BR112016016411A2 - VARIANTES DE REGIÕES-"Fc" COM PROPRIEDADES DE LIGAÇÃO DE "FcRn" MODIFICADAS - Google Patents

VARIANTES DE REGIÕES-"Fc" COM PROPRIEDADES DE LIGAÇÃO DE "FcRn" MODIFICADAS

Info

Publication number
BR112016016411A2
BR112016016411A2 BR112016016411A BR112016016411A BR112016016411A2 BR 112016016411 A2 BR112016016411 A2 BR 112016016411A2 BR 112016016411 A BR112016016411 A BR 112016016411A BR 112016016411 A BR112016016411 A BR 112016016411A BR 112016016411 A2 BR112016016411 A2 BR 112016016411A2
Authority
BR
Brazil
Prior art keywords
binding properties
fcrn
modified
region variants
mutations
Prior art date
Application number
BR112016016411A
Other languages
English (en)
Inventor
Schlothauer Tilman
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112016016411A2 publication Critical patent/BR112016016411A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

VARIANTES DE REGIÕES-Fc COM PROPRIEDADES DE LIGAÇÃO DE FcRn MODIFICADAS· Expõe-se neste contexto um polipeptídeo que compreende um primeiro polipeptídeo e um segundo polipeptídeo, cada um deles compreendendo na direção do terminal N para o terminal C pelo menos uma parte de uma região de articulação de imunoglobulina, que compreende um ou mais resíduos de cisteína, um domínio CH2 de imunoglobulina e um domínio CH3 de imunoglobulina, em que i) o primeiro e o segundo polipeptídeos compreendem as mutações H310A, H433A e Y436A, ou ii) o primeiro o segundo polipeptídeos compreendem as mutações L251D, L314D e L432D, ou iii) o primeiro e o segundos compreendem as mutações L251S, L314S e L432S.
BR112016016411A 2014-01-15 2015-01-12 VARIANTES DE REGIÕES-"Fc" COM PROPRIEDADES DE LIGAÇÃO DE "FcRn" MODIFICADAS BR112016016411A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14151319 2014-01-15
EP14165922 2014-04-25
PCT/EP2015/050425 WO2015107025A1 (en) 2014-01-15 2015-01-12 Fc-region variants with modified fcrn-binding properties

Publications (1)

Publication Number Publication Date
BR112016016411A2 true BR112016016411A2 (pt) 2017-10-03

Family

ID=52462893

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016016411A BR112016016411A2 (pt) 2014-01-15 2015-01-12 VARIANTES DE REGIÕES-"Fc" COM PROPRIEDADES DE LIGAÇÃO DE "FcRn" MODIFICADAS

Country Status (12)

Country Link
US (2) US20170037121A1 (pt)
EP (1) EP3094649A1 (pt)
JP (2) JP6873701B2 (pt)
KR (1) KR20160104009A (pt)
CN (2) CN113248613A (pt)
AR (1) AR099079A1 (pt)
BR (1) BR112016016411A2 (pt)
CA (1) CA2931979A1 (pt)
HK (1) HK1223951A1 (pt)
MX (1) MX2016008540A (pt)
RU (1) RU2730592C2 (pt)
WO (1) WO2015107025A1 (pt)

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Also Published As

Publication number Publication date
EP3094649A1 (en) 2016-11-23
CN105873948A (zh) 2016-08-17
WO2015107025A1 (en) 2015-07-23
JP2021113214A (ja) 2021-08-05
RU2730592C2 (ru) 2020-08-24
JP6873701B2 (ja) 2021-05-19
MX2016008540A (es) 2016-09-26
KR20160104009A (ko) 2016-09-02
CN105873948B (zh) 2021-04-13
US20170037121A1 (en) 2017-02-09
US20190016792A1 (en) 2019-01-17
CA2931979A1 (en) 2015-07-23
JP2017505768A (ja) 2017-02-23
HK1223951A1 (zh) 2017-08-11
RU2016133345A3 (pt) 2018-10-31
RU2016133345A (ru) 2018-02-20
AR099079A1 (es) 2016-06-29
CN113248613A (zh) 2021-08-13

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