JP2020529469A5 - - Google Patents

Download PDF

Info

Publication number
JP2020529469A5
JP2020529469A5 JP2020527838A JP2020527838A JP2020529469A5 JP 2020529469 A5 JP2020529469 A5 JP 2020529469A5 JP 2020527838 A JP2020527838 A JP 2020527838A JP 2020527838 A JP2020527838 A JP 2020527838A JP 2020529469 A5 JP2020529469 A5 JP 2020529469A5
Authority
JP
Japan
Prior art keywords
gal3
tim
cdr
inhibitor
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020527838A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020529469A (ja
JP7368856B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/043513 external-priority patent/WO2019023247A1/en
Publication of JP2020529469A publication Critical patent/JP2020529469A/ja
Publication of JP2020529469A5 publication Critical patent/JP2020529469A5/ja
Priority to JP2023118382A priority Critical patent/JP7789386B2/ja
Application granted granted Critical
Publication of JP7368856B2 publication Critical patent/JP7368856B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020527838A 2017-07-25 2018-07-24 Tim-3とそのリガンドとの相互作用の遮断によるがん治療 Active JP7368856B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023118382A JP7789386B2 (ja) 2017-07-25 2023-07-20 Tim-3とそのリガンドとの相互作用の遮断によるがん治療

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762536886P 2017-07-25 2017-07-25
US62/536,886 2017-07-25
PCT/US2018/043513 WO2019023247A1 (en) 2017-07-25 2018-07-24 TREATMENT OF CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND ITS LIGAND

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023118382A Division JP7789386B2 (ja) 2017-07-25 2023-07-20 Tim-3とそのリガンドとの相互作用の遮断によるがん治療

Publications (3)

Publication Number Publication Date
JP2020529469A JP2020529469A (ja) 2020-10-08
JP2020529469A5 true JP2020529469A5 (enExample) 2021-08-26
JP7368856B2 JP7368856B2 (ja) 2023-10-25

Family

ID=65040896

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020527838A Active JP7368856B2 (ja) 2017-07-25 2018-07-24 Tim-3とそのリガンドとの相互作用の遮断によるがん治療

Country Status (7)

Country Link
US (3) US12227567B2 (enExample)
EP (1) EP3658172A4 (enExample)
JP (1) JP7368856B2 (enExample)
CN (1) CN111201030B (enExample)
AU (1) AU2018308088B2 (enExample)
CA (1) CA3070446A1 (enExample)
WO (1) WO2019023247A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018308088B2 (en) 2017-07-25 2025-05-29 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
US12180285B2 (en) * 2018-02-01 2024-12-31 Memorial Sloan Kettering Cancer Center Antibodies to galectin-3 and methods of use thereof
JP2022523333A (ja) * 2019-01-30 2022-04-22 トゥルーバインディング,インコーポレイテッド 抗gal3抗体およびその使用
CN115279789A (zh) * 2019-12-06 2022-11-01 真和制药有限公司 破坏gal3和胰岛素受体或整联蛋白的相互作用的抗体及其使用方法
AU2021207461A1 (en) * 2020-01-13 2022-09-01 Truebinding, Inc. Anti-Gal3 antibodies and methods of use
JP7421400B2 (ja) * 2020-03-30 2024-01-24 アークレイ株式会社 ヒトガレクチン-3の分析、検出、測定に関する抗体、方法及びキット
US12281166B2 (en) 2020-05-26 2025-04-22 Truebinding, Inc. Methods of treating inflammatory diseases by blocking Galectin-3
EP4259201A4 (en) * 2020-12-08 2025-03-19 Memorial Sloan Kettering Cancer Center Antibodies to galectin-3 and methods of use thereof
EP4326773A4 (en) 2021-04-23 2025-09-24 Suzhou Neologics Bioscience Co Ltd ANTIBODIES TARGETING TIM-3 AND THEIR USES
US20240285740A1 (en) 2021-05-12 2024-08-29 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating cancer
EP4370555A4 (en) 2021-07-13 2025-11-12 Truebinding Inc METHODS FOR PREVENTING PROTEIN AGGREGATION
JP2024544508A (ja) 2021-11-09 2024-12-03 トゥルーバインディング,インコーポレイテッド 心臓血管疾患を治療または阻害する方法

