JP2012100676A5 - - Google Patents

Download PDF

Info

Publication number
JP2012100676A5
JP2012100676A5 JP2011290448A JP2011290448A JP2012100676A5 JP 2012100676 A5 JP2012100676 A5 JP 2012100676A5 JP 2011290448 A JP2011290448 A JP 2011290448A JP 2011290448 A JP2011290448 A JP 2011290448A JP 2012100676 A5 JP2012100676 A5 JP 2012100676A5
Authority
JP
Japan
Prior art keywords
antibody
cell
kit
endosialin
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011290448A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012100676A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2012100676A publication Critical patent/JP2012100676A/ja
Publication of JP2012100676A5 publication Critical patent/JP2012100676A5/ja
Pending legal-status Critical Current

Links

JP2011290448A 2005-04-22 2011-12-29 免疫エフェクター活性を有するエンドシアリン細胞に内部移行する抗体 Pending JP2012100676A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67434405P 2005-04-22 2005-04-22
US60/674,344 2005-04-22

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2008508001A Division JP2008538700A (ja) 2005-04-22 2006-04-24 免疫エフェクター活性を有するエンドシアリン細胞に内部移行する抗体

Publications (2)

Publication Number Publication Date
JP2012100676A JP2012100676A (ja) 2012-05-31
JP2012100676A5 true JP2012100676A5 (enExample) 2013-04-04

Family

ID=37215438

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008508001A Pending JP2008538700A (ja) 2005-04-22 2006-04-24 免疫エフェクター活性を有するエンドシアリン細胞に内部移行する抗体
JP2011290448A Pending JP2012100676A (ja) 2005-04-22 2011-12-29 免疫エフェクター活性を有するエンドシアリン細胞に内部移行する抗体

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2008508001A Pending JP2008538700A (ja) 2005-04-22 2006-04-24 免疫エフェクター活性を有するエンドシアリン細胞に内部移行する抗体

Country Status (6)

