EA201691095A1 - Мутантные фрагменты ospa и связанные с ними способы и применение - Google Patents
Мутантные фрагменты ospa и связанные с ними способы и применениеInfo
- Publication number
- EA201691095A1 EA201691095A1 EA201691095A EA201691095A EA201691095A1 EA 201691095 A1 EA201691095 A1 EA 201691095A1 EA 201691095 A EA201691095 A EA 201691095A EA 201691095 A EA201691095 A EA 201691095A EA 201691095 A1 EA201691095 A1 EA 201691095A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- applications
- related methods
- ospa
- mutant fragments
- borrelia infection
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1207—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
Изобретение относится к композициям и способам для профилактики и лечения инфекции Borrelia. В частности, настоящее изобретение относится к полипептиду, содержащему гибридный С-концевой фрагмент внешнего поверхностного белка A (OspA), нуклеиновой кислоте, кодирующей его, антителу, специфически связывающему его, фармацевтической композиции (в частности, для применения в качестве лекарственного средства или в способе лечения или профилактики инфекции Borrelia), содержащей полипептид и/или нуклеиновую кислоту, и/или антитело, способу лечения или профилактики инфекции Borrelia, а также способу иммунизации субъекта.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14150682 | 2014-01-09 | ||
| PCT/EP2015/050365 WO2015104396A1 (en) | 2014-01-09 | 2015-01-09 | Mutant fragments of ospa and methods and uses relating thereto |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201691095A1 true EA201691095A1 (ru) | 2017-03-31 |
| EA034554B1 EA034554B1 (ru) | 2020-02-19 |
Family
ID=49917594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201691095A EA034554B1 (ru) | 2014-01-09 | 2015-01-09 | МУТАНТНЫЕ ФРАГМЕНТЫ OspA И СВЯЗАННЫЕ С НИМИ СПОСОБЫ И ПРИМЕНЕНИЕ |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US9975927B2 (ru) |
| EP (2) | EP3092246B1 (ru) |
| JP (1) | JP6505110B2 (ru) |
| KR (1) | KR102460165B1 (ru) |
| CN (1) | CN105980398B (ru) |
| AU (1) | AU2015205520B2 (ru) |
| BR (2) | BR112016015678B1 (ru) |
| CA (1) | CA2931110A1 (ru) |
| CY (1) | CY1121734T1 (ru) |
| DK (1) | DK3092246T3 (ru) |
| EA (1) | EA034554B1 (ru) |
| ES (1) | ES2740985T3 (ru) |
| HR (1) | HRP20191086T1 (ru) |
| HU (1) | HUE043779T2 (ru) |
| LT (1) | LT3092246T (ru) |
| MX (1) | MX369195B (ru) |
| NZ (1) | NZ721015A (ru) |
| PL (1) | PL3092246T3 (ru) |
| PT (1) | PT3092246T (ru) |
| RS (1) | RS59075B1 (ru) |
| SI (1) | SI3092246T1 (ru) |
| TR (1) | TR201910117T4 (ru) |
| WO (1) | WO2015104396A1 (ru) |
| ZA (1) | ZA201602690B (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8986704B2 (en) | 2012-07-06 | 2015-03-24 | Valneva Austria Gmbh | Mutant fragments of OspA and methods and uses relating thereto |
| EP3092246B1 (en) | 2014-01-09 | 2019-06-05 | Valneva Austria GmbH | Mutant fragments of ospa and methods and uses relating thereto |
| CA3059817A1 (en) | 2017-04-13 | 2018-10-18 | Valneva Austria Gmbh | Multivalent ospa polypeptides and methods and uses relating thereto |
| CN110483624B (zh) * | 2019-08-22 | 2021-02-09 | 中国疾病预防控制中心传染病预防控制所 | 伽氏疏螺旋体OspA蛋白C端肽段及其应用 |
| WO2021205017A1 (en) * | 2020-04-09 | 2021-10-14 | Valneva Austria Gmbh | Improvements in vaccine formulations for medical use |
| IL297166A (en) | 2020-04-09 | 2022-12-01 | Valneva Austria Gmbh | Compositions containing three ospa fusion proteins for medical use |
| WO2023212520A1 (en) | 2022-04-25 | 2023-11-02 | Pfizer Inc. | Compositions and methods for eliciting an immune response protective against lyme disease |
| WO2024050512A2 (en) * | 2022-09-02 | 2024-03-07 | The Medical College Of Wisconsin, Inc. | Use of immunogenic t cell epitopes for lyme disease vaccination and diagnosis |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7008625B2 (en) | 1993-11-01 | 2006-03-07 | Research Foundation Of The State University Of New York | Recombinant constructs of Borrelia burgdorferi |