Family Cites Families (765)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
JPS5896026A (ja) 1981-10-30 1983-06-07 Nippon Chemiphar Co Ltd 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤
US4609546A (en) 1982-06-24 1986-09-02 Japan Chemical Research Co., Ltd. Long-acting composition
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
JPH01207920A (ja) 1988-02-16 1989-08-21 Oki Electric Ind Co Ltd InP半導体薄膜の製造方法
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5270202A (en) 1989-11-03 1993-12-14 Syamal Raychaudhuri Anti-idiotypic antibodies to human melanoma-associated proteoglycan antigen
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
IE911869A1 (en) 1990-06-01 1991-12-04 Regeneron Pharma A family of map2 protein kinases
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5780587A (en) 1990-08-24 1998-07-14 President And Fellows Of Harvard College Compounds and methods for inhibiting β-protein filament formation and neurotoxicity
MX9205293A (es) 1991-09-20 1993-05-01 Syntex Sinergen Neuroscience J Factores neurotrofico derivado del glial
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
AU3178993A (en) 1991-11-25 1993-06-28 Enzon, Inc. Multivalent antigen-binding proteins
WO1993011231A1 (en) 1991-12-06 1993-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Tools for the diagnosis and treatment of alzheimer's disease
US5624807A (en) 1992-07-22 1997-04-29 The Mclean Hospital Corporation Methods for detecting Alzheimer's disease by measuring ratios of calcium-activated neutral protease isoforms
EP0672142B1 (en) 1992-12-04 2001-02-28 Medical Research Council Multivalent and multispecific binding proteins, their manufacture and use
WO1994021293A1 (en) 1993-03-19 1994-09-29 Duke University Method of treatment of tumors with an antibody binding to tenascin
ES2173130T3 (es) 1993-10-20 2002-10-16 Univ Duke Metodo de fijacion de material al peptido beta-amiloide.
US5985660A (en) 1994-06-15 1999-11-16 Systemix, Inc. Method of identifying biological response modifiers involved in dendritic and/or lymphoid progenitor cell proliferation and/or differentiation
CU22615A1 (es) 1994-06-30 2000-02-10 Centro Inmunologia Molecular Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos
ATE306930T1 (de) 1994-08-12 2005-11-15 Immunomedics Inc Für b-zell-lymphom und leukämiezellen spezifische immunkonjugate und humane antikörper
JPH10504961A (ja) 1994-08-26 1998-05-19 ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド Gaba▲下a▼レセプターイプシロンサブユニット
KR100275591B1 (ko) 1994-10-28 2001-02-01 크리스타 헤르 조크 단백질 키나아제 npk-110
US6835555B1 (en) 1994-11-01 2004-12-28 Human Genome Sciences, Inc. Interleukin-1 β converting enzyme like apoptosis protease-3 and 4
US7427392B1 (en) 1994-11-14 2008-09-23 Elan Pharmaceuticals, Inc. Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau
DE4447287C1 (de) 1994-12-30 1996-11-07 Cevc Gregor Präparat zum Wirkstofftransport durch Barrieren
US5650313A (en) 1995-06-05 1997-07-22 Human Genome Sciences, Inc. Ubiquitin conjugating enzymes 8 and 9
US5786180A (en) 1995-02-14 1998-07-28 Bayer Corporation Monoclonal antibody 369.2B specific for β A4 peptide
GB9506197D0 (en) 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
US6576607B1 (en) 1995-04-19 2003-06-10 Acorda Therapeutics Methods using CNS neurite outgrowth modulators
US5986054A (en) 1995-04-28 1999-11-16 The Hospital For Sick Children, Hsc Research And Development Limited Partnership Genetic sequences and proteins related to alzheimer's disease
US6221645B1 (en) 1995-06-07 2001-04-24 Elan Pharmaceuticals, Inc. β-secretase antibody
DE69635207T2 (de) 1995-07-07 2006-06-22 Darwin Molecular Corp. Auf Chromosom 1 lokalisiertes Gen dessen Genprodukt mit der Alzheimerschen Krankheit assoziiert ist.
US6156311A (en) 1995-07-27 2000-12-05 The American National Red Cross Modulators of expression and function of LRP in alzheimer's disease
US5695937A (en) 1995-09-12 1997-12-09 The Johns Hopkins University School Of Medicine Method for serial analysis of gene expression
FR2741892B1 (fr) 1995-12-04 1998-02-13 Pasteur Merieux Serums Vacc Procede de preparation d'une banque multicombinatoire de vecteurs d'expression de genes d'anticorps, banque et systemes d'expression d'anticorps "coliclonaux" obtenus
US5936078A (en) 1995-12-12 1999-08-10 Kyowa Hakko Kogyo Co., Ltd. DNA and protein for the diagnosis and treatment of Alzheimer's disease
AUPN896596A0 (en) 1996-03-27 1996-04-26 Walter And Eliza Hall Institute Of Medical Research, The Therapeutic molecules
CA2250075C (en) 1996-03-29 2008-06-10 The Trustees Of Boston University Methods for diagnosing and treating alzheimer's disease
US6455277B1 (en) 1996-04-22 2002-09-24 Amgen Inc. Polynucleotides encoding human glial cell line-derived neurotrophic factor receptor polypeptides
US5663059A (en) 1996-05-10 1997-09-02 Incyte Pharmaceuticals, Inc. Human phospholipase inhibitor
US6010878A (en) 1996-05-20 2000-01-04 Smithkline Beecham Corporation Interleukin-1 β converting enzyme like apoptotic protease-6
CA2183901A1 (en) 1996-08-22 1998-02-23 Johanna E. Bergmann Targets for therapy and diagnosis of alzheimer's disease and down syndrome in humans
CA2279231C (en) 1997-02-07 2013-11-26 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Activity dependent neurotrophic factor iii (adnf iii)
US6413940B1 (en) 1997-02-07 2002-07-02 Nymox Corporation Pharmaceutically active agents that impede the formation of amyloid by impeding the genesis of DMS
US6087153A (en) 1997-07-24 2000-07-11 The Trustees Of Columbia University In The City Of New York Sel-10 and uses thereof
IT1293511B1 (it) 1997-07-30 1999-03-01 Gentili Ist Spa Anticorpi monoclonali catalitici ad attivita' proteasica per la lisi selettiva della componente proteica di placche e aggregati correlati
US7384910B2 (en) 1997-10-08 2008-06-10 Castillo Gerardo M Small peptides for the treatment of Alzheimer's disease and other beta-amyloid protein fibrillogenesis disorders
US6242421B1 (en) 1997-11-06 2001-06-05 Richard Lloyd Bowen Methods for preventing and treating Alzheimer's disease
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US7189703B2 (en) 1998-01-09 2007-03-13 Intracell, Llc Treatment and diagnosis of alzheimer's disease
GB9816575D0 (en) 1998-07-31 1998-09-30 Zeneca Ltd Novel compounds
DE69931791T2 (de) 1998-08-06 2007-05-24 Teijin Ltd. Pharmazeutische zusammensetzung die ein inhibierendes effekt auf die überproduktion und akkumulation der extrazellulären matrix hat
US20050032675A1 (en) 1998-08-06 2005-02-10 Teijin Limited Pharmaceutical composition having inhibitory effect on overproduction and accumulation of extracellular matrix
GB9818731D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Compounds
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
DK1193270T3 (da) 1998-08-27 2003-09-15 Spirogen Ltd Pyrrolobenzodiazepiner
BR9913850A (pt) 1998-09-17 2001-10-23 Otsuka Pharma Co Ltd Gene ly6h
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
JP2002531815A (ja) 1998-12-02 2002-09-24 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア オキシダント・ストレス症候群および疾病における脂質の過酸化のレベルを決定する方法および組成物
US6982089B2 (en) 1999-02-24 2006-01-03 Tact Ip, Llc Cytokine antagonists for neurological and neuropsychiatric disorders
DE19909357A1 (de) 1999-03-03 2000-09-07 Gerd Multhaup Kupferagonist, der an die Kupferbindungsstelle von APP bindet und/oder eine hemmende Wirkung auf die Freisetzung des Amyloid-Aß-Peptids ausübt
DE19910108C2 (de) 1999-03-08 2001-02-22 Falk Fahrenholz Zellen, die ein Amyloidvorläuferprotein und eine alpha-Sekretase coexprimieren, ein Testverfahren zur Identifikation alpha-Sekretase-aktiver Substanzen sowie eines zur Identifikation weiterer Sekretasen, ein Testverfahren zur Bestimmung der Anfälligkeit gegenüber Morbus Alzheimer und Verwendung von Nukleinsäuren, die für eine alpha-Sekretase codieren, für die Gentherapie
WO2000062076A1 (en) 1999-04-13 2000-10-19 Hsu Daniel K Galectin expression is induced in cirrhotic liver and hepatocellular carcinoma
US6303576B1 (en) 1999-04-21 2001-10-16 Adherex Technologies Inc. Compounds and methods for modulating β-catenin mediated gene expression
UA81216C2 (en) 1999-06-01 2007-12-25 Prevention and treatment of amyloid disease
WO2001004300A1 (fr) 1999-07-08 2001-01-18 Helix Research Institute Facteur associe a l'apoptose
EP1074634B1 (en) 1999-07-09 2002-10-02 Institut Pasteur De Lille Method for the diagnosis or the prognosis of Alzheimer disease therapeutical composition for preventing or treating Alzheimer disease
DK1255824T3 (da) 1999-08-06 2010-07-19 S I S S A Scuola Internaz Supe Transgene mus til undersøgelse af neurodegenerative syndromer
AU784568B2 (en) 1999-09-03 2006-05-04 Ramot At Tel-Aviv University Ltd Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming diseases
US6255054B1 (en) 1999-09-09 2001-07-03 Jacques Hugon Polymorphism of the human GluR-5 gene and risk factor for alzheimer disease
ATE294859T1 (de) 1999-09-17 2005-05-15 Univ Keio Polypeptid, humanin, welches das absterben von nervenzellen hemmt
US20020094335A1 (en) 1999-11-29 2002-07-18 Robert Chalifour Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases
CN1241940C (zh) 2000-02-14 2006-02-15 株式会社Bf研究所 新型胶原蛋白样蛋白clac、其前体和它们的编码基因
KR100767146B1 (ko) 2000-02-24 2007-10-15 워싱톤 유니버시티 Aβ 펩티드를 격리시키는 인간화 항체
AU2001243622A1 (en) 2000-03-13 2001-09-24 La Jolla Institute For Allergy And Immunology Monocyte chemoattractant activity of galectin-3
US20060148712A1 (en) 2000-03-13 2006-07-06 Fu-Tong Liu Monocyte chemoattractant activity of galectin-3
AU2001268828C1 (en) 2000-06-28 2006-12-14 Prana Biotechnology Limited Neurotoxic oligomers
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
AU2001268005A1 (en) 2000-07-07 2002-01-21 Lars Lannfelt Prevention and treatment of alzheimer's disease
US6825164B1 (en) 2000-08-14 2004-11-30 The Trustees Of Columbia University In The City Of New York Method to increase cerebral blood flow in amyloid angiopathy
CA2392004C (en) 2000-09-20 2005-11-29 Matsushita Electric Industrial Co., Ltd. Probe for scanning probe microscope and method for producing the same, and scanning probe microscope including the probe and molecular processing method using the scanning probe microscope
US7471798B2 (en) * 2000-09-29 2008-12-30 Knowles Electronics, Llc Microphone array having a second order directional pattern
KR100395254B1 (ko) 2000-10-30 2003-08-21 (주)자리타 바이오텍 종양 발생 예측 키트
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US7320793B2 (en) 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
AT500379B8 (de) 2001-02-02 2009-08-15 Axon Neuroscience Tau-proteine
ES2305234T3 (es) 2001-02-27 2008-11-01 Blanchette Rockefeller Neurosciences Institute Diagnostico de la enfermedad de alzheimer basado en la fosforilacion de una proteina quinosa activada por mitogeno.
DE10117281A1 (de) 2001-04-06 2002-10-24 Inst Molekulare Biotechnologie Peptid zur Diagnose und Therapie der Alzheimer-Demenz
EP1379882B1 (en) 2001-04-14 2008-07-16 EVOTEC Neurosciences GmbH Diagnostic and therapeutic use of a nuclear restricted protein for alzheimer's disease and related neurodegenerative disorders
ATE420114T1 (de) 2001-04-30 2009-01-15 Lilly Co Eli Humanisierte antikörper die das beta-amyloid peptid erkennen& x9;
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US6906169B2 (en) 2001-05-25 2005-06-14 United Biomedical, Inc. Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide
DE10130247A1 (de) 2001-06-22 2003-01-16 Elegene Ag I Ins Identifizierung von ses-3 sowie dessen Verwendungen
DE10130166A1 (de) 2001-06-22 2003-01-16 Elegene Ag I Ins Identifizierung von ses-1 sowie dessen Verwendungen
US6831699B2 (en) 2001-07-11 2004-12-14 Chang Industry, Inc. Deployable monitoring device having self-righting housing and associated method
DE60226036T9 (de) 2001-08-03 2016-09-29 Medical & Biological Laboratories Co., Ltd. ANTIKÖRPER, DER DAS GM1-GANGLIOSID-GEBUNDENE AMYLOID-b-PROTEIN ERKENNT, UND DNA, DIE FÜR DIESEN ANTIKÖRPER CODIERT
ATE464567T1 (de) 2001-09-07 2010-04-15 Takeda Pharmaceutical Diagnostische und therapeutische verwendung von f-box-proteinen bei morbus alzheimer und verwandten neurodegenerativen erkrankungen
US6716821B2 (en) 2001-12-21 2004-04-06 Immunogen Inc. Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
DE60303360T2 (de) 2002-02-14 2006-09-21 Evotec Neurosciences Gmbh Diagnostische und therapeutische verwendung des caps
AU2003208212A1 (en) 2002-03-04 2003-09-16 Nymox Corporation Spheron components useful in determining compounds capable of treating symptoms of alzheimer's disease, and treatments and animal models produced therefrom
AU2003225636A1 (en) 2002-03-05 2003-09-22 Ramot At Tel-Aviv University Ltd. Immunizing composition and method for inducing an immune response against the ss-secretase cleavage site of amyloid precursor protein
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
AU2003215667A1 (en) 2002-03-21 2003-10-08 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of human maguin proteins and nucleic acids for neurodegenerative diseases
NZ536064A (en) 2002-04-19 2008-06-30 Univ Toronto Immunological methods and compositions for the treatment of alzheimer's disease
WO2003091734A1 (en) 2002-04-24 2003-11-06 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of ensadin-0477 gene and protein for neurodegenerative diseases
US20050032673A1 (en) 2002-06-10 2005-02-10 John Constance M. Sustained release N-terminally truncated galectin-3 and antibodies to galectin-3 carbohydrate ligands for use in treating disease
AU2003245589A1 (en) 2002-06-21 2004-01-06 Reuven Avrohom Cyrulnik System and method for noninvasive diagnostic imaging
DE60317671T2 (de) 2002-06-27 2008-10-30 Evotec Neurosciences Gmbh Diagnostische und therapeutische verwendung von ensadin-0581 gen und protein für neurodegenerative erkrankungen
US7141137B2 (en) 2002-07-10 2006-11-28 University Of Maine System Board Of Trustees Method of making laminated wood beams with varying lamination thickness throughout the thickness of the beam
JP4414332B2 (ja) 2002-07-12 2010-02-10 アクソン・ニューロサイエンス・フォルシュングス−ウント・エントヴィックルングス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング アルツハイマーtauタンパク質を発現するトランスジェニック動物
RU2450827C2 (ru) 2002-07-19 2012-05-20 Цитос Биотехнологи Аг Композиции вакцин, содержащие наборы антигенов в виде амилоида бета 1-6
CA2802205C (en) 2002-07-31 2016-01-19 Seattle Genetics, Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
MXPA05003621A (es) 2002-10-09 2005-10-19 Rinat Neuroscience Corp Metodos de tratamiento de la enfermedad de alzheimer usando anticuerpos dirigidos contra el peptido beta amiloide y composiciones de los mismos.
AT413945B (de) 2003-01-14 2006-07-15 Mattner Frank Dr Impfstoff für die alzheimer-krankheit
PL378571A1 (pl) 2003-02-01 2006-05-02 Neuralab Limited Czynna immunizacja dla wytworzenia przeciwciał przeciw rozpuszczalnemu A-ß
WO2004070388A1 (en) 2003-02-04 2004-08-19 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of scn2b protein for neurodegenerative diseases
DE602004027348D1 (de) 2003-02-10 2010-07-08 Applied Molecular Evolution Abeta-bindende moleküle
US8663650B2 (en) 2003-02-21 2014-03-04 Ac Immune Sa Methods and compositions comprising supramolecular constructs
US20040223971A1 (en) * 2003-04-07 2004-11-11 Glycogenesys, Inc. Composition and uses of galectin antagonists
