JP2017518965A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017518965A5 JP2017518965A5 JP2016564612A JP2016564612A JP2017518965A5 JP 2017518965 A5 JP2017518965 A5 JP 2017518965A5 JP 2016564612 A JP2016564612 A JP 2016564612A JP 2016564612 A JP2016564612 A JP 2016564612A JP 2017518965 A5 JP2017518965 A5 JP 2017518965A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- domain monomer
- polypeptide
- monomer
- igg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020084900A JP7593745B2 (ja) | 2014-05-02 | 2020-05-14 | エンジニアリングされたＦｃ構築物に関連する組成物および方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461987863P | 2014-05-02 | 2014-05-02 | |
| US61/987,863 | 2014-05-02 | ||
| US201462081923P | 2014-11-19 | 2014-11-19 | |
| US62/081,923 | 2014-11-19 | ||
| PCT/US2015/028926 WO2015168643A2 (en) | 2014-05-02 | 2015-05-01 | Compositions and methods related to engineered fc constructs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020084900A Division JP7593745B2 (ja) | 2014-05-02 | 2020-05-14 | エンジニアリングされたＦｃ構築物に関連する組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017518965A JP2017518965A (ja) | 2017-07-13 |
| JP2017518965A5 true JP2017518965A5 (enExample) | 2018-06-07 |
Family
ID=54359511
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016564612A Pending JP2017518965A (ja) | 2014-05-02 | 2015-05-01 | エンジニアリングされたＦｃ構築物に関連する組成物および方法 |
| JP2020084900A Active JP7593745B2 (ja) | 2014-05-02 | 2020-05-14 | エンジニアリングされたＦｃ構築物に関連する組成物および方法 |
| JP2022066669A Active JP7600172B2 (ja) | 2014-05-02 | 2022-04-14 | エンジニアリングされたＦｃ構築物に関連する組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020084900A Active JP7593745B2 (ja) | 2014-05-02 | 2020-05-14 | エンジニアリングされたＦｃ構築物に関連する組成物および方法 |
| JP2022066669A Active JP7600172B2 (ja) | 2014-05-02 | 2022-04-14 | エンジニアリングされたＦｃ構築物に関連する組成物および方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10239944B2 (enExample) |
| EP (2) | EP3137506B1 (enExample) |
| JP (3) | JP2017518965A (enExample) |
| KR (1) | KR102546875B1 (enExample) |
| CN (2) | CN113501880A (enExample) |
| AU (2) | AU2015252866B2 (enExample) |
| CA (1) | CA2941072A1 (enExample) |
| DK (1) | DK3137506T5 (enExample) |
| ES (1) | ES2962694T3 (enExample) |
| IL (3) | IL286367B2 (enExample) |
| PL (1) | PL3137506T3 (enExample) |
| SG (2) | SG10201913507SA (enExample) |
| WO (1) | WO2015168643A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106068274A (zh) | 2014-03-05 | 2016-11-02 | Ucb生物制药私人有限公司 | 多聚体Fc蛋白 |
| SG10201913507SA (en) | 2014-05-02 | 2020-02-27 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc constructs |
| EP3297672B1 (en) | 2015-05-21 | 2021-09-01 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| IL309260B2 (en) | 2015-07-24 | 2025-01-01 | Gliknik Inc | Fusion proteins of human protein fragments to create ordered multimeric immunoglobulin FC preparations with enhanced complement binding |
| EP3356561B1 (en) | 2015-10-02 | 2021-10-27 | Momenta Pharmaceuticals, Inc. | Therapeutic and diagnostic methods for autoimmune diseases and/or inflammation |
| US12391759B2 (en) | 2016-03-02 | 2025-08-19 | Momenta Pharmaceuticals, Inc. | Methods related to engineered Fc constructs |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| KR102530742B1 (ko) | 2016-05-20 | 2023-05-09 | 하푼 테라퓨틱스, 인크. | 단일 도메인 혈청 알부민 결합 단백질 |
| IL309293A (en) * | 2016-05-23 | 2024-02-01 | Momenta Pharmaceuticals Inc | Compositions and methods relating to engineered FC constructs |
| CA3026420A1 (en) | 2016-06-07 | 2017-12-14 | Gliknik Inc. | Cysteine-optimized stradomers |
