AR094149A1 - Proteinas multifuncion que comprenden chm de clase i multivalente unido mediante disulfuro - Google Patents

Proteinas multifuncion que comprenden chm de clase i multivalente unido mediante disulfuro

Info

Publication number
AR094149A1
AR094149A1 ARP130104873A ARP130104873A AR094149A1 AR 094149 A1 AR094149 A1 AR 094149A1 AR P130104873 A ARP130104873 A AR P130104873A AR P130104873 A ARP130104873 A AR P130104873A AR 094149 A1 AR094149 A1 AR 094149A1
Authority
AR
Argentina
Prior art keywords
antigen
class
multivally
disulfure
chm
Prior art date
Application number
ARP130104873A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR094149A1 publication Critical patent/AR094149A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16133—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory

Abstract

En la presente memoria se informa de una proteína multifunción multivalente unida mediante disulfuro, caracterizada porque comprende dos o más dominios presentadoras de antígeno, exactamente una región Fc de anticuerpo y por lo menos un sitio de unión a antígeno, en la que el dominio presentador de antígeno comprende, en dirección N-terminal a C-terminal, (i) una microglobulina b2, e (ii) los dominios extracelulares a1, a2 y a3 de una molécula de CMH de clase I con una frecuencia relativa inferior a 1%, o (i) un péptido inductor de respuesta de células T, (ii) una microglobulina b2, e (iii) los dominios extracelulares a1, a2 y a3 de una molécula de CMH de clase I con una frecuencia relativa de 1% o superior, en la que el sitio de unión a antígeno se une a un antígeno de superficie de una célula de cáncer o a un antígeno de superficie de una célula infectada por virus y en la que el dominio presentador de antígeno presenta por lo menos dos residuos de cisteína no naturales que forman un enlace disulfuro intracadena/interdominio.
ARP130104873A 2012-12-21 2013-12-19 Proteinas multifuncion que comprenden chm de clase i multivalente unido mediante disulfuro AR094149A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12198904 2012-12-21
EP13175469 2013-07-08

Publications (1)

Publication Number Publication Date
AR094149A1 true AR094149A1 (es) 2015-07-15

Family

ID=49779923

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130104873A AR094149A1 (es) 2012-12-21 2013-12-19 Proteinas multifuncion que comprenden chm de clase i multivalente unido mediante disulfuro

Country Status (16)

Country Link
US (1) US10501521B2 (es)
EP (1) EP2935328B1 (es)
JP (1) JP6475167B2 (es)
KR (1) KR20150097688A (es)
CN (1) CN104884474A (es)
AR (1) AR094149A1 (es)
AU (1) AU2013360775B2 (es)
CA (1) CA2889788A1 (es)
ES (1) ES2700984T3 (es)
HK (1) HK1214276A1 (es)
IL (1) IL238499B (es)
MX (1) MX361076B (es)
PL (1) PL2935328T3 (es)
RU (1) RU2015129640A (es)
SG (1) SG11201504414UA (es)
WO (1) WO2014096015A1 (es)

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JP2016501900A (ja) 2016-01-21
PL2935328T3 (pl) 2019-02-28
EP2935328B1 (en) 2018-10-10
HK1214276A1 (zh) 2016-07-22
RU2015129640A (ru) 2017-01-26
SG11201504414UA (en) 2015-07-30
IL238499B (en) 2018-10-31
EP2935328A1 (en) 2015-10-28
MX2015007239A (es) 2015-08-12
ES2700984T3 (es) 2019-02-20
AU2013360775B2 (en) 2018-04-12
IL238499A0 (en) 2015-06-30
JP6475167B2 (ja) 2019-02-27
MX361076B (es) 2018-11-27
KR20150097688A (ko) 2015-08-26
WO2014096015A1 (en) 2014-06-26
CA2889788A1 (en) 2014-06-26
US10501521B2 (en) 2019-12-10
CN104884474A (zh) 2015-09-02
AU2013360775A1 (en) 2015-05-14
US20150344586A1 (en) 2015-12-03

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