| US6248562B1 (en) | 1993-11-01 | 2001-06-19 | Research Foundation State University Of New York | Chimeric proteins comprising borrelia polypeptides and uses therefor |
| ES2298249T3 (es) | 2000-08-18 | 2008-05-16 | Research Foundation Of State University Of New York | Ospa modificada de borrelia burgdorferi. |
| UA89481C2 (ru) | 2003-09-30 | 2010-02-10 | Центокор, Инк. | Эритропоэтиновые миметические шарнирно-сердцевинные миметитела человека, композиции, способы и применение |
| AU2007295927A1 (en) | 2006-09-15 | 2008-03-20 | Intercell Ag | Borrelia antigens |
| DK2068918T4 (da) | 2006-09-26 | 2024-09-02 | Access To Advanced Health Inst | Vaccinesammensætning omfattende syntetisk adjuvant |
| AU2011252850B2 (en) * | 2010-05-14 | 2016-03-17 | Baxalta GmbH | OspA chimeras and use thereof in vaccines |
| TWI507413B (zh) | 2010-11-15 | 2015-11-11 | Nat Health Research Institutes | 脂質化多抗原表位疫苗 |
| TW201221642A (en) | 2010-11-15 | 2012-06-01 | Nat Health Research Institutes | Method of producing lipidated polypeptides |
| US8986704B2 (en) | 2012-07-06 | 2015-03-24 | Valneva Austria Gmbh | Mutant fragments of OspA and methods and uses relating thereto |
| EP3092246B1 (en) | 2014-01-09 | 2019-06-05 | Valneva Austria GmbH | Mutant fragments of ospa and methods and uses relating thereto |
| CZ2014320A3 (cs) | 2014-05-09 | 2015-11-18 | VÝZKUMNÝ ÚSTAV VETERINÁRNÍHO LÉKAŘSTVÍ, v.v.i. | Polyepitopový antigen, vakcinační konstrukt a vakcína pro prevenci lymeské boreliózy |
| CA3059817A1 (en) | 2017-04-13 | 2018-10-18 | Valneva Austria Gmbh | Multivalent ospa polypeptides and methods and uses relating thereto |
-
2015
- 2015-01-09 EP EP15703228.5A patent/EP3092246B1/en active Active
- 2015-01-09 JP JP2016541706A patent/JP6505110B2/ja active Active
- 2015-01-09 LT LTEP15703228.5T patent/LT3092246T/lt unknown
- 2015-01-09 MX MX2016008989A patent/MX369195B/es active IP Right Grant
- 2015-01-09 BR BR112016015678A patent/BR112016015678B1/pt active IP Right Grant
- 2015-01-09 WO PCT/EP2015/050365 patent/WO2015104396A1/en active Application Filing
- 2015-01-09 DK DK15703228.5T patent/DK3092246T3/da active
- 2015-01-09 KR KR1020167015981A patent/KR102460165B1/ko active IP Right Grant
- 2015-01-09 EA EA201691095A patent/EA034554B1/ru unknown
- 2015-01-09 US US15/110,151 patent/US9975927B2/en active Active
- 2015-01-09 PL PL15703228T patent/PL3092246T3/pl unknown
- 2015-01-09 HU HUE15703228A patent/HUE043779T2/hu unknown
- 2015-01-09 AU AU2015205520A patent/AU2015205520B2/en active Active
- 2015-01-09 PT PT15703228T patent/PT3092246T/pt unknown
- 2015-01-09 CA CA2931110A patent/CA2931110A1/en active Pending
- 2015-01-09 TR TR2019/10117T patent/TR201910117T4/tr unknown
- 2015-01-09 EP EP19177679.8A patent/EP3564257A1/en active Pending
- 2015-01-09 NZ NZ721015A patent/NZ721015A/en unknown
- 2015-01-09 SI SI201530777T patent/SI3092246T1/sl unknown
- 2015-01-09 ES ES15703228T patent/ES2740985T3/es active Active
- 2015-01-09 RS RS20190970A patent/RS59075B1/sr unknown
- 2015-01-09 CN CN201580003319.2A patent/CN105980398B/zh active Active
- 2015-01-09 BR BR122023024315-3A patent/BR122023024315A2/pt unknown
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2016
- 2016-04-19 ZA ZA2016/02690A patent/ZA201602690B/en unknown
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2018
- 2018-04-04 US US15/944,835 patent/US10766931B2/en active Active
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2019
- 2019-06-17 HR HRP20191086 patent/HRP20191086T1/hr unknown
- 2019-06-27 CY CY20191100676T patent/CY1121734T1/el unknown
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2020
- 2020-08-11 US US16/990,023 patent/US11572392B2/en active Active
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2023
- 2023-01-06 US US18/150,971 patent/US20230322869A1/en active Pending
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