JP2009521206A5 - - Google Patents
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- Publication number
- JP2009521206A5 JP2009521206A5 JP2008508006A JP2008508006A JP2009521206A5 JP 2009521206 A5 JP2009521206 A5 JP 2009521206A5 JP 2008508006 A JP2008508006 A JP 2008508006A JP 2008508006 A JP2008508006 A JP 2008508006A JP 2009521206 A5 JP2009521206 A5 JP 2009521206A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- present
- further embodiment
- receptor alpha
- folate receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000010451 Folate receptor alpha Human genes 0.000 claims description 28
- 108050001931 Folate receptor alpha Proteins 0.000 claims description 28
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 230000001419 dependent effect Effects 0.000 claims description 3
- 230000001939 inductive effect Effects 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 230000004540 complement-dependent cytotoxicity Effects 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 36
- 238000000034 method Methods 0.000 description 35
- 239000000126 substance Substances 0.000 description 16
- 230000000973 chemotherapeutic effect Effects 0.000 description 13
- 239000002157 polynucleotide Substances 0.000 description 11
- 102000040430 polynucleotide Human genes 0.000 description 11
- 108091033319 polynucleotide Proteins 0.000 description 11
- 230000003432 anti-folate effect Effects 0.000 description 10
- 229940127074 antifolate Drugs 0.000 description 10
- 239000004052 folic acid antagonist Substances 0.000 description 10
- 102000005962 receptors Human genes 0.000 description 10
- 108020003175 receptors Proteins 0.000 description 10
- 230000012010 growth Effects 0.000 description 9
- 230000002401 inhibitory effect Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 239000012642 immune effector Substances 0.000 description 6
- 229940121354 immunomodulator Drugs 0.000 description 6
- 239000000032 diagnostic agent Substances 0.000 description 4
- 229940039227 diagnostic agent Drugs 0.000 description 4
- 102000006815 folate receptor Human genes 0.000 description 4
- 108020005243 folate receptor Proteins 0.000 description 4
- 210000004962 mammalian cell Anatomy 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 239000000824 cytostatic agent Substances 0.000 description 2
- 230000001085 cytostatic effect Effects 0.000 description 2
- 231100000433 cytotoxic Toxicity 0.000 description 2
- 239000002254 cytotoxic agent Substances 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 230000001472 cytotoxic effect Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229940127557 pharmaceutical product Drugs 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 1
- 238000009175 antibody therapy Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67418505P | 2005-04-22 | 2005-04-22 | |
| PCT/US2006/016004 WO2006116592A2 (en) | 2005-04-22 | 2006-04-24 | Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011290406A Division JP2012100675A (ja) | 2005-04-22 | 2011-12-29 | 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009521206A JP2009521206A (ja) | 2009-06-04 |
| JP2009521206A5 true JP2009521206A5 (enExample) | 2011-09-01 |
Family
ID=37215502
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008508006A Pending JP2009521206A (ja) | 2005-04-22 | 2006-04-24 | 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体 |
| JP2011290406A Pending JP2012100675A (ja) | 2005-04-22 | 2011-12-29 | 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011290406A Pending JP2012100675A (ja) | 2005-04-22 | 2011-12-29 | 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US20060239910A1 (enExample) |
| EP (2) | EP1879922A2 (enExample) |
| JP (2) | JP2009521206A (enExample) |
| AU (1) | AU2006241099B2 (enExample) |
| CA (1) | CA2607444C (enExample) |
| WO (1) | WO2006116592A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004249673A1 (en) * | 2003-05-23 | 2004-12-29 | Morphotek, Inc. | Anti alpha - folate - receptor - tetramer antibodies |
