Calviri, Inc. | Identification and use of novopeptides for the treatment of cancer |
| JP2009528257A (ja) * | 2006-02-28 | 2009-08-06 | オンコセラピー・サイエンス株式会社 | 抗cdh3抗体のエフェクター機能を用いて細胞を障害する方法 |
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| US20100291091A1 (en) * | 2007-07-30 | 2010-11-18 | ONCOTHERAPY SCIENCE ,inc. | Cancer associated gene ly6k |
| CN101827936B (zh) * | 2007-08-20 | 2014-12-10 | 肿瘤疗法科学股份有限公司 | Cdh3肽以及含有cdh3肽的药剂 |
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| TWI543767B (zh) | 2008-08-19 | 2016-08-01 | 腫瘤療法 科學股份有限公司 | Hig2與urlc10抗原決定位胜肽以及含此胜肽之疫苗 |
| RU2532105C2 (ru) | 2008-10-22 | 2014-10-27 | Онкотерапи Сайенс, Инк. | Эпитопные пептиды rab6kifl/kif20a и содержащие их вакцины |
| TWI539160B (zh) | 2008-12-05 | 2016-06-21 | 腫瘤療法 科學股份有限公司 | Wdrpuh抗原決定位胜肽以及含此胜肽之疫苗 |
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| JP6255594B2 (ja) | 2012-07-10 | 2018-01-10 | オンコセラピー・サイエンス株式会社 | Th1細胞のLY6Kエピトープペプチドおよびこれを含有するワクチン |
| JP2016500255A (ja) | 2012-12-11 | 2016-01-12 | アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ | ハイスループットなレセプター:リガンド同定の方法 |
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| GB201315946D0 (en) * | 2013-09-06 | 2013-10-23 | Immune Targeting Systems Its Ltd | Oncology vaccine |
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| US10576097B2 (en) | 2014-08-04 | 2020-03-03 | Oncotherapy Science, Inc. | URLC10-derived peptide and vaccine containing same |
| SG11201701809UA (en) | 2014-09-08 | 2017-04-27 | Nat Cancer Ct | Cancer cell-specific antibody, anticancer drug and cancer testing method |
| EP3227679A1 (en) * | 2014-12-03 | 2017-10-11 | Verik Bio, Inc. | Identification, selection and use of high curative potential t cell epitopes |
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| AU2017268348A1 (en) | 2016-05-18 | 2018-10-25 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| CA3022331A1 (en) | 2016-05-18 | 2017-11-23 | Albert Einstein College Of Medicine, Inc. | Variant pd-l1 polypeptides, t-cell modulatory multimeric polypeptides, and methods of use thereof |
| DE102016123893A1 (de) | 2016-12-08 | 2018-06-14 | Immatics Biotechnologies Gmbh | T-Zellrezeptoren mit verbesserter Bindung |
| IL303806B2 (en) | 2016-12-22 | 2024-05-01 | Cue Biopharma Inc | Multimeric polypeptides modulate T cells and methods for their use |
| WO2018129474A1 (en) | 2017-01-09 | 2018-07-12 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| IL268920B2 (en) * | 2017-03-03 | 2025-05-01 | Treos Bio Zrt | Peptide vaccines |
| WO2018170168A1 (en) | 2017-03-15 | 2018-09-20 | Cue Biopharma, Inc. | Methods for modulating an immune response |
| US11484581B2 (en) | 2017-06-02 | 2022-11-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Method to create personalized canine cancer vaccines |
| US12025615B2 (en) | 2017-09-15 | 2024-07-02 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods of classifying response to immunotherapy for cancer |
| CN111886241A (zh) | 2018-01-09 | 2020-11-03 | 库尔生物制药有限公司 | 多聚体t细胞调节多肽及其使用方法 |
| US11666644B2 (en) | 2018-09-04 | 2023-06-06 | Treos Bio Limited | Peptide vaccines |
| WO2021067550A1 (en) | 2019-10-02 | 2021-04-08 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods and compositions for identifying neoantigens for use in treating and preventing cancer |
| IL296209A (en) | 2020-05-12 | 2022-11-01 | Cue Biopharma Inc | Multimeric t-cell modulatory polypeptides and methods of using them |
