PL397167A1 - Przeciwnowotworowe bialko fuzyjne - Google Patents

Przeciwnowotworowe bialko fuzyjne

Info

Publication number
PL397167A1
PL397167A1 PL397167A PL39716711A PL397167A1 PL 397167 A1 PL397167 A1 PL 397167A1 PL 397167 A PL397167 A PL 397167A PL 39716711 A PL39716711 A PL 39716711A PL 397167 A1 PL397167 A1 PL 397167A1
Authority
PL
Poland
Prior art keywords
domain
fusion protein
amino acid
sequence
fragment
Prior art date
Application number
PL397167A
Other languages
English (en)
Inventor
Jerzy Szczepan Pieczykolan
Sebastian Dominik Pawlak
Bartłomiej Żerek
Michał Szymanik
Anna Maria Pieczykolan
Piotr Kamil Rózga
Urszula Marta Szawłowska
Albert Robert Jaworski
Małgorzata Izabela Teska-Kamińska
Original Assignee
Adamed Spólka Z Ograniczona Odpowiedzialnoscia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adamed Spólka Z Ograniczona Odpowiedzialnoscia filed Critical Adamed Spólka Z Ograniczona Odpowiedzialnoscia
Priority to PL397167A priority Critical patent/PL397167A1/pl
Priority to MX2014006369A priority patent/MX2014006369A/es
Priority to EP12816127.0A priority patent/EP2785362A2/en
Priority to HK15102260.2A priority patent/HK1201727A1/xx
Priority to CN201280058346.6A priority patent/CN103974711A/zh
Priority to CA2856480A priority patent/CA2856480A1/en
Priority to PCT/IB2012/056806 priority patent/WO2013080147A2/en
Priority to EA201491049A priority patent/EA201491049A1/ru
Priority to IN4498CHN2014 priority patent/IN2014CN04498A/en
Priority to BR112014012808A priority patent/BR112014012808A2/pt
Priority to AU2012345494A priority patent/AU2012345494A1/en
Priority to JP2014544020A priority patent/JP2015500228A/ja
Priority to SG11201402312WA priority patent/SG11201402312WA/en
Priority to US14/361,279 priority patent/US20150044162A1/en
Priority to KR1020147018001A priority patent/KR20140097529A/ko
Publication of PL397167A1 publication Critical patent/PL397167A1/pl
Priority to PH12014501083A priority patent/PH12014501083A1/en
Priority to IL232743A priority patent/IL232743A0/en
Priority to ZA2014/04667A priority patent/ZA201404667B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Wynalazek dotyczy dziedziny terapeutycznych bialek fuzyjnych, zwlaszcza rekombinowanych bialek fuzyjnych. Bialko fuzyjne zawiera domene (a), która jest funkcjonalny fragment sekwencji bialka hTRAIL rozpoczynajacy sie aminokwasem w pozycji nie nizszej niz hTRAIL95, i konczacy sie aminokwasem hTRAIL281, lub homolog wspomnianego funkcjonalnego fragmentu hTRAIL o sekwencji aminokwasów przynajmniej w 85% identycznej z tym fragmentem; i przynajmniej jedna domene (b) stanowiaca sekwencje peptydu efektorowego o dzialaniu hamujacym synteze bialka wewnatrz komórki, przy czym sekwencja domeny (b) jest przylaczona na C-koncu i/lub N-koncu domeny (a), bialko fuzyjne nie posiada domeny wiazacej sie z receptorami weglowodanowymi na powierzchni komórki. Bialko fuzyjne znajduje zastosowania w leczeniu chorób nowotworowych.
PL397167A 2011-11-28 2011-11-28 Przeciwnowotworowe bialko fuzyjne PL397167A1 (pl)

Priority Applications (18)

Application Number Priority Date Filing Date Title
PL397167A PL397167A1 (pl) 2011-11-28 2011-11-28 Przeciwnowotworowe bialko fuzyjne
BR112014012808A BR112014012808A2 (pt) 2011-11-28 2012-11-28 proteína de fusão anticâncer
AU2012345494A AU2012345494A1 (en) 2011-11-28 2012-11-28 Anticancer fusion protein
HK15102260.2A HK1201727A1 (en) 2011-11-28 2012-11-28 Anticancer fusion protein
CN201280058346.6A CN103974711A (zh) 2011-11-28 2012-11-28 抗癌融合蛋白
CA2856480A CA2856480A1 (en) 2011-11-28 2012-11-28 Anticancer fusion protein
PCT/IB2012/056806 WO2013080147A2 (en) 2011-11-28 2012-11-28 Anticancer fusion protein
EA201491049A EA201491049A1 (ru) 2011-11-28 2012-11-28 Противораковый слитый белок
IN4498CHN2014 IN2014CN04498A (pl) 2011-11-28 2012-11-28
MX2014006369A MX2014006369A (es) 2011-11-28 2012-11-28 Proteina de fusion anticancerigena.
EP12816127.0A EP2785362A2 (en) 2011-11-28 2012-11-28 Anticancer fusion protein
JP2014544020A JP2015500228A (ja) 2011-11-28 2012-11-28 抗がん融合タンパク質
SG11201402312WA SG11201402312WA (en) 2011-11-28 2012-11-28 Anticancer fusion protein
US14/361,279 US20150044162A1 (en) 2011-11-28 2012-11-28 Anticancer fusion protein
KR1020147018001A KR20140097529A (ko) 2011-11-28 2012-11-28 항암 융합 단백질
PH12014501083A PH12014501083A1 (en) 2011-11-28 2014-05-14 Anticancer fusion protein
IL232743A IL232743A0 (en) 2011-11-28 2014-05-21 anticancer fusion protein
ZA2014/04667A ZA201404667B (en) 2011-11-28 2014-06-25 Anticancer fusion protein