| WO2005011735A1 (en) * | 2003-07-29 | 2005-02-10 | Morphotek, Inc. | Antibodies and methods for generating genetically altered antibodies with enhanced effector function |
| EP2316857A1 (en) | 2004-02-12 | 2011-05-04 | Morphotek, Inc. | Monoclonal antibodies that specifically bind to folate receptor alpha |
| JP4949373B2 (ja) * | 2005-03-10 | 2012-06-06 | モルフォテック、インク. | 抗メソテリン抗体 |
| EP1879922A2 (en) | 2005-04-22 | 2008-01-23 | Morphotek, Inc. | Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells |
| US20090191202A1 (en) * | 2005-09-29 | 2009-07-30 | Jamieson Catriona Helen M | Methods for manipulating phagocytosis mediated by CD47 |
| US11072655B2 (en) | 2008-01-15 | 2021-07-27 | The Board Of Trustees Of The Leland Stanford Junior University | Markers of acute myeloid leukemia stem cells |
| AU2009205706B2 (en) | 2008-01-15 | 2015-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | Markers of acute myeloid leukemia stem cells |
| CA2711938C (en) | 2008-01-15 | 2019-11-12 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for manipulating phagocytosis mediated by cd47 |
| AU2014203172B2 (en) * | 2010-02-24 | 2016-03-10 | Immunogen, Inc. | Folate Receptor 1 Antibodies and Immunoconjugates and Uses Thereof |
| KR20170085143A (ko) * | 2010-02-24 | 2017-07-21 | 이뮤노젠 아이엔씨 | 엽산염 수용체 1 항체와 면역접합체 및 이들의 용도 |
| LT3789038T (lt) | 2010-05-14 | 2022-12-12 | The Board Of Trustees Of The Leland Stanford Junior University | Humanizuoti ir chimeriniai monokloniniai antikūnai prieš cd47 |
| US20120164137A1 (en) * | 2010-10-20 | 2012-06-28 | Morphotek, Inc. | Anti-folate receptor alpha antibody glycoforms |
| RU2764592C2 (ru) * | 2010-11-05 | 2022-01-18 | Эйсэй Инк. | Рецептор фолиевой кислоты альфа в качестве диагностического и прогностического маркера злокачественных опухолей, экспрессирующих рецептор фолиевой кислоты альфа |
| EP2665521A4 (en) * | 2011-01-18 | 2014-09-03 | Univ Pennsylvania | COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER |
| CA2830628A1 (en) | 2011-03-18 | 2012-09-27 | Kagoshima University | Composition for treatment and diagnosis of pancreatic cancer |
| CA3182262A1 (en) | 2011-04-01 | 2012-10-04 | Immunogen, Inc. | Methods for increasing efficacy of folr1 cancer therapy |
| JP6220333B2 (ja) | 2011-07-15 | 2017-10-25 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗葉酸受容体アルファ抗体およびその使用 |
| WO2014036495A2 (en) * | 2012-08-31 | 2014-03-06 | Immunogen Inc. | Diagnostic assays and kits for detection of folate receptor 1 |
| US9598489B2 (en) | 2012-10-05 | 2017-03-21 | The Trustees Of The Univeristy Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
| WO2014087863A1 (ja) * | 2012-12-07 | 2014-06-12 | 協和発酵キリン株式会社 | 抗folr1抗体 |
| WO2014205342A2 (en) | 2013-06-20 | 2014-12-24 | Morphotek, Inc. | Methods for treatment of ovarian cancer |
| RS62240B1 (sr) | 2013-08-30 | 2021-09-30 | Immunogen Inc | Antitela i testovi za detekciju folatnog receptora 1 |
| SG11201704056XA (en) | 2014-11-20 | 2017-06-29 | Hoffmann La Roche | Combination therapy of t cell activating bispecific antigen binding molecules cd3 abd folate receptor 1 (folr1) and pd-1 axis binding antagonists |
| HRP20201156T1 (hr) | 2014-11-20 | 2020-11-13 | F. Hoffmann - La Roche Ag | Zajednički laki lanci i postupci primjene |
| CA2960929A1 (en) | 2014-11-20 | 2016-05-26 | F. Hoffmann-La Roche Ag | T cell activating bispecific antigen binding molecules against folr1 and cd3 |
| BR112017022320A2 (pt) | 2015-04-17 | 2018-07-24 | Morphotek Inc | métodos para tratamento de câncer de pulmão |
| JP6880006B2 (ja) | 2015-09-17 | 2021-06-02 | イミュノジェン, インコーポレイテッド | 抗folr1免疫複合体を含む治療組み合わせ |
| CN108290948B (zh) | 2015-09-21 | 2021-10-29 | 伊拉兹马斯大学医疗中心 | 抗-cd47抗体及使用方法 |
| BR112020016469A2 (pt) | 2018-03-13 | 2020-12-15 | Phanes Therapeutics, Inc. | Anticorpos do receptor anti-folato 1 e seus usos |
