JP2015525791A5 - - Google Patents
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- JP2015525791A5 JP2015525791A5 JP2015525848A JP2015525848A JP2015525791A5 JP 2015525791 A5 JP2015525791 A5 JP 2015525791A5 JP 2015525848 A JP2015525848 A JP 2015525848A JP 2015525848 A JP2015525848 A JP 2015525848A JP 2015525791 A5 JP2015525791 A5 JP 2015525791A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- effector
- combination according
- engineered
- effector moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12179473 | 2012-08-07 | ||
| EP12179473.9 | 2012-08-07 | ||
| PCT/EP2013/066351 WO2014023679A1 (en) | 2012-08-07 | 2013-08-05 | Composition comprising two antibodies engineered to have reduced and increased effector function |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015525791A JP2015525791A (ja) | 2015-09-07 |
| JP2015525791A5 true JP2015525791A5 (enExample) | 2016-10-06 |
| JP6290209B2 JP6290209B2 (ja) | 2018-03-07 |
Family
ID=48916069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015525848A Active JP6290209B2 (ja) | 2012-08-07 | 2013-08-05 | 低下した及び増加したエフェクター機能を有するように操作された２つの抗体を含む組成物。 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9526797B2 (enExample) |
| EP (2) | EP3434695B1 (enExample) |
| JP (1) | JP6290209B2 (enExample) |
| KR (2) | KR102163588B1 (enExample) |
| CN (1) | CN104662045B (enExample) |
| AR (1) | AR092044A1 (enExample) |
| AU (2) | AU2013301582B2 (enExample) |
| BR (1) | BR112014030414A2 (enExample) |
| CA (1) | CA2872195A1 (enExample) |
| ES (2) | ES2848732T3 (enExample) |
| IL (1) | IL236892B (enExample) |
| MX (2) | MX365382B (enExample) |
| MY (1) | MY175687A (enExample) |
| NZ (1) | NZ702241A (enExample) |
| PL (2) | PL3434695T3 (enExample) |
| RU (1) | RU2650788C2 (enExample) |
| SG (2) | SG11201407580YA (enExample) |
| TR (1) | TR201816437T4 (enExample) |
| WO (1) | WO2014023679A1 (enExample) |
Families Citing this family (71)
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| PE20171512A1 (es) | 2010-08-13 | 2017-10-20 | Roche Glycart Ag | Anticuerpos anti-fap |
| CN105440123B (zh) | 2011-02-10 | 2020-10-09 | 罗切格利卡特公司 | 突变体白介素-2多肽 |
| KR101981342B1 (ko) * | 2011-03-02 | 2019-05-22 | 로슈 글리카트 아게 | Cea 항체 |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| KR101870555B1 (ko) | 2011-08-23 | 2018-06-22 | 로슈 글리카트 아게 | T 세포 활성화 항원 및 종양 항원에 대해 특이적인 이중특이적 항체 및 이의 사용 방법 |
| PL3434695T3 (pl) * | 2012-08-07 | 2021-05-17 | Roche Glycart Ag | Ulepszona immunoterapia |
| MX2015003616A (es) | 2012-10-08 | 2015-06-05 | Roche Glycart Ag | Anticuerpos sin fc que comprenden dos fragmentos fab y metodos de uso. |
| JP6636803B2 (ja) | 2013-02-05 | 2020-01-29 | エンクマフ エスアーエールエル | Ｂｃｍａに対する抗体の選択のための方法 |
| CN110437337B (zh) | 2013-02-26 | 2024-07-30 | 罗切格利卡特公司 | 双特异性t细胞活化性抗原结合分子 |
| WO2014131694A1 (en) | 2013-02-26 | 2014-09-04 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| PL3177643T3 (pl) | 2014-08-04 | 2019-09-30 | F.Hoffmann-La Roche Ag | Dwuswoiste cząsteczki wiążące antygen aktywujące komórki T |
| ES2774380T3 (es) * | 2014-08-29 | 2020-07-20 | Hoffmann La Roche | Politerapia de inmunocitocinas de variante de IL-2 dirigida a tumor y anticuerpos frente a PD-L1 humano |
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| ES2808853T3 (es) | 2014-11-20 | 2021-03-02 | Hoffmann La Roche | Cadenas ligeras comunes y procedimientos de uso |
