BR112015020587A2 - proteínas de fusão de apelina e suas utilizações - Google Patents
proteínas de fusão de apelina e suas utilizaçõesInfo
- Publication number
- BR112015020587A2 BR112015020587A2 BR112015020587A BR112015020587A BR112015020587A2 BR 112015020587 A2 BR112015020587 A2 BR 112015020587A2 BR 112015020587 A BR112015020587 A BR 112015020587A BR 112015020587 A BR112015020587 A BR 112015020587A BR 112015020587 A2 BR112015020587 A2 BR 112015020587A2
- Authority
- BR
- Brazil
- Prior art keywords
- apelin
- domain
- fusion
- fusion proteins
- aplnr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Virology (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Endocrinology (AREA)
- AIDS & HIV (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
Abstract
resumo patente de invenção: "proteínas de fusão de apelina e suas utilizações". a presente invenção refere-se a uma proteína de fusão ou polipeptídeo compreendendo um peptídeo de apelina fundido a um componente de multimerização. a invenção também fornece uma proteína de fusão ou polipeptídeo compreendendo um peptídeo de apelina fundido com um domínio fc, um fragmento de um domínio fc, ou uma variante de um domínio fc. polipeptídeos de fusão fc de apelina são capazes de se ligarem ao receptor de apelina (aplnr). polipeptídeos de fusão fc de apelina são capazes de ativar o aplnr e ter propriedades farmacoquinéticas melhoradas em comparação com peptídeos de apelina que não estão fundidos com um fc ou um fragmento fc. polipeptídeos de fusão fc de apelina são úteis em doenças e condições relacionadas com a função cardiovascular, diabetes, câncer, obesidade e outras condições relacionadas com a apelina.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361786172P | 2013-03-14 | 2013-03-14 | |
US201361906567P | 2013-11-20 | 2013-11-20 | |
PCT/US2014/028384 WO2014152955A1 (en) | 2013-03-14 | 2014-03-14 | Apelin fusion proteins and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015020587A2 true BR112015020587A2 (pt) | 2017-10-10 |
Family
ID=50680161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015020587A BR112015020587A2 (pt) | 2013-03-14 | 2014-03-14 | proteínas de fusão de apelina e suas utilizações |
Country Status (16)
Country | Link |
---|---|
US (3) | US9353163B2 (pt) |
EP (1) | EP2970415B1 (pt) |
JP (1) | JP6525951B2 (pt) |
KR (1) | KR20150127596A (pt) |
CN (1) | CN105026423A (pt) |
AU (1) | AU2014236451B2 (pt) |
BR (1) | BR112015020587A2 (pt) |
CA (1) | CA2904731A1 (pt) |
EA (1) | EA201591700A1 (pt) |
ES (1) | ES2708957T3 (pt) |
HK (1) | HK1220466A1 (pt) |
IL (1) | IL240587A0 (pt) |
MX (1) | MX365551B (pt) |
SG (1) | SG11201506335YA (pt) |
WO (1) | WO2014152955A1 (pt) |
ZA (1) | ZA201505927B (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9353163B2 (en) | 2013-03-14 | 2016-05-31 | Regeneron Pharmaceuticals, Inc. | Apelin fusion proteins and uses thereof |
KR20160031551A (ko) | 2013-07-25 | 2016-03-22 | 노파르티스 아게 | 심부전의 치료를 위한 시클릭 폴리펩티드 |
AU2014293387B2 (en) | 2013-07-25 | 2017-04-20 | Novartis Ag | Bioconjugates of synthetic apelin polypeptides |
EA201691027A1 (ru) | 2013-11-20 | 2016-12-30 | Ридженерон Фармасьютикалз, Инк. | Модуляторы aplnr и их применение |
GB201407532D0 (en) * | 2014-04-29 | 2014-06-11 | Univ Ulster | Apelin analogues |
CA2951391C (en) | 2014-06-10 | 2021-11-02 | Amgen Inc. | Apelin polypeptides |
ES2854400T3 (es) | 2014-10-13 | 2021-09-21 | Univ Maryland | Fc-ELA--32 y su uso en el tratamiento de afecciones cardiacas |
EP3220961B1 (en) * | 2014-10-22 | 2023-07-05 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
WO2016102648A1 (en) * | 2014-12-23 | 2016-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Metabolically stable apelin analogs in the treatment of disease mediated by the apelin receptor |
US10172919B2 (en) | 2014-12-29 | 2019-01-08 | Academia Sinica | Method for treating influenza A virus infection |
EA201791668A1 (ru) | 2015-01-23 | 2017-11-30 | Новартис Аг | Синтетические конъюгаты апелина с жирной кислотой с улучшенным периодом полураспада |
