BR112016014810A2 - Antagonistas de fcrn e métodos de uso - Google Patents

Antagonistas de fcrn e métodos de uso

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Publication number
BR112016014810A2
BR112016014810A2 BR112016014810A BR112016014810A BR112016014810A2 BR 112016014810 A2 BR112016014810 A2 BR 112016014810A2 BR 112016014810 A BR112016014810 A BR 112016014810A BR 112016014810 A BR112016014810 A BR 112016014810A BR 112016014810 A2 BR112016014810 A2 BR 112016014810A2
Authority
BR
Brazil
Prior art keywords
fcrn
methods
antagonist compositions
compositions
fcrn antagonist
Prior art date
Application number
BR112016014810A
Other languages
English (en)
Other versions
BR112016014810B1 (pt
Inventor
Ulrichts Peter
Blanchetot Christophe
Dreier Torsten
De Haard Johannes
E Ward Ober Sally
G H Ongenae Nicolas
Original Assignee
Argenx Bvba
Univ Texas
Argen X N V
Argenx Se
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52347464&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112016014810(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Argenx Bvba, Univ Texas, Argen X N V, Argenx Se filed Critical Argenx Bvba
Publication of BR112016014810A2 publication Critical patent/BR112016014810A2/pt
Publication of BR112016014810B1 publication Critical patent/BR112016014810B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

ANTAGONISTAS DE FCRN E MÉTODOS DE USO. A presente invenção fornece novas composições antagonistas de FcRn compreendendo uma região Fc variante que se liga especificamente a FcRn com afinidade aumentada e dependência de pH diminuída relativamente à região Fc nativa. Também são fornecidos antagonistas de FcRn com afinidade de ligação a CD16 aumentada. Também são fornecidos métodos para tratar distúrbios mediados por anticorpos (por exemplo, doenças autoimunes) usando essas composições antagonistas de FcRn, ácidos nucleicos codificando as composições antagonistas de FcRn, vetores de expressão recombinantes e células hospedeiras para produzir as composições antagonistas de FcRn e composições farmacêuticas compreendendo as composições antagonistas de FcRn.
BR112016014810-0A 2013-12-24 2014-12-23 Antagonistas de fcrn e métodos de uso BR112016014810B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361920547P 2013-12-24 2013-12-24
US61/920,547 2013-12-24
PCT/US2014/072087 WO2015100299A1 (en) 2013-12-24 2014-12-23 Fcrn antagonists and methods of use

Publications (2)

Publication Number Publication Date
BR112016014810A2 true BR112016014810A2 (pt) 2017-09-19
BR112016014810B1 BR112016014810B1 (pt) 2023-12-26

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ID=52347464

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BR112016014810-0A BR112016014810B1 (pt) 2013-12-24 2014-12-23 Antagonistas de fcrn e métodos de uso

Country Status (23)

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US (3) US10316073B2 (pt)
EP (2) EP3087095B1 (pt)
JP (2) JP6554473B2 (pt)
KR (3) KR102452173B1 (pt)
CN (2) CN112142843A (pt)
AU (1) AU2014369999B2 (pt)
BR (1) BR112016014810B1 (pt)
CA (1) CA2934644C (pt)
DK (1) DK3087095T3 (pt)
EA (1) EA035324B1 (pt)
ES (1) ES2742682T3 (pt)
FI (1) FIC20230003I1 (pt)
FR (1) FR23C1004I2 (pt)
HU (2) HUE046822T2 (pt)
IL (1) IL246223B (pt)
LT (2) LT3087095T (pt)
MX (1) MX368804B (pt)
NL (1) NL301203I2 (pt)
NZ (1) NZ722055A (pt)
PL (1) PL3087095T3 (pt)
PT (1) PT3087095T (pt)
SG (2) SG11201605203UA (pt)
WO (1) WO2015100299A1 (pt)

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JP7039694B2 (ja) 2017-10-31 2022-03-22 スターテン・バイオテクノロジー・ベー・フェー 抗ａｐｏｃ３抗体およびその使用方法
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EA202190264A1 (ru) * 2018-07-20 2021-05-20 Момента Фармасьютикалз, Инк. КОМПОЗИЦИИ АНТИТЕЛ ПРОТИВ FcRn
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MX2021014756A (es) * 2019-06-07 2022-01-18 Argenx Bvba Formulaciones farmaceuticas de inhibidores de fcrn adecuadas para administracion subcutanea.
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CN114341184B (zh) * 2020-02-10 2023-04-04 北京拓界生物医药科技有限公司 抗FcRn抗体、其抗原结合片段及其医药用途
WO2022271814A2 (en) 2021-06-23 2022-12-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Short apoc-ii mimetic peptides and methods of use
WO2023139107A1 (en) 2022-01-18 2023-07-27 argenx BV Galectin-10 antibodies
TW202337895A (zh) 2022-02-21 2023-10-01 比利時商阿根思公司 使用ｆｃｒｎ拮抗劑治療肌炎之方法
WO2023198806A1 (en) 2022-04-13 2023-10-19 Ose Immunotherapeutics New class of molecules for selective clearance of antibody
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