JP2014524733A5 - - Google Patents
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- Publication number
- JP2014524733A5 JP2014524733A5 JP2013549652A JP2013549652A JP2014524733A5 JP 2014524733 A5 JP2014524733 A5 JP 2014524733A5 JP 2013549652 A JP2013549652 A JP 2013549652A JP 2013549652 A JP2013549652 A JP 2013549652A JP 2014524733 A5 JP2014524733 A5 JP 2014524733A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- represented
- heavy chain
- light chain
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 16
- 102000036639 antigens Human genes 0.000 claims 16
- 108091007433 antigens Proteins 0.000 claims 16
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 12
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 12
- 210000005134 plasmacytoid dendritic cell Anatomy 0.000 claims 12
- 210000004408 hybridoma Anatomy 0.000 claims 9
- 101000591240 Homo sapiens Receptor-type tyrosine-protein phosphatase S Proteins 0.000 claims 7
- 230000000694 effects Effects 0.000 claims 7
- 102000046923 human PTPRS Human genes 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 210000004544 dc2 Anatomy 0.000 claims 6
- 210000000628 antibody-producing cell Anatomy 0.000 claims 5
- 102000014150 Interferons Human genes 0.000 claims 4
- 108010050904 Interferons Proteins 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 229940079322 interferon Drugs 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000004083 survival effect Effects 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 210000004102 animal cell Anatomy 0.000 claims 2
- 230000016396 cytokine production Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 108010044260 Class 2 Receptor-Like Protein Tyrosine Phosphatases Proteins 0.000 claims 1
- 102000006442 Class 2 Receptor-Like Protein Tyrosine Phosphatases Human genes 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013549652A JP6001557B2 (ja) | 2011-04-28 | 2012-04-27 | 抗ヒト受容体型プロテインチロシンホスファターゼσ抗体 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011101752 | 2011-04-28 | ||
| JP2011101752 | 2011-04-28 | ||
| PCT/JP2012/061795 WO2012148003A1 (en) | 2011-04-28 | 2012-04-27 | ANTI-HUMAN RECEPTOR-TYPE PROTEIN TYROSINE PHOSPHATASE σ ANTIBODY |
| JP2013549652A JP6001557B2 (ja) | 2011-04-28 | 2012-04-27 | 抗ヒト受容体型プロテインチロシンホスファターゼσ抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016170634A Division JP6412072B2 (ja) | 2011-04-28 | 2016-09-01 | 抗ヒト受容体型プロテインチロシンホスファターゼσ抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524733A JP2014524733A (ja) | 2014-09-25 |
| JP2014524733A5 true JP2014524733A5 (enExample) | 2015-07-16 |
| JP6001557B2 JP6001557B2 (ja) | 2016-10-05 |
Family
ID=46147004
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013549652A Active JP6001557B2 (ja) | 2011-04-28 | 2012-04-27 | 抗ヒト受容体型プロテインチロシンホスファターゼσ抗体 |
| JP2016170634A Active JP6412072B2 (ja) | 2011-04-28 | 2016-09-01 | 抗ヒト受容体型プロテインチロシンホスファターゼσ抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016170634A Active JP6412072B2 (ja) | 2011-04-28 | 2016-09-01 | 抗ヒト受容体型プロテインチロシンホスファターゼσ抗体 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9803026B2 (enExample) |
| EP (2) | EP2702412B1 (enExample) |
| JP (2) | JP6001557B2 (enExample) |
| KR (1) | KR101873614B1 (enExample) |
| CN (1) | CN103703372B (enExample) |