AR105616A1 (es) * | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
EP3600394A4 (en) * | 2017-03-22 | 2021-04-14 | Research Corporation Technologies, Inc. | MANIPULATED STABLE CH2-POLYPEPTIDES |
EP3604538A4 (en) * | 2017-03-29 | 2020-12-30 | University of Miyazaki | LONG-ACTING ADRENOMEDULLINE DERIVATIVE |
JP7161494B2 (ja) * | 2017-05-06 | 2022-10-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Aplnrアンタゴニストおよびvegf阻害剤によって眼疾患を治療する方法 |
CN109771634A (zh) * | 2017-07-11 | 2019-05-21 | 南华大学 | 含有apelin 12环肽的药物组合物及用途 |
US11365242B2 (en) * | 2017-08-24 | 2022-06-21 | Phanes Therapeutics, Inc. | Anti-apelin antibodies and uses thereof |
GB201805675D0 (en) | 2018-04-05 | 2018-05-23 | Davenport Anthony Peter | Compounds For Use As Apelin Receptor Antagonists |
CN110655577A (zh) * | 2018-06-13 | 2020-01-07 | 鸿运华宁(杭州)生物医药有限公司 | APJ抗体及其与Elabela的融合蛋白质,以及其药物组合物和应用 |
JP2023531368A (ja) * | 2020-06-25 | 2023-07-24 | グリックニック インコーポレイテッド | Ace2-fc融合タンパク質および使用方法 |
CN112546198B (zh) * | 2020-12-17 | 2022-03-25 | 温州医科大学慈溪生物医药研究院 | 一种用于治疗脑中风和急性脑梗的药物组合物 |
CN113648418B (zh) * | 2021-05-08 | 2022-08-05 | 南方医科大学 | Apelin-APJ抑制剂在制备治疗血睾屏障损伤药物中的应用 |
Family Cites Families (50)
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JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
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CN102516393B (zh) | 2011-11-30 | 2017-03-15 | 北京康明百奥新药研发有限公司 | 胰岛素模拟肽融合蛋白和突变体及其应用 |
CN102675470B (zh) * | 2012-04-01 | 2015-06-17 | 江苏省弗泰生物科技有限公司 | SCF-Fc融合蛋白 |
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US9353163B2 (en) | 2013-03-14 | 2016-05-31 | Regeneron Pharmaceuticals, Inc. | Apelin fusion proteins and uses thereof |
EA201691027A1 (ru) | 2013-11-20 | 2016-12-30 | Ридженерон Фармасьютикалз, Инк. | Модуляторы aplnr и их применение |
-
2014
- 2014-03-14 US US14/212,753 patent/US9353163B2/en active Active
- 2014-03-14 EA EA201591700A patent/EA201591700A1/ru unknown
- 2014-03-14 AU AU2014236451A patent/AU2014236451B2/en active Active
- 2014-03-14 MX MX2015011350A patent/MX365551B/es active IP Right Grant
- 2014-03-14 JP JP2016502772A patent/JP6525951B2/ja active Active
- 2014-03-14 WO PCT/US2014/028384 patent/WO2014152955A1/en active Application Filing
- 2014-03-14 KR KR1020157023113A patent/KR20150127596A/ko not_active Application Discontinuation
- 2014-03-14 BR BR112015020587A patent/BR112015020587A2/pt not_active Application Discontinuation
- 2014-03-14 CA CA2904731A patent/CA2904731A1/en active Pending
- 2014-03-14 CN CN201480010429.7A patent/CN105026423A/zh active Pending
- 2014-03-14 ES ES14722458T patent/ES2708957T3/es active Active
- 2014-03-14 SG SG11201506335YA patent/SG11201506335YA/en unknown
- 2014-03-14 EP EP14722458.8A patent/EP2970415B1/en active Active
-
2015
- 2015-08-16 IL IL240587A patent/IL240587A0/en unknown
- 2015-08-17 ZA ZA2015/05927A patent/ZA201505927B/en unknown
-
2016
- 2016-05-04 US US15/146,730 patent/US9751921B2/en active Active
- 2016-07-18 HK HK16108446.5A patent/HK1220466A1/zh unknown
-
2017
- 2017-08-01 US US15/665,973 patent/US20180030099A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP6525951B2 (ja) | 2019-06-05 |
MX365551B (es) | 2019-06-07 |
AU2014236451A1 (en) | 2015-10-15 |
JP2016513733A (ja) | 2016-05-16 |
CA2904731A1 (en) | 2014-09-25 |
WO2014152955A1 (en) | 2014-09-25 |
KR20150127596A (ko) | 2015-11-17 |
SG11201506335YA (en) | 2015-09-29 |
US20180030099A1 (en) | 2018-02-01 |
ZA201505927B (en) | 2017-03-29 |
IL240587A0 (en) | 2015-09-24 |
EP2970415B1 (en) | 2018-12-19 |
EP2970415A1 (en) | 2016-01-20 |
AU2014236451B2 (en) | 2018-08-09 |
US9353163B2 (en) | 2016-05-31 |
CN105026423A (zh) | 2015-11-04 |
MX2015011350A (es) | 2016-01-15 |
EA201591700A1 (ru) | 2015-12-30 |
ES2708957T3 (es) | 2019-04-12 |
US20160237130A1 (en) | 2016-08-18 |
US9751921B2 (en) | 2017-09-05 |
HK1220466A1 (zh) | 2017-05-05 |
US20140275489A1 (en) | 2014-09-18 |
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