| JP2023541366A (ja) | 2020-09-09 | 2023-10-02 | キュー バイオファーマ, インコーポレイテッド | 1型真性糖尿病(t1d)を治療するためのmhcクラスii t細胞調節多量体ポリペプチド及びその使用方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008102557A1 (en) * | 2007-02-21 | 2008-08-28 | Oncotherapy Science, Inc. | Peptide vaccines for cancers expressing tumor-associated antigens |
Family Cites Families (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3322314C2 (de) | 1983-06-21 | 1986-01-02 | Gebhard, Dietrich, 7502 Malsch | Schaltungsanordnung für ein Zugfahrzeug |
| US5089396A (en) | 1985-10-03 | 1992-02-18 | Genentech, Inc. | Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
| NZ217727A (en) | 1985-10-03 | 1990-05-28 | Genentech Inc | Nucleic acid encoding alpha or b chain of inhibin, its production and compositions containing it |
| IL103928A0 (en) | 1991-12-11 | 1993-04-04 | American Home Prod | Expression of specific immunogens using viral antigens |
| WO1995028484A1 (en) | 1994-04-15 | 1995-10-26 | Amgen Inc. | Hek5, hek7, hek8, hek11, new eph-like receptor protein tyrosine kinases |
| AU6795898A (en) | 1997-04-04 | 1998-10-30 | Board Of Regents, The University Of Texas System | Proteins and compositions for modulating mitosis |
| US6800744B1 (en) | 1997-07-02 | 2004-10-05 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
| US5891432A (en) | 1997-07-29 | 1999-04-06 | The Immune Response Corporation | Membrane-bound cytokine compositions comprising GM=CSF and methods of modulating an immune response using same |
| KR100631766B1 (ko) | 1997-10-07 | 2006-10-09 | 오노 야꾸힝 고교 가부시키가이샤 | 폴리펩티드, 그 폴리펩티드를 암호화하는 cDNA 및그들의 용도 |
| US6747137B1 (en) | 1998-02-13 | 2004-06-08 | Genome Therapeutics Corporation | Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics |
| US6551795B1 (en) | 1998-02-18 | 2003-04-22 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics |
| US6783961B1 (en) * | 1999-02-26 | 2004-08-31 | Genset S.A. | Expressed sequence tags and encoded human proteins |
| US20070014787A1 (en) * | 1998-07-15 | 2007-01-18 | Human Genome Sciences, Inc. | 71 human secreted proteins |
| NZ509585A (en) | 1998-07-28 | 2003-05-30 | Sumitomo Pharma | HLA-A2 restraint tumor antigen peptide orignating in SART-1 |
| WO2001064835A2 (en) | 2000-02-28 | 2001-09-07 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| ATE373715T1 (de) | 1999-08-04 | 2007-10-15 | Adelbert Bacher | Isoprenoid biosynthese |
| AU1220001A (en) | 1999-10-20 | 2001-04-30 | Zymogenetics Inc. | Novel proteins and polynucleotides encoding them |
| US6682902B2 (en) | 1999-12-16 | 2004-01-27 | Schering Aktiengesellschaft | DNA encoding a novel RG1 polypeptide |
| US20030013649A1 (en) | 2000-01-31 | 2003-01-16 | Rosen Craig A. | Nucleic acids, proteins, and antibodies |
| AU2000232427A1 (en) | 2000-02-23 | 2001-09-03 | Epimmune Inc. | HLA binding peptides and their uses |
| CN1469926A (zh) | 2000-03-29 | 2004-01-21 | 科里克萨有限公司 | 治疗和诊断肺癌的组合物和方法 |
| CZ20023567A3 (cs) | 2000-03-29 | 2003-11-12 | Corixa Corporation | Sloučeniny a způsoby pro terapii a diagnostiku karcinomu plic |
| AU2001277172A1 (en) | 2000-07-26 | 2002-02-05 | Applied Genomics, Inc. | Bstp-trans protein and related reagents and methods of use thereof |
| US6830885B1 (en) | 2000-08-18 | 2004-12-14 | Phenogene Therapeutiques Inc. | Nucleic acid molecule, method and kit for selecting a nucleic acid having a desired feature |
| US20090062512A1 (en) | 2000-10-10 | 2009-03-05 | Hildebrand William H | Comparative ligand mapping from MHC class I positive cells |