| RU2745648C2 (ru) * | 2016-07-19 | 2021-03-30 | Ибентрус, Инк. | Биспецифические белки и способы их получения |
| KR20190032392A (ko) | 2016-07-22 | 2019-03-27 | 글리크닉 인코포레이티드 | 향상된 fc 수용체 결합을 갖는 규칙적으로 다량체화된 면역글로불린 fc 조성물을 생성하기 위한 인간 단백질 단편의 융합 단백질 |
| BR112019009495A2 (pt) * | 2016-12-09 | 2019-08-06 | Gliknik Inc | métodos de tratamento de distúrbios inflamatórios com compostos de fc multivalentes |
| BR112019009484A2 (pt) | 2016-12-09 | 2019-07-30 | Gliknik Inc | otimização de fabricação de gl-2045, um stradomer multimerizador |
| CN110650748B (zh) * | 2017-01-06 | 2024-01-02 | 动量制药公司 | 与经工程改造的Fc构建体相关的组合物和方法 |
| US20200040084A1 (en) * | 2017-01-06 | 2020-02-06 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered fc-antigen binding domain constructs |
| WO2018160754A2 (en) * | 2017-02-28 | 2018-09-07 | Harpoon Therapeutics, Inc. | Inducible monovalent antigen binding protein |
| SG10202107880XA (en) | 2017-05-12 | 2021-09-29 | Harpoon Therapeutics Inc | Mesothelin binding proteins |
| KR20200016292A (ko) | 2017-06-02 | 2020-02-14 | 화이자 인코포레이티드 | 재조합 robo2 단백질, 조성물, 방법 및 그의 용도 |
| AU2018302343B2 (en) * | 2017-07-21 | 2020-11-26 | Trianni, Inc. | Single chain vh and heavy chain antibodies |
| CN111164104A (zh) | 2017-08-09 | 2020-05-15 | 麻省理工学院 | 白蛋白结合肽缀合物及其方法 |
| CA3078969A1 (en) | 2017-10-13 | 2019-04-18 | Harpoon Therapeutics, Inc. | Trispecific proteins and methods of use |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| US12110332B2 (en) * | 2017-11-20 | 2024-10-08 | Taizhou Mabtech Pharmaceutical Co., Ltd. | Bifunctional fusion protein targeting CD47 and PD-L1 |
| WO2020014419A2 (en) * | 2018-07-11 | 2020-01-16 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc-antigen binding domain constructs targeted to pd-l1 |
| US20210317227A1 (en) * | 2018-07-11 | 2021-10-14 | Momenta Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS RELATED TO ENGINEERED Fc-ANTIGEN BINDING DOMAIN CONSTRUCTS |
| CN113164591A (zh) * | 2018-07-11 | 2021-07-23 | 动量制药公司 | 与工程化Fc-抗原结合结构域构建体有关的组合物和方法 |
| CA3106254A1 (en) * | 2018-07-11 | 2020-01-16 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered fc-antigen binding domain constructs |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| CN119306844A (zh) | 2018-09-25 | 2025-01-14 | 哈普恩治疗公司 | Dll3结合蛋白及使用方法 |
| AU2020298233A1 (en) * | 2019-06-19 | 2022-01-20 | Bioverativ Therapeutics Inc. | Recombinant factor VIII-Fc for treating hemophilia and low bone mineral density |
| AU2020344164A1 (en) | 2019-09-13 | 2022-04-14 | CSL Behring Lengnau AG | Recombinant IgG Fc multimers for the treatment of immune complex-mediated kidney disorders |
| BR112022010096A2 (pt) | 2019-12-06 | 2022-09-06 | CSL Behring Lengnau AG | Composições estáveis de multímeros fc |
| CA3171363A1 (en) * | 2019-12-20 | 2021-06-24 | Kisoji Biotechnology Inc. | Polypeptides, protein complexes and method for making same |
| AU2021304372A1 (en) | 2020-07-10 | 2023-03-02 | Biomolecular Holdings Llc | Tetrahedral antibodies |
| US20240350588A1 (en) * | 2021-08-24 | 2024-10-24 | Sunshine Lake Pharma Co., Ltd. | Gdf15 fusion proteins and use thereof |
| US20250084169A1 (en) | 2022-01-12 | 2025-03-13 | Biomolecular Holdings Llc | Nk/monocyte engagers |
| AU2023313033A1 (en) | 2022-07-27 | 2025-03-13 | Ablynx Nv | Polypeptides binding to a specific epitope of the neonatal fc receptor |
| US20260193306A1 (en) * | 2022-11-02 | 2026-07-09 | Beijing Changping Laboratory | Fusion protein and use thereof |
| US20240294651A1 (en) | 2023-01-30 | 2024-09-05 | Kymab Limited | Antibodies |
