BR112019000770A2 - proteínas de ligação semelhantes a anticorpos biespecíficos que se ligam especificamente às cd3 e cd123 - Google Patents

proteínas de ligação semelhantes a anticorpos biespecíficos que se ligam especificamente às cd3 e cd123

Info

Publication number
BR112019000770A2
BR112019000770A2 BR112019000770A BR112019000770A BR112019000770A2 BR 112019000770 A2 BR112019000770 A2 BR 112019000770A2 BR 112019000770 A BR112019000770 A BR 112019000770A BR 112019000770 A BR112019000770 A BR 112019000770A BR 112019000770 A2 BR112019000770 A2 BR 112019000770A2
Authority
BR
Brazil
Prior art keywords
antibody
specifically bind
binding proteins
bispecific antibody
binding protein
Prior art date
Application number
BR112019000770A
Other languages
English (en)
Inventor
Beil Christian
Lange Christian
Rao Ercole
Albrecht Jana
Beninga Jochen
Kroll Katja
Schneider Marion
Wonerow Peter
Guerif Stéphane
Dirk Leuschner Wulf
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of BR112019000770A2 publication Critical patent/BR112019000770A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

a presente invenção refere-se à proteína de ligação semelhante a anticorpo que se liga especificamente a cd3 e cd123. a invenção refere-se também às composições farmacêuticas compreendendo dita proteína de ligação semelhante a anticorpo e ao uso de ditas composições farmacêuticas e proteína de ligação semelhante a anticorpo para tratar câncer. a invenção refere-se ainda aos ácidos nucleicos isolados, vetores e células hospedeiras que compreendem uma sequência que codifica dita proteína de ligação semelhante a anticorpo.
BR112019000770A 2016-07-18 2017-07-17 proteínas de ligação semelhantes a anticorpos biespecíficos que se ligam especificamente às cd3 e cd123 BR112019000770A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16305923 2016-07-18
PCT/EP2017/068020 WO2018015340A1 (en) 2016-07-18 2017-07-17 Bispecific antibody-like binding proteins specifically binding to cd3 and cd123

Publications (1)

Publication Number Publication Date
BR112019000770A2 true BR112019000770A2 (pt) 2019-07-02

Family

ID=56507555

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019000770A BR112019000770A2 (pt) 2016-07-18 2017-07-17 proteínas de ligação semelhantes a anticorpos biespecíficos que se ligam especificamente às cd3 e cd123

Country Status (24)

Country Link
US (1) US20190241657A1 (pt)
EP (1) EP3484924A1 (pt)
JP (2) JP7071329B2 (pt)
KR (1) KR20190028771A (pt)
CN (1) CN109715665A (pt)
AR (1) AR109264A1 (pt)
AU (1) AU2017299125A1 (pt)
BR (1) BR112019000770A2 (pt)
CA (1) CA3030943A1 (pt)
CL (1) CL2019000119A1 (pt)
CO (1) CO2019001367A2 (pt)
CR (1) CR20190072A (pt)
DO (1) DOP2019000011A (pt)
EA (1) EA201990321A1 (pt)
EC (1) ECSP19011185A (pt)
IL (1) IL264248A (pt)
MA (1) MA45680A (pt)
MX (1) MX2019000844A (pt)
PE (1) PE20190514A1 (pt)
PH (1) PH12019500122A1 (pt)
SG (1) SG11201900400QA (pt)
TN (1) TN2019000015A1 (pt)
TW (1) TWI790206B (pt)
WO (1) WO2018015340A1 (pt)

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EP3247725B1 (en) 2015-01-23 2020-07-01 Sanofi Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123
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TWI829617B (zh) 2015-07-31 2024-01-21 德商安美基研究（慕尼黑）公司 Ｆｌｔ３及ｃｄ３抗體構築體
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CN113368232B (zh) * 2021-06-02 2022-08-26 上海交通大学 多特异性抗原结合蛋白及其应用
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WO2023201226A1 (en) 2022-04-11 2023-10-19 Regeneron Pharmaceuticals, Inc. Compositions and methods for universal tumor cell killing

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Also Published As

Publication number Publication date
IL264248A (en) 2019-02-28
WO2018015340A1 (en) 2018-01-25
CL2019000119A1 (es) 2019-06-14
CO2019001367A2 (es) 2019-02-19
TW201811830A (zh) 2018-04-01
PE20190514A1 (es) 2019-04-10
PH12019500122A1 (en) 2019-04-15
AU2017299125A1 (en) 2019-03-07
US20190241657A1 (en) 2019-08-08
MA45680A (fr) 2019-05-22
DOP2019000011A (es) 2019-05-15
TN2019000015A1 (en) 2020-07-15
SG11201900400QA (en) 2019-02-27
MX2019000844A (es) 2019-07-04
ECSP19011185A (es) 2019-02-28
CN109715665A (zh) 2019-05-03
KR20190028771A (ko) 2019-03-19
JP2019531701A (ja) 2019-11-07
JP2022105138A (ja) 2022-07-12
JP7071329B2 (ja) 2022-05-18
EP3484924A1 (en) 2019-05-22
CR20190072A (es) 2019-06-25
CA3030943A1 (en) 2018-01-25
TWI790206B (zh) 2023-01-21
EA201990321A1 (ru) 2019-06-28
AR109264A1 (es) 2018-11-14

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