BR112019004770A2 - anticorpos do vírus antidengue, polipeptídeos contendo regiões fc variantes, e métodos de uso - Google Patents

anticorpos do vírus antidengue, polipeptídeos contendo regiões fc variantes, e métodos de uso

Info

Publication number
BR112019004770A2
BR112019004770A2 BR112019004770A BR112019004770A BR112019004770A2 BR 112019004770 A2 BR112019004770 A2 BR 112019004770A2 BR 112019004770 A BR112019004770 A BR 112019004770A BR 112019004770 A BR112019004770 A BR 112019004770A BR 112019004770 A2 BR112019004770 A2 BR 112019004770A2
Authority
BR
Brazil
Prior art keywords
methods
nucleic acids
region
variant
antidengue
Prior art date
Application number
BR112019004770A
Other languages
English (en)
Inventor
Fink Katja
ZUEST Roland
Christine Koo Xing'er
Sampei Zenjiro
Original Assignee
Agency Science Tech & Res
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res, Chugai Pharmaceutical Co Ltd filed Critical Agency Science Tech & Res
Publication of BR112019004770A2 publication Critical patent/BR112019004770A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

a presente invenção fornece anticorpos anti-denv e métodos de produção e uso do mesmo. ácidos nucleicos que codificam anticorpos anti-denv e células hospedeiras que compreendem os ácidos nucleicos também são fornecidos. os anticorpos anti-denv possuem uso que inclui o tratamento de infecção por denv. a invenção também forneceu polipeptídeos que contém uma região fc variante e métodos da produção da mesma. ácidos nucleicos que codificam polipeptídeos e células hospedeiras que compreendem os ácidos nucleicos também são fornecidos. os polipeptídeos possuem uso que inclui o tratamento de uma infecção viral. também é reivindicado um polipeptídeo que compreende uma variante fc que compreende pelo menos uma alteração de aminoácido em uma região fc de origem, em que a região fc variante possui uma atividade de ligação a fc¿r substancialmente diminuída e não possui uma atividade de ligação a c1q substancialmente diminuída quando comparada com a região fc de origem.
BR112019004770A 2016-09-16 2017-09-15 anticorpos do vírus antidengue, polipeptídeos contendo regiões fc variantes, e métodos de uso BR112019004770A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201607778XA SG10201607778XA (en) 2016-09-16 2016-09-16 Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
PCT/SG2017/050465 WO2018052375A1 (en) 2016-09-16 2017-09-15 Anti-dengue virus antibodies, polypeptides containing variant fc regions, and methods of use

Publications (1)

Publication Number Publication Date
BR112019004770A2 true BR112019004770A2 (pt) 2019-05-28

Family

ID=61618863

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019004770A BR112019004770A2 (pt) 2016-09-16 2017-09-15 anticorpos do vírus antidengue, polipeptídeos contendo regiões fc variantes, e métodos de uso

Country Status (21)

Country Link
US (4) US10604561B2 (pt)
EP (1) EP3512879A4 (pt)
JP (3) JP6913161B2 (pt)
KR (2) KR20210112418A (pt)
CN (2) CN109790217B (pt)
AR (1) AR109536A1 (pt)
AU (2) AU2017326922B2 (pt)
BR (1) BR112019004770A2 (pt)
CA (1) CA3036505A1 (pt)
CL (1) CL2019000640A1 (pt)
CO (1) CO2019002482A2 (pt)
EC (1) ECSP19018654A (pt)
IL (2) IL306084A (pt)
MX (2) MX2019003057A (pt)
MY (1) MY194289A (pt)
PE (1) PE20190733A1 (pt)
PH (1) PH12019500485A1 (pt)
RU (1) RU2758596C2 (pt)
SG (3) SG10201607778XA (pt)
TW (3) TW202348624A (pt)
WO (1) WO2018052375A1 (pt)

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CA3177572A1 (en) 2013-03-15 2014-09-25 Takeda Vaccines, Inc. Compositions and methods for dengue virus chimeric constructs in vaccines
WO2016125495A1 (en) 2015-02-05 2016-08-11 Chugai Seiyaku Kabushiki Kaisha Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof
RU2766112C2 (ru) 2016-08-05 2022-02-08 Чугаи Сейяку Кабусики Кайся Композиция для профилактики или лечения связанных с il-8 заболеваний
SG10201607778XA (en) 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
KR20200132938A (ko) * 2018-03-15 2020-11-25 추가이 세이야쿠 가부시키가이샤 지카 바이러스에 대해 교차-반응성을 갖는 항-뎅기 바이러스 항체 및 사용 방법
DK3620174T3 (da) 2018-09-05 2022-03-14 Takeda Vaccines Inc Enhedsdosis af dengue-vaccine og indgivelse deraf
US11464815B2 (en) 2018-09-05 2022-10-11 Takeda Vaccines, Inc. Dengue vaccine unit dose and administration thereof
EP4196163A1 (en) * 2020-08-14 2023-06-21 Chugai Seiyaku Kabushiki Kaisha One-armed antigen-binding molecules and uses thereof
WO2023013618A1 (ja) * 2021-08-02 2023-02-09 国立研究開発法人国立長寿医療研究センター ヒトアストロウイルスの感染レセプターとその応用
CN114410588B (zh) * 2022-01-29 2022-11-04 西安电子科技大学 一种α1β1整合素依赖增强型CAR巨噬细胞及其制备方法和应用

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