MA53145A - Agents de liaison cd123 et leurs utilisations - Google Patents

Agents de liaison cd123 et leurs utilisations

Info

Publication number
MA53145A
MA53145A MA053145A MA53145A MA53145A MA 53145 A MA53145 A MA 53145A MA 053145 A MA053145 A MA 053145A MA 53145 A MA53145 A MA 53145A MA 53145 A MA53145 A MA 53145A
Authority
MA
Morocco
Prior art keywords
liaison
agents
liaison agents
Prior art date
Application number
MA053145A
Other languages
English (en)
Inventor
Ricardo Attar
Francois Gaudet
Benjamin C Harman
Yingzhe Li
Jinquan Luo
Ronan Mcdaid
Jennifer F Nemeth
Steven C Pomerantz
Susan H Tam
Alexey Teplyakov
John Wheeler
Sheng-Jiun Wu
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MA53145A publication Critical patent/MA53145A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
MA053145A 2014-09-05 2015-09-03 Agents de liaison cd123 et leurs utilisations MA53145A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462046682P 2014-09-05 2014-09-05

Publications (1)

Publication Number Publication Date
MA53145A true MA53145A (fr) 2021-05-19

Family

ID=54150667

Family Applications (2)

Application Number Title Priority Date Filing Date
MA053145A MA53145A (fr) 2014-09-05 2015-09-03 Agents de liaison cd123 et leurs utilisations
MA40609A MA40609B1 (fr) 2014-09-05 2015-09-03 Agents de liaison cd123 et leurs utilisations

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA40609A MA40609B1 (fr) 2014-09-05 2015-09-03 Agents de liaison cd123 et leurs utilisations

Country Status (39)