AU2004229399B2 (en) 2003-04-07 2010-08-05 Prospect Therapeutics, Inc. Composition and uses of galectin antagonists
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
ES2246177B1 (es) 2003-05-08 2007-03-01 Universidad De Zaragoza. Uso de anticuerpos para el tratamiento de enfermedades amiloideas.
US7276497B2 (en) 2003-05-20 2007-10-02 Immunogen Inc. Cytotoxic agents comprising new maytansinoids
PE20050627A1 (es) 2003-05-30 2005-08-10 Wyeth Corp Anticuerpos humanizados que reconocen el peptido beta amiloideo
WO2004111654A2 (en) 2003-06-06 2004-12-23 Ciphergen Biosystems, Inc. Serum biomarkers in ischaemic heart disease
JP4888876B2 (ja) 2003-06-13 2012-02-29 田平 武 アルツハイマー病の治療のための組換えアデノ随伴ウィルスベクター
US7384523B2 (en) 2003-07-10 2008-06-10 Radiometer Medical Aps Chloride ion selective membrane and sensor
MXPA06001107A (es) 2003-07-28 2006-04-11 Sig Technology Ltd Cierre vertedor con un arreglo de borde perforador para envases combinados o recipientes sellados con material de papel metalizado.
JP4448134B2 (ja) 2003-08-08 2010-04-07 シェーリング コーポレイション ベンズアミド置換基を有する環状アミンbase−1阻害剤
AR045219A1 (es) 2003-08-08 2005-10-19 Pharmacopeia Inc Aminas ciclicas inhibidoras de base - 1 que poseen un sustiuyente heterociclico
EP1669085B1 (en) 2003-09-05 2015-01-07 Hisamitsu Pharmaceutical Co., Inc. Medical agent for prevention and/or treatment of alzheimer disease
AT413336B (de) 2003-09-12 2006-02-15 Mattner Frank Dr Apherese-vorrichtung
EP1670943B1 (en) 2003-09-30 2013-11-13 Evotec International GmbH Diagnostic and therapeutic use of a sulfotransferase for alzheimer's disease
US7700823B2 (en) 2003-10-02 2010-04-20 Aventis Pharma S.A. Transgenic animals exhibiting major disorders related to Alzheimer's disease
BRPI0414924A (pt) * 2003-10-03 2006-11-07 Brigham & Womens Hospital ligantes de tim-3 e seus métodos
GB0416511D0 (en) 2003-10-22 2004-08-25 Spirogen Ltd Pyrrolobenzodiazepines
JP2007514406A (ja) 2003-10-29 2007-06-07 エヴォテック ニューロサイエンシス ゲゼルシャフト ミット ベシュレンクテル ハフツング ヒトdax−1遺伝子およびタンパク質の神経変性疾患に関する診断的および治療的使用
ME01775B (me) 2003-11-05 2011-02-28 Glycart Biotechnology Ag Cd20 antitijela sa povećanim afinitetom vezivanja za fc receptor i efektornom funkcijom
NZ583292A (en) 2003-11-06 2012-03-30 Seattle Genetics Inc Monomethylvaline compounds capable of conjugation to ligands
WO2005058352A2 (en) 2003-12-17 2005-06-30 Entelos, Inc. Treatment of rheumatoid arthritis with galectin-3 antagonists
PT1697370E (pt) 2003-12-19 2007-05-31 Bristol Myers Squibb Co Heterociclos azabicíclicos como moduladores do receptor de canabinóides
JP4824547B2 (ja) 2004-02-20 2011-11-30 インテレクト ニュウロサイエンシス,インク. モノクローナル抗体およびその利用
US8060179B1 (en) 2006-11-16 2011-11-15 Scientific Nanomedicine, Inc. Biomagnetic detection and treatment of Alzheimer's Disease
US20070166718A1 (en) 2004-03-03 2007-07-19 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of mal2 gene and protein for neurodegenerative diseases
JP5166861B2 (ja) 2004-03-09 2013-03-21 スピロゲン リミティッド ピロロベンゾジアゼピン
US20050239836A1 (en) 2004-03-09 2005-10-27 Varghese John Substituted hydroxyethylamine aspartyl protease inhibitors
EP1741783A4 (en) 2004-04-27 2009-05-27 Chemo Sero Therapeut Res Inst HUMAN ANTIAMYLOID BETA PEPTIDE ANTIBODY AND ANTIBODY FRAGMENT THEREOF
US7629443B2 (en) 2004-06-02 2009-12-08 New York Blood Center, Inc. Neutralizing monoclonal antibodies against severe acute respiratory syndrome-associated coronavirus
WO2005123048A2 (en) 2004-06-21 2005-12-29 Proteome Sciences Plc Screening methods using c-abl, fyn and syk in combination with tau protein
SE0401601D0 (sv) 2004-06-21 2004-06-21 Bioarctic Neuroscience Ab Protofibril specific antibodies and uses thereof
CN1969277A (zh) 2004-07-07 2007-05-23 三菱电机株式会社 电力计算装置、电力计算方法、抗侵害性评价装置和抗侵害性评价方法
AT413946B (de) 2004-07-13 2006-07-15 Mattner Frank Dr Impfstoff gegen die alzheimer-krankheit
AT500483B1 (de) 2004-07-13 2006-01-15 Mattner Frank Dr Set zur vorbeugung oder behandlung der alzheimer'schen erkrankung
US7955812B2 (en) 2004-07-19 2011-06-07 The General Hospital Corporation Methods of diagnosing alzheimer's disease by detecting antibodies to cross-linked β-amyloid oligomers
US20060024667A1 (en) 2004-07-29 2006-02-02 Karen Manucharyan Compositions and methods for Alzheimer's disease
AR050184A1 (es) 2004-07-28 2006-10-04 Schering Corp Inhibidores macrociclicos de beta-secretasa
MX2007001559A (es) 2004-08-03 2007-04-10 Transtech Pharma Inc Proteinas de fusion de receptor para productos finales glicados avanzados y metodos de uso.
US20080301821A1 (en) 2004-08-11 2008-12-04 Evotec Neurosciences Gmbh Diagnostic and Therapeutic use of a Plasma Membrane Atpase
AU2005272396A1 (en) 2004-08-11 2006-02-16 Mitsubishi Chemical Corporation Antibody and utilization of the same
GB0421639D0 (en) 2004-09-29 2004-10-27 Proteome Sciences Plc Methods and compositions relating to alzheimer's disease
WO2006037800A1 (en) 2004-10-08 2006-04-13 Université de Liège COMPLEMENTARY PEPTIDES FOR ß-AMYLOID 29-42 PEPTIDE
US9907485B2 (en) 2004-10-15 2018-03-06 Brainlab Ag Targeted immunization and plaque destruction against Alzheimer's disease
WO2006055178A2 (en) 2004-10-25 2006-05-26 Merck & Co., Inc. Anti-addl antibodies and uses thereof
AU2005332660A1 (en) 2004-11-12 2006-12-14 Seattle Genetics, Inc. Auristatins having an aminobenzoic acid unit at the N terminus
EP1838854B1 (en) 2004-12-15 2012-10-31 Janssen Alzheimer Immunotherapy Antibodies that recognize Beta Amyloid Peptide
US8257740B1 (en) 2011-08-15 2012-09-04 Gp Medical, Inc. Pharmaceutical composition of nanoparticles
US20060257359A1 (en) 2005-02-28 2006-11-16 Cedric Francois Modifying macrophage phenotype for treatment of disease
US7632634B2 (en) 2005-04-15 2009-12-15 University Of Maryland Biotechnology Institute Method and assay for early diagnosis of prostate cancer
EP1891215B1 (en) 2005-04-20 2009-10-28 Dnavec Corporation Highly safe intranasally administrable gene vaccines for treating alzheimer's disease
AU2006238686B2 (en) 2005-04-21 2011-10-06 Medimmune Limited Pyrrolobenzodiazepines
UY29504A1 (es) 2005-04-29 2006-10-31 Rinat Neuroscience Corp Anticuerpos dirigidos contra el péptido amiloide beta y métodos que utilizan los mismos.
BRPI0610093A2 (pt) 2005-05-05 2008-12-09 Merck & Co Inc composiÇço farmacÊutica, e, mÉtodo para prevenir ou tratar uma doenÇa associada com os depàsitos de amilàides de alfa-beta no cÉrebro de um paciente
CN109485727A (zh) 2005-05-09 2019-03-19 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
WO2006128879A1 (en) 2005-05-30 2006-12-07 Takeda Pharmaceutical Company Limited Diagnostic and therapeutic target prkx proteins for neurodegenerative diseases
US20090133135A1 (en) 2005-06-01 2009-05-21 Evotec Neurosciences Gmbh Diagnostic and Therapeutic Target SLC39A11 Proteins for Neurodegenerative Diseases
ES2436795T3 (es) 2005-06-14 2014-01-07 Merck Sharp & Dohme Corp. Inhibidores heterocíclicos de aspartil proteasa, preparación y uso de los mismos
DE602006018456D1 (de) 2005-06-14 2011-01-05 Schering Corp Herstellung und verwendung von verbindungen als aspartylproteasehemmer
ATE495269T1 (de) 2005-06-16 2011-01-15 Evotec Neurosciences Gmbh Adarb2 proteine als diagnostische und therapeutische targets für neurodegenerative erkrankungen
CA2611054C (en) 2005-06-17 2017-05-09 National Research Council Of Canada Novel a.beta.-binding polypeptides and derivatives and uses thereof
DE102005029729A1 (de) 2005-06-24 2006-12-28 Röchling Automotive AG & Co. KG Verkleidungs- oder Gehäuseteil eines Fahrzeugs und Verfahren zu seiner Herstellung
US8871720B2 (en) 2005-07-07 2014-10-28 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
US20070021282A1 (en) 2005-07-19 2007-01-25 Karp Shaun A Abdominal exercising and strength testing systems
WO2007022416A2 (en) 2005-08-18 2007-02-22 Ramot At Tel Aviv University Ltd. Single chain antibodies against beta-amyloid peptide
WO2007027559A2 (en) 2005-08-29 2007-03-08 Shashoua Victor E Neuroprotective and neurorestorative methods and compositions
US9133267B2 (en) 2005-11-22 2015-09-15 The Trustees Of The University Of Pennsylvania Antibody treatment of Alzheimer's and related diseases
MX2008006957A (es) 2005-11-30 2008-10-20 Abbott Lab Metodos para la preparacion de formas recombinantes de proteina beta-amiloide humana y usos de estas proteinas.
SG10201706600VA (en) 2005-11-30 2017-09-28 Abbvie Inc Monoclonal antibodies and uses thereof
DK1813614T3 (da) 2006-01-25 2012-01-23 Sanofi Sa Cytotoksiske midler, der omfatter nye tomaymycinderivater
US7750116B1 (en) 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
CA2638775A1 (en) 2006-02-22 2007-08-30 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Peptide vaccine for inducing production of anti-amyloid-.beta.-peptide antibody
AU2007219615B2 (en) 2006-03-03 2013-11-28 Promis Neurosciences Inc. Methods and compositions to treat and detect misfolded-SOD1 mediated diseases
EP2005187A4 (en) 2006-03-23 2010-04-21 Life Technologies Corp METHOD AND REAGENTS FOR IN VIVO IMAGING CANCER CELL LINES
BRPI0709050B1 (pt) 2006-03-23 2018-12-26 Bioarctic Neuroscience Ab anticorpo ou fragmento do mesmo, composição, métodos para detectar protofibrilas ab in vitro, e, uso do anticorpo
US8012936B2 (en) 2006-03-29 2011-09-06 New York University Tau fragments for immunotherapy
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
WO2007129457A1 (ja) 2006-04-25 2007-11-15 The University Of Tokyo アルツハイマー病および癌の治療薬
WO2008042024A2 (en) 2006-06-01 2008-04-10 Elan Pharmaceuticals, Inc. Neuroactive fragments of app
WO2008004346A1 (fr) 2006-07-06 2008-01-10 Nec Corporation Procédé et dispositif de conception d'une hiérarchie de circuit intégré semi-conducteur
WO2008022349A2 (en) 2006-08-18 2008-02-21 Armagen Technologies, Inc. Agents for blood-brain barrier delivery
WO2008029886A1 (en) 2006-09-06 2008-03-13 National University Corporation Tottori University Kit for diagnosis of alzheimer's disease, diagnostic marker, and method for detection of indicator for disease condition
WO2008036717A2 (en) * 2006-09-19 2008-03-27 Emory University Use of soluble galectin-3 (gal-3) for cancer treatment
WO2008085564A2 (en) 2006-09-20 2008-07-17 The Board Of Regents Of The University Of Texas System Compositions and methods involving truncated recombinant seven g-protein coupled receptors
CA2668693A1 (en) 2006-11-15 2008-05-22 David E. Anderson Therapeutic uses of tim-3 modulators
US8420613B2 (en) 2006-11-15 2013-04-16 The J. David Gladstone Institutes Methods and compositions for reducing amyloid beta levels
GB0624500D0 (en) 2006-12-07 2007-01-17 Istituto Superiore Di Sanito A novel passive vaccine for candida infections
US8420591B2 (en) 2006-12-08 2013-04-16 Dana-Farber Cancer Institute, Inc. MUC1 and galectin-3
EP3225251B1 (en) 2006-12-21 2020-02-12 H. Lundbeck A/S Modulation of activity of proneurotrophins
HRP20140049T1 (hr) 2007-01-05 2014-02-28 University Of Zürich Anti beta-amiloid antitijela i njihova upotreba
NO2740744T3 (enExample) 2007-01-09 2018-08-25
AU2008204335B2 (en) 2007-01-11 2013-06-13 Michael Bacher Diagnosis and treatment of Alzheimer's and other neurodementing diseases
ES2535641T3 (es) 2007-01-18 2015-05-13 Eli Lilly & Company Amiloide beta Fab pegilado
WO2008112559A1 (en) 2007-03-09 2008-09-18 Regents Of The University Of California Suppression of galectin-3 for treating an inflammatory condition
TR201802286T4 (tr) 2007-04-20 2018-03-21 The Chemo Sero Therapeutic Res Institute Peptidle bağışıklık yanıtının arttırılması için yöntem.
EP2152744A4 (en) 2007-04-26 2012-02-15 Univ Yale PRION PROTEIN AS RECEPTOR FOR AMYLOID-BETA OLIGOMERS
WO2008133772A1 (en) 2007-04-26 2008-11-06 Ludwig Institute For Cancer Research Method for modulating activity of t lymphocytes
EP2152309B1 (en) 2007-05-14 2013-07-10 Medtronic, Inc. Methods and device to neutralize soluble toxic agents in the brain
BRPI0814256A8 (pt) 2007-07-05 2016-02-10 Schering Corp Inibidores de tetrahidropiranocromeno gama secretase
AU2008276492A1 (en) 2007-07-17 2009-01-22 Merck Sharp & Dohme Corp. Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors
DK2019104T3 (da) 2007-07-19 2013-12-16 Sanofi Sa Cytotoksiske midler, der omfatter nye tomaymycinderivater, og terapeutisk anvendelse deraf
JP5889529B2 (ja) 2007-07-27 2016-03-22 ヤンセン・サイエンシズ・アイルランド・ユーシー アミロイド原性疾患の処置
US8993833B2 (en) 2007-08-14 2015-03-31 Duke University Model of Alzheimer's Disease
US9370531B2 (en) 2007-08-31 2016-06-21 New York University Method of providing patient specific immune response in amyloidoses and protein aggregation disorders
EP2200990A1 (en) 2007-09-06 2010-06-30 Schering Corporation Gamma secretase modulators
EP2527369A3 (en) 2007-09-13 2012-12-19 University Of Zurich Prorektorat Forschung Monoclonal amyloid beta (abeta)-specific antibody and uses thereof
WO2009057664A1 (ja) 2007-10-29 2009-05-07 Mitsubishi Chemical Corporation 抗体及びその利用
NZ585000A (en) 2007-10-29 2012-08-31 Inst Nat Sante Rech Med New antibodies specific of the beta-amyloid peptides and their uses as diagnostic agents or drugs
US20100306868A1 (en) 2007-11-01 2010-12-02 Bernd Bohrmann Quadruple transgenic non-human animal
WO2009061699A1 (en) 2007-11-05 2009-05-14 Schering Corporation Gamma secretase modulators
KR101397554B1 (ko) 2007-11-09 2014-05-21 재단법인서울대학교산학협력재단 치매(알츠하이머 병)의 진단, 예방, 치료제 및 이들의스크리닝 방법
CA2705292C (en) 2007-11-13 2016-06-21 Teva Biopharmaceuticals Usa, Inc. Humanized antibodies against tl1a
ME01026B (me) 2007-11-16 2012-10-20 Univ Rockefeller Antitijela specifična za protofibrilni oblik beta-amiloid proteina
US8349579B2 (en) 2007-12-13 2013-01-08 Wayne State University Galectin-3 cleavage as a marker for matrix metalloproteinase activity in cancer
WO2009087689A2 (en) 2008-01-07 2009-07-16 Council Of Scientific & Industrial Research Novel primers for identification of astrocytoma, it's grades and glioblastoma prognosis
ITNA20080006A1 (it) 2008-01-28 2009-07-29 Consiglio Nazionale Ricerche Proteine chimeriche capaci di formare particelle virus-like, che contengono sequenze peptidiche del beta-amiloide e la componente e2 della alfachetoacido deidrogenasi di "geobacillus stearothermophilus", utili per l'induzione di una risposta anticorp
CA2714413C (en) 2008-02-08 2017-01-24 Immunas Pharma, Inc. Antibody capable of binding specifically to ab-oligomer, and use thereof
US8852874B2 (en) 2008-02-29 2014-10-07 Baxter International Inc. Anti-amyloid β activity of intravenous immunoglobulin (IVIG) in vitro
FR2929292A1 (fr) 2008-03-28 2009-10-02 Exonhit Therapeutics S A Sa Procede et methodes de diagnostic de la maladie d'alzheimer
US9908943B2 (en) 2008-04-03 2018-03-06 Vib Vzw Single domain antibodies capable of modulating BACE activity
CN102065881B (zh) 2008-04-14 2014-03-12 埃尔奇诺瓦公司 稳定的淀粉样beta单体和寡聚体
KR101603917B1 (ko) 2008-05-09 2016-03-17 애브비 인코포레이티드 최종 당화 산물의 수용체(rage)에 대한 항체 및 이의 용도
EP2299812B1 (en) 2008-05-27 2017-07-12 Yale University Targeting tgf-beta as a therapy for alzheimer's disease
US8969023B2 (en) 2008-06-10 2015-03-03 Eleanore Bennett Charitable Trust #2 Methods and compositions for treating alzheimer's disease
US8933295B2 (en) 2008-06-20 2015-01-13 Janssen Biotech, Inc. Identifying agents to treat alzheimer's disease-related decreased sorting behavior by administration to a triple transgenic mouse expressing mutant forms of APP, presenilin or tau
