MX2020004420A - Polipeptidos efectores de la subunidad a de la toxina shiga resistentes a la disociacion por proteasa y moleculas dirigidas a las celulas que los comprenden. - Google Patents

Polipeptidos efectores de la subunidad a de la toxina shiga resistentes a la disociacion por proteasa y moleculas dirigidas a las celulas que los comprenden.

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Publication number
MX2020004420A
MX2020004420A MX2020004420A MX2020004420A MX2020004420A MX 2020004420 A MX2020004420 A MX 2020004420A MX 2020004420 A MX2020004420 A MX 2020004420A MX 2020004420 A MX2020004420 A MX 2020004420A MX 2020004420 A MX2020004420 A MX 2020004420A
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Mexico
Prior art keywords
cell
molecules
targeted molecules
shiga toxin
protease
Prior art date
Application number
MX2020004420A
Other languages
English (en)
Inventor
Eric Poma
Erin Willert
Jason Kim
Jack Higgins
Original Assignee
Molecular Templates Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2015/012970 external-priority patent/WO2015113007A1/en
Application filed by Molecular Templates Inc filed Critical Molecular Templates Inc
Publication of MX2020004420A publication Critical patent/MX2020004420A/es

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Abstract

L a p r e s e n t e i n v e n c i ó n p r o p o r c i o n a m o l é c u l a s r e s i s t e n t e s a l a d i s o c i a c i ó n p o r p r o t e a s a q u e c o m p r e n d e e n l o s p o l i p é p t i d o s e f e c t o r e s d e l a t o x i n a S h i g a c a p a c e s d e e x h i b i r p o t e n t e s f u n c i o n e s d e l a t o x i n a S h i g a ( p o r e j e m p l o , e l e n c a m i n a m i e n t o s u b c e l u l a r y l a c i t o t o x i c i d a d ) . L a p r e s e n t e i n v e n c i ó n t a m b i é n p r o p o r c i o n a m o l é c u l a s r e s i s t e n t e s a l a d i s o c i a c i ó n p o r p r o t e a s a d i r i g i d a s a l a s c é l u l a s p a r a d i r i g i r s e a t i p o s e s p e c í f i c o s d e c é l u l a s , p o r e j e m p l o, l a s c é l u l a s i n f e c t a d a s o m a l i g n a s . C i e r t a s m o l é c u l a s d e l a p r e s e n t e i n v e n c i ó n s o n c i t o t ó x i c a s , y c i e r t a s m o l é c u l a s d i r i g i d a s a l a s c é l u l a s d e l a p r e s e n t e i n v e n c i ó n s e p u e d e u t i l i z a r p a r a l a a n i q u i l a c i ó n d i r i g i d a d e t i p o s e s p e c í f i c o s d e c é l u l a s , y p a r a e l t r a t a m i e n t o d e u n a v a r i e d a d d e e n f e r m e d a d e s , t r a s t o r n o s y a f e c c i o n e s , i n c l u y e n d o c á n c e r e s , t u m o r e s , a n o r m a l i d a d e s d e l c r e c i m i e n t o , t r a s t o r n o s i n m u n o l ó g i c o s e i n f e c c i o n e s m i c r o b i a n a s . C i e r t a s m o l é c u l a s d i r i g i d a s a l a s c é l u l a s d e l a i n v e n c i ó n e x h i b e n u n a m e j o r t o l e r a b i l i d a d i n v i v o c o m p a r á n d o s e c o n l a s m o l é c u l a s d i r i g i d a s a l a s c é l u l a s r e l a c i o n a d a s q u e c o m p r e n d e n l o s p o l i p é p t i d o s e f e c t o r e s d e l a t o x i n a S h i g a d e t i p o s i l v e s t r e s e n s i b l e s a l a d i s o c i a c i ó n p o r p r o t e a s a . L a s m o l é c u l a s d i r i g i d a s a l a s c é l u l a s d e l a i n v e n c i ó n p u e d e n s u m i n i s t r a r m a t e r i a l e s a d i c i o n a l e s , t a l e s c o m o , p o r e j e m p l o , a n t í g e n o s , a g e n t e s c i t o t ó x i c o s y a g e n t e s p r o m o t o r e s d e l a d e t e c c i ó n , h a c i a e l i n t e r i o r d e l a s c é l u l a s o b j e t i v o .
