PE20190733A1 - Anticuerpos contra el virus del dengue, polipeptidos que contienen regiones fc variantes, y metodos de uso - Google Patents

Anticuerpos contra el virus del dengue, polipeptidos que contienen regiones fc variantes, y metodos de uso

Info

Publication number
PE20190733A1
PE20190733A1 PE2019000518A PE2019000518A PE20190733A1 PE 20190733 A1 PE20190733 A1 PE 20190733A1 PE 2019000518 A PE2019000518 A PE 2019000518A PE 2019000518 A PE2019000518 A PE 2019000518A PE 20190733 A1 PE20190733 A1 PE 20190733A1
Authority
PE
Peru
Prior art keywords
hvr
sequence
dengue virus
regions
methods
Prior art date
Application number
PE2019000518A
Other languages
English (en)
Inventor
Zenjiro Sampei
Xing'er Christine Koo
Katja Fink
Roland Zuest
Original Assignee
Chugai Pharmaceutical Co Ltd
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd, Agency Science Tech & Res filed Critical Chugai Pharmaceutical Co Ltd
Publication of PE20190733A1 publication Critical patent/PE20190733A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se refiere a un anticuerpo aislado que se une a la proteina E del virus del dengue (DENV), caracterizado porque el anticuerpo comprende: a) HVR-H3 identico a la secuencia N° 42; HVR-H2 identico a la secuencia N° 41; HVR-H1 identico a la secuencia N°40 y b) HVR-L3 identico a la secuencia N°45, HVR-L2 identico a la secuencia N°44 y HVR-L1 identico a la secuencia N°4. Tambien se refiere a una formulacion farmaceutica y un vehiculo farmaceuticamente aceptable; un polipeptido que comprende una region Fc variante caracterizado porque comprende al menos una alteracion de aminoacidos en una region Fc parental. Dichos anticuerpos actuan como agentes capaces de neutralizar y/o unirse al serotipo del dengue.
PE2019000518A 2016-09-16 2017-09-15 Anticuerpos contra el virus del dengue, polipeptidos que contienen regiones fc variantes, y metodos de uso PE20190733A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SG10201607778XA SG10201607778XA (en) 2016-09-16 2016-09-16 Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use

Publications (1)

Publication Number Publication Date
PE20190733A1 true PE20190733A1 (es) 2019-05-23

Family

ID=61618863

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019000518A PE20190733A1 (es) 2016-09-16 2017-09-15 Anticuerpos contra el virus del dengue, polipeptidos que contienen regiones fc variantes, y metodos de uso

Country Status (21)

Country Link
US (4) US10604561B2 (es)
EP (1) EP3512879A4 (es)
JP (3) JP6913161B2 (es)
KR (2) KR20210112418A (es)
CN (2) CN116375853A (es)
AR (1) AR109536A1 (es)
AU (2) AU2017326922B2 (es)
BR (1) BR112019004770A2 (es)
CA (1) CA3036505A1 (es)
CL (1) CL2019000640A1 (es)
CO (1) CO2019002482A2 (es)
EC (1) ECSP19018654A (es)
IL (2) IL265290B2 (es)
MX (1) MX2019003057A (es)
MY (1) MY194289A (es)
PE (1) PE20190733A1 (es)
PH (1) PH12019500485A1 (es)
RU (1) RU2758596C2 (es)
SG (3) SG10201607778XA (es)
TW (3) TW202124431A (es)
WO (1) WO2018052375A1 (es)

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KR102225009B1 (ko) 2007-09-26 2021-03-08 추가이 세이야쿠 가부시키가이샤 항체 정상영역 개변체
SG10201913435TA (en) 2013-03-15 2020-03-30 Takeda Vaccines Inc Compositions and methods for dengue virus chimeric constructs in vaccines
MX2017008978A (es) 2015-02-05 2017-10-25 Chugai Pharmaceutical Co Ltd Anticuerpos que comprenden un dominio de union al antigeno dependiente de la concentracion ionica, variantes de la region fc, antiocuerpor de union a interleucina 8 (il-8) y usos de los mismos.
US11053308B2 (en) 2016-08-05 2021-07-06 Chugai Seiyaku Kabushiki Kaisha Method for treating IL-8-related diseases
SG10201607778XA (en) 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
CN112119090B (zh) * 2018-03-15 2023-01-13 中外制药株式会社 对寨卡病毒具有交叉反应性的抗登革热病毒抗体及使用方法
US11464815B2 (en) 2018-09-05 2022-10-11 Takeda Vaccines, Inc. Dengue vaccine unit dose and administration thereof
IL281177B2 (en) 2018-09-05 2024-03-01 Takeda Vaccines Inc Dengue fever vaccine unit dose and its administration
US20230265176A1 (en) * 2020-08-14 2023-08-24 Chugai Seiyaku Kabushiki Kaisha One-armed antigen-binding molecules and uses thereof
WO2023013618A1 (ja) * 2021-08-02 2023-02-09 国立研究開発法人国立長寿医療研究センター ヒトアストロウイルスの感染レセプターとその応用
CN114410588B (zh) * 2022-01-29 2022-11-04 西安电子科技大学 一种α1β1整合素依赖增强型CAR巨噬细胞及其制备方法和应用

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