BR112018074032A2 - composições e métodos relacionados a construtos de fc manipulados - Google Patents
composições e métodos relacionados a construtos de fc manipuladosInfo
- Publication number
- BR112018074032A2 BR112018074032A2 BR112018074032-2A BR112018074032A BR112018074032A2 BR 112018074032 A2 BR112018074032 A2 BR 112018074032A2 BR 112018074032 A BR112018074032 A BR 112018074032A BR 112018074032 A2 BR112018074032 A2 BR 112018074032A2
- Authority
- BR
- Brazil
- Prior art keywords
- constructs
- manipulated
- compositions
- methods related
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Prostheses (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662340322P | 2016-05-23 | 2016-05-23 | |
| US62/340,322 | 2016-05-23 | ||
| US201762443451P | 2017-01-06 | 2017-01-06 | |
| US62/443,451 | 2017-01-06 | ||
| PCT/US2017/034087 WO2017205436A1 (en) | 2016-05-23 | 2017-05-23 | Compositions and methods related to engineered fc constructs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018074032A2 true BR112018074032A2 (pt) | 2019-02-26 |
Family
ID=60412547
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018074056-0A BR112018074056A2 (pt) | 2016-05-23 | 2017-05-23 | composições e métodos relacionados a construtos de fc manipulados |
| BR112018074032-2A BR112018074032A2 (pt) | 2016-05-23 | 2017-05-23 | composições e métodos relacionados a construtos de fc manipulados |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018074056-0A BR112018074056A2 (pt) | 2016-05-23 | 2017-05-23 | composições e métodos relacionados a construtos de fc manipulados |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US11155640B2 (enExample) |
| EP (2) | EP3484514B1 (enExample) |
| JP (5) | JP2019519527A (enExample) |
| KR (3) | KR102635635B1 (enExample) |
| CN (4) | CN116063540A (enExample) |
| AU (2) | AU2017272109B2 (enExample) |
| BR (2) | BR112018074056A2 (enExample) |
| CA (2) | CA3025310A1 (enExample) |
| DK (1) | DK3484514T3 (enExample) |
| ES (1) | ES2973251T3 (enExample) |
| IL (3) | IL263213B2 (enExample) |
| NZ (2) | NZ749279A (enExample) |
| PL (1) | PL3484514T3 (enExample) |
| SG (3) | SG11201810465RA (enExample) |
| WO (2) | WO2017205434A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2962694T3 (es) | 2014-05-02 | 2024-03-20 | Momenta Pharmaceuticals Inc | Composiciones y procedimientos relacionados con construcciones de Fc manipuladas |
| ES2972740T3 (es) | 2016-03-02 | 2024-06-14 | Momenta Pharmaceuticals Inc | Procedimientos relacionados con construcciones de Fc modificadas genéticamente |
| IL263213B2 (en) * | 2016-05-23 | 2024-05-01 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc constructs |
| EP3565588A4 (en) | 2017-01-06 | 2020-12-16 | Momenta Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS RELATING TO MODIFIED FC CONSTRUCTIONS |
| EP3820910A4 (en) * | 2018-07-11 | 2022-06-22 | Momenta Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS RELATING TO ENGINEERED FC ANTIGEN-BINDING DOMAIN CONSTRUCTS |
| MX2021000280A (es) * | 2018-07-11 | 2021-11-12 | Momenta Pharmaceuticals Inc | Composiciones y métodos relacionados con constructos de dominio de unión a antígeno-fc modificados genéticamente. |
| CA3106108A1 (en) * | 2018-07-11 | 2020-01-16 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered fc-antigen binding domain constructs targeted to pd-l1 |
| MX2021000288A (es) * | 2018-07-11 | 2021-09-08 | Momenta Pharmaceuticals Inc | Composiciones y métodos relacionados con constructos de dominio de unión a antígeno-fc modificados genéticamente. |
| CN113194990A (zh) * | 2018-07-11 | 2021-07-30 | 动量制药公司 | 与靶向CD38的工程化Fc-抗原结合结构域构建体有关的组合物和方法 |
| MX2021000290A (es) * | 2018-07-11 | 2021-09-08 | Momenta Pharmaceuticals Inc | Composiciones y métodos relacionados con constructos de dominio de unión a antígeno-fc modificados genéticamente dirigidos a ccr4. |
| KR20210042326A (ko) * | 2018-07-11 | 2021-04-19 | 모멘타 파머슈티컬스 인코포레이티드 | 조작된 Fc-항원 결합 도메인 작제물에 관련된 조성물 및 방법 |
| CA3106207A1 (en) * | 2018-07-11 | 2020-01-16 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered fc-antigen binding domain constructs targeted to ctla-4 |
| KR102661494B1 (ko) | 2019-03-08 | 2024-04-29 | 에이치엘만도 주식회사 | 랙구동형 동력 보조 조향장치 |
| EP4028415A1 (en) | 2019-09-13 | 2022-07-20 | CSL Behring Lengnau AG | Recombinant igg fc multimers for the treatment of immune complex-mediated kidney disorders |
| KR20220110818A (ko) | 2019-12-06 | 2022-08-09 | 체에스엘 베링 렝나우 아게 | Fc 다량체의 안정한 조성물 |
| CN111808170A (zh) * | 2020-06-29 | 2020-10-23 | 江苏为真生物医药技术股份有限公司 | 多肽、hla-dr蛋白及其制备方法和应用 |
| CN117043190A (zh) * | 2020-12-07 | 2023-11-10 | 因外泰克斯公司 | 延长治疗剂在家畜动物中的半衰期的组合物和使用方法 |