Country Link
US (3) US7615372B2 (enExample)
EP (1) EP1871809A2 (enExample)
JP (2) JP2008538700A (enExample)
AU (1) AU2006241235B2 (enExample)
CA (1) CA2607455A1 (enExample)
WO (1) WO2006116451A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007500508A (ja) * 2003-07-29 2007-01-18 モルフォテック、インク. 抗体とエフェクター機能が増強された遺伝子組み換え抗体を作成する方法
ATE476449T1 (de) * 2004-12-03 2010-08-15 Morphotek Inc Verwendung von endosialinbindenden proteinen zum isolieren endosialinpositiver zellen
WO2006116451A2 (en) 2005-04-22 2006-11-02 Morphotek, Inc. Antibodies with immune effector activity and that internalize in endosialin-positive cells
CA2682726C (en) 2007-04-05 2017-05-09 Morphotek, Inc. Methods for inhibiting the binding of endosialin to ligands
EP2342334A4 (en) * 2008-09-29 2012-03-14 Univ Pennsylvania VACCINES DIRECTED TO TUMOR VESSEL MARKERS
WO2010118203A2 (en) * 2009-04-09 2010-10-14 Morphotek, Inc. Endosialin binding molecules
US20130305396A1 (en) 2010-09-29 2013-11-14 Luigi Grasso Engineered human endosialin-expressing rodents
NL2007179C2 (en) 2011-07-26 2013-01-29 Stichting Katholieke Universiteit Chitosan-based hydrogels containing enzyme alkaline phosphatase.
WO2014164544A1 (en) 2013-03-09 2014-10-09 Baylor College Of Medicine Vascular-targeted t-cell therapy
GB201702926D0 (en) * 2017-02-23 2017-04-12 Univ Birmingham Modulators
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5965132A (en) * 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
US5342757A (en) 1992-11-13 1994-08-30 Ludwig Institute For Cancer Research Monoclonal antibodies which specifically binds to endosialin, a 165 Kd glycoprotein found on tumor vascular endothelium, and uses thereof
ATE244888T1 (de) * 1993-02-05 2003-07-15 Epigen Inc Humanes carcinoma-antigen (hca), hca antikörper, hca immunoassays, aufzeichnungsmethoden und therapy
DE4335025A1 (de) * 1993-10-14 1995-04-20 Boehringer Ingelheim Int Endosomolytisch wirksame Partikel
CA2185116A1 (en) * 1994-03-08 1995-09-14 Thomas P. Wallace Recombinant humanized anti-fb5 antibodies
DE19541844C1 (de) 1995-11-09 1997-07-24 Gsf Forschungszentrum Umwelt Verfahren zur Herstellung von menschlichen Antikörpern und deren Verwendung
US6146894A (en) 1998-04-14 2000-11-14 The Johns Hopkins University Method for generating hypermutable organisms
CA2355337A1 (en) 1998-09-09 2000-03-16 U.S. Army Institute Of Surgical Research Method for monitoring arterial oxygen saturation
AU2001250381A1 (en) * 2000-03-15 2001-09-24 Epigenomics Ag Diagnosis of diseases associated with tumor suppressor genes and oncogenes
US7402660B2 (en) * 2000-08-02 2008-07-22 The Johns Hopkins University Endothelial cell expression patterns
JP5036119B2 (ja) 2001-01-15 2012-09-26 モーフオテク・インコーポレーテツド ミスマッチ修復の化学阻害剤
US20040043928A1 (en) * 2001-08-02 2004-03-04 Ramesh Kekuda Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US20030124579A1 (en) * 2001-09-05 2003-07-03 Eos Biotechnology, Inc. Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer
US20040014058A1 (en) * 2001-10-05 2004-01-22 Alsobrook John P. Novel human proteins, polynucleotides encoding them and methods of using the same
EP1576131A4 (en) * 2002-08-15 2008-08-13 Genzyme Corp EXPRESSION PATTERN IN BRAIN DENTHELIC CELLS
WO2004048938A2 (en) * 2002-11-26 2004-06-10 Protein Design Labs, Inc. Methods of detecting soft tissue sarcoma, compositions and methods of screening for soft tissue sarcoma modulators
KR20060003860A (ko) * 2003-03-04 2006-01-11 기린 비루 가부시키가이샤 내피 세포 특이적 항체 및 그의 용도
US6905082B1 (en) * 2003-12-05 2005-06-14 Sheng Li Wu Sprayer device having buffering structure
WO2005086713A2 (en) 2004-03-04 2005-09-22 Kirin Brewery Co., Ltd. Role of human endothelial precursor cells and vascular pericytes tumor in angiogenesis
WO2006017759A2 (en) 2004-08-05 2006-02-16 Kirin Brewery Co., Ltd. Tumor endothelial marker-1 (tem1) binding antibodies and uses thereof
WO2006029045A2 (en) 2004-09-03 2006-03-16 Kirin Brewery Co., Ltd. Endothelial cell specific antibodies and uses thereof
DE602005025659D1 (enExample) * 2004-09-23 2011-02-10 Guerbet Sa
ATE476449T1 (de) * 2004-12-03 2010-08-15 Morphotek Inc Verwendung von endosialinbindenden proteinen zum isolieren endosialinpositiver zellen
EP2295601A1 (en) * 2005-02-10 2011-03-16 Oncotherapy Science, Inc. Method of diagnosing bladder cancer
WO2006116451A2 (en) 2005-04-22 2006-11-02 Morphotek, Inc. Antibodies with immune effector activity and that internalize in endosialin-positive cells
DE102005050933A1 (de) * 2005-10-21 2007-04-26 Justus-Liebig-Universität Giessen Erfindung betreffend Expressionsprofile zur Vorhersage von septischen Zuständen
US7908090B2 (en) * 2005-11-30 2011-03-15 The Board Of Trustees Of The Leland Stanford Junior University Signatures for human aging
BRPI0620695A2 (pt) * 2005-12-16 2011-11-22 Genentech, Inc método para tratar um tumor do tipo glioma, métodos de prognóstico e/ou diagnóstico de glioma, método de monitoramento ou diagnóstico, método para inibir o tamanho ou crescimento de um tumor do tipo glioma, métodos para tratar terapeuticamente, método para determinar o nìvel de expressão de marcadores determinantes de glioma ("gdm") de pn, prolif ou mes, método para prognosticar o tempo de sobrevida, método para diagnosticar a severidade de um tumor do tipo glioma e uso
WO2008084331A2 (en) 2006-06-21 2008-07-17 Hopitaux Universitaires De Geneve Biomarkers for renal disorders
EP2041307A2 (en) * 2006-07-13 2009-04-01 Siemens Healthcare Diagnostics GmbH Prediction of breast cancer response to taxane-based chemotherapy
EP2049713A4 (en) * 2006-07-21 2010-06-16 Univ Alberta tissue rejection
WO2008021288A2 (en) 2006-08-11 2008-02-21 Johns Hopkins University Consensus coding sequences of human breast and colorectal cancers
US20080300170A1 (en) * 2006-09-01 2008-12-04 Cohava Gelber Compositions and methods for diagnosis and treatment for type 2 diabetes
US20100092476A1 (en) * 2006-11-17 2010-04-15 Hanash Samir M Pancreatic cancer biomarkers
US20110119776A1 (en) 2007-02-05 2011-05-19 Wong Kwok-Kin Methods of diagnosing and prognosing lung cancer
WO2008101118A2 (en) 2007-02-14 2008-08-21 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services A gene expression signature identifying pro-angiogenic genes in ovarian tumor endothelial cell isolates
CA2682726C (en) * 2007-04-05 2017-05-09 Morphotek, Inc. Methods for inhibiting the binding of endosialin to ligands
EP1986010A1 (en) 2007-04-05 2008-10-29 Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg Methods and tools for discriminating colorectal adenomas and adenocarcinomas
JP5769417B2 (ja) 2007-08-16 2015-08-26 ザ ロイヤル インスティチューション フォー ザ アドバンスメント オブ ラーニング/マギル ユニバーシティ 腫瘍細胞由来微小胞
CN105734128B (zh) * 2008-02-01 2021-05-18 总医院有限公司 微泡在医学疾病和病况的诊断、预后以及治疗中的用途
US20110117551A1 (en) 2008-02-19 2011-05-19 Oncomethylome Sciences Sa Detection and prognosis of lung cancer
US20110117111A1 (en) 2008-03-26 2011-05-19 Johns Hopkins University Microrna-based diagnostic testing and therapies for inflammatory bowel disease and related diseases
US20100092470A1 (en) * 2008-09-22 2010-04-15 Icb International, Inc. Antibodies, analogs and uses thereof
US20100136584A1 (en) * 2008-09-22 2010-06-03 Icb International, Inc. Methods for using antibodies and analogs thereof
US20110256560A1 (en) 2008-10-20 2011-10-20 University Health Network Methods and compositions for the detection of ovarian cancer
CA2749601C (en) 2009-01-14 2020-07-21 Stephen M. Hewitt Ratio based biomarkers and methods of use thereof
WO2010118203A2 (en) * 2009-04-09 2010-10-14 Morphotek, Inc. Endosialin binding molecules