| US7033832B2 (en) | 2000-10-13 | 2006-04-25 | University Of Medicine And Dentistry Of New Jersey | Endothelial cell—cell cohesion |
| JP2005506033A (ja) | 2000-10-13 | 2005-03-03 | イーオーエス バイオテクノロジー インコーポレイテッド | 前立腺癌の診断法、前立腺癌モジュレータースクリーニングの組成物及び方法 |
| US7919467B2 (en) | 2000-12-04 | 2011-04-05 | Immunotope, Inc. | Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
| US7214786B2 (en) | 2000-12-14 | 2007-05-08 | Kovalic David K | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| CN100400099C (zh) | 2001-01-04 | 2008-07-09 | 北京迪威华宇生物技术有限公司 | 预防和治疗人前列腺癌的重组蛋白疫苗 |
| WO2002078524A2 (en) | 2001-03-28 | 2002-10-10 | Zycos Inc. | Translational profiling |
| AU2002309583A1 (en) | 2001-04-18 | 2002-11-05 | Protein Desing Labs, Inc. | Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer |
| WO2002102235A2 (en) | 2001-06-18 | 2002-12-27 | Eos Biotechnology Inc. | Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer |
| US20030124579A1 (en) | 2001-09-05 | 2003-07-03 | Eos Biotechnology, Inc. | Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer |
| US20040142325A1 (en) | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| US20030232350A1 (en) | 2001-11-13 | 2003-12-18 | Eos Biotechnology, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
| US7314974B2 (en) | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
| JP2005536186A (ja) | 2002-03-07 | 2005-12-02 | ルードビッヒ、インスティテュート、フォー、キャンサー、リサーチ | リンパ管および血管内皮細胞遺伝子 |
| US20030194704A1 (en) | 2002-04-03 | 2003-10-16 | Penn Sharron Gaynor | Human genome-derived single exon nucleic acid probes useful for gene expression analysis two |
| US20070015271A1 (en) * | 2002-04-04 | 2007-01-18 | Rosen Craig A | Human secreted proteins |
| CA2499709A1 (en) | 2002-06-19 | 2003-12-31 | Yoichi Furukawa | Method for diagnosis of colorectal tumors |
| AU2003280991A1 (en) | 2002-07-10 | 2004-02-02 | Japan As Represented By The President Of The University Of Tokyo | Method for diagnosis of intestinal-type gastric tumors |
| FI116178B (fi) | 2002-08-22 | 2005-09-30 | Abb Oy | Vaihtosuuntaajan lähtökuristinsovitelma |
| WO2004035732A2 (en) | 2002-08-29 | 2004-04-29 | Five Prime Therapeutics, Inc. | Human polypeptides encoded by polynucleotides and methods of their use |
| ATE397098T1 (de) | 2002-08-30 | 2008-06-15 | Oncotherapy Science Inc | Verfahren zur diagnostik von eierstock endometriose |
| US20050214836A1 (en) | 2002-08-30 | 2005-09-29 | Oncotherapy Science, Inc. | Method of diagnosing ovarian endometriosis |
| US20050259483A1 (en) | 2002-09-30 | 2005-11-24 | Oncotherapy Science, Inc. | Genes and polypeptides relating to prostate cancers |
| TW200413539A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Genes and polypeptides relating to prostate cancers |
| CN1703522A (zh) | 2002-09-30 | 2005-11-30 | 肿瘤疗法科学股份有限公司 | 诊断睾丸精原细胞瘤的方法 |
| US20050260639A1 (en) | 2002-09-30 | 2005-11-24 | Oncotherapy Science, Inc. | Method for diagnosing pancreatic cancer |
| US20060024692A1 (en) | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| US7601826B2 (en) | 2002-09-30 | 2009-10-13 | Oncotherapy Science, Inc. | Genes and polypeptides relating to human pancreatic cancers |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| JP2006516089A (ja) | 2002-10-02 | 2006-06-22 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
