JP2018523686A5 - - Google Patents
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- JP2018523686A5 JP2018523686A5 JP2018508741A JP2018508741A JP2018523686A5 JP 2018523686 A5 JP2018523686 A5 JP 2018523686A5 JP 2018508741 A JP2018508741 A JP 2018508741A JP 2018508741 A JP2018508741 A JP 2018508741A JP 2018523686 A5 JP2018523686 A5 JP 2018523686A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- tumor
- diabody
- cell carcinoma
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims description 46
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- 102000004196 processed proteins & peptides Human genes 0.000 claims description 24
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- 230000027455 binding Effects 0.000 claims description 7
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- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 206010009944 Colon cancer Diseases 0.000 claims 12
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- 208000005718 Stomach Neoplasms Diseases 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 12
- 206010017758 gastric cancer Diseases 0.000 claims 12
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- 206010005003 Bladder cancer Diseases 0.000 claims 8
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- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 8
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- 239000003937 drug carrier Substances 0.000 claims 8
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 8
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- 208000020816 lung neoplasm Diseases 0.000 claims 8
- 208000037819 metastatic cancer Diseases 0.000 claims 8
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- 206010008342 Cervix carcinoma Diseases 0.000 claims 4
- 208000005243 Chondrosarcoma Diseases 0.000 claims 4
- 201000009047 Chordoma Diseases 0.000 claims 4
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims 4
- 206010014967 Ependymoma Diseases 0.000 claims 4
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 4
- 208000021309 Germ cell tumor Diseases 0.000 claims 4
- 208000009164 Islet Cell Adenoma Diseases 0.000 claims 4
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 4
- 208000000172 Medulloblastoma Diseases 0.000 claims 4
- 206010027406 Mesothelioma Diseases 0.000 claims 4
- 208000034578 Multiple myelomas Diseases 0.000 claims 4
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 4
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 4
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 claims 4
- 206010052399 Neuroendocrine tumour Diseases 0.000 claims 4
- 206010033701 Papillary thyroid cancer Diseases 0.000 claims 4
- 206010033963 Parathyroid tumour Diseases 0.000 claims 4
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 4
- 208000008938 Rhabdoid tumor Diseases 0.000 claims 4
- 208000000453 Skin Neoplasms Diseases 0.000 claims 4
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 4
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 4
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 4
- 206010057644 Testis cancer Diseases 0.000 claims 4
- 208000000728 Thymus Neoplasms Diseases 0.000 claims 4
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 4
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 4
- 210000004556 brain Anatomy 0.000 claims 4
- 201000010881 cervical cancer Diseases 0.000 claims 4
- 208000011654 childhood malignant neoplasm Diseases 0.000 claims 4
- 208000009060 clear cell adenocarcinoma Diseases 0.000 claims 4
- 208000029742 colonic neoplasm Diseases 0.000 claims 4
- 201000011523 endocrine gland cancer Diseases 0.000 claims 4
- 230000003352 fibrogenic effect Effects 0.000 claims 4
