JP2019527678A5 - - Google Patents
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- JP2019527678A5 JP2019527678A5 JP2018568229A JP2018568229A JP2019527678A5 JP 2019527678 A5 JP2019527678 A5 JP 2019527678A5 JP 2018568229 A JP2018568229 A JP 2018568229A JP 2018568229 A JP2018568229 A JP 2018568229A JP 2019527678 A5 JP2019527678 A5 JP 2019527678A5
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- Prior art keywords
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- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims description 45
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims description 45
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 32
- 230000001404 mediated effect Effects 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 31
- 201000010099 disease Diseases 0.000 claims description 28
- 239000008194 pharmaceutical composition Substances 0.000 claims description 28
- 206010020751 Hypersensitivity Diseases 0.000 claims description 14
- 206010025135 lupus erythematosus Diseases 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 10
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 10
- 208000023275 Autoimmune disease Diseases 0.000 claims description 8
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 8
- 208000030961 allergic reaction Diseases 0.000 claims description 8
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 8
- 239000013566 allergen Substances 0.000 claims description 7
- 206010002198 Anaphylactic reaction Diseases 0.000 claims description 6
- 208000028185 Angioedema Diseases 0.000 claims description 6
- 208000005034 Angiolymphoid Hyperplasia with Eosinophilia Diseases 0.000 claims description 6
- 206010006474 Bronchopulmonary aspergillosis allergic Diseases 0.000 claims description 6
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 6
- 208000014966 Kimura Disease Diseases 0.000 claims description 6
- 208000007811 Latex Hypersensitivity Diseases 0.000 claims description 6
- 208000000592 Nasal Polyps Diseases 0.000 claims description 6
- 206010033078 Otitis media Diseases 0.000 claims description 6
- 206010034277 Pemphigoid Diseases 0.000 claims description 6
- 206010039085 Rhinitis allergic Diseases 0.000 claims description 6
- 206010039251 Rubber sensitivity Diseases 0.000 claims description 6
- 208000024780 Urticaria Diseases 0.000 claims description 6
- 201000009961 allergic asthma Diseases 0.000 claims description 6
- 208000006778 allergic bronchopulmonary aspergillosis Diseases 0.000 claims description 6
- 208000026935 allergic disease Diseases 0.000 claims description 6
- 201000010105 allergic rhinitis Diseases 0.000 claims description 6
- 230000007815 allergy Effects 0.000 claims description 6
- 230000036783 anaphylactic response Effects 0.000 claims description 6
- 208000003455 anaphylaxis Diseases 0.000 claims description 6
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 6
- 208000006673 asthma Diseases 0.000 claims description 6
- 201000008937 atopic dermatitis Diseases 0.000 claims description 6
- 208000000594 bullous pemphigoid Diseases 0.000 claims description 6
- 229960002204 daratumumab Drugs 0.000 claims description 6
- 235000005911 diet Nutrition 0.000 claims description 6
- 230000000378 dietary effect Effects 0.000 claims description 6
- 230000002327 eosinophilic effect Effects 0.000 claims description 6
- 201000001564 eosinophilic gastroenteritis Diseases 0.000 claims description 6
- 201000005391 latex allergy Diseases 0.000 claims description 6
- 229940124597 therapeutic agent Drugs 0.000 claims description 6
- 241000233866 Fungi Species 0.000 claims description 4
- 108010003272 Hyaluronate lyase Proteins 0.000 claims description 4
- 102000001974 Hyaluronidases Human genes 0.000 claims description 4
- 230000005888 antibody-dependent cellular phagocytosis Effects 0.000 claims description 4
- 229960000106 biosimilars Drugs 0.000 claims description 4
- 230000004540 complement-dependent cytotoxicity Effects 0.000 claims description 4
- 208000004921 cutaneous lupus erythematosus Diseases 0.000 claims description 4
- 208000035475 disorder Diseases 0.000 claims description 4
- 229960002773 hyaluronidase Drugs 0.000 claims description 4
