BR112019022500A2 - Microrganismos e métodos para produzir canabinoides e derivados canabinoides - Google Patents
Microrganismos e métodos para produzir canabinoides e derivados canabinoides Download PDFInfo
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- BR112019022500A2 BR112019022500A2 BR112019022500-5A BR112019022500A BR112019022500A2 BR 112019022500 A2 BR112019022500 A2 BR 112019022500A2 BR 112019022500 A BR112019022500 A BR 112019022500A BR 112019022500 A2 BR112019022500 A2 BR 112019022500A2
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- cannabinoid
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- canabinoid
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- 244000005700 microbiome Species 0.000 title 1
- 229930003827 cannabinoid Natural products 0.000 abstract 8
- 239000003557 cannabinoid Substances 0.000 abstract 8
- 239000002243 precursor Substances 0.000 abstract 4
- 230000002194 synthesizing effect Effects 0.000 abstract 1
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- C12N15/09—Recombinant DNA-technology
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N15/09—Recombinant DNA-technology
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- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
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- C12N15/09—Recombinant DNA-technology
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- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01088—Hydroxymethylglutaryl-CoA reductase (1.1.1.88)
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- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01086—Fatty-acyl-CoA synthase (2.3.1.86)
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- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01206—3,5,7-Trioxododecanoyl-CoA synthase (2.3.1.206)
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- C12Y203/00—Acyltransferases (2.3)
- C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
- C12Y203/0301—Hydroxymethylglutaryl-CoA synthase (2.3.3.10)
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- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/01102—Geranyl-pyrophosphate—olivetolic acid geranyltransferase (2.5.1.102)
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- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/01036—Mevalonate kinase (2.7.1.36)
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- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/04—Phosphotransferases with a phosphate group as acceptor (2.7.4)
- C12Y207/04002—Phosphomevalonate kinase (2.7.4.2)
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- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01033—Diphosphomevalonate decarboxylase (4.1.1.33), i.e. mevalonate-pyrophosphate decarboxylase
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- C12Y503/00—Intramolecular oxidoreductases (5.3)
- C12Y503/03—Intramolecular oxidoreductases (5.3) transposing C=C bonds (5.3.3)
- C12Y503/03002—Isopentenyl-diphosphate DELTA-isomerase (5.3.3.2)
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- C12Y—ENZYMES
- C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
- C12Y602/01—Acid-Thiol Ligases (6.2.1)
- C12Y602/01003—Long-chain-fatty-acid-CoA ligase (6.2.1.3)
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- C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
- C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
- C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Abstract
a presente invenção refere-se a células hospedeiras que produzem um canabinoide, um derivado de canabinoide, um precursor de canabinoides, ou um derivado precursor canabinoide geneticamente modificado. a presente invenção refere-se a métodos de sintetizar um canabinoide, um derivado de canabinoide, um precursor de canabinoides, ou um derivado precursor canabinoide.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762491114P | 2017-04-27 | 2017-04-27 | |
US62/491,114 | 2017-04-27 | ||
US201762569532P | 2017-10-07 | 2017-10-07 | |
US62/569,532 | 2017-10-07 | ||
PCT/US2018/029668 WO2018200888A1 (en) | 2017-04-27 | 2018-04-27 | Microorganisms and methods for producing cannabinoids and cannabinoid derivatives |
Publications (1)
Publication Number | Publication Date |
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BR112019022500A2 true BR112019022500A2 (pt) | 2020-06-16 |
Family
ID=62455816
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019022500-5A BR112019022500A2 (pt) | 2017-04-27 | 2018-04-27 | Microrganismos e métodos para produzir canabinoides e derivados canabinoides |
Country Status (10)
Country | Link |
---|---|
US (4) | US10563211B2 (pt) |
EP (2) | EP3998336A1 (pt) |
JP (1) | JP7198555B2 (pt) |
CN (1) | CN110914416B (pt) |
BR (1) | BR112019022500A2 (pt) |
CA (1) | CA3061718A1 (pt) |
ES (1) | ES2898272T3 (pt) |
IL (1) | IL270202B1 (pt) |
SG (1) | SG11201910019PA (pt) |
WO (1) | WO2018200888A1 (pt) |
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CN110914416B (zh) | 2023-07-21 |
SG11201910019PA (en) | 2019-11-28 |
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