WO2009155609A1 (en) 2008-06-20 2009-12-23 Oklahoma Medical Research Foundation IMMUNOGENIC MEMAPSIN 2 β-SECRETASE PEPTIDES AND METHODS OF USE
MX345039B (es) 2008-06-25 2017-01-16 Esbatech Alcon Biomed Res Unit Anticuerpos estables y solubles que inhiben el tnfa.
ES2397641T3 (es) 2008-07-01 2013-03-08 De Staat Der Nederlanden, Vert. Door De Minister Van Vws Vacuna contra el intermediario de plegado amiloide
WO2010005858A1 (en) 2008-07-08 2010-01-14 Merck & Co., Inc. Vaccine for the treatment of alzheimer's disease
SG192485A1 (en) 2008-07-08 2013-08-30 Incyte Corp 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
GB0813432D0 (en) 2008-07-22 2008-08-27 Spirogen Ltd Pyrrolobenzodiazepines
NZ710443A (en) 2008-08-12 2019-03-29 Zinfandel Pharmaceuticals Inc Method of identifying disease risk factors
US8283322B2 (en) 2008-08-15 2012-10-09 Orthopeutics, Lp Formulations for nonsurgical exogenous crosslink therapy
CA2739076A1 (en) 2008-10-02 2010-04-08 Celtaxsys, Inc. Methods of modulating the negative chemotaxis of immune cells
CA2742265C (en) 2008-10-29 2014-07-15 Bg Medicine, Inc. Galectin-3 immunoassay
US7888035B2 (en) 2008-10-30 2011-02-15 Caris Mpi, Inc. Methods for assessing RNA patterns
US8809318B2 (en) 2008-11-13 2014-08-19 Merck Sharp & Dohme Corp. Gamma secretase modulators
JP5503663B2 (ja) 2008-11-13 2014-05-28 メルク・シャープ・アンド・ドーム・コーポレーション ガンマセクレターゼモジュレータ
DE102008037564A1 (de) 2008-11-19 2010-05-20 Forschungszentrum Jülich GmbH Zusammensetzung zur Herstellung von anti-Amyloid beta-Peptid-Antikörpern mit D-Peptiden
US8912145B2 (en) 2008-11-28 2014-12-16 Hokko Chemical Industry Co., Ltd. Vaccine composition for prophylaxis and/or therapy of Alzheimer's disease
EP3115063A3 (en) * 2008-12-03 2017-04-19 The John Hopkins University Galectin-3 and annexin-a2 as immunological target
US20120046181A1 (en) 2008-12-19 2012-02-23 Chu Nantes Biomarkers for the Diagnosis of Renal Allograft and Kidney Status
US8759337B2 (en) 2008-12-22 2014-06-24 Merck Sharp & Dohme Corp. Gamma secretase modulators
US20100196882A1 (en) * 2009-02-04 2010-08-05 Avraham Raz GALECTIN-3 nsSNP MARKER FOR CANCER
US8426402B2 (en) 2009-02-05 2013-04-23 Immunogen, Inc. Benzodiazepine derivatives
FR2942476B1 (fr) 2009-02-20 2013-03-15 Commissariat Energie Atomique Composes de type pyridocarbazole et leurs applications
SI2408807T1 (sl) 2009-03-18 2021-11-30 Ac Immune Sa Postopek za terapevtsko uporabo
US9173928B2 (en) 2009-03-26 2015-11-03 Yoh Matsumoto DNA vaccine for Alzheimer's disease
JP2010268789A (ja) 2009-04-24 2010-12-02 Kumamoto Univ 細胞医薬の製造方法
FR2945538B1 (fr) 2009-05-12 2014-12-26 Sanofi Aventis Anticorps humanises specifiques de la forme protofibrillaire du peptide beta-amyloide.
EP2258398A1 (en) 2009-05-26 2010-12-08 Araclón Biotech, S. L. Albumin-amyloid peptide conjugates and uses thereof
EP4218794A3 (en) 2009-06-10 2023-09-13 New York University Immunological targeting of pathological tau proteins
JP5944822B2 (ja) 2009-06-15 2016-07-05 フエー・イー・ベー・フエー・ゼツト・ウエー Bace1抑制性抗体
US20120238546A1 (en) 2009-06-16 2012-09-20 Zhaoning Zhu Gamma secretase modulators
PT2448968T (pt) 2009-06-29 2021-04-30 Bioarctic Ab ANTICORPOS SELETIVOS PARA PROTOFIBRILAS/OLIGÓMEROS DE ß- AMILOIDE TRUNCADA EM N-TERMINAL
EP2273273A1 (en) 2009-07-11 2011-01-12 Rheinische Friedrich-Wilhelms-Universität Bonn Inhibitors of the nitration of amyloid ß peptides and their uses in the diagnosis and treatment of alzheimer's disease
CN102439727B (zh) 2009-07-15 2015-05-20 富士电机株式会社 超结半导体器件
JP5769316B2 (ja) 2009-08-06 2015-08-26 イムナス・ファーマ株式会社 Aβオリゴマーに特異的に結合する抗体およびその利用
JP5051806B2 (ja) 2009-08-07 2012-10-17 協和発酵キリン株式会社 抗アミロイドβオリゴマーヒト化抗体
KR20120104167A (ko) 2009-08-25 2012-09-20 비쥐 메디신, 인코포레이티드 갈렉틴―3 및 심장 재동기화 요법
WO2011026031A1 (en) 2009-08-28 2011-03-03 The Board Of Regents Of The University Of Texas System Antibodies that bind tau oligomers
WO2011031720A1 (en) 2009-09-11 2011-03-17 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Bispecific nanobodies as a therapeutic for alzheimer's disease
DE102009043750A1 (de) 2009-09-30 2011-08-04 Carl Zeiss Meditec AG, 07745 Verfahren und Vorrichtung zur Detektion von Ablagerungen im Auge
JPWO2011045945A1 (ja) 2009-10-16 2013-03-04 国立大学法人京都大学 アミロイドβのターン構造を認識する抗体
WO2011102901A1 (en) 2010-02-20 2011-08-25 Ebiotec (Euroespes Biotechnology) Prevention and treatment of alzheimer's disease by amyloid beta peptide and sphingosine-1-phosphate
RU2644335C2 (ru) 2010-03-03 2018-02-08 Зе Юниверсити Оф Бритиш Коламбия Эпитоп, специфичный к олигомеру амилоида бета, и антитела
WO2011119842A1 (en) 2010-03-25 2011-09-29 The J. David Gladstone Institutes Compositions and methods for treating neurological disorders
SG184820A1 (en) 2010-04-13 2012-11-29 Baxter Int Use of ventricular enlargement rate in intravenous immunoglobulin treatment of alzheimer's disease
NZ602932A (en) 2010-04-15 2014-08-29 Seattle Genetics Inc Targeted pyrrolobenzodiazapine conjugates
CN102971329B (zh) 2010-04-15 2016-06-29 麦迪穆有限责任公司 用于治疗增殖性疾病的吡咯并苯并二氮杂卓
JP5904939B2 (ja) 2010-05-25 2016-04-20 株式会社島津製作所 大腸がんマーカーガレクチン、採血試料中のガレクチン濃度の分析方法及び大腸がんマーカーガレクチン検出キット
EP2580326A1 (en) 2010-06-11 2013-04-17 Antisense Pharma GmbH Method for selective oligonucleotide modification
JP5934203B2 (ja) 2010-07-14 2016-06-15 メルク・シャープ・エンド・ドーム・コーポレイション 抗addlモノクローナル抗体およびこの使用
US10420923B1 (en) 2010-08-10 2019-09-24 Amiram Katz Method and device for intrathecal administering of immunoglobulin
LT3042917T (lt) 2010-08-12 2018-05-10 Eli Lilly And Company Antikūnai prieš n3pglu beta amiloidinį peptidą ir jų panaudojimas
WO2012036786A1 (en) 2010-09-17 2012-03-22 University Of L'aquila Nanoparticles of cerium oxide targeted to an amyloid-beta antigen of alzheimer's disease
CA2816681A1 (en) 2010-11-03 2012-05-10 Immunogen, Inc. Cytotoxic agents comprising new ansamitocin derivatives
WO2012066495A2 (en) 2010-11-17 2012-05-24 Ben Gurion University Of The Negev Research And Development Authority T-cell therapy to neurodegenerative diseases
EA034333B1 (ru) 2010-11-30 2020-01-29 Дженентек, Инк. Варианты антитела для переноса соединения через гематоэнцефалический барьер
WO2012091138A1 (ja) 2010-12-28 2012-07-05 大日本住友製薬株式会社 アルツハイマー病の診断薬及び診断方法
WO2012106363A2 (en) 2011-01-31 2012-08-09 Intellect Neurosciences Inc. Treatment of tauopathies
CN103718046B (zh) 2011-03-17 2016-10-12 重症监护诊断股份有限公司 预测不良临床结果的风险的方法
EP2508212A1 (en) 2011-04-05 2012-10-10 Universitätsklinikum Freiburg Biocompatible and biodegradable gradient layer system for regenerative medicine and for tissue support
WO2012136552A1 (en) 2011-04-08 2012-10-11 H. Lundbeck A/S ANTIBODIES SPECIFIC TO PYROGLUTAMATED Αβ
KR101589135B1 (ko) 2011-04-20 2016-01-29 주식회사 셀앤바이오 인간화 항-emapii 항체 및 이의 용도
AU2012250496A1 (en) 2011-05-03 2013-11-28 Commonwealth Scientific And Industrial Research Organisation Method for detection of a neurological disease
GB201108490D0 (en) 2011-05-18 2011-07-06 Ucl Business Plc Methods and uses
WO2012159027A2 (en) 2011-05-19 2012-11-22 President And Fellows Of Harvard College Osw-1 analogs and conjugates, and uses thereof
AR086543A1 (es) * 2011-05-25 2014-01-08 Bg Medicine Inc Inhibidores de galectina-3 y metodos de uso de los mismos, composicion farmaceutica
CA2836927A1 (en) 2011-06-21 2012-12-27 Immunogen, Inc. Novel maytansinoid derivatives with peptide linker and conjugates thereof
WO2013008402A1 (ja) 2011-07-08 2013-01-17 シャープ株式会社 薄膜トランジスタ基板及びそれを備えた表示装置
GB201113482D0 (en) 2011-08-04 2011-09-21 Univ Liverpool Assay
PT2748201T (pt) 2011-08-23 2018-02-08 Roche Glycart Ag Moléculas de ligação ao antigénio biespecíficas que ativam as células t
SMT201800109T1 (it) 2011-09-19 2018-05-02 Axon Neuroscience Se Terapia a base di proteine e diagnosi di una patologia mediata da tau nella malattia di alzheimer
CN103957937B (zh) 2011-09-19 2017-06-06 约翰内斯堡威特沃特斯兰德大学 用于治疗阿尔茨海默病的化合物
ES2754304T3 (es) 2011-09-23 2020-04-16 Siemens Healthcare Diagnostics Inc Ensayo de respuesta celular para detectar cáncer y métodos de producción y uso del mismo
JP6393617B2 (ja) 2011-10-14 2018-09-19 シアトル ジェネティクス,インコーポレーテッド ピロロベンゾジアゼピンおよび標的コンジュゲート
US9549953B2 (en) 2011-12-08 2017-01-24 Eliaz Therapeutics, Inc. Galectin-3 plasmapheresis therapy
EP2788761B1 (en) 2011-12-08 2018-02-28 Eliaz Therapeutics, Inc. Reduction of galectin-3 levels by plasmapheresis
US8764695B2 (en) 2012-09-28 2014-07-01 Isaac Eliaz Reduction of galectin-3 levels by plasmapheresis
AU2012351963A1 (en) 2011-12-15 2014-06-26 The United States of America, as represented by Secretary, Department of Health & Human Services Identification of two novel biomarkers for Niemann-Pick disease type C
US20130164217A1 (en) 2011-12-21 2013-06-27 Meso Scale Technologies, Llc Method of diagnosing, preventing and/or treating dementia & related disorders
KR101948400B1 (ko) 2011-12-29 2019-02-14 타오 헬스 라이프 파마 가부시키가이샤 아밀로스페로이드가 결합하여 성숙 신경 세포사를 유발하는 표적 분자, 아밀로스페로이드가 유도하는 신경 세포사를 억제하는 방법 및 물질, 및 그들의 이용
WO2013106572A1 (en) 2012-01-11 2013-07-18 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Bispecific antibody fragments for neurological disease proteins and methods of use
CN107982548A (zh) 2012-02-07 2018-05-04 全球生物疗法有限公司 核酸输送的区室化方法及其组合物和应用
WO2013120497A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
EP2819700B1 (en) 2012-02-27 2016-12-21 Universitat de Barcelona Protease-resistant compounds useful as shuttles through the blood-brain barrier and shuttle-cargo constructs
ITRM20120383A1 (it) 2012-03-20 2013-09-21 Uni Degli Studi Di Milano B Icocca Metodo e kit per la rivelazione di anticorpi.
ES2819174T3 (es) 2012-03-26 2021-04-15 Yeda Res & Dev Marcadores celulares para el diagnóstico de la enfermedad de Alzheimer y para la progresión de la enfermedad de Alzheimer
RU2644242C2 (ru) 2012-04-05 2018-02-08 Ац Иммуне С.А. Гуманизированное тау-антитело
WO2013152313A1 (en) 2012-04-05 2013-10-10 The Regents Of The University Of California Compositions and methods for treating cancer and diseases and conditions responsive to growth factor inhibition
WO2013169890A1 (en) 2012-05-08 2013-11-14 Bg Medicine, Inc. Systems and methods for assessing disease risk, status, and prognosis
EP3269736B1 (en) 2012-05-10 2019-11-27 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Conformational-specific antibodies against oligomers of amyloid beta
EP2849797B1 (en) 2012-05-15 2019-12-18 Concortis Biosystems, Corp Drug-conjugates, conjugation methods, and uses thereof
US9682143B2 (en) 2012-08-14 2017-06-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
FR2994803B1 (fr) * 2012-08-30 2016-02-26 Oreal Modulation de la forme des fibres keratiniques
US9655977B2 (en) 2012-08-31 2017-05-23 The General Hospital Corporation Biotin complexes for treatment and diagnosis of alzheimer's disease
MX2015002947A (es) 2012-09-07 2015-09-23 Genentech Inc Terapia de combinacion de un anticuerpo ant-cd20 tipo ii con un inhibidor blc-2 selectivo.
BR112015005772A2 (pt) * 2012-09-17 2017-08-08 Galectin Therapeutics Inc método para a intensificação de imunoterapias específicas no tratamento de câncer
JP6306596B2 (ja) 2012-10-04 2018-04-04 リサーチ ディベロップメント ファウンデーション セリンプロテアーゼ分子および療法
ES2802873T3 (es) 2012-10-15 2021-01-21 Medimmune Ltd Anticuerpos a beta amiloide
CA2892490A1 (en) 2012-11-26 2014-05-30 Caris Science, Inc. Biomarker compositions and methods
US9066928B1 (en) 2012-12-04 2015-06-30 University Of Kentucky Research Foundation Method, composition, and kit useful for treatment of alzheimer's disease
US9089614B2 (en) 2012-12-21 2015-07-28 Bioalliance C.V. Hydrophilic self-immolative linkers and conjugates thereof
US9433665B2 (en) 2013-01-11 2016-09-06 Cyvax, Inc. Vaccines for protection from and treatment of alzheimer's disease
EP2955195B1 (en) 2013-02-06 2019-03-27 Yokohama City University Anti-semaphorin 3a antibody and treatment of alzheimer's disease and inflammatory immune diseases using same
DK2961426T3 (da) 2013-02-26 2019-12-02 Baxalta GmbH Behandling af sygdomme i centralnervesystemet ved intranasal indgivelse af immunoglobulin g
RU2015140915A (ru) 2013-02-26 2017-04-03 Роше Гликарт Аг Биспецифические антигенсвязывающие молекулы, активирующие т-клетки
EP3666795A1 (en) 2013-03-12 2020-06-17 Molecular Templates, Inc. Cytotoxic proteins comprising cell-targeting binding regions and shiga toxin a subunit regions for selective killing of specific cell types
CN105307685B (zh) 2013-03-13 2019-03-08 麦迪穆有限责任公司 吡咯并苯并二氮杂卓和其结合物
EP2777714A1 (en) 2013-03-15 2014-09-17 NBE-Therapeutics LLC Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
US9688747B2 (en) 2013-03-15 2017-06-27 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
AU2013203043B2 (en) 2013-03-15 2016-10-06 Takeda Pharmaceutical Company Limited Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs
US9879076B2 (en) 2013-03-15 2018-01-30 Ramot At Tel Aviv University Ltd. Methods and compositions with immune therapy for treatment of dementia
WO2014160871A2 (en) 2013-03-27 2014-10-02 The General Hospital Corporation Methods and agents for treating alzheimer's disease
AU2014262890B2 (en) 2013-05-06 2019-01-31 Takeda Pharmaceutical Company Limited Treatment of Alzheimer's disease subpopulations with pooled immunoglobulin G
JP2016520615A (ja) 2013-05-31 2016-07-14 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. アルツハイマー病を処置するためのil−1アンタゴニストを使用する方法
EP3013355B1 (en) 2013-06-25 2019-08-07 ICM - Institut du Cerveau et da la Moelle Epinière Il-2 for use in treating alzheimer disease and related disorders
WO2015031084A1 (en) 2013-08-28 2015-03-05 Jianfeng Cai Methods of synthesizing y-aapeptides, y-aapeptide building blocks, y-aapeptide libraries, and y-aapeptide inhibitors of ab40 aggregates
EP3043802B1 (en) 2013-09-13 2018-04-18 Merck Sharp & Dohme Corp. C5-spiro iminothiazine dioxides as bace inhibitors, compositions, and their use
WO2015038426A1 (en) 2013-09-13 2015-03-19 Asana Biosciences, Llc Self-immolative linkers containing mandelic acid derivatives, drug-ligand conjugates for targeted therapies and uses thereof
WO2015051850A1 (en) 2013-10-11 2015-04-16 Universität Für Bodenkultur Wien Compositions containing galectin-3 modulators for the treatment of bone disorders
WO2015057876A1 (en) 2013-10-15 2015-04-23 Sorrento Therapeutics Inc. Drug-conjugates with a targeting molecule and two different drugs
GB201319761D0 (en) 2013-11-08 2013-12-25 Nordic Bioscience As Biomarkers of disease progression
CA2932958A1 (en) 2013-12-20 2015-06-25 F. Hoffmann-La Roche Ag Humanized anti-tau(ps422) antibodies and methods of use
CA2930330A1 (en) 2013-12-27 2015-07-02 Dignity Health Diagnosing and treating alzheimer's disease
US10272083B2 (en) 2014-01-21 2019-04-30 Acerta Pharma B.V. Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia using a BTK inhibitor
US20160177284A1 (en) 2014-01-27 2016-06-23 Molecular Templates, Inc. Cell-targeted molecules comprising amino-terminus proximal or amino-terminal shiga toxin a subunit effector regions
US20210138076A2 (en) 2014-01-27 2021-05-13 Molecular Templates, Inc. Cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes
EP3575312A1 (en) 2014-01-27 2019-12-04 Molecular Templates, Inc. De-immunized shiga toxin a subunit effector polypeptides for applications in mammals
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
US10421958B2 (en) 2014-02-05 2019-09-24 Molecular Templates, Inc. Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