MX2020004420A 2014-06-11 2016-12-08 Polipeptidos efectores de la subunidad a de la toxina shiga resistentes a la disociacion por proteasa y moleculas dirigidas a las celulas que los comprenden. MX2020004420A (es)

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Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3868776A1 (en) 2014-01-27 2021-08-25 Molecular Templates, Inc. Mhc class i epitope delivering polypeptides
US11142584B2 (en) 2014-03-11 2021-10-12 Molecular Templates, Inc. CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
ES2717751T3 (es) 2014-06-11 2019-06-25 Molecular Templates Inc Polipéptidos efectores de la subunidad A de la toxina de Shiga resistentes a la escisión por proteasa y moléculas dirigidas a células que los comprenden
US10392425B2 (en) 2015-02-05 2019-08-27 Molecular Templates, Inc. Multivalent CD20-binding molecules comprising Shiga toxin A subunit effector regions and enriched compositions thereof
RS60441B1 (sr) 2015-05-30 2020-07-31 Molecular Templates Inc De-imunizovane, strukture shiga toksin a podjedinice i ciljani ćelijski molekuli koji sadrže isti
EP3325510A2 (en) 2015-07-26 2018-05-30 Molecular Templates, Inc. Cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes
IL302130A (en) * 2016-12-07 2023-06-01 Molecular Templates Inc Shiga toxin A subunit activator polypeptides, Shiga toxin activator scaffolds and cell-targeting molecules for site-specific conjugation
CN110234348A (zh) 2016-12-16 2019-09-13 蓝鳍生物医药公司 抗-含cub结构域蛋白1(cdcp1)抗体、抗体药物缀合物及其使用方法
KR102590672B1 (ko) 2017-01-25 2023-10-18 몰레큘러 템플레이츠, 인코퍼레이션. 탈면역된 시가 독소 a 서브유닛 이펙터 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자
EP3596108A4 (en) 2017-03-15 2020-12-23 Pandion Operations, Inc. TARGETED IMMUNOTOLERANCE
JP2020521452A (ja) 2017-05-24 2020-07-27 パンディオン・セラピューティクス・インコーポレイテッド 標的化免疫寛容
AU2018328223A1 (en) * 2017-09-05 2020-03-12 GLAdiator Biosciences, Inc. Delivery of payloads to stem cells
US10174092B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
WO2019204272A1 (en) 2018-04-17 2019-10-24 Molecular Templates, Inc. Her2-targeting molecules comprising de-immunized, shiga toxin a subunit scaffolds
WO2020081493A1 (en) 2018-10-16 2020-04-23 Molecular Templates, Inc. Pd-l1 binding proteins
WO2020154475A1 (en) 2019-01-23 2020-07-30 Molecular Templates, Inc. Proteins comprising modified immunoglobulin variable light chains
AU2020213103A1 (en) 2019-01-23 2021-07-29 Millennium Pharmaceuticals, Inc. CD38-binding proteins comprising de-immunized Shiga toxin a subunit effectors
JP2022533702A (ja) 2019-05-20 2022-07-25 パンディオン・オペレーションズ・インコーポレイテッド ＭＡｄＣＡＭ標的化免疫寛容
KR20220081977A (ko) * 2019-09-18 2022-06-16 몰레큘러 템플레이츠, 인코퍼레이션. 시가 독소 a 서브유닛 스캐폴드를 포함하는 pd-l1 결합분자(pd-l1 binding molecules comprising shiga toxin a subunit scaffolds)
WO2021055816A1 (en) 2019-09-18 2021-03-25 Molecular Templates, Inc. Pd-l1 binding molecules comprising shiga toxin a subunit scaffolds
