BR112016030467A2 - Microrganismo do gênero escherichia produtor de l-triptofano e método para produzir l- triptofano usando o mesmo - Google Patents

Microrganismo do gênero escherichia produtor de l-triptofano e método para produzir l- triptofano usando o mesmo

Info

Publication number
BR112016030467A2
BR112016030467A2 BR112016030467-5A BR112016030467A BR112016030467A2 BR 112016030467 A2 BR112016030467 A2 BR 112016030467A2 BR 112016030467 A BR112016030467 A BR 112016030467A BR 112016030467 A2 BR112016030467 A2 BR 112016030467A2
Authority
BR
Brazil
Prior art keywords
tryptophan
producer
organism
micro
produce
Prior art date
Application number
BR112016030467-5A
Other languages
English (en)
Korean (ko)
Other versions
BR112016030467B1 (pt
Inventor
Yong Cheong Ki
Rim Kim Kyung
Myung Lee Seok
Ho Lee Kwang
Cheol Lee Keun
Pyo Hong Hyeong
Original Assignee
Cj Cheiljedang Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cj Cheiljedang Corporation filed Critical Cj Cheiljedang Corporation
Publication of BR112016030467A2 publication Critical patent/BR112016030467A2/pt
Publication of BR112016030467B1 publication Critical patent/BR112016030467B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/227—Tryptophan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/02—Aldehyde-lyases (4.1.2)
    • C12Y401/02014—2-Dehydro-3-deoxy-phosphogluconate aldolase (4.1.2.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01012—Phosphogluconate dehydratase (4.2.1.12)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

o presente pedido se refere a um microrganismo do gênero escherichia produtor de l-triptofano e, mais especificamente, a um microrganismo do gênero escherichia com atividade melhorada de produção de l-triptofano por enfraquecimento ou inativação da atividade de 6-fosfogluconato desidratase endógena e 2- ceto-3-desoxi-6-fosfogluconato aldolase. além disso, o presente pedido se refere a um método para a produção de l-triptofano usando o microrganismo do gênero escherichia.
BR112016030467-5A 2014-06-23 2015-06-23 Microrganismo do gênero escherichia produtor de l-triptofano e método para produzir l-triptofano usando o mesmo BR112016030467B1 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KRKR10-2014-0076698 2014-06-23
KR1020140076698A KR101835173B1 (ko) 2014-06-23 2014-06-23 L-트립토판 생산능을 갖는 에스케리키아속 미생물 및 이를 이용한 l-트립토판의 제조 방법
KR10-2014-0076698 2014-06-23
PCT/KR2015/006350 WO2015199406A1 (ko) 2014-06-23 2015-06-23 L-트립토판 생산능을 갖는 에스케리키아속 미생물 및 이를 이용한 l-트립토판의 제조 방법

Publications (2)

Publication Number Publication Date
BR112016030467A2 true BR112016030467A2 (pt) 2018-01-16
BR112016030467B1 BR112016030467B1 (pt) 2023-11-14

Family

ID=54938423

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016030467-5A BR112016030467B1 (pt) 2014-06-23 2015-06-23 Microrganismo do gênero escherichia produtor de l-triptofano e método para produzir l-triptofano usando o mesmo

Country Status (11)

Country Link
US (1) US10815510B2 (pt)
EP (1) EP3159401B1 (pt)
JP (2) JP6687549B2 (pt)
KR (1) KR101835173B1 (pt)
CN (1) CN106574239B (pt)
BR (1) BR112016030467B1 (pt)
DK (1) DK3159401T3 (pt)
ES (1) ES2918459T3 (pt)
MY (1) MY172369A (pt)
RU (1) RU2678139C2 (pt)
WO (1) WO2015199406A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3756654A4 (en) 2018-03-23 2021-04-14 CJ Cheiljedang Corporation GRANULES CONTAINING L-AMINO ACID AND THEIR PREPARATION PROCESS
KR101996767B1 (ko) * 2018-11-29 2019-07-04 씨제이제일제당 (주) cAMP 수용 단백질 변이체 및 이를 이용한 L-아미노산 제조방법
KR102134418B1 (ko) * 2019-06-17 2020-07-16 씨제이제일제당 주식회사 L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법
WO2021007575A1 (en) * 2019-07-11 2021-01-14 Bp Corporation North America Inc. Gluconate dehydratase enzymes and recombinant cells
CN115261365B (zh) * 2022-06-22 2024-01-30 南通紫琅生物医药科技有限公司 色氨酸合成酶突变体及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US913A (en) * 1838-09-12 Improved machine for removing snags and sawyers from the beds of rivers
US4371614A (en) * 1980-08-22 1983-02-01 Ajinomoto Co., Inc. E.Coli bacteria carrying recombinant plasmids and their use in the fermentative production of L-tryptophan
JP3932945B2 (ja) 2002-03-27 2007-06-20 味の素株式会社 Ｌ−アミノ酸の製造法
JP2004166595A (ja) * 2002-11-20 2004-06-17 Ajinomoto Co Inc メチロトローフを用いたｌ−アミノ酸の製造法
RU2288268C2 (ru) 2005-01-26 2006-11-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) 6-фосфоглюконолактоназа из escherichia coli, фрагмент днк, бактерия, принадлежащая к роду escherichia - продуцент l-аминокислоты и способ получения l-аминокислоты
RU2004105179A (ru) * 2004-02-25 2005-08-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) 6-фосфоглюконолактоназа из escherichia coli, фрагмент днк, бактерия, принадлежащая к роду escherichia, -продуцент l-аминокислоты, и способ получения l-аминокислоты
US20050191684A1 (en) * 2004-02-25 2005-09-01 Zimenkov Danila V. Method for producing L-amino acids
JP4670811B2 (ja) 2004-02-25 2011-04-13 味の素株式会社 Ｌ−アミノ酸の生産方法
KR100792095B1 (ko) 2006-12-29 2008-01-04 씨제이 주식회사 Ｌ-페닐알라닌 생산능을 갖는 대장균 변이주로부터유전자조작된 ｌ-트립토판 생산능을 갖는 재조합 대장균균주 및 이를 이용한 트립토판 제조방법
CA2688450C (en) 2007-03-23 2016-10-25 Metabolic Explorer Microorganisms and methods for production of 1,2-propanediol and acetol
WO2009101757A1 (ja) * 2008-02-14 2009-08-20 Panasonic Corporation コンデンサマイクロホン及びｍｅｍｓデバイス
KR20090092373A (ko) * 2008-02-27 2009-09-01 씨제이제일제당 (주) 피루베이트 옥시다아제가 불활성화된 ｌ-트립토판 생산미생물 및 이를 이용한 ｌ-트립토판 생산 방법
CA2860974C (en) * 2012-01-10 2019-03-05 Cj Cheiljedang Corporation A microorganism of the genus escherichia having enhanced l-tryptophan productivity and a method for producing l-tryptophan using the same