| WO2004055050A2 (en) | 2002-12-10 | 2004-07-01 | Endocube Sas | Thap proteins as nuclear receptors for chemokines and roles in transcriptional regulation, cell proliferation and cell differentiation |
| JP2006517788A (ja) | 2002-12-20 | 2006-08-03 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 15986、2188、20743、9148、9151、9791、44252、14184、42461、8204、7970、25552、21657、26492、2411、15088、1905、28899、63380、33935、10480、12686、25501、17694、15701、53062、49908、21612、38949、6216、46863、9235、2201、6985、9883、12238、18057、21617、39228、49928、54476、62113、64316、12264、32362、58198、2887、3205、8557、9600、9693、44867、53058、55556、57658、2208、10252、10302、14218、33877、10317、10485、25964、14815、1363、1397、14827、21708、3801、64698、2179または13249を使用する癌を処置するための方法および組成物 |
| TWI324608B (en) | 2003-02-28 | 2010-05-11 | Oncotherapy Science Inc | Genes and polypeptides relating to human colorectal cancers |
| US7337154B2 (en) | 2003-05-19 | 2008-02-26 | Raytheon Company | Method for solving the binary minimization problem and a variant thereof |
| EP1651775A2 (en) | 2003-06-18 | 2006-05-03 | Arcturus Bioscience, Inc. | Breast cancer survival and recurrence |
| WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| WO2005019475A2 (en) | 2003-08-20 | 2005-03-03 | Oncotherapy Science, Inc. | Hypoxia-inducible protein 2 (hig2), a novel therapeutic potential target of renal cell carcinoma (rcc) |
| TW200512298A (en) | 2003-09-24 | 2005-04-01 | Oncotherapy Science Inc | Method of diagnosing breast cancer |
| EP1762094A4 (en) | 2003-12-08 | 2007-11-14 | Silicon Image Inc | INTEGRATED ADDRESSING SCHEME FOR USE IN A SYSTEM WITH A TREE STRUCTURE |
| US20070253954A1 (en) | 2004-02-27 | 2007-11-01 | Oncotherapy Science, Inc. | Epha4 As Therapeutic Target Of Prc And Pdaca |
| EP1735442A2 (en) | 2004-03-24 | 2006-12-27 | Oncotherapy Science, Inc. | Compositions and methods for treating pancreatic cancer |
| EP2520652B1 (en) | 2004-04-09 | 2015-06-10 | Genecare Research Institute Co., Ltd | Cancer cell-specific apoptosis-inducing agents that target chromosome stabilization-associates genes |
| JP2008509654A (ja) | 2004-06-01 | 2008-04-03 | イノジェネティックス・ナムローゼ・フェンノートシャップ | C型肝炎ウイルスに対するctlおよび/またはhtl応答を誘導するためのペプチド |
| US8143228B2 (en) * | 2004-07-12 | 2012-03-27 | Medical Research Fund Of Tel Aviv Sourasky Medical Center | Agents capable of downregulating an MSF-A dependent HIF-1α and use thereof in cancer treatment |
| WO2006055371A2 (en) | 2004-11-16 | 2006-05-26 | Alexion Pharmaceuticals, Inc. | Functional screening of antibody libraries |
| CN100381460C (zh) | 2004-11-30 | 2008-04-16 | 北京市肿瘤防治研究所 | Her-2模拟抗原表位及含有该表位的肽 |
| CN101175862A (zh) * | 2005-02-10 | 2008-05-07 | 肿瘤疗法科学股份有限公司 | 诊断膀胱癌的方法 |
| AU2006216683A1 (en) | 2005-02-24 | 2006-08-31 | Cemines, Inc. | Compositions and methods for classifying biological samples |
| US8088976B2 (en) | 2005-02-24 | 2012-01-03 | Monsanto Technology Llc | Methods for genetic control of plant pest infestation and compositions thereof |
| DK2325306T3 (en) | 2005-02-25 | 2014-03-03 | Oncotherapy Science Inc | Peptide vaccines against lung cancers expressing TTK, URLC10 or KOC1 polypeptide |
| CA2599875A1 (en) | 2005-03-03 | 2006-09-08 | Takeda Pharmaceutical Company Limited | Preventive/therapeutic agent for cancer |
| CN100348614C (zh) | 2005-06-03 | 2007-11-14 | 北京大学 | 一种肝癌-睾丸特异性抗原蛋白质和抗原肽 |
| CA2615949C (en) | 2005-07-20 | 2017-02-14 | Agriculture Victoria Services Pty Ltd | Modification of flavonoid biosynthesis in plants |