US20210155671A1 (en) 2019-11-24 2021-05-27 Molecular Templates, Inc. Uses of cd20-binding molecules and additional therapeutic agents
US11981715B2 (en) 2020-02-21 2024-05-14 Pandion Operations, Inc. Tissue targeted immunotolerance with a CD39 effector
CN115956086A (zh) * 2020-05-06 2023-04-11 萨摩亚商柏沛生医股份有限公司 用于针对癌症及传染病的免疫疗法的融合蛋白
CA3213295A1 (en) 2021-03-17 2022-09-22 Molecular Templates, Inc. Pd-l1 binding proteins comprising shiga toxin a subunit scaffolds and cd8+ t cell antigens

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5080898A (en) 1982-05-12 1992-01-14 The University Hospital Enzymatically active toxin coupled to a cell-specific ligand
US4894443A (en) 1984-02-08 1990-01-16 Cetus Corporation Toxin conjugates
US5668255A (en) 1984-06-07 1997-09-16 Seragen, Inc. Hybrid molecules having translocation region and cell-binding region
US6022950A (en) 1984-06-07 2000-02-08 Seragen, Inc. Hybrid molecules having translocation region and cell-binding region
US5091178A (en) 1986-02-21 1992-02-25 Oncogen Tumor therapy with biologically active anti-tumor antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5135736A (en) 1988-08-15 1992-08-04 Neorx Corporation Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
WO1991009871A1 (en) * 1989-12-22 1991-07-11 Seragen Incorporated Hybrid molecules having translocation region and cell-binding region
US5635384A (en) 1990-06-11 1997-06-03 Dowelanco Ribosome-inactivating proteins, inactive precursor forms thereof, a process for making and a method of using
US5621083A (en) 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US6146850A (en) 1991-11-04 2000-11-14 Xoma Corporation Proteins encoding gelonin sequences
JPH08510642A (ja) 1993-05-12 1996-11-12 ゾマ コーポレイション ゲロニンおよび抗体から成る免疫毒素
US5612474A (en) 1994-06-30 1997-03-18 Eli Lilly And Company Acid labile immunoconjugate intermediates
AU3374795A (en) 1994-08-29 1996-03-22 Prizm Pharmaceuticals, Inc. Conjugates of vascular endothelial growth factor with targeted agents
JPH11506424A (ja) 1995-03-24 1999-06-08 オフィディアン ファーマシューティカルズ インコーポレーテッド ベロ毒素産生大腸菌に対する治療
US5667786A (en) 1995-06-07 1997-09-16 Novavax, Inc. Method for treating tumors with a toxin
CA2265900C (en) 1996-09-09 2007-07-31 Zealand Pharmaceuticals A/S Improved solid-phase peptide synthesis and agent for use in such synthesis
AR010218A1 (es) 1996-09-10 2000-06-07 Military Henry M Jackson Foundation For The Advancement Of Una familia de proteinas bacterianas multi-unidad
US6306393B1 (en) 1997-03-24 2001-10-23 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
CA2222993A1 (en) 1998-02-04 1999-08-04 The Ontario Cancer Institute A method for using a ribosome-inactivating protein complex as a structural template and a molecular search engine in the design, construction and screening of combinatorial protein libraries
AU770718B2 (en) 1998-06-05 2004-02-26 Mayo Foundation For Medical Education And Research Use of genetically engineered antibodies to CD38 to treat multiple myeloma
