AR103713A1 - Anticuerpos contra tau y sus usos - Google Patents

Anticuerpos contra tau y sus usos

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Publication number
AR103713A1
AR103713A1 ARP160100412A ARP160100412A AR103713A1 AR 103713 A1 AR103713 A1 AR 103713A1 AR P160100412 A ARP160100412 A AR P160100412A AR P160100412 A ARP160100412 A AR P160100412A AR 103713 A1 AR103713 A1 AR 103713A1
Authority
AR
Argentina
Prior art keywords
seq
given
amino acid
acid sequence
tau
Prior art date
Application number
ARP160100412A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR103713A1 publication Critical patent/AR103713A1/es

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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Abstract

Anticuerpos monoclonales que se agregan a tau humana, composiciones que comprenden tales anticuerpos tau, y métodos de uso de tales anticuerpos contra tau para el tratamiento de enfermedades neurodegenerativas incluyendo enfermedad de Alzheimer, Parálisis Supranuclear Progresiva y enfermedad de Pick. Reivindicación 1: Un anticuerpo monoclonal que se une a tau humana que comprende una región variable de cadena ligera (LCVR) y una región variable de cadena pesada (HCVR), donde la LCVR comprende regiones determinantes de complementariedad (CDR) LCDR1, LCDR2 y LCDR3 y la HCVR comprende CDR HCDR1, HCDR2 y HCDR3, donde la secuencia de aminoácidos de LCDR1 está dada por SEQ ID Nº 3, la secuencia de aminoácidos de LCDR2 está dada por SEQ ID Nº 4, la secuencia de aminoácidos de LCDR3 está dada por SEQ ID Nº 5, la secuencia de aminoácidos de HCDR1 está dada por SEQ ID Nº 6, la secuencia de aminoácidos de HCDR2 está dada por SEQ ID Nº 7, y la secuencia de aminoácidos de HCDR3 está dada por SEQ ID Nº 8.
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