Country Link
US (1) US9850310B2 (fr)
EP (2) EP3189081B1 (fr)
JP (2) JP6805130B2 (fr)
KR (1) KR102540192B1 (fr)
CN (1) CN107074956B (fr)
AR (1) AR101765A1 (fr)
AU (1) AU2015311931B2 (fr)
CA (1) CA2959171C (fr)
CL (1) CL2017000515A1 (fr)
CO (1) CO2017002196A2 (fr)
CR (1) CR20170079A (fr)
CY (1) CY1122858T1 (fr)
DK (1) DK3189081T3 (fr)
EA (1) EA037647B1 (fr)
EC (1) ECSP17020812A (fr)
ES (1) ES2791249T3 (fr)
HR (1) HRP20200745T1 (fr)
HU (1) HUE048791T2 (fr)
IL (1) IL250770B (fr)
JO (1) JO3568B1 (fr)
LT (1) LT3189081T (fr)
MA (2) MA53145A (fr)
ME (1) ME03724B (fr)
MX (1) MX384424B (fr)
MY (1) MY186337A (fr)
NI (1) NI201700025A (fr)
PE (1) PE20171556A1 (fr)
PH (1) PH12017500472A1 (fr)
PL (1) PL3189081T3 (fr)
PT (1) PT3189081T (fr)
RS (1) RS60305B1 (fr)
SG (1) SG11201701599UA (fr)
SI (1) SI3189081T1 (fr)
SM (1) SMT202000253T1 (fr)
TW (1) TWI693233B (fr)
UA (1) UA120060C2 (fr)
UY (1) UY36289A (fr)
WO (1) WO2016036937A1 (fr)
ZA (1) ZA201702369B (fr)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2560993T3 (da) 2010-04-20 2024-10-14 Genmab As Heterodimeric antibody fc-containing proteins and methods for production thereof
CR20170383A (es) 2015-01-23 2017-11-22 Sanofi Sa Anticuerpos anti-cd3, anticuerpos anti-cd-123 y anticuerpos biespecíficos que se unen específicamente a cd3 y/o cd123
US10100118B2 (en) 2015-04-08 2018-10-16 Sorrento Therapeutics, Inc. Antibody therapeutics that bind CD123
EA201792573A1 (ru) 2015-05-21 2018-04-30 Харпун Терапьютикс, Инк. Триспецифические связанные белки и способы их применения
ES2887273T3 (es) * 2015-06-29 2021-12-22 Immunogen Inc Anticuerpos anti-CD123 y conjugados y derivados de los mismos
IL319047A (en) 2015-08-28 2025-04-01 Amunix Operating Inc Chimeric polypeptide composition and methods for its preparation and use
US10954301B2 (en) 2015-12-14 2021-03-23 Macrogenics, Inc. Bispecific molecules having immunoreactivity with PD-1 and CTLA-4, and methods of use thereof
JP7101621B2 (ja) 2016-05-20 2022-07-15 ハープーン セラピューティクス，インク． 単一ドメイン血清アルブミン結合タンパク質
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
CN116987189A (zh) * 2016-05-20 2023-11-03 哈普恩治疗公司 单链可变片段cd3结合蛋白质
KR102187751B1 (ko) 2016-06-06 2020-12-08 에프. 호프만-라 로슈 아게 눈 잔류가 증가된 안과학용 융합 단백질
MX2018014950A (es) 2016-06-07 2019-04-25 Macrogenics Inc Terapia de combinacion.
TWI790206B (zh) * 2016-07-18 2023-01-21 法商賽諾菲公司 特異性結合至ｃｄ３和ｃｄ１２３的雙特異性抗體樣結合蛋白
TWI781108B (zh) * 2016-07-20 2022-10-21 比利時商健生藥品公司 抗ｇｐｒｃ５ｄ抗體、結合ｇｐｒｃ５ｄ與ｃｄ３之雙特異性抗原結合分子及其用途
CN107840889A (zh) * 2016-09-19 2018-03-27 上海吉倍生物技术有限公司 高亲和力的抗cd123抗体及其应用
IL265484B2 (en) * 2016-09-21 2026-01-01 Aptevo Res & Development Llc CD123 binding proteins, related methods and compositions
EP3544629A4 (fr) 2016-11-23 2020-06-17 Harpoon Therapeutics, Inc. Protéines trispécifiques ciblang le psma et procédés d'utilisation
CN110198955A (zh) 2016-11-23 2019-09-03 哈普恩治疗公司 前列腺特异性膜抗原结合蛋白质
CN110352068A (zh) 2016-12-02 2019-10-18 南加利福尼亚大学 合成的免疫受体及其使用方法
JP7231549B2 (ja) * 2017-02-06 2023-03-01 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 抗体媒介性受容体シグナル伝達を増強するための組成物及び方法
IL268836B2 (en) 2017-02-24 2024-04-01 Macrogenics Inc Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof
EP3589662A4 (fr) 2017-02-28 2020-12-30 Harpoon Therapeutics, Inc. Protéine monovalente inductible de fixation d' antigène
EP4470551A3 (fr) * 2017-03-14 2025-02-26 Sunshine Lake Pharma Co., Ltd. Protéines de fusion à double cible comprenant la partie fc d'une immunoglobuline
WO2018209304A1 (fr) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Protéines trispécifiques ciblant la msln et procédés d'utilisation
AU2018265856B2 (en) 2017-05-12 2023-04-27 Harpoon Therapeutics, Inc. Mesothelin binding proteins
US11472880B2 (en) 2017-08-14 2022-10-18 Morphosys Ag Humanized antibodies for CD3
WO2019050521A1 (fr) * 2017-09-07 2019-03-14 Macrogenics, Inc. Schémas posologiques de diacorps bispécifiques cd123 x cd3 dans le traitement de malignités hématologiques
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
HRP20241268T1 (hr) 2017-10-13 2024-12-06 Harpoon Therapeutics, Inc. Trispecifični proteini i postupci primjene
JP7324749B2 (ja) * 2017-10-27 2023-08-10 ファイザー・インク Ｃｄ１２３に特異的な抗体および抗体－薬物コンジュゲートならびにその使用