EP3900738A1 (en) 2014-02-08 2021-10-27 F. Hoffmann-La Roche AG Methods of treating alzheimer's disease
US20170014446A1 (en) * 2014-03-10 2017-01-19 La Jolla Pharmaceutical Company Compositions and methods for administering galectin antagonists
ES2723774T3 (es) 2014-03-11 2019-09-02 Molecular Templates Inc Proteínas que comprenden regiones de unión, regiones efectoras de la subunidad A de toxina Shiga y motivos señal de localización de retículo endoplasmático carboxi terminal
SI3604333T1 (sl) 2014-03-11 2021-08-31 Molecular Templates, Inc. Proteini, ki obsegajo aminoterminalne proksimalne Shiga toksin podenota A efektorske regije in celico-ciljajoče vezavne regije imunogobulinskega tipa, ki so sposobne specifične vezave CD38
ES3040431T3 (en) 2014-03-12 2025-10-31 Yeda Res & Dev Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns
SG11201607896YA (en) 2014-04-10 2016-10-28 Pfizer 2-AMINO-6-METHYL-4,4a,5,6-TETRAHYDROPYRANO[3,4-d][1,3]THIAZIN-8a(8H)-YL-1,3-THIAZOL-4-YL AMIDES
US10232056B2 (en) 2014-04-16 2019-03-19 Kyowa Hakko Kirin Co., Ltd. Method for measuring toxicity of human CSF
US9737505B2 (en) 2014-04-29 2017-08-22 Glaxosmithkline Intellectual Property Development Limited Prodrug of 1,1′-(1,6-dioxo-1,6-hexanediyl)bis-D-proline
WO2015176069A2 (en) 2014-05-16 2015-11-19 Synaptec Development Llc CLEARANCE OF AMYLOID ß
EP3137488B1 (en) 2014-06-11 2019-01-02 Molecular Templates, Inc. Protease-cleavage resistant, shiga toxin a subunit effector polypeptides and cell-targeting molecules comprising the same
US20150377905A1 (en) 2014-06-25 2015-12-31 The Board Of Trustees Of The Leland Stanford Junior University Methods for diagnosis of kawasaki disease
AR100978A1 (es) 2014-06-26 2016-11-16 Hoffmann La Roche LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS
EP3161671A4 (en) 2014-06-30 2017-06-28 Microsoft Technology Licensing, LLC Managing data with flexible schema
WO2016004093A2 (en) 2014-07-01 2016-01-07 Stealth Biotherapeutics Corp Therapeutic compositions including galectin-3 inhibitors and uses thereof
US10132818B2 (en) 2014-07-08 2018-11-20 New York University Tau imaging ligands and their uses in the diagnosis and treatment of tauopathy
SI3166970T1 (sl) 2014-07-10 2021-09-30 Bioarctic Ab Izboljšana A-beta protofibril vezavna protitelesa
KR102411972B1 (ko) 2014-08-04 2022-06-23 에프. 호프만-라 로슈 아게 이중특이적 t 세포 활성화 항원 결합 분자
TW201618772A (zh) 2014-08-11 2016-06-01 艾森塔製藥公司 Btk抑制劑、pi3k抑制劑、jak-2抑制劑及/或bcl-2抑制劑之治療組合物
JP6736002B2 (ja) 2014-08-14 2020-08-05 国立大学法人広島大学 早産および/または低体重児出産のリスク判定を行うための方法およびキット
JO3663B1 (ar) 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
JP7072384B2 (ja) 2014-09-15 2022-05-20 ジェネンテック, インコーポレイテッド 抗体製剤
TWI599358B (zh) 2014-09-16 2017-09-21 美國禮來大藥廠 組合療法
WO2016046162A1 (en) 2014-09-22 2016-03-31 Salama Zoser B Proline or proline derivatives for the treatment of dementia
JP2017531571A (ja) 2014-10-01 2017-10-26 ダウ グローバル テクノロジーズ エルエルシー 多層構造及びそれから作製される熱成形物品
US9921230B2 (en) 2014-10-08 2018-03-20 Rhode Island Hospital Methods for diagnosis and treatment of concussion or brain injury
WO2016059453A1 (en) 2014-10-16 2016-04-21 Fundacion Fraunhofer Chile Research Biomarkers and therapeutic targets for alzheimer's disease
WO2016073299A1 (en) 2014-11-04 2016-05-12 Dana-Farber Cancer Institute, Inc. Anti-galectin antibody biomarkers predictive of anti-immune checkpoint and anti-angiogenesis responses
PT3221349T (pt) 2014-11-19 2021-01-21 Axon Neuroscience Se Anticorpos tau humanizados na doença de alzheimer
MA41115A (fr) 2014-12-02 2017-10-10 Biogen Int Neuroscience Gmbh Procédé de traitement de la maladie d'alzheimer
CA2874083C (en) 2014-12-05 2024-01-02 Universite Laval Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases
WO2016094639A1 (en) 2014-12-10 2016-06-16 Wisconsin Alumni Research Foundation Mini-intronic plasmid dna vaccines in combination with lag3 blockade
US10464999B2 (en) 2015-01-28 2019-11-05 Prothena Biosciences Limited Anti-transthyretin antibodies
SG11201705986QA (en) 2015-01-29 2017-08-30 Technophage Investigação E Desenvolvimento Em Biotecnologia Sa Antibody molecules and peptide delivery systems for use in alzheimer's disease and related disorders
EP3253788A4 (en) 2015-02-06 2018-08-08 Cell IDX, Inc. Antigen-coupled immunoreagents
TWI669314B (zh) 2015-02-26 2019-08-21 美國禮來大藥廠 針對tau之抗體及其用途
GB201504432D0 (en) 2015-03-17 2015-04-29 Electrophoretics Ltd Materials and methods for diagnosis and treatment of alzheimers disease
EP3274010B1 (en) 2015-03-27 2019-10-02 Eliaz Therapeutics, Inc. Patient selective apheresis
GB201505239D0 (en) 2015-03-27 2015-05-13 Neuro Bio Ltd Antibody
US12109346B2 (en) 2015-03-27 2024-10-08 Eliaz Therapeutics, Inc. Galectin-3 plasmapheresis therapy
ES2914243T3 (es) 2015-04-15 2022-06-08 Anaptysbio Inc Anticuerpos dirigidos contra el receptor de la interleuquina 36 (IL-36R)
AU2016257929B2 (en) 2015-05-04 2022-10-20 Cytomx Therapeutics, Inc Anti-CD166 antibodies, activatable anti-CD166 antibodies, and methods of use thereof
CN107592812A (zh) 2015-05-11 2018-01-16 豪夫迈·罗氏有限公司 治疗狼疮性肾炎的组合物和方法
GB201508276D0 (en) 2015-05-14 2015-06-24 Electrophoretics Ltd A casein kinase 1 delta inhibitor
UY36692A (es) 2015-05-29 2016-12-30 Abbvie Inc Anticuerpos anti-cd40 y usos de los mismos
MX2017015493A (es) 2015-05-30 2018-02-09 Molecular Templates Inc Andamiajes de la subunidad a de la toxina shiga desinmunizados y moleculas con direccion a las celulas que los comprenden.
JP6979877B2 (ja) 2015-06-08 2021-12-15 デビオファーム インターナショナル, エス. アー. 抗cd37イムノコンジュゲートおよび抗cd20抗体の組み合わせ
US10203342B2 (en) 2015-06-11 2019-02-12 Nanosomix, Inc. Biomarkers and differential diagnosis of alzheimer's disease and other neurodegenerative disorders
ES2809728T3 (es) 2015-06-24 2021-03-05 Hoffmann La Roche Anticuerpos anti-tau(pS422) humanizados y procedimientos de uso
IL302486A (en) 2015-06-24 2023-06-01 Hoffmann La Roche Antibodies against the transnephrine receptor with adapted affinity
SG10201913518XA (en) 2015-06-30 2020-02-27 Nanotics Llc Compositions and methods related to scavanger particles
JO3711B1 (ar) 2015-07-13 2021-01-31 H Lundbeck As أجسام مضادة محددة لبروتين تاو وطرق استعمالها
EA039859B1 (ru) 2015-07-31 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3
FI3334761T3 (fi) 2015-08-13 2023-08-14 Univ New York Vasta-ainepohjaisia molekyylejä, jotka ovat selektiivisiä Taun {p}Ser404-epitoopille, ja niiden käyttöjä tauopatian diagnosoinnissa ja hoidossa
JP6913078B2 (ja) 2015-08-13 2021-08-04 ニューヨーク・ユニバーシティ タウの短縮型Asp421エピトープに特異的な、抗体を基にした分子、ならびにタウ異常症の診断および治療におけるそれらの使用
EP3827846B1 (en) 2015-08-18 2024-10-02 Rakuten Medical, Inc. Compositions, combinations and related methods for photoimmunotherapy
IL319047A (en) 2015-08-28 2025-04-01 Amunix Operating Inc Chimeric polypeptide composition and methods for its preparation and use
CA2997947A1 (en) 2015-09-09 2017-03-16 The Trustees Of Columbia University In The City Of New York Reduction of er-mam-localized app-c99 and methods of treating alzheimer's disease
EP3353214B1 (en) 2015-09-25 2021-08-18 Universität Duisburg-Essen Agents inhibiting kallikrein-8 for use in the prevention or treatment of alzheimer's disease
US10358497B2 (en) 2015-09-29 2019-07-23 Amgen Inc. Methods of treating cardiovascular disease with an ASGR inhibitor
JP6657392B2 (ja) 2015-10-02 2020-03-04 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 二重特異性抗ヒトcd20/ヒトトランスフェリン受容体抗体及び使用方法
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
WO2017075119A1 (en) 2015-10-28 2017-05-04 The Trustees Of The Univeresity Of Pennsylvania Intrathecal administration of adeno-associated-viral vectors for gene therapy
EP3374368B1 (en) 2015-11-09 2022-06-01 Galecto Biotech AB 1,1'-sulfanediyl-di-beta-d-galactopyranosides as inhibitors of galectins
IL257696B2 (en) 2015-12-09 2024-11-01 Hoffmann La Roche Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies
EP3397645A1 (en) 2015-12-28 2018-11-07 Innate Pharma VARIABLE REGIONS FOR NKp46 BINDING PROTEINS
CA3010027A1 (en) 2015-12-28 2017-07-06 Massachusetts Institute Of Technology Bispecific antibodies having constant region mutations and uses therefor
EP3416661A4 (en) 2016-02-18 2020-03-04 Enlivex Therapeutics Ltd. COMBINATION OF IMMUNOTHERAPY AND CYTOKINE CONTROL THERAPY FOR THE TREATMENT OF CANCER
JP2019517991A (ja) 2016-03-01 2019-06-27 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 低減したadcpを有するオビヌツズマブ及びリツキシマブ変異体
AU2017236431A1 (en) 2016-03-24 2018-09-27 Bayer Pharma Aktiengesellschaft Prodrugs of cytotoxic active agents having enzymatically cleavable groups
US10894823B2 (en) 2016-03-24 2021-01-19 Gensun Biopharma Inc. Trispecific inhibitors for cancer treatment
WO2017172757A1 (en) 2016-03-29 2017-10-05 Acadia Pharmaceuticals Inc. 5-ht2a serotonin receptor inverse agonists or antagonists for use in reducing amyloid-beta peptides and accumulation of amyloid plaques
EP3436037A4 (en) 2016-03-31 2019-12-04 University of Southern California HIGHLY SENSITIVE AND SPECIFIC LUCIFERASE-BASED REPORTER TEST FOR ANTIGEN DETECTION
WO2017180587A2 (en) 2016-04-11 2017-10-19 Obsidian Therapeutics, Inc. Regulated biocircuit systems
WO2017186928A1 (en) 2016-04-29 2017-11-02 Curevac Ag Rna encoding an antibody
US11326182B2 (en) 2016-04-29 2022-05-10 Voyager Therapeutics, Inc. Compositions for the treatment of disease
US9933440B2 (en) 2016-05-31 2018-04-03 Edward J. Goetzl Drug efficacy test method for dementias utilizing astrocyte-derived exosomes
WO2017218911A1 (en) 2016-06-17 2017-12-21 Abbott Laboratories BIOMARKERS TO PREDICT NEW ONSET HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFpEF)
CN118416082A (zh) 2016-06-28 2024-08-02 应急生物防御行动兰辛有限责任公司 布林西多福韦的制剂
RU2760875C1 (ru) 2016-07-12 2021-12-01 Х. Лундбекк А/С Антитела, специфичные к гиперфосфорилированному тау-белку, и способы их применения
US12123874B2 (en) 2016-07-18 2024-10-22 Cell Idx, Inc. Reagent compounds, compositions, kits, and methods for amplified assays
US10570196B2 (en) 2016-07-20 2020-02-25 Anahit Ghochikyan Humanized anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies
WO2018019188A1 (zh) 2016-07-23 2018-02-01 博瑞生物医药(苏州)股份有限公司 核苷氨基磷酸酯类前药的多晶型及其制备方法
US10730937B2 (en) 2016-08-09 2020-08-04 National University Corporation Tokyo Medical And Dental University Antibodies against HMB1, and composition comprising same for treating or preventing alzheimer's disease
US10076552B2 (en) 2016-08-09 2018-09-18 DATT MEDIPRODUCTS LIMITED and DATT LIFE SCIENCE PVT. LTD. Multifunctional formulation comprised of natural ingredients and method of preparation/manufacturing thereof
KR102497742B1 (ko) 2016-08-30 2023-02-10 다나-파버 캔서 인스티튜트 인크. 약물 전달 조성물 및 그의 용도
US20190275040A1 (en) 2016-09-26 2019-09-12 Yale University Compounds and methods for treating or preventing alzheimer's disease
US10662226B2 (en) 2016-10-28 2020-05-26 The Regents of the University of Caiifomia Synthetic beta-amyloid peptides capable of forming stable antigenic oligomers
TW201827467A (zh) 2016-11-03 2018-08-01 比利時商健生藥品公司 焦穀胺酸類澱粉蛋白-β之抗體及其用途
ES2834484T3 (es) 2016-11-21 2021-06-17 Univ Ruhr Bochum Método para la preselección de fármacos para enfermedades de plegamiento incorrecto de proteínas
CA3044682A1 (en) 2016-12-02 2018-06-07 University Of Southern California Synthetic immune receptors and methods of use thereof
AU2017373962B2 (en) 2016-12-07 2022-03-31 Molecular Templates, Inc. Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation
WO2018115003A2 (en) 2016-12-19 2018-06-28 Glenmark Pharmaceuticals S.A. Novel tnfr agonists and uses thereof
JP7247091B2 (ja) 2016-12-20 2023-03-28 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト 抗cd20/抗cd3二重特異性抗体と4-1bb(cd137)アゴニストの併用療法
MX2019007641A (es) 2016-12-21 2019-09-09 Bayer Pharma AG Conjugados de ligando-farmaco (adcs) con grupos escindibles enzimaticamente.
US10364286B2 (en) 2016-12-22 2019-07-30 H. Lundbeck A/S Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation
EP3559043A4 (en) 2016-12-23 2020-08-05 Bluefin Biomedicine, Inc. ANTI-SEZ6L2 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES
AU2018213194B2 (en) 2017-01-25 2023-01-12 Molecular Templates, Inc. Cell-targeting molecules comprising de-immunized, Shiga toxin A Subunit effectors and CD8+ T-cell epitopes
JP7449092B2 (ja) 2017-01-30 2024-03-13 ナショナル リサーチ カウンシル オブ カナダ 血液脳関門移動化合物及びその使用
CN108395482B (zh) 2017-02-08 2021-02-05 西比曼生物科技(香港)有限公司 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定
US10473672B2 (en) 2017-02-09 2019-11-12 Kaohsiung Chang Gung Memorial Hospital Methods for diagnosing and treating Alzheimers disease using G72 protein and SLC7A11 mRNA as biomarkers
WO2018156250A1 (en) 2017-02-21 2018-08-30 Remd Biotherapeutics, Inc. Cancer treatment using antibodies that bind cytotoxic t-lymphocyte antigen-4 (ctla-4)
US20190374650A1 (en) 2017-02-22 2019-12-12 The Regents Of The University Of Michigan Compositions and methods for delivery of polymer/biomacromolecule conjugates
AU2018241624B2 (en) 2017-03-27 2024-01-25 F. Hoffmann-La Roche Ag Improved antigen binding receptors
US20230399414A1 (en) 2017-03-31 2023-12-14 Genmab Holding B.V, Bispecific anti-cd37 antibodies, monoclonal anti-cd37 antibodies and methods of use thereof
EP3601354A1 (en) 2017-03-31 2020-02-05 Genmab Holding B.V. Bispecific anti-cd37 antibodies, monoclonal anti-cd37 antibodies and methods of use thereof
MY200973A (en) 2017-04-11 2024-01-26 Inhibrx Inc Multispecific Polypeptide Constructs Having Constrained Cd3 Binding And Methods Of Using The Same
CN108728465A (zh) 2017-04-14 2018-11-02 深圳新诺微环生物科技有限公司 一种表达靶细胞-效应细胞桥接器的微环dna载体及其制备方法和应用
SG11201909955XA (en) 2017-05-02 2019-11-28 Merck Sharp & Dohme Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies
KR102714455B1 (ko) 2017-05-08 2024-10-07 상하이 제이엠티-바이오 테크노로지 컴퍼니 리미티드 이중특이성 재조합단백질 및 이의 응용
AU2018265813A1 (en) 2017-05-12 2019-12-05 Galectin Sciences, Llc Compounds for the treatment of systemic insulin resistance disorders and the use thereof
AU2018269498A1 (en) 2017-05-18 2019-10-24 F. Hoffmann-La Roche Ag Reduction of application-related side reaction of a therapeutic antibody
MX2019014577A (es) 2017-06-05 2020-07-29 Janssen Biotech Inc Anticuerpos que se unen especificamente a pd-1 y metodos de uso.
US11214835B1 (en) 2017-06-06 2022-01-04 University Of South Florida Methods and compositions for diagnosis and management of neurodegerative diseases
MA49403A (fr) 2017-06-12 2021-03-24 Obsidian Therapeutics Inc Compositions de pde5 et méthodes d'immunothérapie
CA3069105A1 (en) 2017-07-03 2019-01-10 Torque Therapeutics, Inc. Polynucleotides encoding immunostimulatory fusion molecules and uses thereof
US10662246B2 (en) 2017-07-10 2020-05-26 New York University Monoclonal antibody to treat alzheimer's disease, prion disease, frontotemporal dementias and traumatic brain injury/chronic traumatic encephalopathy
US11220544B2 (en) 2017-07-14 2022-01-11 Cytomx Therapeutics, Inc. Anti-CD166 antibodies and uses thereof
AU2018308088B2 (en) 2017-07-25 2025-05-29 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
US20190029970A1 (en) 2017-07-31 2019-01-31 The Chinese University Of Hong Kong Fatty acid conjugated nanoparticles and uses thereof
JP7498108B2 (ja) 2017-08-03 2024-06-11 ガレクティン・サイエンシーズ・リミテッド・ライアビリティ・カンパニー 医学的障害の予防および治療のための化合物およびその使用