| EP2295571A1 (en) | 2005-07-27 | 2011-03-16 | Oncotherapy Science, Inc. | Method of diagnosing small cell lung cancer |
| WO2007013671A2 (en) | 2005-07-27 | 2007-02-01 | Oncotherapy Science, Inc. | Method of diagnosing esophageal cancer |
| JP2009502112A (ja) | 2005-07-28 | 2009-01-29 | オンコセラピー・サイエンス株式会社 | 腎細胞癌を診断および処置するための方法 |
| CN101283279A (zh) | 2005-07-29 | 2008-10-08 | 肿瘤疗法科学股份有限公司 | 以cdca1-kntc2复合物为靶标的筛选和nsclc治疗方法 |
| JP4803460B2 (ja) * | 2005-08-09 | 2011-10-26 | 学校法人 久留米大学 | Hla−a24分子結合性扁平上皮癌抗原由来ペプチド |
| DE602005020046D1 (de) | 2005-09-05 | 2010-04-29 | Immatics Biotechnologies Gmbh | Tumor-assoziierte Peptide, welche an unterschiedliche menschliche Leukozytenantigene der Klasse II binden |
| WO2007064743A2 (en) | 2005-11-30 | 2007-06-07 | Cell Signaling Technology, Inc. | Reagents for the detection of protein phosphorylation in leukemia signaling pathways |
| RU2429246C2 (ru) | 2006-02-28 | 2011-09-20 | Онкотерапи Сайенс, Инк. | СПОСОБЫ РАЗРУШЕНИЯ КЛЕТОК С ИСПОЛЬЗОВАНИЕМ ЭФФЕКТОРНЫХ ФУНКЦИЙ АНТИ-EphA4 АНТИТЕЛ |
| JP2009528257A (ja) | 2006-02-28 | 2009-08-06 | オンコセラピー・サイエンス株式会社 | 抗cdh3抗体のエフェクター機能を用いて細胞を障害する方法 |
| ES2487637T3 (es) | 2006-04-10 | 2014-08-22 | Genentech, Inc. | Moduladores de PDZ Disheveled |
| WO2008072777A2 (en) | 2006-12-13 | 2008-06-19 | Oncotherapy Science, Inc. | Ttk as tumor marker and therapeutic target for lung cancer |
| WO2008102906A1 (en) | 2007-02-20 | 2008-08-28 | Oncotherapy Science, Inc. | Hspc-hrpc transition genes |
| EP1972639A3 (en) | 2007-03-07 | 2008-12-03 | Cell Signaling Technology, Inc. | Reagents for the detection of protein phosphorylation in carcinoma signaling pathways |
| EP1983003A3 (en) | 2007-04-19 | 2009-03-11 | Peter Hornbeck | Tyrosine phosphorylation sites and antibodies specific for them |
| US20100291091A1 (en) | 2007-07-30 | 2010-11-18 | ONCOTHERAPY SCIENCE ,inc. | Cancer associated gene ly6k |
| CN101827936B (zh) | 2007-08-20 | 2014-12-10 | 肿瘤疗法科学股份有限公司 | Cdh3肽以及含有cdh3肽的药剂 |
| EP2080812A1 (en) | 2008-01-18 | 2009-07-22 | Transmedi SA | Compositions and methods of detecting post-stop peptides |
| TWI543767B (zh) | 2008-08-19 | 2016-08-01 | 腫瘤療法 科學股份有限公司 | Hig2與urlc10抗原決定位胜肽以及含此胜肽之疫苗 |
| WO2011039289A1 (de) | 2009-09-29 | 2011-04-07 | Protagen Ag | Markersequenzen für pankreaskrebserkrankungen, pankreaskarzinom und deren verwendung |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008102557A1 (en) * | 2007-02-21 | 2008-08-28 | Oncotherapy Science, Inc. | Peptide vaccines for cancers expressing tumor-associated antigens |
Non-Patent Citations (1)
| Title |
|---|
| JPN6014009086; Acta Pharmaceutica Sinica,2000,35(7),p.505-7 * |
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| EP2326718A1 (en) | 2011-06-01 |
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| US8383590B2 (en) | 2013-02-26 |
| US20130189291A1 (en) | 2013-07-25 |
| TW201008574A (en) | 2010-03-01 |
| EP2326718A4 (en) | 2012-03-07 |
| AU2009283762A1 (en) | 2010-02-25 |
| US20140141027A1 (en) | 2014-05-22 |
| KR20110063456A (ko) | 2011-06-10 |
| US8623829B2 (en) | 2014-01-07 |
| US20160200764A1 (en) | 2016-07-14 |
| SG193214A1 (en) | 2013-09-30 |
| MX2011001880A (es) | 2011-03-29 |
| CA2734515A1 (en) | 2010-02-25 |
| US20120321649A1 (en) | 2012-12-20 |
| US20140248300A1 (en) | 2014-09-04 |
| CN102186977A (zh) | 2011-09-14 |
| US9067973B2 (en) | 2015-06-30 |
| WO2010021111A1 (en) | 2010-02-25 |
| US9284349B2 (en) | 2016-03-15 |
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