| KR102275930B1 (ko) | 2018-03-14 | 2021-07-12 | (주)알테오젠 | Folr1에 특이적으로 결합하는 항체 및 그의 용도 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| JP7426661B2 (ja) * | 2018-12-17 | 2024-02-02 | 株式会社カネカ | 特定抗原特異的抗体を産生する細胞のスクリーニング方法 |
| JP7585230B2 (ja) | 2019-04-29 | 2024-11-18 | イミュノジェン, インコーポレイテッド | バイパラトピックFR-α抗体及びイムノコンジュゲート |
| WO2024104431A1 (zh) * | 2022-11-16 | 2024-05-23 | 迈威(上海)生物科技股份有限公司 | 一种靶向FRα的抗体或其抗原结合片段及其应用 |
| US12378314B1 (en) * | 2024-02-02 | 2025-08-05 | Medicovestor, Inc. | Proteins that bind folate receptor alpha including fully-human antibodies |
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| US4694778A (en) * | 1984-05-04 | 1987-09-22 | Anicon, Inc. | Chemical vapor deposition wafer boat |
| US4851332A (en) | 1985-04-01 | 1989-07-25 | Sloan-Kettering Institute For Cancer Research | Choriocarcinoma monoclonal antibodies and antibody panels |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5006470A (en) * | 1987-04-16 | 1991-04-09 | Sloan-Kettering Institute For Cancer Research | Human monoclonal antibodies to cell surface antigens of melanoma |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5108921A (en) * | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5688488A (en) * | 1989-04-03 | 1997-11-18 | Purdue Research Foundation | Composition and method for tumor imaging |
| US5789650A (en) * | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| ATE171207T1 (de) * | 1990-10-12 | 1998-10-15 | Us Health | Monoklonaler antikörper |
| US5965132A (en) * | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US5646253A (en) | 1994-03-08 | 1997-07-08 | Memorial Sloan-Kettering Cancer Center | Recombinant human anti-LK26 antibodies |
| US6191268B1 (en) * | 1993-12-17 | 2001-02-20 | Dana-Farber Cancer Institute | Compositions and methods relating to DNA mismatch repair genes |
| WO1995020678A1 (en) * | 1994-01-27 | 1995-08-03 | Human Genome Sciences, Inc. | Human dna mismatch repair proteins |
| DE19513676A1 (de) * | 1995-04-11 | 1996-10-17 | Behringwerke Ag | Cytoplasmatische Expression von Antikörpern, Antikörperfragmenten und Antikörperfragmentfusionsmolekülen in E.coli |
| DE19541844C1 (de) * | 1995-11-09 | 1997-07-24 | Gsf Forschungszentrum Umwelt | Verfahren zur Herstellung von menschlichen Antikörpern und deren Verwendung |
| ATE254931T1 (de) * | 1996-01-05 | 2003-12-15 | Us Gov Health & Human Serv | Mesothelinantigen, verfahren und testsatz zur targetierung |
| CN1217750A (zh) | 1996-05-04 | 1999-05-26 | 曾尼卡有限公司 | 抗cea的单克隆抗体,包括所述抗体的偶联物及其在adept系统中的治疗应用 |
| US6809184B1 (en) * | 1997-12-01 | 2004-10-26 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use |
| US6146894A (en) | 1998-04-14 | 2000-11-14 | The Johns Hopkins University | Method for generating hypermutable organisms |
| US6365410B1 (en) * | 1999-05-19 | 2002-04-02 | Genencor International, Inc. | Directed evolution of microorganisms |
| WO2000073346A1 (en) | 1999-05-27 | 2000-12-07 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Immunoconjugates having high binding affinity |
| WO2003084469A2 (en) | 2002-04-01 | 2003-10-16 | Utah Ventures Ii, L.P. | Tissue-specific endothelial membrane proteins |
| EP1345495B1 (en) | 2000-11-07 | 2009-02-25 | Morphotek Inc. | Methods for generating genetically altered antibody-producing cell lines with improved antibody characteristics |
| US6808894B1 (en) * | 2000-11-07 | 2004-10-26 | Morphotek, Inc. | Methods for generating genetically altered antibody producing cell lines with improved antibody characteristics |
| CA2434926C (en) | 2001-01-15 | 2014-04-01 | Morphotek, Inc. | Chemical inhibitors of mismatch repair |
| KR20040015234A (ko) * | 2001-05-02 | 2004-02-18 | 펄듀 리서치 파운데이션 | 대식세포 매개된 질환의 치료와 진단 |
| JP2005504517A (ja) | 2001-05-18 | 2005-02-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | CD44v6特異的抗体 |
| EP1258255A1 (en) | 2001-05-18 | 2002-11-20 | Boehringer Ingelheim International GmbH | Conjugates of an antibody to CD44 and a maytansinoid |
| EP1551988B1 (en) | 2002-07-19 | 2010-11-24 | Morphotek, Inc. | Methods for generating enhanced antibody-producing cell lines with improved growth characteristics |