| AU (2) | AU2012248158C1 (enExample) |
| CA (1) | CA2834243C (enExample) |
| ES (2) | ES2788183T3 (enExample) |
| HU (2) | HUE034752T2 (enExample) |
| IL (1) | IL229127A (enExample) |
| MX (1) | MX352599B (enExample) |
| PL (2) | PL2702412T3 (enExample) |
| PT (2) | PT3232202T (enExample) |
| RU (2) | RU2013152816A (enExample) |
| SG (3) | SG194614A1 (enExample) |
| WO (1) | WO2012148003A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3424529A1 (en) | 2007-07-02 | 2019-01-09 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for treating and diagnosing cancer |
| HUE034752T2 (en) * | 2011-04-28 | 2018-02-28 | Sbi Biotech Co Ltd | Antibody against human receptor protein tyrosine phosphatase |
| RU2014101669A (ru) | 2011-07-15 | 2015-09-20 | Онкомед Фармасьютикалс, Инк. | Агенты, связывающие белки r-спондины (rspo), и способы их применения |
| KR20150036603A (ko) * | 2012-07-13 | 2015-04-07 | 온코메드 파마슈티칼스, 인크. | Rspo3 결합제 및 그의 용도 |
| US20150175979A1 (en) * | 2012-07-23 | 2015-06-25 | La Jolla Institute For Allergy And Immunology | Ptprs and proteoglycans in autoimmune disease |
| EP3102940B1 (en) * | 2014-02-04 | 2019-06-26 | Monash University | Anti-metalloprotease antibody for diagnosis and treatment of cancers |
| US11160873B2 (en) * | 2014-02-04 | 2021-11-02 | Monash University | Anti-metalloprotease antibody for diagnosis and treatment of cancers |
| TW201628648A (zh) | 2014-09-16 | 2016-08-16 | 安可美德藥物股份有限公司 | 纖維變性疾病之治療 |
| WO2016096788A1 (en) * | 2014-12-18 | 2016-06-23 | F. Hoffmann-La Roche Ag | Assay and method for determining cdc eliciting antibodies |
| MX2019011252A (es) * | 2017-03-23 | 2020-01-23 | Univ Pennsylvania | Anticuerpos anti-c5a y usos de los mismos. |
| WO2018176019A1 (en) * | 2017-03-24 | 2018-09-27 | The Regents Of The University Of California | Proteoglycan irregularities in abnormal fibroblasts and therapies based therefrom |
| WO2019028182A2 (en) * | 2017-08-01 | 2019-02-07 | Remd Biotherapeutics, Inc. | TREATMENT OF CANCER USING ANTIBODIES BINDING TO THE HUMAN CD134 RECEPTOR (OX40) |
| CN112770723B (zh) * | 2018-07-25 | 2024-08-02 | 阿克罗斯生物科学公司 | Cldn 18.2特异性单克隆抗体及其使用方法 |
| GB201910899D0 (en) * | 2019-07-31 | 2019-09-11 | Scancell Ltd | Binding members |
| WO2021067633A2 (en) * | 2019-10-04 | 2021-04-08 | Albert Einstein College Of Medicine | Kir3dl3 is an inhibitory receptor of the immune system and uses thereof |
| WO2023010132A1 (en) | 2021-07-30 | 2023-02-02 | The Regents Of The University Of California | Ptprs in autoimmunity |
| CN114426582B (zh) * | 2022-01-07 | 2022-11-25 | 陕西脉元生物科技有限公司 | 一种神经特异性烯醇化酶单克隆抗体及其制备方法和应用 |
| CN116041526B (zh) * | 2022-11-14 | 2023-09-29 | 华中农业大学 | 一种鼠抗草鱼IgT单克隆抗体及其制备方法和应用 |
| WO2024124164A2 (en) * | 2022-12-09 | 2024-06-13 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of immunostimulatory cytokines to chimeric antigen receptor immune cells |
| AU2024231685A1 (en) * | 2023-03-03 | 2025-09-25 | Case Western Reserve University | Cell adhesion molecule targeted immunotherapies |
| CN118994384B (zh) * | 2024-08-09 | 2025-09-26 | 陕西脉元生物科技有限公司 | 抗Ri的人源化单克隆抗体及其应用和基于其的检测方法 |
| CN119874900B (zh) * | 2025-03-06 | 2025-10-17 | 吉林大学 | 一种单克隆抗体及其在制备治疗肿瘤药物中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995009656A1 (en) | 1993-10-01 | 1995-04-13 | New York University | Novel receptor-type phosphotyrosine phosphatase-sigma |