Also Published As

Publication number Publication date
US20170137854A1 (en) 2017-05-18
RU2678139C2 (ru) 2019-01-23
JP6687549B2 (ja) 2020-04-22
EP3159401B1 (en) 2022-05-18
CN106574239B (zh) 2024-05-14
EP3159401A1 (en) 2017-04-26
EP3159401A4 (en) 2018-01-10
JP2017518759A (ja) 2017-07-13
DK3159401T3 (da) 2022-07-04
BR112016030467B1 (pt) 2023-11-14
RU2016152662A (ru) 2018-07-23
JP2019013256A (ja) 2019-01-31
ES2918459T3 (es) 2022-07-15
KR20160000082A (ko) 2016-01-04
CN106574239A (zh) 2017-04-19
US10815510B2 (en) 2020-10-27
MY172369A (en) 2019-11-21
WO2015199406A1 (ko) 2015-12-30
KR101835173B1 (ko) 2018-03-07
RU2016152662A3 (pt) 2018-07-23

Similar Documents

Publication Publication Date Title
BR112019022500A2 (pt) Microrganismos e métodos para produzir canabinoides e derivados canabinoides
BR112017024384A2 (pt) bactérias modificadas para reduzir hiperfenilalaninemia
PH12020550529A1 (en) Recombinant bacterium capable of producing l-lysine, construction method thereof and production method of l-lysine
BR112017013748A2 (pt) método de produção & processamento de diaminas
BR112015029716A2 (pt) microrganismo produtor de o-acetil homoserina e método de produção o-acetil homoserina usando o mesmo
BR112015024674A2 (pt) método para aumentar a capacidade de sobrevivência de um ou mais microrganismos benéficos e para revestir uma semente, e, composição
BR112018009393A8 (pt) produção microbiana de nicotinamida ribosídeo
BR112016030467A2 (pt) Microrganismo do gênero escherichia produtor de l-triptofano e método para produzir l- triptofano usando o mesmo
EA201600026A1 (ru) Бактериальная гиалуронидаза и способ ее производства
PH12017501035A1 (en) Method for the production of a pharmaceutical delivery system
MY188962A (en) A microorganism of genus corynebacterium having an ability to produce l-arginine and an method for producing l-arginine using the same
BR112017018620A2 (pt) método de administração de tradipitanto, e, tradipitanto.
BR112017023969A2 (pt) ?microrganismo do gênero escherichia que produz l-triptofano e um método para produzir l- triptofano com o uso do mesmo?
BR112016026164A2 (pt) novo microrganismo e método para a produção de 1,2-propanodiol com base em acetol redutase dependente de nadph e suprimento de nadph aprimorado
BR112016007182A2 (pt) método para produzir um l-aminoácido
BR112018000074A2 (pt) micro-organismo para produzir l-lisina e método para produzir l-lisina com o uso do mesmo
BR112016028316A2 (pt) composição farmacêutica oral de isotretinoina, seu processo de preparação e método de tratamento
BR112016002105A2 (pt) Microrganismo modificado, método para produzir alanina e uso de um microrganismo modificado
MY175834A (en) A microorganism of the genus escherichia producing l-tryptophan and method for producing l-tryptophan using the same
BR112017003644A2 (pt) métodos de tratamento de distúrbios do sono e para regular produção de melatonina.
CL2016000672A1 (es) Bacteria aislada del género streptomyces
BR112016026484A2 (pt) microrganismo do gênero corynebacterium que produz l-lisina, e método para a produção de l-lisina
BR112018007394A2 (pt) processo para produzir uma suspensão aquosa de carbonato de cálcio precipitado, suspensão aquosa de carbonato de cálcio precipitado, produto, carbonato de cálcio precipitado, e, uso de uma suspensão aquosa de carbonato de cálcio precipitado
RS54777B1 (sr) Postupak za biološku borbu protiv pseudomonas
BR112016018195A2 (pt) micro-organismo modificado, método de produção de um composto orgânico e uso de um micro-organismo modificado

Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/06/2015, OBSERVADAS AS CONDICOES LEGAIS