CN111032692A (zh) 2017-08-08 2020-04-17 豪夫迈·罗氏有限公司 一种dlbcl患者亚组的奥滨尤妥珠单抗治疗
CN107881160A (zh) 2017-08-11 2018-04-06 百奥泰生物科技(广州)有限公司 一种由基因组被编辑的cho宿主细胞产生的具有独特糖谱的重组抗体及其制备方法
JP2021500861A (ja) 2017-09-27 2021-01-14 ユニバーシティ オブ サザン カリフォルニア 共刺激のための新規のプラットフォーム、新規のcar設計、および養子細胞療法のための他の増強
EP3466975A1 (en) 2017-10-05 2019-04-10 Laboratoire Français du Fractionnement et des Biotechnologies A specific binding molecule directed against galectin-3 protein
US20200330592A1 (en) 2017-10-09 2020-10-22 Keith Black Compositions and methods of treating alzheimer's and other amyloid related diseases
AU2018350992A1 (en) 2017-10-18 2020-05-21 Regenxbio Inc. Fully-human post-translationally modified antibody therapeutics
CN118772271A (zh) 2017-10-25 2024-10-15 爱兰细胞技术公司 H1.0k180me2抗体、其制造方法和用途
AU2018361991A1 (en) 2017-10-31 2020-05-14 Galectin Sciences, Llc Selenogalactoside compounds for the treatment of systemic insulin resistance disorders and the use thereof
WO2019094679A1 (en) 2017-11-10 2019-05-16 The Regents Of The University Of California BRAIN DELIVERY OF THE BACE INHIBITOR SAPPALPHA, ANTIBODIES, OR INHIBITORY RNA's USING SYNTHETIC EXOSOMES (DEFORMABLE NANOVESICLES, DNVs)
PE20211453A1 (es) 2017-11-29 2021-08-05 Prothena Biosciences Ltd Formulacion liofilizada de un anticuerpo monoclonal contra transtirretina
BR112020011431A2 (pt) 2017-12-06 2020-11-24 Basf As derivados de ácido graxo para o tratamento de esteato-hepatite não alcoólica
CN111492243B (zh) 2017-12-21 2024-11-01 豪夫迈·罗氏有限公司 用于新颖抗原结合模块的特异性测试的car-t细胞测定法
CN109985231A (zh) 2018-01-02 2019-07-09 上海清流生物医药科技有限公司 一种蛋白在制备预防和治疗痴呆症的药物中的应用
WO2019137922A1 (en) 2018-01-09 2019-07-18 Leibniz-Institut Für Naturstoff-Forschung Und Infektionsbiologie Modulators of c1q, in particular of the interaction of apoe with c1q, and uses of the modulators in the therapy of neuronal diseases and inflammation
KR101868343B1 (ko) 2018-01-16 2018-06-18 재단법인대구경북과학기술원 콧물 시료의 베타 아밀로이드 올리고머를 이용한 알츠하이머 질환의 진행 단계 스크리닝용 조성물 및 이를 이용한 알츠하이머 질환의 진행 단계 스크리닝 방법
US12180285B2 (en) 2018-02-01 2024-12-31 Memorial Sloan Kettering Cancer Center Antibodies to galectin-3 and methods of use thereof
US12398201B2 (en) 2018-02-19 2025-08-26 New York University Tau single domain antibodies
WO2019165240A1 (en) 2018-02-23 2019-08-29 Rhnanopharma Nanosuspensions of salsalate and methods of using the same
JP7084569B2 (ja) 2018-02-23 2022-06-15 トゥルーバインディング,インコーポレイテッド Vista及びその結合パートナーの相互作用を遮断することによる癌治療
CN112272677B (zh) 2018-02-26 2024-10-29 米纳瓦生物技术公司 使用抗muc1*抗体的诊断方法
NL2020520B1 (en) 2018-03-02 2019-09-12 Labo Bio Medical Invest B V Multispecific binding molecules for the prevention, treatment and diagnosis of neurodegenerative disorders
MX2020009991A (es) 2018-03-28 2020-10-14 Axon Neuroscience Se Metodos basados en anticuerpos para detectar y tratar la enfermedad de alzheimer.
KR20210018789A (ko) 2018-03-29 2021-02-18 마이크로바스큘러 테라퓨틱스 엘엘씨 알츠하이머 병을 검출하고 치료하기 위한 조성물 및 방법
CN112584901A (zh) 2018-04-04 2021-03-30 真和制药有限公司 用于阻断非糖基化的pd-1多肽之间的相互作用的方法和组合物
IL323061A (en) 2018-04-11 2025-10-01 Inhibrx Biosciences Inc Multispecific polypeptide constructs with forced CD3 binding and related methods and uses
JP7318948B2 (ja) 2018-04-13 2023-08-01 国立大学法人京都大学 微生物由来化合物を用いたアルツハイマー病の予防、治療、または診断薬
MA52545B1 (fr) 2018-04-16 2024-08-30 F. Hoffmann-La Roche Ag Anticorps pour radionucléides chélatés
EP3784274A1 (en) 2018-04-27 2021-03-03 Fondazione Ebri Rita Levi-Montalcini Antibody directed against a tau-derived neurotoxic peptide and uses thereof
US11085935B2 (en) 2018-05-03 2021-08-10 Washington University Methods of treating based on site-specific tau phosphorylation
EP3793686A1 (en) 2018-05-16 2021-03-24 Voyager Therapeutics, Inc. Aav serotypes for brain specific payload delivery
WO2019231957A1 (en) 2018-05-30 2019-12-05 National Health Research Institutes Anti-abeta antibodies and uses thereof
WO2019241315A1 (en) 2018-06-12 2019-12-19 Obsidian Therapeutics, Inc. Pde5 derived regulatory constructs and methods of use in immunotherapy
PL3810128T3 (pl) 2018-06-19 2023-01-30 Universidad Pablo De Olavide Kompozycje do leczenia i/lub zapobiegania chorobom związanym z agregacją białek
US12280063B2 (en) 2018-06-20 2025-04-22 Sanford Burnham Prebys Medical Discovery Institute Anti-retroviral therapies and reverse transcriptase inhibitors for treatment of Alzheimer's disease
BR112021000392A2 (pt) 2018-07-11 2021-04-06 Momenta Pharmaceuticals, Inc. Composições e métodos relacionados a construtos do domínio de ligação fc-antígeno manipulados
CA3107370A1 (en) 2018-07-24 2020-01-30 Eisai R&D Management Co., Ltd. Methods of treatment and prevention of alzheimer's disease
CN112584863B (zh) 2018-08-17 2025-10-28 Ab工作室有限公司 催化抗体和其使用方法
EP3845559A4 (en) 2018-08-31 2022-12-28 Bloom Technology Corporation ANTIBODIES FOR ADVANCED GLYCATION TERMINAL PRODUCTS AND THEIR USE
CN113164572A (zh) 2018-09-11 2021-07-23 华盛顿大学 抗trem-2激动剂抗体
BR112021005086A2 (pt) 2018-09-18 2021-06-08 1Globe Biomedical Co., Ltd. tratamento para doença hepática gordurosa não alcoólica
JP7475687B2 (ja) 2018-09-21 2024-04-30 国立大学法人 東京医科歯科大学 ヒトhmgb1に特異的に結合するヒトモノクローナル抗体、及びそれを含有するアルツハイマー病を治療又は予防するための医薬組成物
EP3861023A1 (en) 2018-10-04 2021-08-11 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Humanised anti-n-truncated amyloid beta monoclonal antibody
WO2020069621A1 (en) 2018-10-04 2020-04-09 University Of Manitoba Novel biomarker for alzheimer's disease in human
US11208485B2 (en) 2018-10-11 2021-12-28 Inhibrx, Inc. PD-1 single domain antibodies and therapeutic compositions thereof
CN112867731A (zh) 2018-10-18 2021-05-28 基本制药有限公司 调节nmda受体介导的毒性的新方法
EP3643319A1 (en) 2018-10-25 2020-04-29 Grifols Worldwide Operations Limited Use of low volume plasma exchange for the treatment of alzheimer's disease in early and middle stages
EA202191179A1 (ru) 2018-10-29 2021-09-09 Байоджен Ма Инк. Гуманизированные и стабилизированные варианты fc5 для улучшения транспорта через гематоэнцефалический барьер
US11925659B2 (en) 2018-10-29 2024-03-12 Cyclo Therapeutics, Inc. Methods for treating Alzheimer's disease
CN111153995B (zh) 2018-11-07 2020-12-25 上海怀越生物科技有限公司 Nkg2a抗体及其制备方法和应用
US20230132366A9 (en) 2018-11-26 2023-04-27 Denali Therapeutics Inc. Methods for treating dysregulated lipid metabolism
WO2020113164A1 (en) 2018-11-30 2020-06-04 Memorial Sloan Kettering Cancer Center Heterodimeric tetravalency and specificity antibody compositions and uses thereof
CN113412089A (zh) 2018-12-04 2021-09-17 脑部保护私人有限公司 包括用于治疗病症的可植入阻尼装置和治疗剂的组合疗法及相关系统和使用方法
WO2020123492A1 (en) 2018-12-10 2020-06-18 New York University Monoclonal antibodies targeting c-terminal region of phosphorylated tau
WO2020127618A1 (en) 2018-12-21 2020-06-25 F. Hoffmann-La Roche Ag Tumor-targeted agonistic cd28 antigen binding molecules
JP2022037257A (ja) 2018-12-27 2022-03-09 クリニジェン株式会社 アルツハイマー病を治療又は予防する為の抗ウイルス剤及びその使用
AU2020207962A1 (en) 2019-01-18 2021-07-22 University Of Southern California Methods and compositions to improve the safety and efficacy of cellular therapies
WO2020154475A1 (en) 2019-01-23 2020-07-30 Molecular Templates, Inc. Proteins comprising modified immunoglobulin variable light chains
JP2022523333A (ja) * 2019-01-30 2022-04-22 トゥルーバインディング,インコーポレイテッド 抗gal3抗体およびその使用
CN111518205B (zh) 2019-02-01 2022-03-29 长春金赛药业有限责任公司 人源化抗Aβ单克隆抗体及其应用
KR20210125048A (ko) 2019-02-08 2021-10-15 에이씨 이뮨 에스.에이. 인산화 타우 펩티드 백신의 안전한 투여 방법
JP7681316B2 (ja) 2019-02-08 2025-05-22 プロセナ バイオサイエンシーズ リミテッド タウを認識する抗体
PL240124B1 (pl) 2019-02-21 2022-02-21 Univ Jagiellonski Sposób określania stopnia uszkodzenia nerek pojawiającego się u chorych z cukrzycą
BR112021016398A2 (pt) 2019-02-22 2021-11-23 Memorial Sloan Kettering Cancer Center Anticorpos cd33 e métodos de uso dos mesmos para tratar o câncer
WO2020176672A1 (en) 2019-02-26 2020-09-03 Cytomx Therapeutics, Inc. Combined therapies of activatable immune checkpoint inhibitors and conjugated activatable antibodies
US20220160710A1 (en) 2019-03-08 2022-05-26 University Of Virginia Patent Foundation Compositions and methods for treating or preventing alzheimer's disease
WO2020191306A1 (en) 2019-03-21 2020-09-24 Immunogen, Inc. Methods of preparing cell-binding agent-drug conjugates
WO2020193644A1 (en) 2019-03-26 2020-10-01 Janssen Pharmaceutica Nv ANTIBODIES TO PYROGLUTAMATE AMYLOID-ß AND USES THEREOF
MX2021011653A (es) 2019-03-29 2021-10-22 Torque Therapeutics Inc Composiciones inmunoterapeuticas y uso de las mismas.
CN113661172A (zh) 2019-03-29 2021-11-16 伊缪诺金公司 用于抑制异常细胞生长或治疗增生性疾病的细胞毒性双苯并二氮杂䓬衍生物及其与细胞结合剂的缀合物
CA3132202A1 (en) 2019-04-08 2020-10-15 Phanes Therapeutics, Inc. Humanized anti-dll3 chimeric antigen receptors and uses thereof
CN114173812A (zh) 2019-04-24 2022-03-11 杨森制药公司 Tau疫苗的异源给予
BR112021021156A2 (pt) 2019-04-24 2022-02-08 Regenxbio Inc Terapêuticos anticorpos totalmente humanos pós-tradução modificados
IL286846B2 (en) 2019-04-26 2025-06-01 Immunogen Inc Camptothecin derivatives
JP7675441B2 (ja) 2019-05-06 2025-05-13 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 移植拒絶反応の非hlaマーカー
EP3965798A4 (en) 2019-05-09 2023-06-14 University of the Witwatersrand, Johannesburg METHOD OF REDUCING THE CONCENTRATION OF TAU (T) PROTEIN AND/OR PHOSPHORYLATED TAU (T) PROTEIN
JP7550794B2 (ja) 2019-05-14 2024-09-13 ジェネンテック, インコーポレイテッド 濾胞性リンパ腫を処置するための抗cd79b免疫複合体の使用方法
WO2020236679A1 (en) 2019-05-17 2020-11-26 Cytomx Therapeutics, Inc. Methods and compositions for determining the biodistribution of activatable anti-cd166 antibody conjugates
TW202110891A (zh) 2019-06-04 2021-03-16 美商維西歐製藥公司 抗psgl-1組合物及其用於調節骨髓細胞發炎表型之方法及用途
CN112111012B (zh) 2019-06-20 2023-07-04 成都恩沐生物科技有限公司 共价多特异性抗体
US20220227815A1 (en) 2019-06-21 2022-07-21 University Of Kansas Compositions and methods useful in treating brain diseases
CN115175933A (zh) 2019-06-26 2022-10-11 阿穆尼克斯制药公司 Cd3抗原结合片段和包含其的组合物
CN114401744B (zh) 2019-06-26 2024-11-05 纪念斯隆凯特琳癌症中心 用于治疗癌症的抗cd33抗体
KR20220027993A (ko) 2019-06-28 2022-03-08 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 알츠하이머 질환을 치료하기 위한 방법 및 조성물
MA56466A (fr) 2019-07-01 2022-05-11 Eisai R&D Man Co Ltd Anticorps anti-epha4
US20220267776A1 (en) 2019-07-05 2022-08-25 University Of Florida Research Foundation, Incorporated Methods for treating ran protein-associated neurological diseases
JP7194085B2 (ja) 2019-07-09 2022-12-21 日立Astemo株式会社 操舵制御装置、操舵制御方法、及び操舵制御システム
EP3999169A4 (en) 2019-07-15 2023-09-06 Cochlear Limited TRANSCUTANEOUS DATA AND ENERGY COMMUNICATION LINK
CA3147239A1 (en) 2019-07-16 2021-01-21 Sanofi Neutralizing anti-amyloid beta antibodies for the treatment of alzheimer's disease
EP4002490A4 (en) 2019-07-17 2023-04-05 Kabushiki Kaisha Toshiba SOLAR BATTERY MODULE AND TANDEM SOLAR BATTERY
DE102019119426A1 (de) 2019-07-17 2021-01-21 Endress+Hauser SE+Co. KG Feldgerät der Automatisierungstechnik
US20220275037A1 (en) 2019-07-19 2022-09-01 Dingding MO ß-AMYLOID CYCLIC RIBONUCLEIC ACID, POLYPEPTIDE, AND APPLICATION THEREOF
US11142586B2 (en) 2019-08-07 2021-10-12 Aqualung Therapeutics Anti-human nicotinamide phosphoribosyltransferase (NAMPT) antibodies
CA3149433A1 (en) 2019-08-14 2021-02-18 Boehringer Ingelheim Rcv Gmbh & Co Kg Caspase-2 variants
AU2020336440A1 (en) 2019-08-30 2022-03-24 Qilu Puget Sound Biotherapeutics Corporation Anti-CD20 antibodies, anti-CD37 antibodies, and mixtures thereof
CN114450292B (zh) 2019-09-09 2024-07-23 武汉友芝友生物制药股份有限公司 断裂型内含肽、使用其的重组多肽的制备方法
JP7696335B2 (ja) 2019-09-09 2025-06-20 スクライブ・セラピューティクス・インコーポレイテッド 免疫療法に使用するための組成物および方法
US20220402979A1 (en) 2019-09-09 2022-12-22 Axon Neuroscience Se Biomarkers and treatments of alzheimer's disease and mild cognitive impairment
EP4438057A3 (en) 2019-09-12 2025-01-01 F. Hoffmann-La Roche AG Compositions and methods of treating lupus nephritis
US11202068B2 (en) 2019-09-16 2021-12-14 Mediatek Inc. Method and apparatus of constrained cross-component adaptive loop filtering for video coding
JP7749543B2 (ja) 2019-09-17 2025-10-06 オハイオ・ステイト・イノベーション・ファウンデーション ヒト抗pd-l1ペプチドワクチン及びその使用方法
US20220372142A1 (en) 2019-09-19 2022-11-24 Igm Biosciences, Inc. Multimeric antibodies with enhanced selectivity for cells with high target density
US20240050562A1 (en) 2019-10-04 2024-02-15 Chugai Seiyaku Kabushiki Kaisha Inhibitor of cell proliferation in obinutuzumab resistant cd20-positive cancer, and medicinal composition, medicine, production, method for inhibiting cell proliferation, therapeutic method, type ii anti-cd20 antibody, compounds, combination of same, enhancer and inducer, each relating thereto
EP4041308A1 (en) 2019-10-07 2022-08-17 University of Virginia Patent Foundation Modulating lymphatic vessels in neurological disease
CN112641953A (zh) 2019-10-10 2021-04-13 复旦大学 一种靶向功能分子修饰的抗体复合物
JP2022553329A (ja) 2019-10-22 2022-12-22 バイオジェン・エムエイ・インコーポレイテッド アルツハイマー病を治療するための抗ベータ-アミロイド抗体
ES2821599A1 (es) 2019-10-24 2021-04-26 Univ Del Pais Vasco / Euskal Herriko Unibertsitatea Compuestos y metodos para el tratamiento de la enfermedad de alzheimer
US20220402998A1 (en) 2019-10-30 2022-12-22 The Texas A&M University System Protease switch for dual targets chimeric antigen receptor t cell therapy
GB201915855D0 (en) 2019-10-31 2019-12-18 Univ Oxford Innovation Ltd An extracellular vesicle
CA3157605A1 (en) 2019-11-13 2021-05-20 Volker Schellenberger Barcoded xten polypeptides and compositions thereof, and methods for making and using the same
CN114761438A (zh) 2019-11-28 2022-07-15 麦克马斯特大学 用于编程细胞外囊泡的重组多肽
CN115279789A (zh) 2019-12-06 2022-11-01 真和制药有限公司 破坏gal3和胰岛素受体或整联蛋白的相互作用的抗体及其使用方法
US20230046007A1 (en) 2019-12-17 2023-02-16 Cirlo Gmbh Tubular shaped elongated catheter device assemblies for interacting with components of bodily fluids, method for recovering cells, cell aggregates and exosomes from a tubular shaped elongated catheter device and smart tubular shaped elongated catheter device assemblies for monitoring interaction with components of bodily fluids
US11913945B2 (en) 2020-01-02 2024-02-27 Hoffmann-La Roche Inc. Method for determining the amount of a therapeutic antibody in the brain
AU2021207461A1 (en) 2020-01-13 2022-09-01 Truebinding, Inc. Anti-Gal3 antibodies and methods of use
KR20220131279A (ko) 2020-01-21 2022-09-27 상하이 헨리우스 바이오테크, 인크. 항lag3단일 클론 항체 및 그 제조 방법과 응용
CN115380047A (zh) 2020-01-29 2022-11-22 印希比股份有限公司 Cd28单结构域抗体及其多价和多特异性构建体
TWI853145B (zh) 2020-02-05 2024-08-21 日商住友製藥股份有限公司 Tau蛋白病變及失智症相關疾病之判定藥及判定方法
IL295122A (en) 2020-02-12 2022-09-01 Scripps Research Inst Long-acting gm-csf and methods of use
WO2021163681A2 (en) 2020-02-14 2021-08-19 The Trustees Of Columbia University In The City Of New York Combination of retromer pharmacological chaperones and exogenous retromer for the treatment of alzheimer's disease and other neurodegenerative diseases and disorders
WO2021167723A1 (en) 2020-02-17 2021-08-26 Board Of Regents, The University Of Texas System Chimeric scavenger receptors targeted to phosphorylated tau (ptau) and uses thereof
EP4114861A4 (en) 2020-03-02 2024-05-08 The Regents Of The University Of California CHIMERIC ANTIGEN RECEPTORS AND RELATED COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
GB202003428D0 (en) 2020-03-10 2020-04-22 Univ Dundee IL-10 mutiens
CN113384710A (zh) 2020-03-14 2021-09-14 杭州星鳌生物科技有限公司 新型免疫激动剂复合物的组成及其在抗多种疾病药物中的应用
IL296411A (en) 2020-03-16 2022-11-01 Univ Southern California Novel antigen binding domains and synthetic antigen receptors incorporating them