| IL322519A (en) | 2023-02-17 | 2025-10-01 | Ablynx Nv | Polypeptides that bind to the neonatal fc receptor |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2556219B1 (fr) | 1983-12-07 | 1987-06-26 | Merieux Inst | Nouveau medicament immunomodulateur, a base de fragments fc d'igg humaines |
| US5426641A (en) | 1994-01-28 | 1995-06-20 | Bell Communications Research, Inc. | Adaptive class AB amplifier for TDMA wireless communications systems |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| WO1997047732A2 (en) | 1996-06-14 | 1997-12-18 | Smithkline Beecham Corporation | Hexameric fusion proteins and uses therefor |
| US20090074839A1 (en) | 1997-01-22 | 2009-03-19 | Marton Milankovits | Pharmaceutical Compositions Primarily for the Treatment and Prevention of Genitourinary Infections and their Extragenital Complications |
| US20020062010A1 (en) * | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US7951917B1 (en) | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US7608681B2 (en) | 1999-12-24 | 2009-10-27 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| US20050089932A1 (en) | 2001-04-26 | 2005-04-28 | Avidia Research Institute | Novel proteins with targeted binding |
| EP1697520A2 (en) | 2003-12-22 | 2006-09-06 | Xencor, Inc. | Fc polypeptides with novel fc ligand binding sites |
| US20060074225A1 (en) * | 2004-09-14 | 2006-04-06 | Xencor, Inc. | Monomeric immunoglobulin Fc domains |
| KR101374454B1 (ko) | 2005-03-31 | 2014-03-17 | 추가이 세이야쿠 가부시키가이샤 | 회합제어에 의한 폴리펩티드 제조방법 |
| US8354109B2 (en) * | 2005-12-13 | 2013-01-15 | Suppremol Gmbh | Multimeric Fc receptor polypeptides |
| GB0614780D0 (en) | 2006-07-25 | 2006-09-06 | Ucb Sa | Biological products |
| PE20081140A1 (es) | 2006-10-25 | 2008-09-22 | Amgen Inc | Agentes terapeuticos a base de peptidos derivados de toxinas |
| BRPI0620639A2 (pt) | 2006-12-21 | 2011-11-22 | Micromet Ag | anticorpos de cadeia simples biespecìficos e composição farmacêutica compreendendo os mesmos |
| CA2682605A1 (en) | 2007-04-18 | 2008-10-30 | Zymogenetics, Inc. | Single chain fc, methods of making and methods of treatment |
| MX2009012343A (es) | 2007-05-14 | 2010-02-10 | Biogen Idec Inc | Regiones fc (sc fc) de cadena sencilla, polipeptidos de enlace que comprenden las mismas, y metodos relacionados con ello. |
| SI2185589T1 (sl) * | 2007-06-01 | 2016-04-29 | University Of Maryland Baltimore | Vezavna sredstva za Fc receptor konstantne regije imunoglobulina |
| EP3663318A1 (en) * | 2008-01-07 | 2020-06-10 | Amgen Inc. | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
| SG189730A1 (en) | 2008-04-02 | 2013-05-31 | Macrogenics Inc | Her2/neu-specific antibodies and methods of using same |
| US20110262477A1 (en) | 2008-10-06 | 2011-10-27 | University Of Chicago | Compositions and Methods Related to Bacterial EAP, EMP, and/or ADSA Proteins |
| WO2010065578A2 (en) | 2008-12-04 | 2010-06-10 | Leukosight Inc. | POLYPEPTIDES COMPRISING Fc FRAGMENTS OF IMMUNOGLOBULIN G (IgG) AND METHODS OF USING THE SAME |
| ES2550384T3 (es) | 2008-12-18 | 2015-11-06 | Dana-Farber Cancer Institute, Inc. | NKG2D-Fc para la inmunoterapia |
| JP2012515556A (ja) | 2009-01-23 | 2012-07-12 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 低下したエフェクタ機能を有する安定化Ｆｃポリペプチドおよび使用方法 |
| WO2010135534A2 (en) | 2009-05-20 | 2010-11-25 | Children's Medical Center Corporation | Compositions for the treatment of metastatic cancer and methods of use thereof |
| CA2762302A1 (en) | 2009-05-20 | 2010-11-25 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| CN102549016B (zh) | 2009-06-30 | 2015-05-06 | 研究发展基金会 | 免疫球蛋白fc多肽 |
