MX2019006656A - Polipeptidos efectores de la sub-unidad a de la toxina shiga andamiajes de los efectores de la toxina shiga y moleculas con direccion hacia las celulas para la conjugacion especifica del sitio. - Google Patents
Polipeptidos efectores de la sub-unidad a de la toxina shiga andamiajes de los efectores de la toxina shiga y moleculas con direccion hacia las celulas para la conjugacion especifica del sitio.Info
- Publication number
- MX2019006656A MX2019006656A MX2019006656A MX2019006656A MX2019006656A MX 2019006656 A MX2019006656 A MX 2019006656A MX 2019006656 A MX2019006656 A MX 2019006656A MX 2019006656 A MX2019006656 A MX 2019006656A MX 2019006656 A MX2019006656 A MX 2019006656A
- Authority
- MX
- Mexico
- Prior art keywords
- molecules
- cell
- shiga toxin
- present
- site
- Prior art date
Links
- 108010079723 Shiga Toxin Proteins 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 239000012636 effector Substances 0.000 title 2
- 230000021615 conjugation Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 abstract 1
- 208000026350 Inborn Genetic disease Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000016361 genetic disease Diseases 0.000 abstract 1
- 230000009546 growth abnormality Effects 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/25—Shigella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6829—Bacterial toxins, e.g. diphteria toxins or Pseudomonas exotoxin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/05—Fusion polypeptide containing a localisation/targetting motif containing a GOLGI retention signal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Birds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
Abstract
La presente invención proporciona polipéptidos derivados de la sub-unidad A de la toxina Shiga, andamiajes, y moléculas con dirección hacia las células que comprenden sustituciones de aminoácidos que equipan a las moléculas con posiciones específicas del sitio (y con frecuencia con residuos de aminoácidos únicos en la molécula) para su enlace con otras moléculas mientras que conservan las funciones de la toxina Shiga, tales como, por ejemplo, el encaminamiento intra-celular eficiente y/o una potente citotoxicidad. La presente invención también proporciona moléculas con dirección hacia las células, y/o componentes de las mismas, que comprenden posiciones específicas del sitio para su enlace con otras moléculas, tales como, por ejemplo, los agentes que alteran una propiedad de la molécula con dirección hacia las células o una carga para el suministro. Ciertas moléculas que comprenden un polipéptido de la presente invención exhiben una inmunogenicidad reducida y/o son bien toleradas por los mamíferos. Las moléculas con dirección hacia las células de la presente invención, y las composiciones de las mismas, tienen usos, por ejemplo, para el suministro selectivo de las cargas a las células que expresan el objetivo, y como moléculas de diagnóstico y/o terapéuticas para el tratamiento de una variedad de enfermedades, trastornos y afecciones, las cuales incluyen trastornos genéticos, predisposiciones genéticas, infecciones, cánceres, tumores, anormalidades del crecimiento, y/o trastornos inmunológicos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662431036P | 2016-12-07 | 2016-12-07 | |
PCT/US2017/065074 WO2018106895A1 (en) | 2016-12-07 | 2017-12-07 | Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019006656A true MX2019006656A (es) | 2019-09-09 |
Family
ID=60888632
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019006656A MX2019006656A (es) | 2016-12-07 | 2017-12-07 | Polipeptidos efectores de la sub-unidad a de la toxina shiga andamiajes de los efectores de la toxina shiga y moleculas con direccion hacia las celulas para la conjugacion especifica del sitio. |
MX2022006511A MX2022006511A (es) | 2016-12-07 | 2019-06-06 | Polipeptidos efectores de la sub-unidad a de la toxina shiga, andamiajes de los efectores de la toxina shiga, y moleculas con direccion hacia las celulas para la conjugacion especifica del sitio. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022006511A MX2022006511A (es) | 2016-12-07 | 2019-06-06 | Polipeptidos efectores de la sub-unidad a de la toxina shiga, andamiajes de los efectores de la toxina shiga, y moleculas con direccion hacia las celulas para la conjugacion especifica del sitio. |