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| MA43028B1 (fr) | 2015-10-02 | 2021-09-30 | Hoffmann La Roche | Anticorps bispécifiques pour pd1 et tim3 |
| JP7044700B2 (ja) | 2015-10-02 | 2022-03-30 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 二重特異性抗ｃｅａｘｃｄ３ ｔ細胞活性化抗原結合分子 |
| MY206406A (en) | 2015-10-02 | 2024-12-16 | Hoffmann La Roche | Bispecific antibodies specific for a costimulatory tnf receptor |
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| IL313608A (en) | 2015-12-09 | 2024-08-01 | Hoffmann La Roche | Antibody against CD20 type II to reduce the formation of antibodies against drugs |
| BR112018011029A2 (pt) | 2016-01-08 | 2018-11-21 | Hoffmann La Roche | métodos para tratar ou atrasar a progressão do câncer e para melhorar a função imune em um indivíduo com câncer, usos de um antagonista de ligação e de um anticorpo biespecífico, composições e kits |
| WO2017148880A1 (en) | 2016-03-01 | 2017-09-08 | F. Hoffmann-La Roche Ag | Obinutuzumab variants having altered cell death induction |
| JP7015244B2 (ja) | 2016-03-22 | 2022-02-02 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | プロテアーゼ活性化ｔ細胞二重特異性分子 |
| KR102379464B1 (ko) | 2016-06-20 | 2022-03-29 | 키맵 리미티드 | 항-pd-l1 항체 |
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| EP3511340B1 (en) | 2016-08-10 | 2024-10-02 | Ajou University Industry-Academic Cooperation Foundation | Heterodimeric fc-fused cytokine and pharmaceutical composition comprising the same |
| CN109843926B (zh) | 2016-09-30 | 2023-01-20 | 豪夫迈·罗氏有限公司 | 针对cd3的双特异性抗体 |
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| JP7125400B2 (ja) | 2016-12-19 | 2022-08-24 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 標的化４－１ｂｂ（ｃｄ１３７）アゴニストとの併用療法 |
| BR112019018915A2 (pt) | 2017-03-15 | 2020-04-14 | Pandion Therapeutics Inc | imunotolerância direcionada |
| PT3431105T (pt) | 2017-03-29 | 2020-03-11 | Shionogi & Co | Composição medicinal para tratamento de cancro |
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| KR102920712B1 (ko) | 2017-05-24 | 2026-01-30 | 노파르티스 아게 | 항체-사이토카인 생착된 단백질 및 암 치료에 있어서의 사용 방법 |
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| CN118126157A (zh) | 2017-08-03 | 2024-06-04 | 美国安进公司 | 白介素-21突变蛋白和治疗方法 |
| KR102777151B1 (ko) | 2017-11-21 | 2025-03-05 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 인터루킨-2의 부분 효능제 |
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2013
- 2013-08-05 PL PL18187423T patent/PL3434695T3/pl unknown
- 2013-08-05 WO PCT/EP2013/066351 patent/WO2014023679A1/en not_active Ceased
- 2013-08-05 MX MX2015001630A patent/MX365382B/es active IP Right Grant
- 2013-08-05 EP EP18187423.1A patent/EP3434695B1/en active Active
- 2013-08-05 TR TR2018/16437T patent/TR201816437T4/tr unknown
- 2013-08-05 PL PL13745096T patent/PL2882777T3/pl unknown
- 2013-08-05 SG SG11201407580YA patent/SG11201407580YA/en unknown
- 2013-08-05 KR KR1020157003238A patent/KR102163588B1/ko active Active
- 2013-08-05 CN CN201380029551.4A patent/CN104662045B/zh active Active
- 2013-08-05 CA CA2872195A patent/CA2872195A1/en not_active Abandoned
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- 2013-08-05 RU RU2015107889A patent/RU2650788C2/ru active
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- 2013-08-05 JP JP2015525848A patent/JP6290209B2/ja active Active
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