| CN102712696A (zh) | 2009-09-16 | 2012-10-03 | 弗·哈夫曼-拉罗切有限公司 | 包含卷曲螺旋和/或系链的蛋白质复合体及其用途 |
| MX2012004029A (es) | 2009-10-07 | 2012-05-08 | Macrogenics Inc | Polipeptidos que contienen la region fc que exhiben funcion efectora mejorada debido a alteraciones del grado de fucosilacion, y metodos para su uso. |
| EP2504360B1 (en) | 2009-11-23 | 2018-08-15 | Amgen Inc. | Monomeric antibody fc |
| GB0922209D0 (en) | 2009-12-18 | 2010-02-03 | Univ Nottingham | Proteins, nucleic acid molecules and compositions |
| US8691771B2 (en) | 2010-05-21 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Bi-specific fusion proteins for tissue repair |
| PT2591006T (pt) | 2010-07-09 | 2019-07-29 | Bioverativ Therapeutics Inc | Moléculas de cadeia simples processáveis e polipéptidos preparados utilizando as mesmas |
| WO2012016073A2 (en) * | 2010-07-28 | 2012-02-02 | Gliknik Inc. | Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions |
| JP2013537416A (ja) | 2010-08-13 | 2013-10-03 | メディミューン リミテッド | 変異型Ｆｃ領域を含むモノマーポリペプチド及び使用方法 |
| CN103429620B (zh) | 2010-11-05 | 2018-03-06 | 酵活有限公司 | 在Fc结构域中具有突变的稳定异源二聚的抗体设计 |
| SG191233A1 (en) | 2010-12-23 | 2013-07-31 | Janssen Biotech Inc | Active protease-resistant antibody fc mutants |
| EP2686348B1 (en) | 2011-03-17 | 2015-12-30 | Ramot at Tel-Aviv University Ltd. | Bi- and monospecific, asymmetric antibodies and methods of generating the same |
| JP2014511836A (ja) | 2011-03-25 | 2014-05-19 | グレンマーク ファーマシューティカルズ， エセ．アー． | ヘテロ二量体免疫グロブリン |
| US20140370012A1 (en) * | 2012-01-27 | 2014-12-18 | Gliknik Inc. | Fusion proteins comprising igg2 hinge domains |
| AU2013270682A1 (en) | 2012-06-08 | 2014-12-11 | Biogen Ma Inc. | Procoagulant compounds |
| MX2014015557A (es) | 2012-06-21 | 2015-02-24 | Univ Indiana Res & Tech Corp | Polipeptidos de fusion de region fc de polipeptido de ligando receptor de incretina y conjugados con función efectora fc alterada. |
| KR20150058236A (ko) | 2012-08-20 | 2015-05-28 | 글리크닉 인코포레이티드 | 항원 결합 및 다가 fc 감마 수용체 결합 활성을 가진 분자 |
| CA2888519C (en) * | 2012-10-17 | 2023-02-21 | Liverpool School Of Tropical Medicine | Immunomodulatory proteins |
| CN104558194B (zh) | 2013-10-17 | 2018-04-27 | 泰州迈博太科药业有限公司 | 一类抗CD20-Flex双功能融合蛋白、其制备方法及用途 |
| EP3068892A4 (en) | 2013-11-13 | 2017-05-31 | Zymeworks Inc. | Monovalent antigen binding constructs targeting egfr and/or her2 and uses thereof |
| US10137170B2 (en) | 2013-12-20 | 2018-11-27 | Indiana University Research And Technology Corporation | Lipidated incretin receptor ligand human immunoglobulin Fc-region fusion polypeptides |
| CN113248613B (zh) | 2014-01-15 | 2024-08-23 | 豪夫迈·罗氏有限公司 | 具有修饰的FCRN结合性质的Fc区变体 |
| CN110903398B (zh) | 2014-01-15 | 2023-08-15 | 豪夫迈·罗氏有限公司 | 具有修饰的FCRN和保持的蛋白A结合性质的Fc区变体 |
| CN106068274A (zh) | 2014-03-05 | 2016-11-02 | Ucb生物制药私人有限公司 | 多聚体Fc蛋白 |
| CN106132994A (zh) | 2014-03-05 | 2016-11-16 | Ucb生物制药私人有限公司 | 多聚体Fc蛋白 |
| JP2017513481A (ja) | 2014-04-16 | 2017-06-01 | ユーシービー バイオファルマ エスピーアールエル | 多量体Ｆｃタンパク質 |
| SG10201913507SA (en) | 2014-05-02 | 2020-02-27 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc constructs |
| US10647768B2 (en) | 2014-05-29 | 2020-05-12 | Macrogenics, Inc. | Multi-chain polypeptide-containing tri-specific binding molecules |
| US12391759B2 (en) | 2016-03-02 | 2025-08-19 | Momenta Pharmaceuticals, Inc. | Methods related to engineered Fc constructs |
| IL309293A (en) | 2016-05-23 | 2024-02-01 | Momenta Pharmaceuticals Inc | Compositions and methods relating to engineered FC constructs |