- 208000006926 Discoid Lupus Erythematosus Diseases 0.000 claims description 2
- 208000006877 Insect Bites and Stings Diseases 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims description 2
- 230000001154 acute effect Effects 0.000 claims description 2
- 230000006907 apoptotic process Effects 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 201000004997 drug-induced lupus erythematosus Diseases 0.000 claims description 2
- 239000000428 dust Substances 0.000 claims description 2
- 239000013568 food allergen Substances 0.000 claims description 2
- 239000004816 latex Substances 0.000 claims description 2
- 229920000126 latex Polymers 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000011272 standard treatment Methods 0.000 claims description 2
- 208000011834 subacute cutaneous lupus erythematosus Diseases 0.000 claims description 2
- 206010051841 Exposure to allergen Diseases 0.000 claims 1
- 230000001270 agonistic effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000003462 vein Anatomy 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 10
- 230000030833 cell death Effects 0.000 description 3
- 208000016366 nasal cavity polyp Diseases 0.000 description 2
- 239000000556 agonist Substances 0.000 description 1
- 230000010666 regulation of catalytic activity Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662355526P | 2016-06-28 | 2016-06-28 | |
| US62/355,526 | 2016-06-28 | ||
| PCT/EP2017/066063 WO2018002181A1 (en) | 2016-06-28 | 2017-06-28 | TREATMENT OF IgE-MEDIATED DISEASES WITH ANTIBODIES THAT SPECIFICALLY BIND CD38 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019527678A JP2019527678A (ja) | 2019-10-03 |
| JP2019527678A5 true JP2019527678A5 (enExample) | 2020-08-06 |
Family
ID=59298446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568229A Pending JP2019527678A (ja) | 2016-06-28 | 2017-06-28 | ＣＤ３８に特異的に結合する抗体によるＩｇＥ媒介疾患の治療 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20190233533A1 (enExample) |
| EP (1) | EP3474895A1 (enExample) |
| JP (1) | JP2019527678A (enExample) |
| WO (1) | WO2018002181A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9603927B2 (en) | 2014-02-28 | 2017-03-28 | Janssen Biotech, Inc. | Combination therapies with anti-CD38 antibodies |
| US9732154B2 (en) | 2014-02-28 | 2017-08-15 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia |
| MY192918A (en) | 2014-09-09 | 2022-09-15 | Janssen Biotech Inc | Combination therapies with anti-cd38 antibodies |
| EP3227338A4 (en) | 2014-12-04 | 2018-05-16 | Janssen Biotech, Inc. | Anti-cd38 antibodies for treatment of acute myeloid leukemia |
| CR20170526A (es) | 2015-05-20 | 2018-04-03 | Janssen Biotech Inc | ANTICUERPOS ANTI-CD38 PARA EL TRATAMIENTO DE AMILOIDOSIS DE CADENA LIGERA y OTRAS ENFERMEDADES MALIGNAS HEMATOLÓGICAS POSITIVAS PARA CD38 |
| MY192978A (en) | 2015-06-22 | 2022-09-20 | Janssen Biotech Inc | Combination therapies for heme malignancies with anti-cd38 antibodies and survivin inhibitors |
| US20170044265A1 (en) | 2015-06-24 | 2017-02-16 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
| US10781261B2 (en) | 2015-11-03 | 2020-09-22 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-CD38 antibodies and their uses |
| PL3827845T3 (pl) | 2015-11-03 | 2022-07-11 | Janssen Biotech, Inc. | Formulacje podskórne przeciwciał anty-cd38 i ich zastosowania |
| CA3079242A1 (en) | 2017-10-31 | 2019-05-09 | Janssen Biotech, Inc. | Methods of treating high risk multiple myeloma |
| WO2019173902A1 (en) * | 2018-03-13 | 2019-09-19 | Trillium Therapeutics Inc. | Cd47 blockade therapy with cd38 antibody |
| WO2020194241A1 (en) * | 2019-03-28 | 2020-10-01 | Janssen Biotech, Inc. | Clinically proven subcutaneous pharmaceutical compositions comprising anti-cd38 antibodies and their uses |
| US20220233689A1 (en) * | 2020-12-28 | 2022-07-28 | Bristol-Myers Squibb Company | Methods of treating tumors |
| RS66849B1 (sr) * | 2020-12-28 | 2025-06-30 | Bristol Myers Squibb Co | Kompozicije antitela i postupci njihove upotrebe |
| JP2024503432A (ja) | 2021-01-14 | 2024-01-25 | モルフォシス・アーゲー | 抗ｃｄ３８抗体及び抗ｃｄ３８抗体の使用 |