AU2004202331A1 (en) * 1998-07-22 2004-06-24 Osprey Pharmaceuticals Limited Methods and Compositions for Treating Secondary Tissue Damage and Other Inflammatory Conditions and Disorders
DK1098664T3 (da) 1998-07-22 2003-11-17 Osprey Pharmaceuticals Ltd Sammensætninger og deres anvendelser til at behandle sekundær vævsskade og andre inflammatoriske tilstande og forstyrrelser
US7157418B1 (en) 1998-07-22 2007-01-02 Osprey Pharmaceuticals, Ltd. Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
US6770456B1 (en) 1998-07-29 2004-08-03 Ludwig Institute For Cancer Research Endogenous retrovirus tumor associated nucleic acids and antigens
US8663692B1 (en) 1999-05-07 2014-03-04 Pharmasol Gmbh Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same
US7527787B2 (en) 2005-10-19 2009-05-05 Ibc Pharmaceuticals, Inc. Multivalent immunoglobulin-based bioactive assemblies
US6492498B1 (en) 1999-11-15 2002-12-10 Regents Of The University Of Minnesota Multimeric immunotoxins
US20010031485A1 (en) 2000-03-22 2001-10-18 Sibtech, Inc. Recombinant proteins containing Shiga-like toxin and vascular endothelial growth factor fragments
US7267973B2 (en) 2000-03-22 2007-09-11 Sibtech, Inc. Nucleic acids encoding recombinant proteins containing Shiga-like toxin and vascular endothelial growth factor
PL357939A1 (en) 2000-04-11 2004-08-09 Genentech, Inc. Multivalent antibodies and uses therefor
US20050163807A1 (en) 2002-02-04 2005-07-28 Xiaoyan Liu Anticancer agents using vero toxin variants
EP1386927B1 (en) * 2002-08-02 2005-03-30 Institut Curie Shiga toxin B-subunit as a vector for tumor diagnosis and drug delivery to GB3 expressing tumors
EP1944320A1 (en) 2002-12-16 2008-07-16 Genentech, Inc. Immunoglobulin variants and uses thereof
AU2003303374A1 (en) 2002-12-20 2004-07-22 The Johns Hopkins University Treatment of metastatic cancer with the b-subunit of shiga toxin
US7834258B2 (en) 2003-06-30 2010-11-16 Mu-Hyeon Choe Dimer of chimeric recombinant binding domain-functional group fusion formed via disulfide-bond-bridge and the processes for producing the same
US8147832B2 (en) 2003-08-14 2012-04-03 Merck Patent Gmbh CD20-binding polypeptide compositions and methods
AU2004293471C1 (en) 2003-11-25 2011-02-24 The Government Of The United States, As Represented By The Secretary Of Health And Human Services Mutated anti-CD22 antibodies and immunoconjugates
US7585942B2 (en) 2003-11-25 2009-09-08 Anjin Corporation Diphtheria toxin variant
DE602004027168D1 (de) 2004-03-26 2010-06-24 Molecular Templates Inc Bibliothek von toxin mutanten und deren verwendung
SI2567976T1 (sl) 2005-03-23 2017-11-30 Genmab A/S Protitelesa usmerjena proti cd38 za zdravljenje multiplega mieloma
US7771955B2 (en) 2005-06-09 2010-08-10 University Of Maryland Affinity membrane for capture of a target biomolecule and formation thereof by site-directed immobilization of a capture biomolecule
MX2007015942A (es) 2005-07-01 2008-03-07 Medarex Inc Anticuerpos monoclonales humanos para ligandos 1 (pd-l1) de muerte programada.