Country Status (10)
Country | Link |
---|---|
US (4) | US20210008208A1 (es) |
EP (2) | EP3608333A1 (es) |
JP (2) | JP7075134B2 (es) |
KR (2) | KR102580647B1 (es) |
CN (2) | CN110494443A (es) |
AU (2) | AU2017373962B2 (es) |
CA (1) | CA3043333A1 (es) |
IL (3) | IL293710B1 (es) |
MX (2) | MX2019006656A (es) |
WO (1) | WO2018106895A1 (es) |
Families Citing this family (23)
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IL285403B2 (en) | 2014-01-27 | 2023-10-01 | Molecular Templates Inc | Polypeptides that remove an epitope for MHC group I |
US11142584B2 (en) | 2014-03-11 | 2021-10-12 | Molecular Templates, Inc. | CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same |
CN106604934A (zh) | 2014-06-11 | 2017-04-26 | 分子模板公司 | 耐受蛋白酶切割的志贺毒素a亚基效应子多肽和包含其的细胞靶向分子 |
JP6444486B2 (ja) | 2015-02-05 | 2018-12-26 | モレキュラー テンプレーツ, インク.Molecular Templates, Inc. | 志賀毒素aサブユニットエフェクター領域を含む多価cd20結合分子及びそれらの強化組成物 |
MX2017015493A (es) | 2015-05-30 | 2018-02-09 | Molecular Templates Inc | Andamiajes de la subunidad a de la toxina shiga desinmunizados y moleculas con direccion a las celulas que los comprenden. |
IL293710B1 (en) | 2016-12-07 | 2024-06-01 | Molecular Templates Inc | Shiga toxin A subunit activator polypeptides, Shiga toxin activator scaffolds and cell-targeting molecules for site-specific conjugation |
US20200024312A1 (en) | 2017-01-25 | 2020-01-23 | Molecular Templates, Inc. | Cell-targeting molecules comprising de-immunized, shiga toxin a subunit effectors and cd8+ t-cell epitopes |
CN112105376A (zh) | 2018-03-08 | 2020-12-18 | 应用分子运输公司 | 用于经口递送的毒素衍生的递送构建体 |
IL268443B2 (en) * | 2018-04-17 | 2024-07-01 | Molecular Templates Inc | HER2-targeted molecules containing Shiga toxin subunit A scaffolds, without vaccination |
WO2020081493A1 (en) | 2018-10-16 | 2020-04-23 | Molecular Templates, Inc. | Pd-l1 binding proteins |
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CA3127660A1 (en) | 2019-01-23 | 2020-07-30 | Millennium Pharmaceuticals, Inc. | Cd38-binding proteins comprising de-immunized shiga toxin a subunit effectors |
BR112022002962A2 (pt) | 2019-08-16 | 2022-07-05 | Applied Molecular Transport Inc | Composições, formulações e produção e purificação de interleucina |
US11918649B2 (en) | 2019-09-18 | 2024-03-05 | Molecular Templates, Inc. | PD-L1-binding molecules comprising Shiga toxin a subunit scaffolds |
JP2022548078A (ja) | 2019-09-18 | 2022-11-16 | モレキュラー テンプレーツ,インク. | 志賀毒素aサブユニット足場を含むpd-l1結合分子 |
WO2021087248A1 (en) * | 2019-10-31 | 2021-05-06 | R.P. Scherer Technologies, Llc | Anti-cd37 antibody-maytansine conjugates and methods of use thereof |
CN110862459A (zh) * | 2019-11-18 | 2020-03-06 | 温州医科大学 | Hpv16e7亲和体负载颗粒酶b的亲和毒素靶向分子及其用途 |
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WO2022270901A1 (ko) * | 2021-06-25 | 2022-12-29 | 장재원 | 동적 형광 또는 x-선의 표준편차와 자기상관을 활용한 조기 진단 시스템 |
WO2023278424A1 (en) * | 2021-06-28 | 2023-01-05 | The Regents Of The University Of California | Methods for treating and ameliorating t cell related diseases |
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KR102580647B1 (ko) | 2023-09-20 |
JP2020511935A (ja) | 2020-04-23 |
IL266583A (en) | 2019-07-31 |
IL266583B2 (en) | 2023-09-01 |
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EP3551645A1 (en) | 2019-10-16 |
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AU2017373962B2 (en) | 2022-03-31 |
CN110494443A (zh) | 2019-11-22 |
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AU2022203538B2 (en) | 2023-11-02 |
KR20190089977A (ko) | 2019-07-31 |
CN114773439A (zh) | 2022-07-22 |
EP3608333A1 (en) | 2020-02-12 |
US20210008208A1 (en) | 2021-01-14 |
US20220152213A1 (en) | 2022-05-19 |
JP7370625B2 (ja) | 2023-10-30 |
AU2022203538A1 (en) | 2022-06-16 |
IL293710B1 (en) | 2024-06-01 |
AU2017373962A1 (en) | 2019-05-30 |
CA3043333A1 (en) | 2018-06-14 |
KR102557126B1 (ko) | 2023-07-18 |
WO2018106895A1 (en) | 2018-06-14 |
IL293710A (en) | 2022-08-01 |
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