SG11202005557TA (en) 2017-12-12 2020-07-29 Macrogenics Inc Bispecific cd 16-binding molecules and their use in the treatment of disease
SG11202007572VA (en) 2018-02-15 2020-09-29 Macrogenics Inc Variant cd3-binding domains and their use in combination therapies for the treatment of disease
US11203646B2 (en) 2018-03-14 2021-12-21 Novimmune Sa Anti-CD3 epsilon antibodies and methods of use thereof
KR20210020903A (ko) 2018-05-14 2021-02-24 하푼 테라퓨틱스, 인크. 면역글로불린 분자의 조건부 활성화를 위한 결합 모이어티
US12012461B2 (en) 2018-05-16 2024-06-18 Janssen Biotech, Inc. Methods of treating cancers and enhancing efficacy of T cell redirecting therapeutics
JOP20190116A1 (ar) * 2018-05-24 2019-11-24 Janssen Biotech Inc الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها
MA52772A (fr) 2018-05-24 2021-04-14 Janssen Biotech Inc Anticorps anti-tmeff2 monospécifiques et multispécifiques et leurs utilisations
SG11202011633SA (en) 2018-05-24 2020-12-30 Janssen Biotech Inc Psma binding agents and uses thereof
WO2020061482A1 (fr) 2018-09-21 2020-03-26 Harpoon Therapeutics, Inc. Protéines de liaison egfr et méthodes d'utilisation
SG11202103022WA (en) 2018-09-25 2021-04-29 Harpoon Therapeutics Inc Dll3 binding proteins and methods of use
CN113056485A (zh) * 2018-10-17 2021-06-29 古德T细胞有限公司 Lrig-1蛋白的特异性结合分子及其用途
TWI874341B (zh) 2018-12-18 2025-03-01 美商健生生物科技公司 產生異二聚體抗體之方法
JP7566766B2 (ja) * 2019-03-11 2024-10-15 ヤンセン バイオテツク，インコーポレーテツド 抗Ｖβ１７／抗ＣＤ１２３二重特異性抗体
BR112021020532A2 (pt) 2019-04-19 2022-03-15 Janssen Biotech Inc Métodos para tratamento de câncer de próstata com um anticorpo anti-psma/cd3
EP3965818A4 (fr) * 2019-05-08 2023-05-31 Janssen Biotech, Inc. Matières et méthodes pour moduler l'immunité médiée par les lymphocytes t
US12516128B2 (en) 2019-05-14 2026-01-06 Harpoon Therapeutics, Inc. EpCAM binding proteins and methods of use
PE20220568A1 (es) 2019-05-21 2022-04-20 Novartis Ag Moleculas de union a cd19 y usos de las mismas
CN113912695B (zh) * 2019-07-24 2023-05-30 暨南大学 靶向cd133的结合蛋白及应用
GB201912681D0 (en) 2019-09-04 2019-10-16 Eth Zuerich Bispecific binding agent that binds to cd117/c-kit and cd3
EP4106813A4 (fr) 2020-02-21 2024-03-27 MacroGenics, Inc. Molécules de liaison à cd137 et leurs utilisations
CA3170833A1 (fr) 2020-02-21 2021-08-26 Harpoon Therapeutics, Inc. Proteines de liaison a flt3 et methodes d'utilisation
KR20220154728A (ko) 2020-03-13 2022-11-22 얀센 바이오테크 인코포레이티드 Siglec-3/cd33을 결합시키기 위한 물질 및 방법
US20210363252A1 (en) * 2020-05-19 2021-11-25 Janssen Biotech, Inc. Compositions comprising a t cell redirection therapeutic and a vla-4 adhesion pathway inhibitor
JP7770339B2 (ja) 2020-05-19 2025-11-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 免疫応答を誘導するためのコンジュゲートポリペプチドおよびワクチン
MX2023002948A (es) 2020-09-11 2023-05-22 Janssen Biotech Inc Métodos y composiciones para modular la inmunidad mediada por cadena beta.
EP4232071A4 (fr) * 2020-10-23 2024-08-28 Asher Biotherapeutics, Inc. Fusions avec des molécules de liaison à l'antigène cd8 pour moduler la fonction de cellules immunitaires
MX2023007901A (es) 2020-12-31 2023-07-11 Sanofi Sa Acopladores de celulas asesinas naturales (nk) multifuncionales que se unen a nkp46 y a cd123.
FI4284512T3 (fi) 2021-01-28 2025-05-22 Regeneron Pharma Koostumuksia ja menetelmiä sytokiinien vapautumisoireyhtymän hoitamiseksi
WO2022243838A1 (fr) 2021-05-18 2022-11-24 Janssen Biotech, Inc. Compositions comprenant un agent thérapeutique de redirection des lymphocytes t et un agent thérapeutique anti-cd44
AU2022275666A1 (en) 2021-05-19 2023-12-07 Asher Biotherapeutics, Inc. Il-21 polypeptides and targeted constructs
EP4384218A4 (fr) * 2021-08-09 2025-11-05 Merck Patent Gmbh Protéines désaccouplant la cytotoxicité tumorale à médiation par les lymphocytes t de la libération de cytokines pro-inflammatoires
WO2023138666A1 (fr) * 2022-01-19 2023-07-27 Utc Therapeutics (Shanghai) Co., Ltd. Arn circulaire et son utilisation
CN119546329A (zh) 2022-04-11 2025-02-28 瑞泽恩制药公司 用于通用肿瘤细胞杀伤的组合物和方法
IL317227A (en) 2022-05-27 2025-01-01 Sanofi Sa Combined natural killer (NK) cells bind to NKP46 and BCMA variants with FC engineering
KR20250151441A (ko) 2023-02-17 2025-10-21 리제너론 파마슈티칼스 인코포레이티드 Cd3/taa 이중특이적 항체에 대해 반응성인 유도된 nk 세포