| TW202302642A (zh) | 2021-03-01 | 2023-01-16 | 德商莫菲西斯公司 | 用於治療抗體介導移植物排斥用途之抗ｃｄ３８抗體 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| DE3785186T2 (de) | 1986-09-02 | 1993-07-15 | Enzon Lab Inc | Bindungsmolekuele mit einzelpolypeptidkette. |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| US5932448A (en) | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
| ATE408012T1 (de) | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| EP0672142B1 (en) | 1992-12-04 | 2001-02-28 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| AUPO591797A0 (en) | 1997-03-27 | 1997-04-24 | Commonwealth Scientific And Industrial Research Organisation | High avidity polyvalent and polyspecific reagents |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US6833441B2 (en) | 2001-08-01 | 2004-12-21 | Abmaxis, Inc. | Compositions and methods for generating chimeric heteromultimers |
| CA2517145C (en) | 2003-03-05 | 2017-08-01 | Halozyme, Inc. | Soluble hyaluronidase glycoprotein (shasegp), process for preparing the same, uses and pharmaceutical compositions comprising thereof |
| US8597911B2 (en) | 2003-06-11 | 2013-12-03 | Chugai Seiyaku Kabushiki Kaisha | Process for producing antibodies |
| JP2008504013A (ja) | 2004-02-06 | 2008-02-14 | モルフォシス・アクチェンゲゼルシャフト | 抗ｃｄ３８ヒト抗体及びその用途 |
| EA015584B1 (ru) * | 2005-03-23 | 2011-10-31 | Генмаб А/С | Антитело к cd38 человека и его применение |
| JP5620626B2 (ja) | 2005-03-31 | 2014-11-05 | 中外製薬株式会社 | 会合制御によるポリペプチド製造方法 |
| AR053489A1 (es) | 2005-05-24 | 2007-05-09 | Morphosys Ag | Generacion perfilado de anticuerpos terapeuticos totalmente derivados de hucal gold humanos especificos para cd38 humano |
| JP5362359B2 (ja) | 2005-10-12 | 2013-12-11 | モルフォシス アーゲー | ヒトＣＤ３８に特異的な完全ヒトＨｕＣＡＬＧＯＬＤ由来の治療抗体の生成とプロファイリング |
| WO2007110205A2 (en) | 2006-03-24 | 2007-10-04 | Merck Patent Gmbh | Engineered heterodimeric protein domains |
| WO2007147901A1 (en) | 2006-06-22 | 2007-12-27 | Novo Nordisk A/S | Production of bispecific antibodies |
| EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
| AU2008234248C1 (en) | 2007-03-29 | 2015-01-22 | Genmab A/S | Bispecific antibodies and methods for production thereof |
| ES2564523T3 (es) | 2007-12-19 | 2016-03-23 | Janssen Biotech, Inc. | Diseño y generación de bibliotecas de presentación en fago por pIX de novo humanas mediante fusión con pIX o pVII, vectores, anticuerpos y métodos |
| PT2235064E (pt) | 2008-01-07 | 2016-03-01 | Amgen Inc | Método de preparação de moléculas heterodiméricas de fc de anticorpos utilizando efeitos de indução eletrostática |
| CN102076355B (zh) | 2008-04-29 | 2014-05-07 | Abbvie公司 | 双重可变结构域免疫球蛋白及其用途 |
| CN102459346B (zh) | 2009-04-27 | 2016-10-26 | 昂考梅德药品有限公司 | 制造异源多聚体分子的方法 |
| US9084743B2 (en) * | 2009-09-17 | 2015-07-21 | Baxter International Inc. | Stable co-formulation of hyaluronidase and immunoglobulin, and methods of use thereof |
| CN110066339A (zh) | 2010-04-20 | 2019-07-30 | 根马布股份公司 | 含异二聚体抗体fc的蛋白及其制备方法 |
| EP2569337A1 (en) | 2010-05-14 | 2013-03-20 | Rinat Neuroscience Corp. | Heterodimeric proteins and methods for producing and purifying them |
| EP2580243B1 (en) * | 2010-06-09 | 2019-10-16 | Genmab A/S | Antibodies against human cd38 |
| EP2420253A1 (en) | 2010-08-20 | 2012-02-22 | Leadartis, S.L. | Engineering multifunctional and multivalent molecules with collagen XV trimerization domain |
| RU2604490C2 (ru) | 2010-11-05 | 2016-12-10 | Займворкс Инк. | ДИЗАЙН УСТОЙЧИВОГО ГЕТЕРОДИМЕРНОГО АНТИТЕЛА С МУТАЦИЯМИ В Fc ДОМЕНЕ |
| JOP20210044A1 (ar) * | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| ES2774976T3 (es) | 2013-04-29 | 2020-07-23 | Teva Pharmaceuticals Australia Pty Ltd | Anticuerpos anti-CD38 y fusiones con interferón alfa-2b atenuado |
| WO2015195555A1 (en) * | 2014-06-16 | 2015-12-23 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Blocking cd38 using anti-cd38 antibody conjugated to protein g to protect nk cells |
-
2017
- 2017-06-28 JP JP2018568229A patent/JP2019527678A/ja active Pending
- 2017-06-28 WO PCT/EP2017/066063 patent/WO2018002181A1/en not_active Ceased
- 2017-06-28 EP EP17737235.6A patent/EP3474895A1/en not_active Withdrawn
- 2017-06-28 US US16/312,133 patent/US20190233533A1/en not_active Abandoned
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