| WO2024206820A1 (en) * | 2023-03-30 | 2024-10-03 | Dna Twopointo, Inc. | Fc engineering for heterodimeric antibody format |
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| FR2556219B1 (fr) | 1983-12-07 | 1987-06-26 | Merieux Inst | Nouveau medicament immunomodulateur, a base de fragments fc d'igg humaines |
| US5426641A (en) | 1994-01-28 | 1995-06-20 | Bell Communications Research, Inc. | Adaptive class AB amplifier for TDMA wireless communications systems |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| EP0975355A2 (en) | 1996-06-14 | 2000-02-02 | Smithkline Beecham Corporation | Hexameric fusion proteins and uses therefor |
| US20090074839A1 (en) | 1997-01-22 | 2009-03-19 | Marton Milankovits | Pharmaceutical Compositions Primarily for the Treatment and Prevention of Genitourinary Infections and their Extragenital Complications |
| US20020062010A1 (en) * | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US7951917B1 (en) * | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
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| RU2604490C2 (ru) | 2010-11-05 | 2016-12-10 | Займворкс Инк. | ДИЗАЙН УСТОЙЧИВОГО ГЕТЕРОДИМЕРНОГО АНТИТЕЛА С МУТАЦИЯМИ В Fc ДОМЕНЕ |
| HUE033205T2 (en) * | 2010-12-23 | 2017-11-28 | Janssen Biotech Inc | Active protease-resistant antibody fc mutants |
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| EA201791693A1 (ru) | 2011-03-25 | 2018-05-31 | Гленмарк Фармасьютикалс С.А. | Гетеродимерные иммуноглобулины |
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| KR20150058236A (ko) | 2012-08-20 | 2015-05-28 | 글리크닉 인코포레이티드 | 항원 결합 및 다가 fc 감마 수용체 결합 활성을 가진 분자 |
| CN104870055A (zh) | 2012-10-17 | 2015-08-26 | 利物浦热带医学院 | 免疫调节蛋白 |
| US20140302037A1 (en) * | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| CN104558194B (zh) * | 2013-10-17 | 2018-04-27 | 泰州迈博太科药业有限公司 | 一类抗CD20-Flex双功能融合蛋白、其制备方法及用途 |
| WO2015095684A1 (en) * | 2013-12-20 | 2015-06-25 | Indiana University Research And Technology Corporation | Lipidated incretin receptor ligand human immunoglobulin fc-region fusion polypeptides |
| JP6786392B2 (ja) | 2014-01-15 | 2020-11-18 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ＦｃＲｎ結合特性が改変され、プロテインＡ結合特性が保持されているＦｃ領域変異体 |
| CN105873948B (zh) | 2014-01-15 | 2021-04-13 | 豪夫迈·罗氏有限公司 | 具有修饰的FCRN结合性质的Fc区变体 |
| TW201619188A (zh) | 2014-03-05 | 2016-06-01 | 優稀美生物醫藥公司 | 多聚體Ｆｃ蛋白質 |
| WO2015132365A1 (en) | 2014-03-05 | 2015-09-11 | Ucb Biopharma Sprl | Multimeric fc proteins |
| US20170029505A1 (en) | 2014-04-16 | 2017-02-02 | Ucb Biopharma Sprl | Multimeric fc proteins |
| ES2962694T3 (es) | 2014-05-02 | 2024-03-20 | Momenta Pharmaceuticals Inc | Composiciones y procedimientos relacionados con construcciones de Fc manipuladas |
| TN2016000525A1 (en) | 2014-05-29 | 2018-04-04 | Macrogenics Inc | Tri-specific binding molecules and methods of use thereof |
| ES2972740T3 (es) | 2016-03-02 | 2024-06-14 | Momenta Pharmaceuticals Inc | Procedimientos relacionados con construcciones de Fc modificadas genéticamente |
| IL263213B2 (en) | 2016-05-23 | 2024-05-01 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc constructs |
| EP3565588A4 (en) * | 2017-01-06 | 2020-12-16 | Momenta Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS RELATING TO MODIFIED FC CONSTRUCTIONS |
-
2017
- 2017-05-23 IL IL263213A patent/IL263213B2/en unknown
- 2017-05-23 WO PCT/US2017/034084 patent/WO2017205434A1/en not_active Ceased
- 2017-05-23 JP JP2018561639A patent/JP2019519527A/ja not_active Withdrawn
- 2017-05-23 US US16/303,793 patent/US11155640B2/en active Active
- 2017-05-23 AU AU2017272109A patent/AU2017272109B2/en active Active
- 2017-05-23 CN CN202210924611.XA patent/CN116063540A/zh active Pending
- 2017-05-23 KR KR1020227037780A patent/KR102635635B1/ko active Active
- 2017-05-23 CA CA3025310A patent/CA3025310A1/en active Pending
- 2017-05-23 BR BR112018074056-0A patent/BR112018074056A2/pt active Search and Examination
- 2017-05-23 IL IL309293A patent/IL309293A/en unknown
- 2017-05-23 EP EP17803463.3A patent/EP3484514B1/en active Active
- 2017-05-23 JP JP2018561641A patent/JP7045333B6/ja active Active
- 2017-05-23 US US16/303,831 patent/US11623964B2/en active Active
- 2017-05-23 SG SG11201810465RA patent/SG11201810465RA/en unknown
- 2017-05-23 CA CA3025306A patent/CA3025306A1/en active Pending
- 2017-05-23 KR KR1020187037345A patent/KR102590061B1/ko active Active
- 2017-05-23 IL IL263211A patent/IL263211B2/en unknown
- 2017-05-23 BR BR112018074032-2A patent/BR112018074032A2/pt unknown
- 2017-05-23 CN CN201780045688.7A patent/CN109963869A/zh active Pending
- 2017-05-23 SG SG10202011624SA patent/SG10202011624SA/en unknown
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