JP2016509582A5 - - Google Patents
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- JP2016509582A5 JP2016509582A5 JP2015549737A JP2015549737A JP2016509582A5 JP 2016509582 A5 JP2016509582 A5 JP 2016509582A5 JP 2015549737 A JP2015549737 A JP 2015549737A JP 2015549737 A JP2015549737 A JP 2015549737A JP 2016509582 A5 JP2016509582 A5 JP 2016509582A5
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- Prior art keywords
- antibody
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- molecule
- variable region
- chain variable
- Prior art date
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- 108010079206 V-Set Domain-Containing T-Cell Activation Inhibitor 1 Proteins 0.000 claims description 90
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 64
- 206010028980 Neoplasm Diseases 0.000 claims description 54
- 210000004027 cell Anatomy 0.000 claims description 44
- 101000955999 Homo sapiens V-set domain-containing T-cell activation inhibitor 1 Proteins 0.000 claims description 32
- 102000055298 human VTCN1 Human genes 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 31
- 201000011510 cancer Diseases 0.000 claims description 28
- 210000004981 tumor-associated macrophage Anatomy 0.000 claims description 20
- 201000010099 disease Diseases 0.000 claims description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
- 208000035473 Communicable disease Diseases 0.000 claims description 16
- 208000015181 infectious disease Diseases 0.000 claims description 16
- 230000001404 mediated effect Effects 0.000 claims description 16
- 210000004881 tumor cell Anatomy 0.000 claims description 16
- 230000001629 suppression Effects 0.000 claims description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 238000011282 treatment Methods 0.000 claims description 14
- 239000002246 antineoplastic agent Substances 0.000 claims description 13
- 239000000427 antigen Substances 0.000 claims description 10
- 102000036639 antigens Human genes 0.000 claims description 10
- 108091007433 antigens Proteins 0.000 claims description 10
- 238000003556 assay Methods 0.000 claims description 10
- 239000012634 fragment Substances 0.000 claims description 10
- 230000002380 cytological effect Effects 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 8
- 230000001747 exhibiting effect Effects 0.000 claims description 8
- 208000024891 symptom Diseases 0.000 claims description 8
- 230000001684 chronic effect Effects 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 230000003612 virological effect Effects 0.000 claims description 6
- 230000001413 cellular effect Effects 0.000 claims description 5
- 230000002147 killing effect Effects 0.000 claims description 5
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 206010062016 Immunosuppression Diseases 0.000 claims description 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 4
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 4
- 238000001815 biotherapy Methods 0.000 claims description 4
- 238000002512 chemotherapy Methods 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 238000001794 hormone therapy Methods 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 4
- 230000001506 immunosuppresive effect Effects 0.000 claims description 4
- 238000009169 immunotherapy Methods 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 239000003446 ligand Substances 0.000 claims description 4
- 210000002540 macrophage Anatomy 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 238000001959 radiotherapy Methods 0.000 claims description 4
- 238000001356 surgical procedure Methods 0.000 claims description 4
- 239000003053 toxin Substances 0.000 claims description 4
- 231100000765 toxin Toxicity 0.000 claims description 4
- 230000005909 tumor killing Effects 0.000 claims description 4
- 230000034994 death Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 101100370002 Mus musculus Tnfsf14 gene Proteins 0.000 claims description 2
- 238000003364 immunohistochemistry Methods 0.000 claims description 2
- 210000004882 non-tumor cell Anatomy 0.000 claims description 2
- 230000006037 cell lysis Effects 0.000 claims 2
- 238000011394 anticancer treatment Methods 0.000 claims 1
- 206010057248 Cell death Diseases 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261739287P | 2012-12-19 | 2012-12-19 | |
| US201261739353P | 2012-12-19 | 2012-12-19 | |
| US201261739272P | 2012-12-19 | 2012-12-19 | |
| US61/739,287 | 2012-12-19 | ||
| US61/739,353 | 2012-12-19 | ||
| US61/739,272 | 2012-12-19 | ||
| PCT/US2013/076701 WO2014100483A1 (en) | 2012-12-19 | 2013-12-19 | Anti-human b7-h4 antibodies and their uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016509582A JP2016509582A (ja) | 2016-03-31 |
| JP2016509582A5 true JP2016509582A5 (enExample) | 2017-01-19 |
Family
ID=49917300
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015549721A Pending JP2016505843A (ja) | 2012-12-19 | 2013-12-19 | Ｂ７−ｈ４特異的抗体、並びにその組成物及び使用方法 |
| JP2015549737A Pending JP2016509582A (ja) | 2012-12-19 | 2013-12-19 | 抗ヒトｂ７−ｈ４抗体およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015549721A Pending JP2016505843A (ja) | 2012-12-19 | 2013-12-19 | Ｂ７−ｈ４特異的抗体、並びにその組成物及び使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9574000B2 (enExample) |
| EP (2) | EP2934575A2 (enExample) |
| JP (2) | JP2016505843A (enExample) |
| KR (1) | KR20150100716A (enExample) |
| CN (1) | CN104955475A (enExample) |
| AU (2) | AU2013361275B2 (enExample) |
| BR (1) | BR112015014063A2 (enExample) |
| CA (2) | CA2894879A1 (enExample) |
| HK (1) | HK1210027A1 (enExample) |
| MX (1) | MX2015007846A (enExample) |
| RU (1) | RU2015129551A (enExample) |
| SG (1) | SG11201504764SA (enExample) |
| WO (2) | WO2014100439A2 (enExample) |
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2013
- 2013-12-19 CA CA2894879A patent/CA2894879A1/en not_active Abandoned
- 2013-12-19 CA CA2894689A patent/CA2894689A1/en not_active Abandoned
- 2013-12-19 WO PCT/US2013/076619 patent/WO2014100439A2/en not_active Ceased
- 2013-12-19 AU AU2013361275A patent/AU2013361275B2/en not_active Ceased
- 2013-12-19 MX MX2015007846A patent/MX2015007846A/es unknown
- 2013-12-19 WO PCT/US2013/076701 patent/WO2014100483A1/en not_active Ceased
- 2013-12-19 EP EP13815940.5A patent/EP2934575A2/en not_active Withdrawn
- 2013-12-19 JP JP2015549721A patent/JP2016505843A/ja active Pending
- 2013-12-19 EP EP13818155.7A patent/EP2934576A1/en not_active Withdrawn
- 2013-12-19 HK HK15110787.9A patent/HK1210027A1/xx unknown
- 2013-12-19 JP JP2015549737A patent/JP2016509582A/ja active Pending
- 2013-12-19 RU RU2015129551A patent/RU2015129551A/ru not_active Application Discontinuation
- 2013-12-19 CN CN201380066946.1A patent/CN104955475A/zh active Pending
- 2013-12-19 AU AU2013361231A patent/AU2013361231A1/en not_active Abandoned
- 2013-12-19 BR BR112015014063-7A patent/BR112015014063A2/en not_active IP Right Cessation
- 2013-12-19 KR KR1020157017826A patent/KR20150100716A/ko not_active Withdrawn
- 2013-12-19 SG SG11201504764SA patent/SG11201504764SA/en unknown
- 2013-12-19 US US14/654,074 patent/US9574000B2/en not_active Expired - Fee Related
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