FI20055417A0 (fi) 2005-07-20 2005-07-20 Glykos Finland Oy Syöpäpesifiset glykaanit ja niiden käyttö
CA2616386A1 (en) 2005-07-25 2007-02-01 Trubion Pharmaceuticals Inc. Single dose use of cd20-specific binding molecules
CA2619048A1 (en) * 2005-08-15 2007-02-22 The Regents Of The University Of California Vegf-activated fas ligands
ES2493465T3 (es) 2005-09-26 2014-09-11 Molecular Templates, Inc. Biblioteca a partir de toxinas mutantes y procesos de utilización de la misma
GB0524788D0 (en) 2005-12-05 2006-01-11 Affibody Ab Polypeptides
CN101389791A (zh) 2005-12-23 2009-03-18 维文蒂阿生物技术股份有限公司 融合蛋白文库的产生和筛选方法及其应用
EP1991565B1 (en) 2006-02-16 2015-01-21 The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Shiga toxoid chimeric proteins
JP4954293B2 (ja) * 2006-12-29 2012-06-13 オスプレイ・ファーマシューティカルズ・ユーエスエイ・インコーポレイテッド 改変毒素を選択および生産する方法、改変毒素を含む複合体、およびそれらの使用
EP2167528B1 (en) 2007-06-21 2018-01-10 Angelica Therapeutics, INC. Modified toxins
EP2187971A2 (en) 2007-08-01 2010-05-26 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services A fold-back diabody diphtheria toxin immunotoxin and methods of use
CA2698357C (en) 2007-09-04 2017-06-06 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Deletions in domain ii of pseudomonas exotoxin a that reduce non-specific toxicity
EP2215247B1 (en) 2007-11-13 2014-09-24 The Scripps Research Institute Production of cytotoxic antibody-toxin fusion in eukaryotic algae
US8975382B2 (en) 2007-11-27 2015-03-10 Ablynx N.V. Amino acid sequences directed against HER2 and polypeptides comprising the same for the treatment of cancers and/or tumors
US8315343B2 (en) 2007-12-17 2012-11-20 Telefonaktiebolaget Lm Ericsson (Publ) Multi-antenna receiver interference cancellation method and apparatus
WO2009110944A1 (en) 2008-02-29 2009-09-11 Angelica Therapeutics, Inc. Modified toxins
MX2011000891A (es) 2008-07-21 2011-06-01 Immunomedics Inc Variantes estructurales de anticuerpos para caracteristicas terapeuticas mejoradas.
AU2009293640A1 (en) 2008-09-22 2010-03-25 Calmune Corporation Methods and vectors for display of 2G12 -derived domain exchanged antibodies
CA2748873C (en) 2009-01-23 2017-09-12 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Methods and compositions based on shiga toxin type 2 protein
CA2757079C (en) 2009-04-20 2015-05-19 Pfizer Inc. Control of protein glycosylation and compositions and methods relating thereto
WO2011009624A1 (en) 2009-07-22 2011-01-27 Cenix Bioscience Gmbh Delivery system and conjugates for compound delivery via naturally occurring intracellular transport routes
EP2371864A1 (en) 2010-03-23 2011-10-05 Ganymed Pharmaceuticals AG Monoclonal antibodies for treatment of cancer
CN107253992B (zh) 2010-05-27 2022-03-11 根马布股份公司 针对her2的单克隆抗体
GB201013989D0 (en) 2010-08-20 2010-10-06 Univ Southampton Biological materials and methods of using the same
PL219845B1 (pl) 2011-01-05 2015-07-31 Adamed Spółka Z Ograniczoną Odpowiedzialnością Przeciwnowotworowe białko fuzyjne
EP2476441A1 (en) * 2011-01-13 2012-07-18 Universitat Autònoma De Barcelona Methods and reagents for efficient and targeted delivery of therapeutic molecules to CXCR4 cells
WO2012101235A1 (en) 2011-01-26 2012-08-02 Cenix Bioscience Gmbh Delivery system and conjugates for compound delivery via naturally occurring intracellular transport routes
SG10201608138RA (en) * 2011-02-01 2016-11-29 Genmab As Human antibodies and antibody-drug conjugates against cd74
US8895006B2 (en) 2011-03-04 2014-11-25 Rutgers, The State University Of New Jersey Ricin ribosome binding protein compositions and methods of use thereof