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL397167A PL397167A1 (pl) 2011-11-28 2011-11-28 Przeciwnowotworowe bialko fuzyjne

Publications (1)

Publication Number Publication Date
PL397167A1 true PL397167A1 (pl) 2013-06-10

Family

ID=47561689

Family Applications (1)

Application Number Title Priority Date Filing Date
PL397167A PL397167A1 (pl) 2011-11-28 2011-11-28 Przeciwnowotworowe bialko fuzyjne

Country Status (18)

Country Link
US (1) US20150044162A1 (pl)
EP (1) EP2785362A2 (pl)
JP (1) JP2015500228A (pl)
KR (1) KR20140097529A (pl)
CN (1) CN103974711A (pl)
AU (1) AU2012345494A1 (pl)
BR (1) BR112014012808A2 (pl)
CA (1) CA2856480A1 (pl)
EA (1) EA201491049A1 (pl)
HK (1) HK1201727A1 (pl)
IL (1) IL232743A0 (pl)
IN (1) IN2014CN04498A (pl)
MX (1) MX2014006369A (pl)
PH (1) PH12014501083A1 (pl)
PL (1) PL397167A1 (pl)
SG (1) SG11201402312WA (pl)
WO (1) WO2013080147A2 (pl)
ZA (1) ZA201404667B (pl)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014141094A1 (en) 2013-03-14 2014-09-18 Adamed Sp. Z O.O. Anticancer conjugate

