JP2013518912A5 - - Google Patents

Info

Publication number

JP2013518912A5

JP2013518912A5 JP2012552152A JP2012552152A JP2013518912A5 JP 2013518912 A5 JP2013518912 A5 JP 2013518912A5 JP 2012552152 A JP2012552152 A JP 2012552152A JP 2012552152 A JP2012552152 A JP 2012552152A JP 2013518912 A5 JP2013518912 A5 JP 2013518912A5

Authority

JP

Japan

Prior art keywords

antibody

drug conjugate

fragment

antibody drug

pharmaceutical composition

Prior art date

2011-02-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000611 antibody drug conjugate Substances 0.000 claims 33
• 229940049595 antibody-drug conjugate Drugs 0.000 claims 33
• 239000012634 fragment Substances 0.000 claims 26
• 239000008194 pharmaceutical composition Substances 0.000 claims 19
• 239000000427 antigen Substances 0.000 claims 16
• 102000036639 antigens Human genes 0.000 claims 16
• 108091007433 antigens Proteins 0.000 claims 16
• MFRNYXJJRJQHNW-DEMKXPNLSA-N (2s)-2-[[(2r,3r)-3-methoxy-3-[(2s)-1-[(3r,4s,5s)-3-methoxy-5-methyl-4-[methyl-[(2s)-3-methyl-2-[[(2s)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 MFRNYXJJRJQHNW-DEMKXPNLSA-N 0.000 claims 11
• 108010059074 monomethylauristatin F Proteins 0.000 claims 11
• 206010028980 Neoplasm Diseases 0.000 claims 10
• 125000003275 alpha amino acid group Chemical group 0.000 claims 10
• 201000011510 cancer Diseases 0.000 claims 9
• 241000124008 Mammalia Species 0.000 claims 5
• 230000001268 conjugating effect Effects 0.000 claims 5
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 4
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 4
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 4
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
• 206010038389 Renal cancer Diseases 0.000 claims 4
• 201000010982 kidney cancer Diseases 0.000 claims 4
• 201000007270 liver cancer Diseases 0.000 claims 4
• 208000014018 liver neoplasm Diseases 0.000 claims 4
• 150000007523 nucleic acids Chemical group 0.000 claims 4
• 229940127089 cytotoxic agent Drugs 0.000 claims 3
• 229940079593 drug Drugs 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 230000004614 tumor growth Effects 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 239000000562 conjugate Substances 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 239000002552 dosage form Substances 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 230000005907 cancer growth Effects 0.000 claims 1
• 231100000433 cytotoxic Toxicity 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 230000001472 cytotoxic effect Effects 0.000 claims 1
• 229940039227 diagnostic agent Drugs 0.000 claims 1
• 239000000032 diagnostic agent Substances 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 230000005855 radiation Effects 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1