BR112017001463A2 - célula hospedeira melhorada para produzir proteínas - Google Patents

célula hospedeira melhorada para produzir proteínas

Info

Publication number
BR112017001463A2
BR112017001463A2 BR112017001463A BR112017001463A BR112017001463A2 BR 112017001463 A2 BR112017001463 A2 BR 112017001463A2 BR 112017001463 A BR112017001463 A BR 112017001463A BR 112017001463 A BR112017001463 A BR 112017001463A BR 112017001463 A2 BR112017001463 A2 BR 112017001463A2
Authority
BR
Brazil
Prior art keywords
host cell
produce proteins
improved host
interest
protein
Prior art date
Application number
BR112017001463A
Other languages
English (en)
Inventor
michel Benjamin
Szpirer Cédric
Cavrenne Jonathan
Original Assignee
Delphi Genetics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delphi Genetics filed Critical Delphi Genetics
Publication of BR112017001463A2 publication Critical patent/BR112017001463A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07006—DNA-directed RNA polymerase (2.7.7.6)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

a presente invenção se refere a uma célula hospedeira para produzir um peptídeo, polipeptídeo ou proteína recombinantes de interesse, em que a dita célula hospedeira compreende pelo menos 2 cópias de uma sequência de ácido nucléico codificando uma proteína veneno; e ao uso da mesma para produzir peptídeos, polipeptídeos ou proteínas de interesse.
BR112017001463A 2014-07-25 2015-07-24 célula hospedeira melhorada para produzir proteínas BR112017001463A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14178656 2014-07-25
EP14182341 2014-08-26
PCT/EP2015/067036 WO2016012607A1 (en) 2014-07-25 2015-07-24 Improved host cell for producing proteins

Publications (1)

Publication Number Publication Date
BR112017001463A2 true BR112017001463A2 (pt) 2018-02-20

Family

ID=53718025

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017001463A BR112017001463A2 (pt) 2014-07-25 2015-07-24 célula hospedeira melhorada para produzir proteínas

Country Status (10)

Country Link
US (1) US10718001B2 (pt)
EP (1) EP3172334B1 (pt)
JP (3) JP7126824B2 (pt)
CN (1) CN106715681B (pt)
AU (1) AU2015293825B2 (pt)
BR (1) BR112017001463A2 (pt)
CA (1) CA2956107A1 (pt)
CL (1) CL2017000200A1 (pt)
ES (1) ES2903413T3 (pt)
WO (1) WO2016012607A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11504404B2 (en) 2016-02-24 2022-11-22 Crown Laboratories, Inc. Skin probiotic formulation
US11180541B2 (en) * 2017-09-28 2021-11-23 Geltor, Inc. Recombinant collagen and elastin molecules and uses thereof
CN110373422B (zh) * 2019-07-12 2022-05-10 扬州大学 重组裂解猪霍乱沙门菌及其构建方法和应用
CN114829578A (zh) * 2019-08-05 2022-07-29 瓦克化学股份公司 用于在发酵方法中释放重组蛋白的细菌菌株
CN114540394A (zh) * 2020-11-25 2022-05-27 中国科学院深圳先进技术研究院 一种噬菌体相关的基因诱导表达系统
WO2023069900A1 (en) * 2021-10-18 2023-04-27 Modernatx, Inc. Custom bacterial strain for recombinant protein production

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952496A (en) 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
DE69942249D1 (de) 1998-05-07 2010-05-27 Univ Bruxelles Auf cytotoxinen basierendes biologisches einschlusssystem
US6355412B1 (en) 1999-07-09 2002-03-12 The European Molecular Biology Laboratory Methods and compositions for directed cloning and subcloning using homologous recombination
EP1111061A1 (en) * 1999-12-20 2001-06-27 Universite Libre De Bruxelles Double selection vector
AU2002235676B2 (en) * 2001-02-23 2006-10-26 Universite Libre De Bruxelles Method for the selection of recombinant clones comprising a sequence encoding an antidote protein to a toxic molecule
JP4191037B2 (ja) 2001-11-02 2008-12-03 日本テクノ株式会社 滅菌用振動攪拌装置並びに振動攪拌装置を用いる滅菌装置及び滅菌方法
CA2477194A1 (en) 2002-03-19 2003-09-25 Universite Libre De Bruxelles Poison/antidote genetic systems for the selection of genetically modified eucaryote cells or organisms
US8318497B2 (en) * 2002-09-03 2012-11-27 Universite Libre De Bruxelles Reversible, parallel and multitask cloning method and kit
GB0609124D0 (en) * 2006-05-09 2006-06-21 Univ Birmingham Plasmid curing
JP2010187541A (ja) 2007-05-29 2010-09-02 Ajinomoto Co Inc Ｌ−リジンの製造法
CA2730741C (en) * 2008-07-18 2016-10-25 Regis Sodoyer Self-replicating vector lacking an antibiotic-resistance gene
JP5729702B2 (ja) 2009-03-23 2015-06-03 国立研究開発法人産業技術総合研究所 コウジ酸の産生に必須の遺伝子を利用してコウジ酸の産生量を向上する方法
JP5918125B2 (ja) 2009-05-22 2016-05-18 メリアル リミテッド 抗生物質フリープラスミド
EP2689020B1 (en) * 2011-03-22 2018-05-16 OPX Biotechnologies Inc. Microbial production of chemical products and related compositions, methods and systems
US20140147890A1 (en) * 2011-07-07 2014-05-29 Delphi Genetics Genetically modified phage and use thereof
US9920323B2 (en) 2011-07-07 2018-03-20 Delphi Genetics Genetically modified phage and use thereof
JP6174019B2 (ja) * 2011-07-07 2017-08-02 デルフィ ジェネティクス 遺伝子組換えファージ及びその利用
EP2570134A1 (en) * 2011-09-15 2013-03-20 De la Cueva-Mendez, Guillermo Systems and methods for diminishing cell growth and including selective killing of target cells
EP2848687B1 (en) 2012-04-27 2017-09-13 JCR Pharmaceuticals Co., Ltd. Novel expression vector
DE102012213206A1 (de) * 2012-07-26 2014-01-30 Trumpf Laser- Und Systemtechnik Gmbh Vorrichtung zum Drehen eines Laserbearbeitungskopfes mittels eines Torque-Motors
JP2014057546A (ja) * 2012-09-18 2014-04-03 Osaka Univ トキシン−アンチトキシン系を利用したベクター

Also Published As

Publication number Publication date
JP7194711B2 (ja) 2022-12-22
US10718001B2 (en) 2020-07-21
JP7126824B2 (ja) 2022-08-29
CN106715681A (zh) 2017-05-24
EP3172334B1 (en) 2021-11-10
US20170211118A1 (en) 2017-07-27
WO2016012607A1 (en) 2016-01-28
CN106715681B (zh) 2021-08-24
AU2015293825B2 (en) 2019-06-13
EP3172334A1 (en) 2017-05-31
AU2015293825A1 (en) 2017-02-16
JP2020202828A (ja) 2020-12-24
CL2017000200A1 (es) 2017-07-14
JP2022162124A (ja) 2022-10-21
JP2017523780A (ja) 2017-08-24
CA2956107A1 (en) 2016-01-28
ES2903413T3 (es) 2022-04-01

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B25A Requested transfer of rights approved

Owner name: R.P. SCHERER TECHNOLOGIES, LLC (US)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]