Similar Documents

Publication Publication Date Title
JP2012100675A5 (enExample)
JP2012100676A5 (enExample)
TWI853077B (zh) 新型抗cd39抗體
US12453770B2 (en) CLEC9A binding agents
US20240392002A1 (en) Anti-ror antibody constructs
US20200197497A1 (en) Peptidic chimeric antigen receptor t cell switches and uses thereof
US20220002418A1 (en) Anti-pd-l1/vegf bifunctional antibody and use thereof
JP2009521206A5 (enExample)
ES2688941T3 (es) Antagonistas del receptor 1 del factor de necrosis tumoral para tratar enfermedades respiratorias
US20160130338A1 (en) Antibody Neutralizers of Human Granulocyte Macrophage Colony Stimulating Factor
JP7800946B2 (ja) 抗tslpナノ抗体およびその使用
JP2016509582A5 (enExample)
WO2018050039A1 (zh) 新的抗pd-1纳米抗体及其应用
WO2015032906A4 (en) Cd70-binding peptides and method, process and use relating thereto
JP2017526339A5 (enExample)
DE102009045006A1 (de) Anti-CD33 Antikörper und ihre Anwendung zum Immunotargeting bei der Behandlung von CD33-assoziierten Erkrankungen
HRP20170254T1 (hr) Humanizirana i kimerna monoklonska protutijela usmjerena na cd47
JP2010526028A5 (enExample)
CN109485729A (zh) Bcma和cd3的结合分子
EP3178847B1 (en) Anti-tnf-alpha fully human monoclonal antibodies with low immunogenicity and application thereof
JP2014524733A5 (enExample)
WO2013001065A1 (de) Antikörper gegen das prostata-spezifische stammzellantigen und dessen verwendung
SA518400327B1 (ar) أجسام مضادة لبيتا انتيرفيرون واستخداماتها
JP2009521956A5 (enExample)
JP2014500862A5 (enExample)