| AU2004249673A1 (en) * | 2003-05-23 | 2004-12-29 | Morphotek, Inc. | Anti alpha - folate - receptor - tetramer antibodies |
| WO2005011735A1 (en) | 2003-07-29 | 2005-02-10 | Morphotek, Inc. | Antibodies and methods for generating genetically altered antibodies with enhanced effector function |
| US20050054056A1 (en) | 2003-08-05 | 2005-03-10 | Wolfgang Ebel | Variant cell surface molecule associated with cancer |
| EP2316857A1 (en) * | 2004-02-12 | 2011-05-04 | Morphotek, Inc. | Monoclonal antibodies that specifically bind to folate receptor alpha |
| JP2008515438A (ja) | 2004-10-05 | 2008-05-15 | ワイス | 組換えタンパク質産生の改善方法および組成物 |
| JP4949373B2 (ja) * | 2005-03-10 | 2012-06-06 | モルフォテック、インク. | 抗メソテリン抗体 |
| CA2602585A1 (en) * | 2005-03-30 | 2006-10-05 | Purdue Research Foundation | Method for cancer prognosis using cellular folate vitamin receptor quantification |
| EP1879922A2 (en) | 2005-04-22 | 2008-01-23 | Morphotek, Inc. | Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells |
| WO2007038346A2 (en) * | 2005-09-23 | 2007-04-05 | Purdue Research Foundation | Multiphoton in vivo flow cytometry method and device |
| US20080015160A1 (en) * | 2005-11-04 | 2008-01-17 | Johji Inazawa | Method for detecting cancer and a method for suppressing cancer |
| EP1900752A1 (en) * | 2006-09-15 | 2008-03-19 | DOMPE' pha.r.ma s.p.a. | Human anti-folate receptor alpha antibodies and antibody fragments for the radioimmunotherapy of ovarian carcinoma |
| CA2668197A1 (en) * | 2006-11-03 | 2008-05-15 | Philip S. Low | Ex vivo flow cytometry method and device |
| RU2523909C2 (ru) | 2007-06-25 | 2014-07-27 | Эндосайт, Инк. | Конъюгаты, содержащие гидрофильные спейсеры линкеров |
| WO2009032974A2 (en) * | 2007-09-06 | 2009-03-12 | Tripath Imaging, Inc. | Nucleic acid-based methods for the detection of ovarian cancer |
| GB0725077D0 (en) | 2007-12-21 | 2008-01-30 | Univ Murcia | Antifolate com[ounds for the treatment of melanoma |
| WO2009132081A2 (en) | 2008-04-24 | 2009-10-29 | The Research Foundation Of State University Of New York | Monoclonal antibody-based targeting of folate receptors |
| US20120164137A1 (en) * | 2010-10-20 | 2012-06-28 | Morphotek, Inc. | Anti-folate receptor alpha antibody glycoforms |
| RU2764592C2 (ru) * | 2010-11-05 | 2022-01-18 | Эйсэй Инк. | Рецептор фолиевой кислоты альфа в качестве диагностического и прогностического маркера злокачественных опухолей, экспрессирующих рецептор фолиевой кислоты альфа |
| JP6122948B2 (ja) * | 2012-05-15 | 2017-04-26 | モルフォテック, インコーポレイテッド | 胃癌の治療のための方法 |
| WO2014087863A1 (ja) * | 2012-12-07 | 2014-06-12 | 協和発酵キリン株式会社 | 抗folr1抗体 |
| WO2014205342A2 (en) * | 2013-06-20 | 2014-12-24 | Morphotek, Inc. | Methods for treatment of ovarian cancer |
| BR112017022320A2 (pt) * | 2015-04-17 | 2018-07-24 | Morphotek Inc | métodos para tratamento de câncer de pulmão |
| RS62108B1 (sr) * | 2016-03-02 | 2021-08-31 | Eisai R&D Man Co Ltd | Antitelo-lek konjugati na bazi eribulina i postupci primene |
-
2006
- 2006-04-24 EP EP06758662A patent/EP1879922A2/en not_active Withdrawn
- 2006-04-24 CA CA2607444A patent/CA2607444C/en active Active
- 2006-04-24 WO PCT/US2006/016004 patent/WO2006116592A2/en not_active Ceased
- 2006-04-24 JP JP2008508006A patent/JP2009521206A/ja active Pending
- 2006-04-24 US US11/410,442 patent/US20060239910A1/en not_active Abandoned
- 2006-04-24 AU AU2006241099A patent/AU2006241099B2/en active Active
- 2006-04-24 EP EP20090176155 patent/EP2172487A1/en not_active Withdrawn
-
2009
- 2009-07-16 US US12/503,983 patent/US8124083B2/en active Active
-
2011
- 2011-12-29 JP JP2011290406A patent/JP2012100675A/ja active Pending
-
2012
- 2012-01-24 US US13/356,724 patent/US9144614B2/en active Active
-
2015
- 2015-07-27 US US14/809,887 patent/US9522195B2/en active Active
-
2016
- 2016-11-08 US US15/346,332 patent/US10253106B2/en active Active
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