CN113402612A (zh) 2020-03-17 2021-09-17 西比曼生物科技(香港)有限公司 靶向cd19和cd20的联合嵌合抗原受体及其应用
US20230212255A1 (en) 2020-03-17 2023-07-06 Cellular Biomedicine Group Inc. Combined chimeric antigen receptor targeting cd19 and cd20 and applications thereof
US20230104705A1 (en) 2020-03-17 2023-04-06 Cellular Biomedicine Group Inc. Combined chimeric antigen receptor targeting cd19 and cd20 and application thereof
WO2021186079A1 (en) 2020-03-20 2021-09-23 Heidelberg University Colloidal carrier systems for transfer of agents to a desired site of action
US20230107479A1 (en) 2020-03-23 2023-04-06 G3 Pharmaceuticals, Inc. Methods and compositions for preventing and treating fibrosis resulting from a coronavirus infection
TW202342093A (zh) 2020-03-24 2023-11-01 大陸商深圳瑞健生命科學研究院有限公司 一種治療阿茲海默症的方法和藥物
CA3176937A1 (en) 2020-03-24 2021-09-30 Talengen International Limited Method and drug for promoting degradation of misfolded protein and aggregate thereof
US20230141177A1 (en) 2020-03-31 2023-05-11 The University Of British Columbia Antibodies to misfolded amyloid beta
CA3174646A1 (en) 2020-04-07 2021-10-14 Pieter Muntendam Methods and compositions for preventing and treating retinal nerve damage
JP2023522853A (ja) 2020-04-07 2023-06-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 中枢神経系及び非中枢神経系への治療薬の送達のための合成エキソソームの製造
WO2021216832A1 (en) 2020-04-23 2021-10-28 Remd Biotherapeutics, Inc. Chemokine receptor 4 (cxcr4) antagonist antibodies
US20230265204A1 (en) 2020-04-24 2023-08-24 Hoffmann-La Roche Inc. Enzyme and pathway modulation with sulfhydryl compounds and their derivatives
CN115916822A (zh) 2020-04-24 2023-04-04 基因泰克公司 使用抗CD79b免疫缀合物的方法
BR112022023366A2 (pt) 2020-05-19 2023-05-02 Othair Prothena Ltd Vacina com múltiplos epítopos para o tratamento de mal de alzheimer
US12281166B2 (en) 2020-05-26 2025-04-22 Truebinding, Inc. Methods of treating inflammatory diseases by blocking Galectin-3
WO2021242545A1 (en) 2020-05-29 2021-12-02 The Regents Of The University Of California Agents and methods for treating tauopathies
KR20230037532A (ko) 2020-06-02 2023-03-16 다이내믹큐어 바이오테크놀로지 엘엘씨 항-cd93 구축물 및 그의 용도
CN116529260A (zh) 2020-06-02 2023-08-01 当康生物技术有限责任公司 抗cd93构建体及其用途
TWI838626B (zh) 2020-06-03 2024-04-11 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
US20230235036A1 (en) 2020-06-05 2023-07-27 The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads Acvr1 (alk2) receptor inhibition to treat neurological diseases
KR102225447B1 (ko) 2020-06-16 2021-03-08 부산대학교 산학협력단 구강 세균의 군집을 이용한 알츠하이머 진단용 바이오마커 및 이의 용도
AR122657A1 (es) 2020-06-19 2022-09-28 Hoffmann La Roche Moléculas de unión al dominio fc de activación inmunitaria
IL299215A (en) 2020-06-25 2023-02-01 Medimmune Ltd Prevention of axonal damage through binding of an antibody to amyloid beta 1-42
US20210403644A1 (en) 2020-06-29 2021-12-30 University Of South Carolina Method For The Degradation Of Endogenous Protein
US20230256092A1 (en) 2020-06-30 2023-08-17 Shionogi & Co., Ltd. Combined use of anti-ccr8 antibody and chemotherapeutic agent
KR20230066317A (ko) 2020-07-10 2023-05-15 바이오몰레큘러 홀딩스 엘엘씨 사면체 항체
AU2021313128B2 (en) 2020-07-20 2025-05-22 Genentech, Inc. Methods for middle down antibody characterization
WO2022018726A1 (en) 2020-07-20 2022-01-27 Neotx Therapeutics Ltd. Superantigen conjugate for use in methods and compositions for treating cancer
BR112022027096A2 (pt) 2020-07-21 2023-04-25 Amunix Pharmaceuticals Inc Composições e métodos relacionados a agentes terapêuticos ativáveis
KR20230133832A (ko) 2020-07-29 2023-09-19 다이내믹큐어 바이오테크놀로지 엘엘씨 항-cd93 구축물 및 그의 용도
CN116406295A (zh) 2020-07-30 2023-07-07 安奈普泰斯生物有限公司 针对鱼鳞病的抗白介素36受体(il-36r)疗法
WO2022026740A1 (en) 2020-07-30 2022-02-03 Unigen, Inc. A standardized bioflavonoid composition for regulation of homeostasis of host defense mechanism
EP4189121A1 (en) 2020-08-03 2023-06-07 Genentech, Inc. Diagnostic and therapeutic methods for lymphoma
WO2022029051A1 (en) 2020-08-03 2022-02-10 F. Hoffmann-La Roche Ag Improved antigen binding receptors
AR122129A1 (es) 2020-08-07 2022-08-17 Prothena Biosciences Ltd Vacuna de tau para el tratamiento de la enfermedad de alzheimer
KR20230080397A (ko) 2020-08-07 2023-06-07 오타이르 프로테나 리미티드 알츠하이머 질환을 치료하기 위한 멀티에피토프 백신
US20230295258A1 (en) 2020-08-11 2023-09-21 Kanaph Therapeutics Inc. Fusion protein comprising il-12 and anti-fap antibody, and use thereof
MX2023002511A (es) 2020-08-28 2023-04-20 Harbour Biomed Us Inc Anticuerpo anti-ccr8 y aplicacion del mismo.
CA3161919A1 (en) 2020-09-01 2022-03-10 Remegen Co., Ltd. Anti-c-met antibody-drug conjugate and applications thereof
AU2021345451A1 (en) 2020-09-17 2023-04-13 Othair Prothena Limited Beta-amyloid vaccine for the treatment of alzheimer's disease
CA3192387A1 (en) 2020-09-18 2022-03-24 Othair Prothena Limited Multiepitope vaccine for the treatment of alzheimer's disease
EP4213946A1 (en) 2020-09-18 2023-07-26 Pieris Pharmaceuticals GmbH Biomarker methods and uses
CN116322691A (zh) 2020-09-24 2023-06-23 豪夫迈·罗氏有限公司 T细胞双特异性抗体相关不良反应的预防或减轻
WO2022072538A1 (en) 2020-09-30 2022-04-07 Biotheryx, Inc. Antibody-drug conjugates, pharmaceutical compositions thereof, and their therapeutic applications
KR20230104617A (ko) 2020-10-07 2023-07-10 드렌 바이오, 인크. 항-덱틴-1 항체 및 이의 사용 방법
MX2023004349A (es) 2020-10-16 2023-08-22 Lanova Medicines Ltd Anticuerpos monoclonales anti-ccr8 y sus usos.
EP4237449A1 (en) 2020-10-28 2023-09-06 F. Hoffmann-La Roche AG Improved antigen binding receptors
KR20230107235A (ko) 2020-11-10 2023-07-14 에프. 호프만-라 로슈 아게 T 세포 관여제 관련 부정적인 효과의 예방 또는 완화
EP4259201A4 (en) 2020-12-08 2025-03-19 Memorial Sloan Kettering Cancer Center Antibodies to galectin-3 and methods of use thereof
CN114656562B (zh) 2020-12-23 2023-11-03 北京天广实生物技术股份有限公司 结合人和猴cd3的抗体及其应用
IL304067A (en) 2021-01-06 2023-08-01 Hoffmann La Roche Combined treatment using PD1-LAG3 bispecific antibody and CD20 T cell bispecific antibody
WO2022150644A1 (en) 2021-01-08 2022-07-14 Anaptysbio, Inc. Anti-interleukin 36 receptor (il-36r) therapy for acne
US20240084021A1 (en) 2021-01-08 2024-03-14 Anaptysbio, Inc. Anti-interleukin 36 receptor (il-36r) therapy for hidradenitis suppurativa
EP4284824A4 (en) 2021-01-27 2025-03-12 AbelZeta Inc. CHIMERIC ANTIGEN RECEPTORS TARGETING CD20
EP4286406A4 (en) 2021-01-29 2025-07-23 Illimis Therapeutics Inc FUSION MOLECULE WITH NON-INFLAMMATORY PHAGOCYTOSIS-INDUCING ACTIVITY
CA3208717A1 (en) 2021-02-19 2022-08-25 Preet M. Chaudhary Single-chain and multi-chain synthetic antigen receptors for diverse immune cells
MX2023010812A (es) 2021-03-15 2023-09-27 Genentech Inc Composiciones y metodos para tratar la nefritis lupica.
TW202300179A (zh) 2021-03-18 2023-01-01 美商西根公司 內化的生物活性化合物偶聯物選擇性釋放藥物
US12036286B2 (en) 2021-03-18 2024-07-16 Seagen Inc. Selective drug release from internalized conjugates of biologically active compounds
CN117355319A (zh) 2021-03-23 2024-01-05 皮里斯制药有限责任公司 用于癌症治疗的her2/4-1bb双特异性融合蛋白
WO2022200478A1 (en) 2021-03-24 2022-09-29 Pieris Pharmaceuticals Gmbh Tumor treatment with a 4-1bb/her2-bispecific agent and a her2-targeted tyrosine kinase inhibitor
WO2022204282A1 (en) 2021-03-24 2022-09-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bicistronic chimeric antigen receptors designed to reduce retroviral recombination and uses thereof
US20240199750A1 (en) 2021-03-26 2024-06-20 Innate Pharma Multispecific proteins comprising an nkp46-binding site, a cancer antgienge binding site fused to a cytokine for nk cell engaging
EP4314050A4 (en) 2021-04-02 2025-02-26 The Board of Trustees of the Leland Stanford Junior University BISPECIFIC MOLECULES AND RELATED COMPOSITIONS AND METHODS
MX2023012364A (es) 2021-04-20 2023-11-01 Seagen Inc Modulacion de citotoxicidad celular dependiente de anticuerpos.
EP4326271A1 (en) 2021-04-23 2024-02-28 F. Hoffmann-La Roche AG Prevention or mitigation of nk cell engaging agent-related adverse effects
EP4329804A4 (en) 2021-04-26 2025-03-19 TrueBinding, Inc. Anti-gal3 antibody formulations and methods of use thereof
MX2023012408A (es) 2021-04-30 2023-10-31 Hoffmann La Roche Dosis para tratamiento conjunto con anticuerpo biespecifico anti-cd20/anti-cd3 y conjugado anticuerpo farmaco anti-cd79b.
TW202244059A (zh) 2021-04-30 2022-11-16 瑞士商赫孚孟拉羅股份公司 用抗cd20/抗cd3雙特異性抗體進行治療之給藥
WO2022235622A2 (en) 2021-05-04 2022-11-10 Biocove Llc Cd20 targeting fusion proteins and methods of use thereof
MX2023013264A (es) 2021-05-12 2023-11-30 Genentech Inc Metodos para usar inmunoconjugados anti-cd79b para tratar linfoma difuso de linfocitos b grandes.
US20240285740A1 (en) 2021-05-12 2024-08-29 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating cancer
CA3218343A1 (en) 2021-05-12 2022-11-17 Anaptysbio, Inc. Antibody composition
WO2022251850A1 (en) 2021-05-28 2022-12-01 Seagen Inc. Anthracycline antibody conjugates
AR126009A1 (es) 2021-06-02 2023-08-30 Hoffmann La Roche Moléculas agonistas de unión al antígeno cd28 que se dirigen a epcam
CN118139641A (zh) 2021-06-04 2024-06-04 Xencor股份有限公司 结合cd20和cd3的双重特异性抗体的剂量施用
JP2024524870A (ja) 2021-06-08 2024-07-09 トゥルーバインディング,インコーポレイテッド 抗gal3抗体およびインスリン抵抗性に使用する方法
WO2022258691A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a
EP4351733A1 (en) 2021-06-09 2024-04-17 Innate Pharma Multispecific antibodies binding to cd20, nkp46, cd16 and conjugated to il-2
AU2022288037A1 (en) 2021-06-09 2023-12-14 Shanghai Epimab Biotherapeutics Co., Ltd. Antibodies and bispecific binding proteins that bind ox40 and/or pd-l1
KR20240019297A (ko) 2021-06-09 2024-02-14 이나뜨 파르마 에스.에이. Nkp46, 사이토카인 수용체, 종양 항원 및 cd16a 에 결합하는 다중특이적 단백질
WO2022258678A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a
AU2022294106A1 (en) 2021-06-18 2024-01-25 Therini Bio, Inc. ANTIBODIES WHICH BIND HUMAN FIBRIN OR FIBRINOGEN γC DOMAIN AND METHODS OF USE
EP4355772A4 (en) 2021-06-18 2025-07-30 Therini Bio Inc ANTIBODIES THAT BIND TO THE ?C DOMAIN OF HUMAN FIBRIN OR FIBRINOGEN AND METHODS OF USE
US20240189341A1 (en) 2021-06-22 2024-06-13 Remegen Co., Ltd. Pharmaceutical combination and use thereof
JP2024527288A (ja) 2021-06-25 2024-07-24 ナンキン イムノファージ バイオテック カンパニー リミテッド 抗ccr8抗体及びその使用
US20230201365A1 (en) 2021-07-09 2023-06-29 Bright Peak Therapeutics Ag Modified cd20 antibodies and uses thereof
US20230201364A1 (en) 2021-07-09 2023-06-29 Bright Peak Therapeutics Ag Antibody conjugates and manufacture thereof
EP4370555A4 (en) 2021-07-13 2025-11-12 Truebinding Inc METHODS FOR PREVENTING PROTEIN AGGREGATION
US20230197278A1 (en) 2021-07-13 2023-06-22 Genentech, Inc. Multi-variate model for predicting cytokine release syndrome
EP4370541A1 (en) 2021-07-14 2024-05-22 2seventy bio, Inc. Engineered t cell receptors fused to binding domains from antibodies
CN117730102A (zh) 2021-07-22 2024-03-19 豪夫迈·罗氏有限公司 异二聚体Fc结构域抗体
US20240336697A1 (en) 2021-08-07 2024-10-10 Genentech, Inc. Methods of using anti-cd79b immunoconjugates to treat diffuse large b-cell lymphoma
WO2023019216A2 (en) 2021-08-13 2023-02-16 The Board Of Trustees Of The Leland Stanford Junior University Methods for diagnosing and treating ischemic eye disease
CN118591388A (zh) 2021-09-29 2024-09-03 摩德斯医疗股份有限公司 抗原结合多肽、抗原结合多肽复合物及其使用方法
MX2024003808A (es) 2021-09-29 2024-06-11 Modex Therapeutics Inc Polipeptidos de union a antigeno, complejos de polipeptidos de union a antigeno y metodos de uso de los mismos.
WO2023051727A1 (zh) 2021-09-30 2023-04-06 上海君实生物医药科技股份有限公司 结合cd3的抗体及其用途
AR127271A1 (es) 2021-10-09 2024-01-03 Hutchmed Ltd Anticuerpos biespecíficos que se unen específicamente a cd47 y cd20, y usos de los mismos
CN115746134A (zh) 2021-10-15 2023-03-07 深圳市睿盟创新生物科技有限公司 半乳糖凝集素-3的免疫测定
KR20230060546A (ko) 2021-10-22 2023-05-04 상트네어바이오사이언스 주식회사 두개의 Fc 도메인을 포함하는 항원 결합 단백질 및 이의 용도
EP4423125A1 (en) 2021-10-29 2024-09-04 Zielbio, Inc. Cancer specific plectin-1 specific antibodies and methods of use thereof
JP2024544508A (ja) 2021-11-09 2024-12-03 トゥルーバインディング,インコーポレイテッド 心臓血管疾患を治療または阻害する方法
AU2022397540A1 (en) 2021-11-25 2024-05-16 F. Hoffmann-La Roche Ag Improved antigen binding receptors
TW202342105A (zh) 2021-12-17 2023-11-01 大陸商北京加科思新藥研發有限公司 包含可用作sting激動劑的化合物的化合物-連接基構建體及其用途
US20250368744A1 (en) 2021-12-23 2025-12-04 Concept To Medicine Biotech Co., Ltd. Anti-ccr8 antibodies and uses thereof
EP4458861A1 (en) 2021-12-29 2024-11-06 Sichuan Huiyu Pharmaceutical Co., Ltd. Antibody targeting cd3, multispecific antibody, and uses thereof
WO2023137387A2 (en) 2022-01-12 2023-07-20 Biomolecular Holdings Llc Tetrahedral antibodies
WO2023137373A1 (en) 2022-01-12 2023-07-20 Biomolecular Holdings Llc Tetrahedral antibodies
JP2025508317A (ja) 2022-01-20 2025-03-26 上海君▲実▼生物医▲薬▼科技股▲分▼有限公司 抗cd3及び抗cd20二重特異性抗体、並びにその使用
CN119053342A (zh) 2022-01-21 2024-11-29 礼进生物医药控股有限公司 用于亲合力受体交联和免疫调节的多特异性抗体
KR20230119859A (ko) 2022-02-08 2023-08-16 연세대학교 산학협력단 신규 이중타겟 융합항체를 유효성분으로 포함하는 암의 예방 또는 치료용 조성물
TW202400643A (zh) 2022-02-28 2024-01-01 日商帝人製藥股份有限公司 神經退化性疾病之治療劑
GB202203070D0 (en) 2022-03-04 2022-04-20 Iksuda Therapeutics Ltd Anti-canag antibody conjugate
EP4493223A2 (en) 2022-03-17 2025-01-22 Seagen Inc. Camptothecin conjugates
CN116789820A (zh) 2022-03-18 2023-09-22 北京天诺健成医药科技有限公司 一种新型免疫调节剂的开发和应用
KR20240164782A (ko) 2022-03-23 2024-11-20 에프. 호프만-라 로슈 아게 항-cd20/항-cd3 이중특이적 항체와 화학요법의 병용 치료
EP4499685A1 (en) 2022-03-25 2025-02-05 CytomX Therapeutics, Inc. Activatable dual-anchored masked molecules and methods of use thereof
WO2023180533A1 (en) 2022-03-25 2023-09-28 Les Laboratoires Servier Anti-gal3 antibodies and compositions
CA3255392A1 (en) 2022-04-04 2023-10-12 Dren Bio Inc Anti-Dectin-1 Antibodies and Their Methods of Use
US20250223364A1 (en) 2022-04-04 2025-07-10 Dren Bio, Inc. Multispecific binding proteins that bind dectin-1 and cd20 and methods of use thereof
CN119546327A (zh) 2022-04-08 2025-02-28 再生元制药公司 多部分受体和信号传导复合物
CN118974091A (zh) 2022-04-11 2024-11-15 阿斯利康(瑞典)有限公司 T细胞结合蛋白
AR129062A1 (es) 2022-04-13 2024-07-10 Genentech Inc Composiciones farmacéuticas de proteínas terapéuticas y métodos de uso
KR20250004776A (ko) 2022-04-13 2025-01-08 에프. 호프만-라 로슈 아게 항-cd20/항-cd3 이중특이성 항체의 약학 조성물 및 사용 방법
CN119365479A (zh) 2022-04-15 2025-01-24 慕宝盛科生物医药(上海)有限公司 包含Toll样受体激动剂的缀合物
CN117003872A (zh) 2022-04-28 2023-11-07 北京天广实生物技术股份有限公司 含有突变轻链可变区骨架的单链抗体片段
CN119546335A (zh) 2022-05-03 2025-02-28 Xencor股份有限公司 治疗淋巴瘤的方法
WO2023215740A1 (en) 2022-05-06 2023-11-09 Seagen Inc. Immunomodulatory antibody-drug conjugates
IL316140A (en) 2022-05-25 2024-12-01 Innate Pharma NECTIN-4 binding agents
US20230416412A1 (en) 2022-05-31 2023-12-28 Hoffmann-La Roche Inc. Prevention or mitigation of t-cell engaging agent-related adverse effects
CN117323429A (zh) 2022-07-01 2024-01-02 广东克冠达医药科技有限公司 Cd101的抗体及其用途
CN119630428A (zh) 2022-07-12 2025-03-14 西托姆克斯治疗公司 Epcam免疫缀合物及其用途
WO2024026407A1 (en) 2022-07-28 2024-02-01 The Board Of Regents Of The University Of Oklahoma Biomarkers, diagnostic methods, treatments, and therapeutics for autoimmune disorders and diseases
AR130111A1 (es) 2022-08-03 2024-11-06 Seagen Inc Conjugados de anticuerpo y fármaco inmunoestimuladores
WO2024036148A1 (en) 2022-08-08 2024-02-15 A2 Biotherapeutics, Inc. Compositions and methods for treating blood cancers
EP4321522A1 (en) 2022-08-12 2024-02-14 Seagen Inc. Cytotoxic compounds and conjugates thereof
EP4572772A1 (en) 2022-08-17 2025-06-25 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
CN117051537A (zh) 2023-07-03 2023-11-14 五邑大学 一种乙酰化葡甘聚糖静电纺丝膜及其制备方法与应用

