EA201691304A1 - АНТАГОНИСТЫ НЕОНАТАЛЬНЫХ Fc-РЕЦЕПТОРОВ (FcRn) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ - Google Patents

АНТАГОНИСТЫ НЕОНАТАЛЬНЫХ Fc-РЕЦЕПТОРОВ (FcRn) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ

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Publication number
EA201691304A1
EA201691304A1 EA201691304A EA201691304A EA201691304A1 EA 201691304 A1 EA201691304 A1 EA 201691304A1 EA 201691304 A EA201691304 A EA 201691304A EA 201691304 A EA201691304 A EA 201691304A EA 201691304 A1 EA201691304 A1 EA 201691304A1
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Eurasian Patent Office
Prior art keywords
fcrn
compositions
presented
fcrn antagonist
antagonists
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EA201691304A
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English (en)
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EA035324B1 (ru
Inventor
Петер Ульрихтс
Кристоф Бланшето
Торстен Дрейер
Йоханнес Де Хард
Э. Салли Вард Обер
Николас Г.Х. Онгена
Original Assignee
арДЖЕН-ИКС Н.В.
Дзе Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем
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Publication of EA201691304A1 publication Critical patent/EA201691304A1/ru
Publication of EA035324B1 publication Critical patent/EA035324B1/ru

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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Abstract

Представлены новые композиции антагониста FcRn, включающие вариантный Fc-участок, который специфически связывается с FcRn с повышенной аффинностью и сниженной рН-зависимостью по сравнению с нативным Fc-участком. Также представлены антагонисты FcRn с усиленной аффинностью связывания с CD16. Также представлены способы лечения заболеваний, опосредованных антителами (например, аутоиммунных заболеваний), при помощи данных композиций антагониста FcRn, нуклеиновых кислот, кодирующих композиции антагониста FcRn, рекомбинантных экспрессионных векторов и клеток-хозяев для получения композиций антагониста FcRn, а также фармацевтических композиций, включающих композиции антагониста FcRn.
EA201691304A 2013-12-24 2014-12-23 АНТАГОНИСТЫ НЕОНАТАЛЬНЫХ Fc-РЕЦЕПТОРОВ (FCRN) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ EA035324B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361920547P 2013-12-24 2013-12-24
PCT/US2014/072087 WO2015100299A1 (en) 2013-12-24 2014-12-23 Fcrn antagonists and methods of use

Publications (2)

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EA201691304A1 true EA201691304A1 (ru) 2016-10-31
EA035324B1 EA035324B1 (ru) 2020-05-28

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ID=52347464

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EA201691304A EA035324B1 (ru) 2013-12-24 2014-12-23 АНТАГОНИСТЫ НЕОНАТАЛЬНЫХ Fc-РЕЦЕПТОРОВ (FCRN) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ

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US (3) US10316073B2 (ru)
EP (2) EP3626738A1 (ru)
JP (2) JP6554473B2 (ru)
KR (3) KR20240033084A (ru)
CN (2) CN112142843B (ru)
AU (1) AU2014369999B2 (ru)
BR (1) BR112016014810B1 (ru)
CA (1) CA2934644C (ru)
DK (1) DK3087095T3 (ru)
EA (1) EA035324B1 (ru)
ES (1) ES2742682T3 (ru)
FI (1) FIC20230003I1 (ru)
FR (1) FR23C1004I2 (ru)
HU (2) HUE046822T2 (ru)
IL (1) IL246223B (ru)
LT (2) LT3087095T (ru)
MX (1) MX368804B (ru)
NL (1) NL301203I2 (ru)
NO (1) NO2022049I1 (ru)
NZ (1) NZ722055A (ru)
PL (1) PL3087095T3 (ru)
PT (1) PT3087095T (ru)
SG (2) SG10202009832XA (ru)
WO (1) WO2015100299A1 (ru)

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EA035324B1 (ru) 2013-12-24 2020-05-28 Ардженкс Бвба АНТАГОНИСТЫ НЕОНАТАЛЬНЫХ Fc-РЕЦЕПТОРОВ (FCRN) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
DK3268391T3 (da) * 2015-03-09 2021-09-13 Argenx Bvba Fremgangsmåder til reduktion af serumniveauer af Fc-indeholdende midler ved anvendelse af FcRn-antagonister
FR3038517B1 (fr) * 2015-07-06 2020-02-28 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Utilisation de fragments fc modifies en immunotherapie
CN106957364B (zh) * 2016-01-11 2021-03-16 上海交通大学 一种单克隆抗体FnAb12及其应用
CN106957365B (zh) * 2016-01-11 2021-03-16 上海交通大学 一种单克隆抗体FnAb8及其应用
EP3257866A1 (en) * 2016-06-17 2017-12-20 Academisch Medisch Centrum Modified anti-tnf antibody and use thereof in the treatment of ibd
AU2017292184A1 (en) 2016-07-08 2019-02-07 Staten Biotechnology B.V. Anti-Apoc3 antibodies and methods of use thereof
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US11459396B2 (en) 2016-12-02 2022-10-04 The Texas A&M University System Fusion proteins (Seldegs) for selectively depleting antigen-specific antibodies and methods of use thereof
AU2018255938A1 (en) 2017-04-21 2019-10-31 Staten Biotechnology B.V. Anti-ApoC3 antibodies and methods of use thereof
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MX2020004512A (es) 2017-10-31 2020-08-13 Anticuerpos anti apolipoproteina c-iii (anti-apoc3) y metodos de uso de los mismos.
JP7422659B2 (ja) 2017-12-08 2024-01-26 アルジェニクス ビーブイ 全身型重症筋無力症治療のためのＦｃＲｎアンタゴニストの使用
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AU2019307959A1 (en) * 2018-07-20 2021-02-04 Momenta Pharmaceuticals, Inc. FcRn antibody compositions
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