BR112018074032A2 - composições e métodos relacionados a construtos de fc manipulados - Google Patents

composições e métodos relacionados a construtos de fc manipulados

Info

Publication number
BR112018074032A2
BR112018074032A2 BR112018074032-2A BR112018074032A BR112018074032A2 BR 112018074032 A2 BR112018074032 A2 BR 112018074032A2 BR 112018074032 A BR112018074032 A BR 112018074032A BR 112018074032 A2 BR112018074032 A2 BR 112018074032A2
Authority
BR
Brazil
Prior art keywords
constructs
manipulated
compositions
methods related
methods
Prior art date
Application number
BR112018074032-2A
Other languages
English (en)
Portuguese (pt)
Inventor
C. Lansing Jonathan
J. Bosques Carlos
Ortiz Daniel
Original Assignee
Momenta Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Momenta Pharmaceuticals, Inc. filed Critical Momenta Pharmaceuticals, Inc.
Publication of BR112018074032A2 publication Critical patent/BR112018074032A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Prostheses (AREA)
BR112018074032-2A 2016-05-23 2017-05-23 composições e métodos relacionados a construtos de fc manipulados BR112018074032A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662340322P 2016-05-23 2016-05-23
US62/340,322 2016-05-23
US201762443451P 2017-01-06 2017-01-06
US62/443,451 2017-01-06
PCT/US2017/034087 WO2017205436A1 (en) 2016-05-23 2017-05-23 Compositions and methods related to engineered fc constructs

Publications (1)

Publication Number Publication Date
BR112018074032A2 true BR112018074032A2 (pt) 2019-02-26

Family

ID=60412547

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112018074032-2A BR112018074032A2 (pt) 2016-05-23 2017-05-23 composições e métodos relacionados a construtos de fc manipulados
BR112018074056-0A BR112018074056A2 (pt) 2016-05-23 2017-05-23 composições e métodos relacionados a construtos de fc manipulados

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112018074056-0A BR112018074056A2 (pt) 2016-05-23 2017-05-23 composições e métodos relacionados a construtos de fc manipulados

Country Status (14)

Country Link
US (4) US11623964B2 (enExample)
EP (2) EP3464376A4 (enExample)
JP (5) JP7045333B6 (enExample)
KR (3) KR102590061B1 (enExample)
CN (4) CN116063540A (enExample)
AU (2) AU2017272111B2 (enExample)
BR (2) BR112018074032A2 (enExample)
CA (2) CA3025310A1 (enExample)
DK (1) DK3484514T3 (enExample)
ES (1) ES2973251T3 (enExample)
IL (3) IL309293A (enExample)
PL (1) PL3484514T3 (enExample)
SG (3) SG11201810465RA (enExample)
WO (2) WO2017205434A1 (enExample)

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CN110650748B (zh) 2017-01-06 2024-01-02 动量制药公司 与经工程改造的Fc构建体相关的组合物和方法
CN113164591A (zh) * 2018-07-11 2021-07-23 动量制药公司 与工程化Fc-抗原结合结构域构建体有关的组合物和方法
WO2020014419A2 (en) * 2018-07-11 2020-01-16 Momenta Pharmaceuticals Inc Compositions and methods related to engineered fc-antigen binding domain constructs targeted to pd-l1
US20210317227A1 (en) * 2018-07-11 2021-10-14 Momenta Pharmaceuticals, Inc. COMPOSITIONS AND METHODS RELATED TO ENGINEERED Fc-ANTIGEN BINDING DOMAIN CONSTRUCTS
CA3106254A1 (en) * 2018-07-11 2020-01-16 Momenta Pharmaceuticals, Inc. Compositions and methods related to engineered fc-antigen binding domain constructs
CN113395978A (zh) * 2018-07-11 2021-09-14 动量制药公司 与靶向CTLA-4的工程化Fc-抗原结合结构域构建体有关的组合物和方法
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CN111808170A (zh) * 2020-06-29 2020-10-23 江苏为真生物医药技术股份有限公司 多肽、hla-dr蛋白及其制备方法和应用
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Also Published As

Publication number Publication date
JP2022095685A (ja) 2022-06-28
US12297291B2 (en) 2025-05-13
JP7045333B6 (ja) 2022-05-06
KR102635635B1 (ko) 2024-02-14
EP3484514A4 (en) 2020-08-12
DK3484514T3 (da) 2024-01-29
SG11201810466PA (en) 2018-12-28
CA3025306A1 (en) 2017-11-30
US20210221917A1 (en) 2021-07-22
KR20190021255A (ko) 2019-03-05
IL263213B2 (en) 2024-05-01
AU2017272109A1 (en) 2019-01-17
JP7045333B2 (ja) 2022-03-31
CN109963869A (zh) 2019-07-02
KR102462084B1 (ko) 2022-11-02
JP7295301B2 (ja) 2023-06-20
AU2017272111B2 (en) 2024-05-16
CA3025310A1 (en) 2017-11-30
CN109789203B (zh) 2022-08-05
US20190284305A1 (en) 2019-09-19
AU2017272109B2 (en) 2024-07-25
US11155640B2 (en) 2021-10-26
JP2019519528A (ja) 2019-07-11
US20240067757A1 (en) 2024-02-29
JP2025026880A (ja) 2025-02-26
IL263211A (en) 2018-12-31
JP2019519527A (ja) 2019-07-11
IL263211B1 (en) 2023-05-01
KR20190026684A (ko) 2019-03-13
CN116063540A (zh) 2023-05-05
PL3484514T3 (pl) 2024-04-29
CN118206639A (zh) 2024-06-18
NZ749279A (en) 2025-08-29
US11623964B2 (en) 2023-04-11
IL263213B1 (en) 2024-01-01
JP2022068176A (ja) 2022-05-09
KR20220151025A (ko) 2022-11-11
EP3464376A4 (en) 2020-03-18
SG10202011624SA (en) 2021-01-28
NZ749292A (en) 2025-08-29
KR102590061B1 (ko) 2023-10-18
CN109789203A (zh) 2019-05-21
AU2017272111A1 (en) 2019-01-17
IL263213A (en) 2018-12-31
IL309293A (en) 2024-02-01
WO2017205436A1 (en) 2017-11-30
ES2973251T3 (es) 2024-06-19
EP3464376A1 (en) 2019-04-10
SG11201810465RA (en) 2018-12-28
US20220049019A1 (en) 2022-02-17
BR112018074056A2 (pt) 2019-03-06
WO2017205434A1 (en) 2017-11-30
EP3484514B1 (en) 2023-12-06
EP3484514A1 (en) 2019-05-22
IL263211B2 (en) 2023-09-01

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