Similar Documents

Publication Publication Date Title
JP2020529469A5 (enExample)
US11866509B2 (en) Humanized antibodies against CEACAM1
US11154617B2 (en) Means and methods for the treament of B cell non-hodgkin lymphoma and B cell leukemia
CN103429618B (zh) 抗ror1抗体及其用途
CN104684552B (zh) 组合及其用途
CN104487088A (zh) 治疗gd2阳性癌的方法
Sinha et al. Pemphigus vulgaris: approach to treatment
KR20160024391A (ko) 종양 성장 및 전이를 억제하기 위한 면역 조절 요법과 병용되는 세마포린-4d 억제성 분자의 용도
JP2024001125A (ja) Il-17アンタゴニストを用いて初発プラーク型乾癬を治療する方法
KR102104296B1 (ko) 종양성 질병들에 대한 치료
WO2017205213A1 (en) Combination therapy of abemaciclib and immune checkpoint modulators for use in the treatment of cancer
KR20200010472A (ko) 항-cd19 항체 및 베네토클락스 조합 치료에 대한 치료 패러다임
JP6999286B2 (ja) 腫瘍関連抗原に対し特異的な治療用モノクローナル抗体および免疫アジュバントを用いたがん治療
JP2020500161A5 (enExample)
CN111655725A (zh) 用于治疗癌症的组合产品
WO2015101996A1 (en) Antibodies to ceacam1 and kinase inhibitors for treating braf-mutated cells
CN113993543B (zh) 使用抗cd38抗体的组合疗法
CN107106676A (zh) 用于治疗肉瘤的组合物和方法
US20230302168A1 (en) Dr5 radioimmunotherapy in the treatment of solid cancers
US20220016142A1 (en) Combination therapy for treatment of cancer
CN113616664A (zh) 丁香酸葡萄糖苷在制备抑制pd1和pd-l1蛋白之间相互作用药物中的应用
US20240092934A1 (en) Assessment of ceacam1 expression on tumor infiltrating lymphocytes
CN103041387B (zh) 恶性b细胞淋巴瘤抗体药物的新用途
AU2020320187B2 (en) Antibody pre-loaded CD16+NK-92 cells as an effective therapeutic product for tumor lysis
EP3652206A1 (en) Treatment of b cell malignancies using afucosylated pro-apoptotic anti-cd19 antibodies in combination with anti cd20 antibodies or chemotherapeutics