- 208000003884 gestational trophoblastic disease Diseases 0.000 claims 4
- 201000010536 head and neck cancer Diseases 0.000 claims 4
- 208000014829 head and neck neoplasm Diseases 0.000 claims 4
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 4
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 4
- 238000001990 intravenous administration Methods 0.000 claims 4
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- 239000007788 liquid Substances 0.000 claims 4
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- 206010027191 meningioma Diseases 0.000 claims 4
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- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 4
- 210000000578 peripheral nerve Anatomy 0.000 claims 4
- 208000028591 pheochromocytoma Diseases 0.000 claims 4
- 201000002267 posterior uveal melanoma Diseases 0.000 claims 4
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- 201000003120 testicular cancer Diseases 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 208000008732 thymoma Diseases 0.000 claims 4
- 210000001685 thyroid gland Anatomy 0.000 claims 4
- 208000030045 thyroid gland papillary carcinoma Diseases 0.000 claims 4
- 208000017997 tumor of parathyroid gland Diseases 0.000 claims 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 4
- 206010024612 Lipoma Diseases 0.000 claims 1
- 206010024627 liposarcoma Diseases 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 description 14
- 210000001744 T-lymphocyte Anatomy 0.000 description 12
- 238000000375 direct analysis in real time Methods 0.000 description 12
- 238000012063 dual-affinity re-targeting Methods 0.000 description 12
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 8
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- 231100000135 cytotoxicity Toxicity 0.000 description 6
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- 239000012636 effector Substances 0.000 description 6
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 5
- 230000001404 mediated effect Effects 0.000 description 5
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 5
- 229960002685 biotin Drugs 0.000 description 4
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- 238000006243 chemical reaction Methods 0.000 description 4
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- 238000002843 lactate dehydrogenase assay Methods 0.000 description 4
- 210000004986 primary T-cell Anatomy 0.000 description 4
- 231100000416 LDH assay Toxicity 0.000 description 3
- 230000000259 anti-tumor effect Effects 0.000 description 3
- 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 2
- 238000011579 SCID mouse model Methods 0.000 description 2
- 108010090804 Streptavidin Proteins 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000015861 cell surface binding Effects 0.000 description 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
- 235000018417 cysteine Nutrition 0.000 description 2
- 231100000673 dose–response relationship Toxicity 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- 102100025137 Early activation antigen CD69 Human genes 0.000 description 1
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 description 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 description 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 description 1
- 230000006044 T cell activation Effects 0.000 description 1
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- 230000022534 cell killing Effects 0.000 description 1
- 238000003501 co-culture Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562206051P | 2015-08-17 | 2015-08-17 | |
| US62/206,051 | 2015-08-17 | ||
| US201662280318P | 2016-01-19 | 2016-01-19 | |
| US62/280,318 | 2016-01-19 | ||
