AU2006241235B2 - Antibodies with immune effector activity and that internalize in endosialin-positive cells - Google Patents
Antibodies with immune effector activity and that internalize in endosialin-positive cells Download PDFInfo
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- AU2006241235B2 AU2006241235B2 AU2006241235A AU2006241235A AU2006241235B2 AU 2006241235 B2 AU2006241235 B2 AU 2006241235B2 AU 2006241235 A AU2006241235 A AU 2006241235A AU 2006241235 A AU2006241235 A AU 2006241235A AU 2006241235 B2 AU2006241235 B2 AU 2006241235B2
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Classifications
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- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39583—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials not provided for elsewhere, e.g. haptens, coenzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6819—Plant toxins
- A61K47/6825—Ribosomal inhibitory proteins, i.e. RIP-I or RIP-II, e.g. Pap, gelonin or dianthin
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- General Health & Medical Sciences (AREA)
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- Molecular Biology (AREA)
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- Epidemiology (AREA)
- Nanotechnology (AREA)
- Toxicology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Botany (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| US67434405P | 2005-04-22 | 2005-04-22 | |
| US60/674,344 | 2005-04-22 | ||
| PCT/US2006/015724 WO2006116451A2 (en) | 2005-04-22 | 2006-04-24 | Antibodies with immune effector activity and that internalize in endosialin-positive cells |
Publications (2)
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| AU2006241235A1 AU2006241235A1 (en) | 2006-11-02 |
| AU2006241235B2 true AU2006241235B2 (en) | 2012-04-05 |
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| EP (1) | EP1871809A2 (enExample) |
| JP (2) | JP2008538700A (enExample) |
| AU (1) | AU2006241235B2 (enExample) |
| CA (1) | CA2607455A1 (enExample) |
| WO (1) | WO2006116451A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2005011735A1 (en) * | 2003-07-29 | 2005-02-10 | Morphotek, Inc. | Antibodies and methods for generating genetically altered antibodies with enhanced effector function |
| DE602005022757D1 (de) * | 2004-12-03 | 2010-09-16 | Morphotek Inc | Verwendung von endosialinbindenden proteinen zum isolieren endosialinpositiver zellen |
| EP1871809A2 (en) | 2005-04-22 | 2008-01-02 | Morphotek, Inc. | Antibodies with immune effector activity and that internalize in endosialin-positive cells |
| HUE031269T2 (en) | 2007-04-05 | 2017-06-28 | Morphotek Inc | Methods for inhibiting the binding of endosial ligands |
| WO2010037124A1 (en) * | 2008-09-29 | 2010-04-01 | The Trustees Of The University Of Pennsylvania | Tumor vascular marker-targeted vaccines |
| US20100260769A1 (en) * | 2009-04-09 | 2010-10-14 | Morphotek, Inc. | Endosialin binding molecules |
| JP2013543379A (ja) | 2010-09-29 | 2013-12-05 | モルフォテック， インコーポレイテッド | 操作されたヒトエンドシアリン発現齧歯動物 |
| NL2007179C2 (en) | 2011-07-26 | 2013-01-29 | Stichting Katholieke Universiteit | Chitosan-based hydrogels containing enzyme alkaline phosphatase. |
| HK1219980A1 (zh) | 2013-03-09 | 2017-04-21 | Baylor College Of Medicine | 靶向血管的t细胞疗法 |
| GB201702926D0 (en) * | 2017-02-23 | 2017-04-12 | Univ Birmingham | Modulators |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
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| WO2004078942A2 (en) * | 2003-03-04 | 2004-09-16 | Kirin Beer Kabushiki Kaisha | Endothelial cell specific antibodies and uses thereof |
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| US5965132A (en) * | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| EP0686260B1 (en) * | 1993-02-05 | 2003-07-09 | Epigen, Inc. | Human carcinoma antigen (hca), hca antibodies, hca immunoassays, methods of imaging and therapy |
| DE4335025A1 (de) * | 1993-10-14 | 1995-04-20 | Boehringer Ingelheim Int | Endosomolytisch wirksame Partikel |
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| US20040048254A1 (en) * | 2000-03-15 | 2004-03-11 | Alexander Olek | Diagnosis of diseases associated with tumor supressor genes and oncogenes |
| US7402660B2 (en) | 2000-08-02 | 2008-07-22 | The Johns Hopkins University | Endothelial cell expression patterns |
| ATE501635T1 (de) | 2001-01-15 | 2011-04-15 | Morphotek Inc | Chemische hemmstoffe des mismatch-repair |
| US20040043928A1 (en) * | 2001-08-02 | 2004-03-04 | Ramesh Kekuda | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
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| CA2749601C (en) | 2009-01-14 | 2020-07-21 | Stephen M. Hewitt | Ratio based biomarkers and methods of use thereof |
| US20100260769A1 (en) * | 2009-04-09 | 2010-10-14 | Morphotek, Inc. | Endosialin binding molecules |
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2006
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- 2006-04-24 AU AU2006241235A patent/AU2006241235B2/en active Active
- 2006-04-24 WO PCT/US2006/015724 patent/WO2006116451A2/en not_active Ceased
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2011
- 2011-12-29 JP JP2011290448A patent/JP2012100676A/ja active Pending
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2012
- 2012-11-26 US US13/685,231 patent/US8524237B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5342757A (en) * | 1992-11-13 | 1994-08-30 | Ludwig Institute For Cancer Research | Monoclonal antibodies which specifically binds to endosialin, a 165 Kd glycoprotein found on tumor vascular endothelium, and uses thereof |
| WO2004078942A2 (en) * | 2003-03-04 | 2004-09-16 | Kirin Beer Kabushiki Kaisha | Endothelial cell specific antibodies and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2607455A1 (en) | 2006-11-02 |
| US7615372B2 (en) | 2009-11-10 |
| US20130078242A1 (en) | 2013-03-28 |
| JP2012100676A (ja) | 2012-05-31 |
| EP1871809A2 (en) | 2008-01-02 |
| US20100021454A1 (en) | 2010-01-28 |
| WO2006116451A2 (en) | 2006-11-02 |
| US20060239911A1 (en) | 2006-10-26 |
| US8389691B2 (en) | 2013-03-05 |
| AU2006241235A1 (en) | 2006-11-02 |
| JP2008538700A (ja) | 2008-11-06 |
| WO2006116451A3 (en) | 2007-04-12 |
| US8524237B2 (en) | 2013-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| PC | Assignment registered |
Owner name: EISAI, INC. Free format text: FORMER OWNER(S): MORPHOTEK, INC. |