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10450354B2 (en) 2013-03-12 2019-10-22 Molecular Templates, Inc. CD20-binding immunotoxins for inducing cellular internalization and methods using same
IL285403B2 (en) 2014-01-27 2023-10-01 Molecular Templates Inc Polypeptides that remove an epitope for MHC group I
JP6935195B2 (ja) * 2014-03-11 2021-09-15 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. 結合領域、志賀毒素ａサブユニットのエフェクター領域、及びカルボキシ末端小胞体局在化シグナルモチーフを含むタンパク質
US11142584B2 (en) 2014-03-11 2021-10-12 Molecular Templates, Inc. CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
EP3137488B1 (en) * 2014-06-11 2019-01-02 Molecular Templates, Inc. Protease-cleavage resistant, shiga toxin a subunit effector polypeptides and cell-targeting molecules comprising the same
KR20170110601A (ko) 2015-02-05 2017-10-11 몰레큘러 템플레이츠, 인코퍼레이션. 시가 독소 a 서브유닛 작동체 영역을 포함하는 다가 cd20 결합 분자 및 이들의 강화된 조성물
US10428132B2 (en) 2015-02-11 2019-10-01 West China Hospital, Sichuan University Tumor necrosis factor-related apoptosis-inducing ligand variant, as well as a preparation method and use thereof
HUE051246T2 (hu) * 2015-05-30 2021-03-01 Molecular Templates Inc Deimmunizált shigatoxin alegység vázak és azokat tartalmazó, sejthez irányító molekulák
CN112574316A (zh) 2015-07-02 2021-03-30 博际生物医药科技(杭州)有限公司 用于肿瘤靶向治疗的白细胞介素-15融合蛋白
KR101732126B1 (ko) 2015-11-05 2017-05-02 한국생명공학연구원 췌장암 치료용 융합 단백질 및 이의 용도
PL233352B1 (pl) * 2016-09-15 2019-10-31 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Przeciwnowotworowe białko fuzyjne
JP7075134B2 (ja) 2016-12-07 2022-05-25 モレキュラー テンプレーツ，インク． 部位特異的コンジュゲーションのための志賀毒素ａサブユニットエフェクターポリペプチド、志賀毒素エフェクター足場、及び細胞標的化分子
CN106632680A (zh) * 2016-12-27 2017-05-10 上海交通大学 植物体系表达人源化抗agr2单克隆抗体18a4的质粒构建
JP7082424B2 (ja) 2017-01-25 2022-06-08 モレキュラー テンプレーツ，インク． 脱免疫化された志賀毒素ａサブユニットエフェクター及びｃｄ８＋ｔ細胞エピトープを含む細胞標的化分子
US12186376B2 (en) * 2018-03-06 2025-01-07 The Johns Hopkins University Methods of treating or preventing cancer with an agent that depletes tregs and a checkpoint inhibitor
KR20200143634A (ko) 2018-04-17 2020-12-24 몰레큘러 템플레이츠, 인코퍼레이션. 탈면역된 시가 독소 a 서브유닛 스캐폴드를 포함하는 her2-표적화 분자
US20220211872A1 (en) * 2019-05-15 2022-07-07 Universidad De Granada Gene therapy with the genes hokd and ldrb for cancer treatments
CN113354738B (zh) * 2020-03-05 2022-09-09 绍兴德方华生物技术有限公司 融合毒素VEGF165b/mGEL及其编码基因与应用
JP7818834B2 (ja) * 2020-08-17 2026-02-24 エーティービー セラピューティクス リボトキシンまたはＲＮＡｓｅを含む組換え免疫毒素
CN114681599B (zh) * 2020-12-31 2024-07-02 中国科学院上海药物研究所 一种阳离子脂质体疫苗及其制备方法和用途
AU2022321271A1 (en) * 2021-08-06 2024-02-29 Kao Corporation Nucleic acid structure utilizing snare
CN117384859B (zh) * 2023-12-13 2024-03-22 北京翊博生物集团有限公司 一种树突状细胞来源的外泌体的制备方法及应用
CN118792375B (zh) * 2024-06-25 2025-09-23 华南农业大学 一种具有补肾壮阳功效的瓜蒌多肽及其制备方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100510234B1 (ko) 1995-06-29 2005-11-25 임뮤넥스 코포레이션 세포소멸을 유도하는 시토킨
AU2001238501A1 (en) 2000-02-16 2001-08-27 Bechtel Bwxt Idaho, Llc Selective destruction of cells infected with human immunodeficiency virus
ZA200305980B (en) 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
CN1257187C (zh) * 2003-10-22 2006-05-24 上海恰尔生物技术有限公司 钙网蛋白－肿瘤坏死因子相关凋亡诱导配体的融合蛋白及其制法和用途
JP4688678B2 (ja) 2003-11-03 2011-05-25 北京沙東生物技術有限公司 抗癌作用を有する組換えタンパク質、それをコードする遺伝子、及びそれらの使用
US7252993B2 (en) 2004-03-12 2007-08-07 Battelle Energy Alliance, Llc Plasmids encoding therapeutic agents
WO2007016150A2 (en) 2005-07-29 2007-02-08 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH Mutated pseudomonas exotoxins with reduced antigenicity
AU2006279618A1 (en) 2005-08-16 2007-02-22 Genentech, Inc. Apoptosis sensitivity to Apo2L/TRAIL by testing for 'GalNac-T14 expression in cells/tissues
EP2079840A4 (en) 2006-10-30 2010-06-30 Viventia Biotech Inc IMMUNOTOXIN FUSIONS COMPRISING PROTEASEPLATABLE LINKER-ASSOCIATED ANTIBODY FRAGMENT AND PLANT TOXIN
EP2097529A4 (en) 2006-12-29 2010-03-24 Osprey Pharmaceuticals Usa Inc METHOD FOR SELECTION AND PRODUCTION OF MODIFIED TOXINS, MODIFIED TOXINE CONJUGATES AND USES THEREOF
US20090131317A1 (en) 2007-06-22 2009-05-21 Affymax, Inc. Compounds and peptides that bind the trail receptor
GB0723059D0 (en) 2007-11-23 2008-01-02 Nat Univ Ireland Improved cytokine design
GB0724532D0 (en) 2007-12-17 2008-01-30 Nat Univ Ireland Trail variants for treating cancer
KR101863136B1 (ko) * 2008-01-24 2018-05-31 에스퍼란스 파마슈티컬스, 인코포레이티드 용해 도메인 융합 구성물 및 이를 제조하고 사용하는 방법
TW200950778A (en) 2008-05-14 2009-12-16 Genentech Inc Methods of using Apo2L/TRAIL to treat cancer
EP2460827A1 (en) * 2008-06-30 2012-06-06 The Trustees Of The University Of Pennsylvania Fusion proteins comprising Fn14 and an inhibitory protein

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014141094A1 (en) 2013-03-14 2014-09-18 Adamed Sp. Z O.O. Anticancer conjugate

Also Published As

Publication number Publication date
IL232743A0 (en) 2014-07-31
KR20140097529A (ko) 2014-08-06
JP2015500228A (ja) 2015-01-05
EA201491049A1 (ru) 2014-10-30
AU2012345494A1 (en) 2014-07-10
WO2013080147A3 (en) 2014-02-13
US20150044162A1 (en) 2015-02-12
CN103974711A (zh) 2014-08-06
PH12014501083A1 (en) 2014-08-04
EP2785362A2 (en) 2014-10-08
BR112014012808A2 (pt) 2019-09-24
CA2856480A1 (en) 2013-06-06
ZA201404667B (en) 2015-09-30
SG11201402312WA (en) 2014-06-27
WO2013080147A2 (en) 2013-06-06
MX2014006369A (es) 2014-07-09
IN2014CN04498A (pl) 2015-09-11
HK1201727A1 (en) 2015-09-11

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