| PCT/US2016/046680 WO2017030926A1 (en) | 2015-08-17 | 2016-08-12 | Bispecific monovalent diabodies that are capable of binding b7-h3 and cd3, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018523686A JP2018523686A (ja) | 2018-08-23 |
| JP2018523686A5 true JP2018523686A5 (enExample) | 2019-08-08 |
Family
ID=58051498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018508741A Pending JP2018523686A (ja) | 2015-08-17 | 2016-08-12 | Ｂ７‐ｈ３及びｃｄ３に結合できる二重特異性１価ダイアボディ並びにその使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20190002563A1 (enExample) |
| EP (1) | EP3337507A4 (enExample) |
| JP (1) | JP2018523686A (enExample) |
| KR (1) | KR20180038045A (enExample) |
| CN (1) | CN107921130A (enExample) |
| AU (1) | AU2016307955A1 (enExample) |
| CA (1) | CA2995709A1 (enExample) |
| CL (1) | CL2018000422A1 (enExample) |
| CO (1) | CO2018001485A2 (enExample) |
| CR (1) | CR20180105A (enExample) |
| EA (1) | EA201890443A1 (enExample) |
| EC (1) | ECSP18011248A (enExample) |
| HK (1) | HK1249423A1 (enExample) |
| IL (1) | IL257562A (enExample) |
| MA (1) | MA42665A (enExample) |
| MX (1) | MX2018001954A (enExample) |
| PE (1) | PE20181066A1 (enExample) |
| PH (1) | PH12018500363A1 (enExample) |
| TW (1) | TW201718652A (enExample) |
| WO (1) | WO2017030926A1 (enExample) |
| ZA (1) | ZA201800955B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ726520A (en) | 2014-05-29 | 2018-12-21 | Macrogenics Inc | Tri-specific binding molecules that specifically bind to multiple cancer antigens and methods of use thereof |
| AU2015321546B2 (en) | 2014-09-26 | 2020-09-03 | Macrogenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD19 and CD3, and uses thereof |
| TW202208440A (zh) | 2015-12-14 | 2022-03-01 | 美商宏觀基因股份有限公司 | 對於pd-1和ctla-4具有免疫反應性的雙特異性分子及其使用方法 |
| EP3585431A4 (en) | 2017-02-24 | 2020-12-16 | MacroGenics, Inc. | BISPECIFIC BINDING MOLECULES CAPABLE OF BINDING TO CD137 AND TUMOR ANTIGENS, AND THEIR USES |
| MY200973A (en) | 2017-04-11 | 2024-01-26 | Inhibrx Inc | Multispecific Polypeptide Constructs Having Constrained Cd3 Binding And Methods Of Using The Same |
| MX2020002667A (es) * | 2017-09-08 | 2020-08-03 | Maverick Therapeutics Inc | Proteinas de unión condicionalmente activadas restringidas. |
| CN109939231A (zh) * | 2017-12-21 | 2019-06-28 | 张曼 | 关于cd3×b7h3双特异性抗体定向杀伤膀胱癌细胞t24的应用 |
| CN109939126A (zh) * | 2017-12-21 | 2019-06-28 | 张曼 | Cd3×b7h3双特异抗体定向杀伤耐阿霉素膀胱癌细胞pumc-91/adm的应用 |
| CN109939232A (zh) * | 2017-12-21 | 2019-06-28 | 张曼 | 关于cd3×b7h3双特异性抗体定向杀伤膀胱癌细胞pumc-91的应用 |
| CN109939230A (zh) * | 2017-12-21 | 2019-06-28 | 张曼 | 关于cd3×b7h3双特异性抗体定向杀伤耐顺铂膀胱癌细胞t24/ddp的应用 |
| CN109971711A (zh) * | 2017-12-27 | 2019-07-05 | 张曼 | 关于cd3×b7h3双特异性抗体定向杀伤人膀胱癌细胞的应用 |
| AU2019222666B2 (en) | 2018-02-15 | 2025-12-04 | Macrogenics, Inc. | Variant CD3-binding domains and their use in combination therapies for the treatment of disease |
| IL323061A (en) | 2018-04-11 | 2025-10-01 | Inhibrx Biosciences Inc | Multispecific polypeptide constructs with forced CD3 binding and related methods and uses |
| TWI848953B (zh) | 2018-06-09 | 2024-07-21 | 德商百靈佳殷格翰國際股份有限公司 | 針對癌症治療之多特異性結合蛋白 |
| CN112789294A (zh) | 2018-07-24 | 2021-05-11 | 印希比股份有限公司 | 含有受限cd3结合结构域和受体结合区的多特异性多肽构建体及其使用方法 |
| CN109762068A (zh) * | 2018-08-09 | 2019-05-17 | 源道隆（苏州）医学科技有限公司 | 一种可靶向ctla4和pd-1的单基因双特异性抗体及其应用 |
| US11208485B2 (en) | 2018-10-11 | 2021-12-28 | Inhibrx, Inc. | PD-1 single domain antibodies and therapeutic compositions thereof |
| WO2020076970A1 (en) | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | B7h3 single domain antibodies and therapeutic compositions thereof |
| TW202033218A (zh) * | 2018-12-07 | 2020-09-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 多特異性蛋白分子 |