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US6177078B1 (en) 1995-12-29 2001-01-23 Medvet Science Pty Limited Monoclonal antibody antagonists to IL-3
PT1538206E (pt) 1997-09-16 2010-04-12 Centocor Ortho Biotech Inc Método para a síntese química e construção completa de genes e genomas
US6670127B2 (en) 1997-09-16 2003-12-30 Egea Biosciences, Inc. Method for assembly of a polynucleotide encoding a target polypeptide
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
EP1789446A2 (fr) 2004-09-02 2007-05-30 Genentech, Inc. Molecules heteromultimeriques
EP3050963B1 (fr) 2005-03-31 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Procédé pour la production de polypeptide au moyen de la régulation d'un ensemble
DE102005028778A1 (de) 2005-06-22 2006-12-28 SUNJÜT Deutschland GmbH Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage
US10155816B2 (en) 2005-11-28 2018-12-18 Genmab A/S Recombinant monovalent antibodies and methods for production thereof
WO2007147901A1 (fr) 2006-06-22 2007-12-27 Novo Nordisk A/S Production d'anticorps bispécifiques
JP2011507519A (ja) 2007-12-19 2011-03-10 セントコア・オーソ・バイオテツク・インコーポレーテツド ｐＩＸ又はｐＶＩＩへの融合を介したヒトデノボｐＩＸファージディスプレイライブラリの設計及び作製、ベクター、抗体、及び方法
JP2012525149A (ja) 2009-04-27 2012-10-22 オンコメッド ファーマシューティカルズ インコーポレイテッド ヘテロ多量体分子を作製するための方法
US8492119B2 (en) * 2009-04-27 2013-07-23 Kyowa Hakko Kirin Co., Ltd Antibody to human IL-3 receptor alpha chain
CN102597775A (zh) * 2009-09-25 2012-07-18 佐马技术有限公司 筛选方法
DK2560993T3 (da) 2010-04-20 2024-10-14 Genmab As Heterodimeric antibody fc-containing proteins and methods for production thereof
NZ604510A (en) * 2010-08-17 2013-10-25 Csl Ltd Dilutable biocidal compositions and methods of use
PL2635607T3 (pl) 2010-11-05 2020-05-18 Zymeworks Inc. Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC
CA2854233C (fr) 2011-11-04 2020-05-12 Zymeworks Inc. Structure d'anticorps heterodimerique stable comprenant des mutations dans le domaine fc
US9745381B2 (en) * 2012-05-18 2017-08-29 Scott & White Healthcare (Swh) Bispecific scFv immunofusion (BIf)