| CN110650748B (zh) | 2017-01-06 | 2024-01-02 | 动量制药公司 | 与经工程改造的Fc构建体相关的组合物和方法 |
-
2015
- 2015-05-01 SG SG10201913507SA patent/SG10201913507SA/en unknown
- 2015-05-01 ES ES15785583T patent/ES2962694T3/es active Active
- 2015-05-01 PL PL15785583.4T patent/PL3137506T3/pl unknown
- 2015-05-01 WO PCT/US2015/028926 patent/WO2015168643A2/en not_active Ceased
- 2015-05-01 CA CA2941072A patent/CA2941072A1/en active Pending
- 2015-05-01 SG SG11201607070VA patent/SG11201607070VA/en unknown
- 2015-05-01 EP EP15785583.4A patent/EP3137506B1/en active Active
- 2015-05-01 CN CN202110761899.9A patent/CN113501880A/zh active Pending
- 2015-05-01 AU AU2015252866A patent/AU2015252866B2/en active Active
- 2015-05-01 EP EP23193565.1A patent/EP4299595A3/en active Pending
- 2015-05-01 JP JP2016564612A patent/JP2017518965A/ja active Pending
- 2015-05-01 IL IL286367A patent/IL286367B2/en unknown
- 2015-05-01 DK DK15785583.4T patent/DK3137506T5/da active
- 2015-05-01 KR KR1020167029772A patent/KR102546875B1/ko active Active
- 2015-05-01 CN CN201580020385.0A patent/CN106661125B/zh active Active
-
2016
- 2016-04-28 US US15/141,413 patent/US10239944B2/en active Active
- 2016-08-23 IL IL247442A patent/IL247442B/en active IP Right Grant
-
2019
- 2019-03-25 US US16/363,846 patent/US11124573B2/en active Active
-
2020
- 2020-05-14 JP JP2020084900A patent/JP7593745B2/ja active Active
- 2020-05-18 IL IL274735A patent/IL274735B/en unknown
-
2021
- 2021-04-27 AU AU2021202578A patent/AU2021202578B2/en active Active
- 2021-08-20 US US17/407,814 patent/US12071482B2/en active Active
-
2022
- 2022-04-14 JP JP2022066669A patent/JP7600172B2/ja active Active
-
2024
- 2024-06-25 US US18/753,820 patent/US20250011432A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7600172B2 (ja) | エンジニアリングされたＦｃ構築物に関連する組成物および方法 | |
| US12448423B2 (en) | Targeted heterodimeric Fc fusion proteins containing NKG2D antigen binding domains | |
| US12404339B2 (en) | Method of depleting target antigen-specific antibody from a patient by administering a fusion protein (Seldeg) for selectively depleting antigen-specific antibodies | |
| AU2019235433B2 (en) | Bispecific EGFR/CD16 antigen-binding protein | |
| ES2973251T3 (es) | Composiciones y procedimientos relacionados con construcciones de Fc modificadas genéticamente | |
| US9458245B2 (en) | ANTI-C-MET tandem Fc bispecific antibodies | |
| TWI804572B (zh) | 雙特異性抗體 | |
| US20140294834A1 (en) | Tandem fc bispecific antibodies | |
| JP2018512145A5 (enExample) | ||
| JP2016527314A5 (enExample) | ||
| SI2802606T1 (en) | Improves the transfer of healing molecules through the hematoencephalic barrier | |
| TW201803899A (zh) | 三特異性和／或三價結合蛋白 | |
| JP2015531751A (ja) | 選択的対である軽鎖および重鎖を含む免疫グロブリン構築物 | |
| US20260109748A1 (en) | Modulation of dendritic cell lineages | |
| JP2019519527A5 (enExample) | ||
| CN108473571A (zh) | 结合人Fc受体的融合蛋白 | |
| CA3164646A1 (en) | Antibodies conjugated with fatty acid molecules and uses thereof | |
| BR112019013955A2 (pt) | Composições e métodos relacionados a construtos de fc manipulados | |
| WO2022056197A1 (en) | Immune targeting molecules and uses thereof | |
| WO2021126538A1 (en) | Bispecific antibodies with alternatively matched interchain cycteines and uses thereof | |
| US20240124574A1 (en) | Bispecific Antibodies with Charge Pairs and Uses Thereof | |
| ES2960329T3 (es) | Proteínas de unión triespecíficas y/o trivalentes | |
| TW202102544A (zh) | 雙特異性抗體 | |
| JP2017524675A5 (enExample) | ||
| JP2026513991A (ja) | Ｓｔｅａｐ２指向性ｔ細胞エンゲージャー及びその組成物 |