| BR112021010026A2 (pt) | 2018-12-07 | 2021-08-17 | Jiangsu Hengrui Medicine Co., Ltd. | anticorpo cd3 e seu uso farmacêutico |
| KR102732027B1 (ko) * | 2019-07-09 | 2024-11-20 | 주식회사 와이바이오로직스 | B7-h3(cd276)에 특이적으로 결합하는 항체 및 그의 용도 |
| CN111454357B (zh) * | 2019-08-14 | 2022-03-15 | 康诺亚生物医药科技（成都）有限公司 | 一种含有抗体的肿瘤治疗剂的开发和应用 |
| EP3822288A1 (en) * | 2019-11-18 | 2021-05-19 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Antibodies targeting, and other modulators of, the cd276 antigen, and uses thereof |
| WO2021133653A1 (en) * | 2019-12-23 | 2021-07-01 | Macrogenics, Inc. | Therapy for the treatment of cancer |
| CN115380047A (zh) | 2020-01-29 | 2022-11-22 | 印希比股份有限公司 | Cd28单结构域抗体及其多价和多特异性构建体 |
| US20240218069A1 (en) * | 2021-04-28 | 2024-07-04 | Lyvgen Biopharma Holdings Limited | Bi-specific antibodies comprising anti-b7h3 binding molecules |
| CN113527493B (zh) * | 2021-07-20 | 2023-10-27 | 广州爱思迈生物医药科技有限公司 | 一种b7-h3抗体及其应用 |
| US20230151095A1 (en) | 2021-11-12 | 2023-05-18 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and nkg2d |
| CN114539420B (zh) * | 2022-01-20 | 2024-05-17 | 荣昌生物制药(烟台)股份有限公司 | 抗b7-h3单克隆抗体、抗b7-h3×cd3双特异性抗体、制备方法及其应用 |
| CN117903311B (zh) * | 2024-03-20 | 2024-10-25 | 湖南卓润生物科技有限公司 | sST2特异性结合蛋白及其制备方法和应用 |
| WO2025245264A1 (en) * | 2024-05-21 | 2025-11-27 | Briapro Therapeutics Corp. | Anti-b7-h3 antibodies and methods of use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9150656B2 (en) * | 2010-03-04 | 2015-10-06 | Macrogenics, Inc. | Antibodies reactive with B7-H3, immunologically active fragments thereof and uses thereof |
| ME03440B (me) * | 2011-05-21 | 2020-01-20 | Macrogenics Inc | Cd3-vezujući molekuli sposobni za vezivanje za humani i nehumani cd3 |
| US10851178B2 (en) * | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US9487587B2 (en) * | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| US20140302037A1 (en) * | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| UA116479C2 (uk) * | 2013-08-09 | 2018-03-26 | Макродженікс, Інк. | БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ |
| EP2839842A1 (en) * | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
| IL258521B2 (en) * | 2015-10-08 | 2024-01-01 | Macrogenics Inc | Combination therapy for the treatment of cancer |
-
2016
- 2016-08-12 MA MA042665A patent/MA42665A/fr unknown
- 2016-08-12 HK HK18109035.8A patent/HK1249423A1/zh unknown
- 2016-08-12 WO PCT/US2016/046680 patent/WO2017030926A1/en not_active Ceased
- 2016-08-12 EA EA201890443A patent/EA201890443A1/ru unknown
- 2016-08-12 KR KR1020187007443A patent/KR20180038045A/ko not_active Withdrawn
- 2016-08-12 CR CR20180105A patent/CR20180105A/es unknown
- 2016-08-12 MX MX2018001954A patent/MX2018001954A/es unknown
- 2016-08-12 PE PE2018000249A patent/PE20181066A1/es unknown
- 2016-08-12 CN CN201680048182.7A patent/CN107921130A/zh active Pending
- 2016-08-12 EP EP16837560.8A patent/EP3337507A4/en not_active Withdrawn
- 2016-08-12 CA CA2995709A patent/CA2995709A1/en not_active Abandoned
- 2016-08-12 US US15/752,367 patent/US20190002563A1/en not_active Abandoned
- 2016-08-12 JP JP2018508741A patent/JP2018523686A/ja active Pending
- 2016-08-12 AU AU2016307955A patent/AU2016307955A1/en not_active Abandoned
- 2016-08-16 TW TW105126154A patent/TW201718652A/zh unknown
-
2018
- 2018-02-13 ZA ZA2018/00955A patent/ZA201800955B/en unknown
- 2018-02-15 PH PH12018500363A patent/PH12018500363A1/en unknown
- 2018-02-15 CO CONC2018/0001485A patent/CO2018001485A2/es unknown
- 2018-02-15 EC ECIEPI201811248A patent/ECSP18011248A/es unknown
- 2018-02-15 IL IL257562A patent/IL257562A/en unknown
- 2018-02-15 CL CL2018000422A patent/CL2018000422A1/es unknown
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