CN103648525B (zh) 2011-05-06 2016-08-24 由卫生与公共服务部部长代表的美国政府 靶向间皮素的重组免疫毒素
PL397167A1 (pl) * 2011-11-28 2013-06-10 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Przeciwnowotworowe bialko fuzyjne
EP2817341A4 (en) 2012-02-23 2015-12-02 Harvard College MODIFIED MICROBIAL TOXIN RECEPTOR FOR ADMINISTERING AGENTS IN CELLS
JP6548630B2 (ja) 2013-03-12 2019-07-24 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. 特定の細胞型の選択的死滅のための細胞標的化結合領域と志賀毒素ａサブユニット領域とを含む細胞毒性タンパク質
GB2519786A (en) 2013-10-30 2015-05-06 Sergej Michailovic Kiprijanov Multivalent antigen-binding protein molecules
US20160177284A1 (en) 2014-01-27 2016-06-23 Molecular Templates, Inc. Cell-targeted molecules comprising amino-terminus proximal or amino-terminal shiga toxin a subunit effector regions
US20210138076A2 (en) 2014-01-27 2021-05-13 Molecular Templates, Inc. Cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes
EP3868776A1 (en) 2014-01-27 2021-08-25 Molecular Templates, Inc. Mhc class i epitope delivering polypeptides
JP6814634B2 (ja) 2014-02-05 2021-01-20 モレキュラー テンプレーツ，インク．Ｍｏｌｅｃｕｌａｒ Ｔｅｍｐｌａｔｅｓ， Ｉｎｃ． リボ毒性の一時的な減少に基づき、細胞毒性組換えポリペプチドをスクリーニングし、選択し、同定する方法
US11142584B2 (en) 2014-03-11 2021-10-12 Molecular Templates, Inc. CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
ES2717751T3 (es) 2014-06-11 2019-06-25 Molecular Templates Inc Polipéptidos efectores de la subunidad A de la toxina de Shiga resistentes a la escisión por proteasa y moléculas dirigidas a células que los comprenden
AU2015276136A1 (en) 2014-06-18 2016-12-22 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus Car-expressing NK-92 cells as cell therapeutic agents
CN105713087B (zh) 2014-11-12 2020-05-08 北京康乐卫士生物技术股份有限公司 人乳头瘤病毒58型单克隆抗体及其应用
US10392425B2 (en) 2015-02-05 2019-08-27 Molecular Templates, Inc. Multivalent CD20-binding molecules comprising Shiga toxin A subunit effector regions and enriched compositions thereof
SG11201707144VA (en) 2015-03-04 2017-09-28 Igm Biosciences Inc Cd20 binding molecules and uses thereof
EP4293979A3 (en) 2015-04-07 2024-04-17 Umbra Technologies Ltd. System and method for virtual interfaces and advanced smart routing in a global virtual network
RS60441B1 (sr) 2015-05-30 2020-07-31 Molecular Templates Inc De-imunizovane, strukture shiga toksin a podjedinice i ciljani ćelijski molekuli koji sadrže isti
EP3325510A2 (en) 2015-07-26 2018-05-30 Molecular Templates, Inc. Cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes
US11326182B2 (en) 2016-04-29 2022-05-10 Voyager Therapeutics, Inc. Compositions for the treatment of disease
KR102543323B1 (ko) 2016-10-30 2023-06-14 상하이 헨리우스 바이오테크, 인크. 항-pd-l1 항체 및 변이체
IL302130A (en) 2016-12-07 2023-06-01 Molecular Templates Inc Shiga toxin A subunit activator polypeptides, Shiga toxin activator scaffolds and cell-targeting molecules for site-specific conjugation
US11597914B2 (en) 2016-12-26 2023-03-07 Dankook University Cheonan Campus Industry Academic Cooperation Foundation IgG type monoclonal antibodies specifically binding to odontoblast surface
KR102590672B1 (ko) 2017-01-25 2023-10-18 몰레큘러 템플레이츠, 인코퍼레이션. 탈면역된 시가 독소 a 서브유닛 이펙터 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자

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AU2015274647A1 (en) 2016-12-15
ES2717751T3 (es) 2019-06-25
MX2016016288A (es) 2017-10-12
AU2019240612B2 (en) 2020-09-17
IL286804A (en) 2021-10-31
AU2015274647B2 (en) 2019-08-22
KR102496206B1 (ko) 2023-02-06
CA2947048C (en) 2023-10-17
CN106604934A (zh) 2017-04-26
IL249006A0 (en) 2017-01-31
CN113831416A (zh) 2021-12-24
JP2020180154A (ja) 2020-11-05
EP3137488B1 (en) 2019-01-02
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