| JP4498136B2 (ja) | 2002-08-01 | 2010-07-07 | Ｓｂｉバイオテック株式会社 | マウスインターフェロン産生細胞の検出方法 |
| CA2519105A1 (en) * | 2003-03-14 | 2004-09-23 | Taisho Pharmaceutical Co., Ltd. | Monoclonal antibody and hybridoma producing the same |
| EP1732650A4 (en) | 2004-03-27 | 2008-06-11 | Univ Arizona | COMPOSITION AND METHOD FOR CANCER TREATMENT |
| US20080008719A1 (en) | 2004-07-10 | 2008-01-10 | Bowdish Katherine S | Methods and compositions for the treatment of prostate cancer |
| EP1928916A2 (en) | 2005-09-29 | 2008-06-11 | Viral Logic Systems Technology Corp. | Immunomodulatory compositions and uses therefor |
| WO2009003274A1 (en) | 2007-06-29 | 2009-01-08 | The Hospital For Sick Children | Susceptibility gene for inflammatory bowel disease |
| EP3978928A1 (en) | 2008-11-14 | 2022-04-06 | The Brigham and Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
| WO2011022462A2 (en) * | 2009-08-18 | 2011-02-24 | President And Fellows Of Harvard College | Neural regeneration |
| WO2011097327A2 (en) * | 2010-02-02 | 2011-08-11 | La Jolla Institute For Allergy & Immunology | Compositions and methods of modulating receptor protein tyrosine phosphatases |
| HUE034752T2 (en) * | 2011-04-28 | 2018-02-28 | Sbi Biotech Co Ltd | Antibody against human receptor protein tyrosine phosphatase |
-
2012
- 2012-04-27 HU HUE12722557A patent/HUE034752T2/en unknown
- 2012-04-27 SG SG2013079066A patent/SG194614A1/en unknown
- 2012-04-27 EP EP12722557.1A patent/EP2702412B1/en active Active
- 2012-04-27 MX MX2013012393A patent/MX352599B/es active IP Right Grant
- 2012-04-27 US US14/113,904 patent/US9803026B2/en active Active
- 2012-04-27 SG SG10201503257WA patent/SG10201503257WA/en unknown
- 2012-04-27 PL PL12722557T patent/PL2702412T3/pl unknown
- 2012-04-27 ES ES17174348T patent/ES2788183T3/es active Active
- 2012-04-27 ES ES12722557.1T patent/ES2638088T3/es active Active
- 2012-04-27 AU AU2012248158A patent/AU2012248158C1/en active Active
- 2012-04-27 PT PT171743487T patent/PT3232202T/pt unknown
- 2012-04-27 CN CN201280020580.XA patent/CN103703372B/zh active Active
- 2012-04-27 PT PT127225571T patent/PT2702412T/pt unknown
- 2012-04-27 CA CA2834243A patent/CA2834243C/en active Active
- 2012-04-27 RU RU2013152816/10A patent/RU2013152816A/ru not_active Application Discontinuation
- 2012-04-27 SG SG10202108240VA patent/SG10202108240VA/en unknown
- 2012-04-27 WO PCT/JP2012/061795 patent/WO2012148003A1/en not_active Ceased
- 2012-04-27 JP JP2013549652A patent/JP6001557B2/ja active Active
- 2012-04-27 KR KR1020137028325A patent/KR101873614B1/ko active Active
- 2012-04-27 EP EP17174348.7A patent/EP3232202B1/en active Active
- 2012-04-27 HU HUE17174348A patent/HUE054211T2/hu unknown
- 2012-04-27 PL PL17174348T patent/PL3232202T3/pl unknown
- 2012-04-27 RU RU2017118262A patent/RU2715642C2/ru active
-
2013
- 2013-10-28 IL IL229127A patent/IL229127A/en active IP Right Grant
-
2016
- 2016-09-01 JP JP2016170634A patent/JP6412072B2/ja active Active
- 2016-11-23 AU AU2016262677A patent/AU2016262677B2/en active Active
-
2017
- 2017-10-06 US US15/726,669 patent/US10730955B2/en active Active
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