Also Published As

Publication number Publication date
SG11201701599UA (en) 2017-03-30
ME03724B (fr) 2021-01-20
EP3189081A1 (fr) 2017-07-12
MX2017002891A (es) 2017-10-11
CO2017002196A2 (es) 2017-07-28
CL2017000515A1 (es) 2018-03-16
UY36289A (es) 2016-04-01
CN107074956A (zh) 2017-08-18
KR102540192B1 (ko) 2023-06-02
MY186337A (en) 2021-07-13
TW201625687A (zh) 2016-07-16
EA201790530A1 (ru) 2018-03-30
BR112017004322A2 (pt) 2017-12-05
CA2959171C (fr) 2023-11-14
HRP20200745T1 (hr) 2020-08-07
JP2021050216A (ja) 2021-04-01
RS60305B1 (sr) 2020-07-31
TWI693233B (zh) 2020-05-11
AU2015311931B2 (en) 2020-09-03
US20160068605A1 (en) 2016-03-10
UA120060C2 (uk) 2019-09-25
CR20170079A (es) 2017-04-27
JP2017529838A (ja) 2017-10-12
DK3189081T3 (da) 2020-05-04
KR20170049554A (ko) 2017-05-10
NI201700025A (es) 2017-06-22
AU2015311931A1 (en) 2017-03-16
HUE048791T2 (hu) 2020-09-28
PE20171556A1 (es) 2017-10-27
ECSP17020812A (es) 2018-07-31
PL3189081T3 (pl) 2020-10-05
MA40609B1 (fr) 2020-05-29
EP3722315A1 (fr) 2020-10-14
EP3189081B1 (fr) 2020-02-19
PH12017500472A1 (en) 2017-07-31
ES2791249T3 (es) 2020-11-03
CN107074956B (zh) 2021-11-26
MX384424B (es) 2025-03-14
IL250770B (en) 2020-10-29
LT3189081T (lt) 2020-05-11
CY1122858T1 (el) 2021-05-05
JO3568B1 (ar) 2020-07-05
AR101765A1 (es) 2017-01-11
US9850310B2 (en) 2017-12-26
JP6805130B2 (ja) 2020-12-23
EA037647B1 (ru) 2021-04-27
ZA201702369B (en) 2018-12-19
PT3189081T (pt) 2020-05-25
WO2016036937A1 (fr) 2016-03-10
CA2959171A1 (fr) 2016-03-10
SMT202000253T1 (it) 2020-07-08
SI3189081T1 (sl) 2020-07-31
IL250770A0 (en) 2017-04-30

Similar Documents

Publication Publication Date Title
MA53145A (fr) Agents de liaison cd123 et leurs utilisations
FIC20230014I1 (fi) Foslevodopa ja foskarbidopa
EP3334706A4 (fr) Pillararènes et utilisations de ceux-ci
MA42622A (fr) Agents de liaison à tigit et leurs utilisations
MA50618A (fr) Polyrhérapies et leurs utilisations
EP3344275A4 (fr) Macrocycles peptidomimétiques et leurs utilisations
MA40933A (fr) Difluorométhyl-aminopyridines et difluorométhyl-aminopyrimidines
EP3313530A4 (fr) Dérivés de 4,6-pyrimidinylène et utilisations de ceux-ci
EP3337486A4 (fr) Composés deutérés et leurs utilisations
EP3294318A4 (fr) Macrocycles peptidomimétiques et leurs utilisations
BR112017019682A2 (pt) fluoropolímeros modificados
EP3334572A4 (fr) Exosquelette
EP3333833A4 (fr) Simulateur de technique
EP3341387A4 (fr) Inhibiteurs de sialyltransférase et utilisations de ceux-ci
EP3538261A4 (fr) Catalyseurs en pérovskite et leurs utilisations
EP3347021A4 (fr) Cyano-thiénotriazoloazépines et leurs utilisations
EP3302490A4 (fr) Inhibiteurs d'autotaxine et leurs utilisations
EP3347020A4 (fr) Acétamide thiénotriazoldiazépines et leurs utilisations
MA46901A (fr) Agents psychotropes et leurs utilisations
MA41022A (fr) Ciblage lysosomial et utilisations correspondantes
EP3450444A4 (fr) Composés de type crocine et utilisations correspondantes
EP3377897A4 (fr) Biocapteurs de lactate et leurs utilisations
EP3370771A4 (fr) Conjugués anti-cd3-folate et leurs utilisations
EP3405044A4 (fr) Composition bioconservatrice alimentaire et ses utilisations
MA46945A (fr) Exopolysaccharides et leurs utilisations